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公开(公告)号：WO2019030173A1
公开(公告)日：2019-02-14
申请号：PCT/EP2018/071268
申请日：2018-08-06
发明人： LUTZ, Christian , SIMON, Werner , WERNER-SIMON, Susanne , MÜLLER, Christoph , HECHLER, Thorsten , KULKE, Michael
摘要： The invention relates to novel methods for synthesizing amanitin derivatives having a hydroxy group attached to the central tryptophan moiety. The invention furthermore relates to novel amanitin derivatives having a hydroxy group attached to position 4', 5' or 7' of the central tryptophan moiety, novel conjugates of such amanitin derivatives, and pharmaceutical compositions comprising such conjugates.
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公开(公告)号：WO2014135282A8
公开(公告)日：2015-09-17
申请号：PCT/EP2014000614
申请日：2014-03-10
发明人： MÜLLER CHRISTOPH , ANDERL JAN , SIMON WERNER , LUTZ CHRISTIAN , HECHLER TORSTEN
CPC分类号： C07K7/64 , A61K47/6831 , A61K47/6851 , A61K47/6855 , C07K16/32
摘要： The invention relates to tumour therapy. In one aspect, the present invention relates to conjugates of an amatoxin and a target-binding moiety, e.g. an antibody, connected by certain linkages, which are useful in the treatment of cancer and other disorders and diseases. In a further aspect the invention relates to pharmaceutical compositions comprising such conjugates.
摘要翻译： 本发明涉及肿瘤治疗。 在一个方面，本发明涉及阿莫地辛和靶结合部分的缀合物，例如， 通过某些连接相连的抗体，其可用于治疗癌症和其它疾病和疾病。 在另一方面，本发明涉及包含这种缀合物的药物组合物。
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公开(公告)号：WO2017149077A1
公开(公告)日：2017-09-08
申请号：PCT/EP2017/054911
申请日：2017-03-02
发明人： LUTZ, Christian , ANDERL, Jan , MÜLLER, Christoph , SIMON, Werner , WERNER-SIMON, Susanne , HECHLER, Torsten , KULKE, Michael
摘要： The invention relates to a conjugate comprising (a) an amatoxin comprising (i) an amino acid 4 with a 6'-deoxy position; and (ii) an amino acid 8 with an S-deoxy position; (b) a target-binding moiety; and (c) optionally a linker linking said amatoxin and said target-binding moiety. The invention furthermore relates to a pharmaceutical composition comprising such conjugate.
摘要翻译： 本发明涉及一种缀合物，其包含（a）包含（i）具有6'-脱氧位置的氨基酸4; 和（ii）具有S-脱氧位置的氨基酸8; （b）靶标结合部分; 和（c）任选地连接所述番薯软骨素和所述靶结合部分的接头。 本发明还涉及包含这种缀合物的药物组合物。
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4.发明申请USE OF ETHER-LINKED LYSOPHOSPHATIDYLCHOLINES AND ALKYLPHOSPHOCHOLINES FOR THE TREATMENT OF PAPILLOMA VIRUS INDUCED WARTS AND SARCOIDS 审中-公开用于治疗斑马鱼病毒诱导的战争和SARCOIDS的醚连接的赖氨酸磷脂酰胆碱和烷基磷酰胆碱的使用
公开(公告)号：WO2006122716A1
公开(公告)日：2006-11-23
申请号：PCT/EP2006/004477
申请日：2006-05-12
IPC分类号： A61K31/685 , A61P31/20
CPC分类号： A61K31/685
摘要： The invention refers to the use of ether-linked lysophosphatidylcholines and alkylphosphocholines, preferentially hexadecylphosphocholine (Miltefosine) for the treatment of papilloma virus induced warts like hand and plantar warts, external anogenital warts and genital warts in human beings and papilloma virus induced sarcoids in animals, preferably horses.
摘要翻译： 本发明涉及使用醚连接的溶血磷脂酰胆碱和烷基磷酰胆碱，优选十六烷基磷酸胆碱（Miltefosine）用于治疗乳头状瘤病毒诱导的疣如手和跖疣，外部肛门生殖器疣和人类中的生殖器疣和动物中的乳头状瘤病毒诱导的结节， 最好是马。
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公开(公告)号：WO2014135282A1
公开(公告)日：2014-09-12
申请号：PCT/EP2014/000614
申请日：2014-03-10
CPC分类号： C07K7/64 , A61K47/6831 , A61K47/6851 , A61K47/6855 , C07K16/32
摘要： The invention relates to tumour therapy. In one aspect, the present invention relates to conjugates of an amatoxin and a target-binding moiety, e.g. an antibody, connected by certain linkages, which are useful in the treatment of cancer and other disorders and diseases. In a further aspect the invention relates to pharmaceutical compositions comprising such conjugates.
