公开(公告)号：WO2013176970A1

公开(公告)日：2013-11-28

申请号：PCT/US2013/041492

申请日：2013-05-17

申请人： MERCK SHARP & DOHME CORP. ,  STACHEL, Shawn, J. ,  EGBERTSON, Melissa ,  BRNARDIC, Edward ,  JONES, Kristen ,  SANDERS, John, M. ,  HENZE, Darrell, A.

发明人： STACHEL, Shawn, J. ,  EGBERTSON, Melissa ,  BRNARDIC, Edward ,  JONES, Kristen ,  SANDERS, John, M. ,  HENZE, Darrell, A.

IPC分类号： A01N47/28 ,  A61K31/17

CPC分类号： C07D487/04 ,  C07D239/34 ,  C07D239/42 ,  C07D277/28 ,  C07D277/30 ,  C07D277/32 ,  C07D277/66 ,  C07D403/04 ,  C07D417/10 ,  C07D417/12 ,  C07D471/04

摘要： The present invention is directed to benzyl urea compounds, which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence may be useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor Trk-A, Trk-B and/or Trk-C.

摘要翻译： 本发明涉及苄基脲化合物，其是原肌球蛋白相关激酶（Trk）家族蛋白激酶抑制剂，因此可用于治疗疼痛，炎症，癌症，再狭窄，动脉粥样硬化，牛皮癣，血栓形成，疾病， 与神经生长因子（NGF）受体Trk-A，Trk-B和/或Trk-C的异常活动相关的疾病或障碍或与脱髓鞘或脱髓鞘相关的疾病，损伤或功能障碍。

公开(公告)号：WO2011094209A1

公开(公告)日：2011-08-04

申请号：PCT/US2011/022412

申请日：2011-01-25

申请人： MERCK SHARP & DOHME CORP. ,  CHOBANIAN, Harry ,  LIN, Linus, S. ,  LIU, Ping ,  CHIODA, Marc, D. ,  DEVITA, Robert, J. ,  NARGUND, Ravi, P. ,  GUO, Yan ,  HAMILL, Terence ,  LI, Wenping ,  HENZE, Darrell, A.

发明人： CHOBANIAN, Harry ,  LIN, Linus, S. ,  LIU, Ping ,  CHIODA, Marc, D. ,  DEVITA, Robert, J. ,  NARGUND, Ravi, P. ,  GUO, Yan ,  HAMILL, Terence ,  LI, Wenping ,  HENZE, Darrell, A.

IPC分类号： A61K31/42

CPC分类号： A61K31/422 ,  A61K31/4178

摘要： The present invention is directed to a composition useful for the treatment of a FAAH mediated disease, disorder or conditions comprising a FAAH inhibitor and a second activation, comprising a selected imidazole or oxazole FAAH inhibitor and a second active agent. The compositions will be useful in the treatment of a wide range of disease, disorder, or conditions including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzheimer disease, and Parkinson's disease. In another aspect the invention discloses herein is directed to compositions useful in the treatment of neuropathic and nociceptive pain, said compositions comprising etoricoxib.

摘要翻译： 本发明涉及可用于治疗包含选择的咪唑或恶唑FAAH抑制剂和第二活性剂的FAAH介导的疾病，病症或包含FAAH抑制剂和第二活化的病症的组合物。 该组合物可用于治疗广泛的疾病，病症或病症，包括骨关节炎，类风湿性关节炎，糖尿病性神经病，带状疱疹后神经痛，肌肉痛和纤维肌痛，以及急性疼痛，偏头痛，睡眠障碍，阿尔茨海默病 ，和帕金森病。 另一方面，本发明公开了本发明涉及用于治疗神经性疼痛和伤害性疼痛的组合物，所述组合物包含埃托考昔。

公开(公告)号：WO2009032838A1

公开(公告)日：2009-03-12

申请号：PCT/US2008/075111

申请日：2008-09-03

申请人： MERCK & CO., INC. ,  HENZE, Darrell, A.

发明人： HENZE, Darrell, A.

IPC分类号： A61B19/00

CPC分类号： A61B34/70 ,  A61B34/72 ,  A61B90/11

摘要： Microdrive and modular microdrive assembly for positioning both flexible and inflexible medical and scientific instruments, such as electrodes, mechanical probes and needles in the body of an animal, especially a conscious and freely-moving animal. The microdrive comprises a frame, a drive rod rotatably mounted to the frame, and a carriage with a threaded bore configured to hold the instrument in a position adjacent to a location on the surface of the body where the instrument is to be inserted. The drive rod has a threaded shaft, which passes through the threaded bore on the carriage so that the threads of the threaded shaft are in complementary contact with the threads of the threaded bore. Rotating the drive rod in one direction (e.g., clockwise) produces a force at the complementary contact that urges the carriage closer to the surface.

摘要翻译： 微驱动器和模块化微驱动器组件，用于在动物身体，特别是有意识和自由移动的动物中定位柔性和不灵活的医疗和科学仪器，例如电极，机械探针和针。 微驱动器包括框架，可旋转地安装到框架的驱动杆和具有螺纹孔的托架，该螺纹孔构造成将仪器保持在与器械的待插入的身体表面上的位置相邻的位置。 驱动杆具有螺纹轴，其穿过滑架上的螺纹孔，使得螺纹轴的螺纹与螺纹孔的螺纹互补接触。 驱动杆沿一个方向（例如顺时针方向）旋转会在互相接触处产生一个力，以便使滑架靠近表面。