公开(公告)号：WO2011069061A1

公开(公告)日：2011-06-09

申请号：PCT/US2010/058881

申请日：2010-12-03

Applicant: ABB RESEARCH LTD ,  WANG, Zhenyuan ,  LI, Wenping

Inventor： WANG, Zhenyuan ,  LI, Wenping

IPC: G06N3/12

CPC classification number: G06N3/126 ,  H02J3/006 ,  H02J13/0006 ,  H02J2003/007 ,  Y02E60/76 ,  Y04S10/525 ,  Y04S40/22

Abstract: A method for generating switching plans to restore power to out-of-service areas after fault isolation through back feeding. A chromosome architecture is defined to create chromosomes representing candidate post-restoration systems. The chromosomes are evaluated are repeatedly genetically altered until an acceptable solution is identified. The solution identifies a plurality of switching operations that back feed power to the out-of-service areas in the most optimal manner.

Abstract translation: 一种用于在通过反馈进行故障隔离之后产生切换计划以恢复到不在服务区域的电力的方法。 染色体结构被定义为创建代表候选修复后系统的染色体。 评估的染色体被重复遗传改变，直到识别出可接受的溶液。 该解决方案识别多个切换操作，其以最优的方式将失去服务区域的功率返回。

公开(公告)号：WO2013166654A1

公开(公告)日：2013-11-14

申请号：PCT/CN2012/075185

申请日：2012-05-08

Applicant: MERCK SHARP & DOHME CORP. ,  ALECTOS THERAPEUTICS INC. ,  SELNICK, Harold G. ,  LI, Wenping ,  HOSTETLER, Eric ,  LIU, Kun ,  MCEACHERN, Ernest J. ,  ZHOU, Yuanxi ,  WEI, Zhongyong ,  MU, Changwei ,  WANG, Yaode ,  CHANG, Jiang

Inventor： SELNICK, Harold G. ,  LI, Wenping ,  HOSTETLER, Eric ,  LIU, Kun ,  MCEACHERN, Ernest J. ,  ZHOU, Yuanxi ,  WEI, Zhongyong ,  MU, Changwei ,  WANG, Yaode ,  CHANG, Jiang

IPC: C07D513/04 ,  A61K31/429 ,  A61P25/16 ,  A61P37/06 ,  A61P37/08 ,  A61P11/06 ,  A61P29/00 ,  A61P37/04 ,  A61P9/10 ,  A61P11/02 ,  A61P17/06 ,  A61P25/28

CPC classification number: C07D513/04

Abstract: Disclosed are compounds of Formula (I), wherein each substituent of Formula (I) is defined as in the specification, pharmaceutical formulations comprising these compounds which are useful as 0-linked N-acetylglucosaminidase (O-GlcNAcase) inhibitors, and thus are useful for the treatment of certain disorders such as Alzheimer' s disease including reducing NFTs and/or hyperphosphorylated tau. Also disclosed is the use of the compounds as O-GlcNAcase imaging agents.

Abstract translation: 公开了式（I）的化合物，其中式（I）的每个取代基如说明书中所定义，包含可用作O-连接的N-乙酰氨基葡糖苷酶（O-GlcNAcase）抑制剂的这些化合物的药物制剂，因此是有用的 用于治疗诸如阿尔茨海默病的某些疾病，包括减少NFT和/或高度磷酸化的tau。 还公开了化合物作为O-GlcNAcase显像剂的用途。

公开(公告)号：WO2013169576A1

公开(公告)日：2013-11-14

申请号：PCT/US2013/039377

申请日：2013-05-03

Applicant: MERCK SHARP & DOHME CORP. ,  ALECTOS THERAPEUTICS INC. ,  SELNICK, Harold, G. ,  LI, Wenping ,  HOSTETLER, Eric ,  LIU, Kun ,  MCEACHERN, Ernest, J. ,  ZHOU, Yuanxi ,  WEI, Zhongyong ,  MU, Changwei ,  WANG, Yaode ,  CHANG, Jiang

Inventor： SELNICK, Harold, G. ,  LI, Wenping ,  HOSTETLER, Eric ,  LIU, Kun ,  MCEACHERN, Ernest, J. ,  ZHOU, Yuanxi ,  WEI, Zhongyong ,  MU, Changwei ,  WANG, Yaode ,  CHANG, Jiang

IPC: C07D513/04

CPC classification number: C07D513/04 ,  C07B59/005 ,  C07B2200/05 ,  C07H9/06

Abstract: The present invention is directed to compounds and pharmaceutical formulations comprising these compounds which are useful as O-linked N-acetylglucosaminidase (O-GlcNAcase) inhibitors, and thus may be useful for the treatment of certain disorders such as Alzheimer's disease including reducing NFTs and/or hyperphosphorylated tau. The invention is also directed to use of the compounds as O-GlcNAcase imaging agents.