摘要翻译： 本发明涉及肿瘤治疗。 在一个方面，本发明涉及阿莫地辛和靶结合部分的缀合物，例如， 通过某些连接相连的抗体，其可用于治疗癌症和其它疾病和疾病。 在另一方面，本发明涉及包含这种缀合物的药物组合物。
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6.发明申请METHODS FOR SYNTHESIZING AMATOXIN BUILDING BLOCK AND AMATOXINS 审中-公开合成AMATOXIN BUILDING BLOCK和AMATOXINS的方法
公开(公告)号：WO2014009025A1
公开(公告)日：2014-01-16
申请号：PCT/EP2013/002084
申请日：2013-07-12
IPC分类号： C07C229/22 , C07K7/52
CPC分类号： C07C227/16 , C07C229/22 , C07D207/16 , C07K1/065 , C07K1/10 , Y02P20/55
摘要： The invention relates to novel methods for synthesizing a synthon for γ,δ- dihydroxyisoleucine 1 (CAS No. 55399-94-5] as building block for the synthesis of amatoxins, and for novel methods for synthesizing amatoxins using such building block.
摘要翻译： 本发明涉及用于合成γ，δ-二羟基异亮氨酸1（CAS号55399-94-5）的合成子的新方法，作为用于合成氨氧化还原酶的结构单元，以及使用这种结构单元合成氨氧化还原的新方法。
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公开(公告)号：WO2012119787A1
公开(公告)日：2012-09-13
申请号：PCT/EP2012/001072
申请日：2012-03-09
发明人： SIMON, Werner , LUTZ, Christian , MÜLLER, Christoph , ANDERL, Jan
CPC分类号： A61K47/6813 , A61K38/12 , A61K47/61 , A61K47/64 , A61K47/66 , A61K47/6831 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6891
摘要： The invention relates to tumour therapy. In one aspect, the present invention relates to conjugates of an amatoxin and a target-binding moiety, e.g. an antibody, connected by certain linkages, which are useful in the treatment of cancer. In a further aspect the invention relates to pharmaceutical compositions comprising such conjugates.
摘要翻译： 本发明涉及肿瘤治疗。 在一个方面，本发明涉及阿莫地辛和靶结合部分的缀合物，例如， 通过某些连接相连的抗体，其可用于治疗癌症。 在另一方面，本发明涉及包含这种缀合物的药物组合物。
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公开(公告)号：WO2019030171A1
公开(公告)日：2019-02-14
申请号：PCT/EP2018/071265
申请日：2018-08-06
发明人： WERNER, Simon , WERNER-SIMON, Susanne , LUTZ, Christian , MÜLLER, Christoph , HECHLER, Thorsten , KULKE, Michael
摘要： The invention relates to novel methods for synthesizing amanitin derivatives having an amino group attached to position 6' of the central tryptophan moiety. The invention furthermore relates to a novel amanitin derivative having an amino group attached to position 6' of the central tryptophan moiety, novel conjugates of such amanitin derivative, and pharmaceutical compositions comprising such conjugates.
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公开(公告)号：WO2016142049A1
公开(公告)日：2016-09-15
申请号：PCT/EP2016/000397
申请日：2016-03-07
CPC分类号： A61K47/6855 , A61K38/12 , A61K47/6831 , A61K47/6851 , C07K7/64 , C07K16/30 , C07K16/32 , C07K2317/24 , C07K2317/52 , C07K2319/55
摘要： The invention relates to conjugates comprising amatoxins and antibodies, in particular amatoxins linked to antibodies comprising specific cysteine residues.
摘要翻译： 本发明涉及包含阿姆斯敏毒素和抗体的缀合物，特别是与包含特异性半胱氨酸残基的抗体连接的氨苄西毒素。
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公开(公告)号：WO2012041504A1
公开(公告)日：2012-04-05
申请号：PCT/EP2011/004875
申请日：2011-09-29
发明人： ANDERL, Jan , SIMON, Werner , MÜLLER, Christoph
CPC分类号： C07K16/30 , A61K47/6811 , A61K47/6849 , A61K47/6851 , A61K47/6855
摘要： The invention relates to tumour therapy. In one aspect, the present invention relates to conjugates of an amatoxin and a target-binding moiety, e.g. an antibody, connected by a linker comprising a urea moiety, which are useful in the treatment of cancer. In a further aspect the invention relates to pharmaceutical compositions comprising such conjugates.
摘要翻译： 本发明涉及肿瘤治疗。 在一个方面，本发明涉及阿莫地辛和靶结合部分的缀合物，例如， 通过包含尿素部分的接头连接的抗体，其可用于治疗癌症。 在另一方面，本发明涉及包含这种缀合物的药物组合物。
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