Abstract translation: 本发明涉及包含这些化合物的化合物和药物制剂，其可用作O-连接的N-乙酰氨基葡糖苷酶（O-GlcNAcase）抑制剂，因此可用于治疗某些疾病，例如阿尔茨海默病，包括减少NFT和/ 或超磷酸化tau。 本发明还涉及将化合物用作O-GlcNAcase显像剂。

公开(公告)号：WO2011094209A1

公开(公告)日：2011-08-04

申请号：PCT/US2011/022412

申请日：2011-01-25

Applicant: MERCK SHARP & DOHME CORP. ,  CHOBANIAN, Harry ,  LIN, Linus, S. ,  LIU, Ping ,  CHIODA, Marc, D. ,  DEVITA, Robert, J. ,  NARGUND, Ravi, P. ,  GUO, Yan ,  HAMILL, Terence ,  LI, Wenping ,  HENZE, Darrell, A.

Inventor： CHOBANIAN, Harry ,  LIN, Linus, S. ,  LIU, Ping ,  CHIODA, Marc, D. ,  DEVITA, Robert, J. ,  NARGUND, Ravi, P. ,  GUO, Yan ,  HAMILL, Terence ,  LI, Wenping ,  HENZE, Darrell, A.

IPC: A61K31/42

CPC classification number: A61K31/422 ,  A61K31/4178

Abstract: The present invention is directed to a composition useful for the treatment of a FAAH mediated disease, disorder or conditions comprising a FAAH inhibitor and a second activation, comprising a selected imidazole or oxazole FAAH inhibitor and a second active agent. The compositions will be useful in the treatment of a wide range of disease, disorder, or conditions including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzheimer disease, and Parkinson's disease. In another aspect the invention discloses herein is directed to compositions useful in the treatment of neuropathic and nociceptive pain, said compositions comprising etoricoxib.

Abstract translation: 本发明涉及可用于治疗包含选择的咪唑或恶唑FAAH抑制剂和第二活性剂的FAAH介导的疾病，病症或包含FAAH抑制剂和第二活化的病症的组合物。 该组合物可用于治疗广泛的疾病，病症或病症，包括骨关节炎，类风湿性关节炎，糖尿病性神经病，带状疱疹后神经痛，肌肉痛和纤维肌痛，以及急性疼痛，偏头痛，睡眠障碍，阿尔茨海默病 ，和帕金森病。 另一方面，本发明公开了本发明涉及用于治疗神经性疼痛和伤害性疼痛的组合物，所述组合物包含埃托考昔。

公开(公告)号：WO2010078132A3

公开(公告)日：2010-07-08

申请号：PCT/US2009/069096

申请日：2009-12-22

Applicant: ABB RESEARCH LTD. ,  WANG, Zhenyuan ,  STOUPIS, James ,  DONDE, Vaibhav ,  LI, Wenping ,  PETERSON, William

Inventor： WANG, Zhenyuan ,  STOUPIS, James ,  DONDE, Vaibhav ,  LI, Wenping ,  PETERSON, William

IPC: H02J3/00 ,  H02H7/26 ,  H02J13/00 ,  H02H7/30

Abstract: A power outage restoration system manages a power network including a plurality of switching devices. The power outage restoration system includes an outage management system having a network model of said power network. A plurality of local restoration controllers are in communication with the outage management system and each said local restoration controller includes a trimmed network model correlating to a respective area of responsibility.

公开(公告)号：WO2010078132A2

公开(公告)日：2010-07-08

申请号：PCT/US2009069096

申请日：2009-12-22

Applicant: ABB RESEARCH LTD ,  WANG ZHENYUAN ,  STOUPIS JAMES ,  DONDE VAIBHAV ,  LI WENPING ,  PETERSON WILLIAM

Inventor： WANG ZHENYUAN ,  STOUPIS JAMES ,  DONDE VAIBHAV ,  LI WENPING ,  PETERSON WILLIAM

IPC: H02J13/00

CPC classification number: H02J3/006 ,  H02H3/063 ,  H02H7/261 ,  H02J13/0062 ,  Y02E60/725 ,  Y02E60/74 ,  Y02E60/7838 ,  Y04S10/20 ,  Y04S10/30 ,  Y04S10/525 ,  Y04S40/124

Abstract: A power outage restoration system manages a power network including a plurality of switching devices. The power outage restoration system includes an outage management system having a network model of said power network. A plurality of local restoration controllers are in communication with the outage management system and each said local restoration controller includes a trimmed network model correlating to a respective area of responsibility.

Abstract translation: 停电恢复系统管理包括多个交换设备的电力网络。 停电恢复系统包括具有所述电力网络的网络模型的停电管理系统。 多个本地恢复控制器与中断管理系统通信，并且每个所述本地恢复控制器包括与相应责任区相关的修整网络模型。

公开(公告)号：WO2006133262A2

公开(公告)日：2006-12-14

申请号：PCT/US2006/022067

申请日：2006-06-06

Applicant: SEPARATION ENGINEERS, INC. ,  DROUGHTON, Charlotte, R. ,  LI, Wenping

Inventor： DROUGHTON, Charlotte, R. ,  LI, Wenping

IPC: C10G31/00 ,  C10G33/00 ,  C10G45/00 ,  C10G17/00 ,  C10G29/00 ,  C10G19/00 ,  C10G21/00

CPC classification number: C10G25/003

Abstract: The disclosed process removes or reduces impurities such as asphaltenes, solids (especially solid fines), sulfur, metals, chlorides, water, salts, and acids from bitumen, oil sands, and crude oils with a wide range of gravities. A crude source composition is contacted with one or more zeolite materials to remove asphaltenes, solids, sulfur, NSO, metals, chlorides, water, salts, and/or acids from the composition. The crude source is typically diluted with a hydrocarbon solvent such as naphtha before contacting the zeolite(s). The disclosed processes represent an improvement over prior and presently available processes because the disclosed processes are capable of processing emulsions.

Abstract translation: 所公开的方法从具有广泛重量的沥青，油砂和原油中除去或减少诸如沥青质，固体（特别是固体细粉），硫，金属，氯化物，水，盐和酸的杂质。 将粗源组合物与一种或多种沸石材料接触以从组合物中除去沥青质，固体，硫，NSO，金属，氯化物，水，盐和/或酸。 在与沸石接触之前，粗产物通常用烃溶剂如石脑油稀释。 所公开的方法代表了相对于现有和现有的方法的改进，因为所公开的方法能够加工乳液。

公开(公告)号：WO03053863A8

公开(公告)日：2003-10-09

申请号：PCT/US0240905

申请日：2002-12-19

Applicant: LI WENPING ,  DROUGHTON CHARLOTTE

Inventor： LI WENPING ,  DROUGHTON CHARLOTTE

IPC: C02F1/56 ,  C02F11/12

CPC classification number: C02F11/12

Abstract: Processes and apparatus are presented which allow efficient use of solid/liquid and liquid/liquid stages with chemical additives in separations technology.

Abstract translation: 介绍了使用分离技术中化学添加剂固体/液体和液体/液体阶段有效使用的方法和设备。

公开(公告)号：WO2011068989A1

公开(公告)日：2011-06-09

申请号：PCT/US2010/058759

申请日：2010-12-02

Applicant: ABB RESEARCH LTD ,  WANG, Zhenyuan ,  DONDE, Vaibhav ,  STOUPIS, James ,  LI, Wenping ,  PETERSON, William

Inventor： WANG, Zhenyuan ,  DONDE, Vaibhav ,  STOUPIS, James ,  LI, Wenping ,  PETERSON, William

IPC: G06N3/12

CPC classification number: G06N3/126

Abstract: The method of determining back-feed paths is capable of efficiently solving multi-layer restoration problems by minimizing a fitness function using an iterative genetic algorithm. The method optimizes back-feeding of out-of-service areas by minimizing power loss, switching, unserved loads and voltage/current violations. The efficiency of the algorithm is further increased through the use of a reactive Tabu search to prevent duplicate candidate systems.

Abstract translation: 确定回馈路径的方法能够通过使用迭代遗传算法最小化适应度函数来有效地解决多层恢复问题。 该方法通过最大限度地减少功率损耗，切换，不受服务的负载和电压/电流违规来优化服务区域的反馈。 通过使用反应性Tabu搜索来进一步提高算法的效率，以防止重复的候选系统。

公开(公告)号：WO2010101724A1

公开(公告)日：2010-09-10

申请号：PCT/US2010/024871

申请日：2010-02-22

Applicant: MERCK SHARP & DOHME CORP. ,  LIU, Ping ,  DEVITA, Robert, J. ,  LIN, Linus, S. ,  CHIODA, Marc, D. ,  HAMILL, Terence, G. ,  LI, Wenping

Inventor： LIU, Ping ,  DEVITA, Robert, J. ,  LIN, Linus, S. ,  CHIODA, Marc, D. ,  HAMILL, Terence, G. ,  LI, Wenping

IPC: A01N43/50 ,  A01N43/52 ,  A61K31/415

CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D413/10 ,  C07D413/14

Abstract: The present invention is directed to certain Inidazole derivatives which are useful as modulators of Fatty Acid Amide Hydrolase (FAAH) and as FAAH imaging agents. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzeimer Disease, and Parkinson's Disease.

Abstract translation: 本发明涉及可用作脂肪酸酰胺水解酶（FAAH）和FAAH显像剂的调节剂的某些咪唑衍生物。 本发明还涉及包含这些化合物作为活性成分的药物制剂，以及这些化合物及其制剂在治疗某些障碍（包括骨关节炎，类风湿性关节炎，糖尿病性神经病变，带状疱疹后神经痛，ke肉肌痛和纤维肌痛）中的用途以及 作为急性疼痛，偏头痛，睡眠障碍，阿尔茨海默病和帕金森病。