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1.发明申请MICROORGANISMS WITH A REACTIVATION SYSTEM FOR COB(I)ALAMIN-DEPENDENT METHIONINE SYNTHASE 审中-公开具有COB（I）亚胺依赖性甲硫氨酸合成酶的反应体系的微生物
公开(公告)号：WO2009144270A1
公开(公告)日：2009-12-03
申请号：PCT/EP2009/056528
申请日：2009-05-28
Applicant: EVONIK DEGUSSA GMBH , ZELDER, Oskar , SCHRÖDER, Hartwig , KLOPPROGGE, Corinna , HEROLD, Andrea , HAEFNER, Stefan , YOCUM, R. Rogers , PATTERSON, Thomas A. , WILLIAMS, Mark
Inventor： ZELDER, Oskar , SCHRÖDER, Hartwig , KLOPPROGGE, Corinna , HEROLD, Andrea , HAEFNER, Stefan , YOCUM, R. Rogers , PATTERSON, Thomas A. , WILLIAMS, Mark
CPC classification number: C12P13/12 , C12N9/1007
Abstract: The present invention relates to microorganisms and methods for producing methionine by reactivation of the MetH enzyme.
Abstract translation: 本发明涉及通过MetH酶的再活化来生产甲硫氨酸的微生物和方法。
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公开(公告)号：WO2009103547A1
公开(公告)日：2009-08-27
申请号：PCT/EP2009/001225
申请日：2009-02-20
Applicant: BASF SE , ZELDER, Oskar , JEONG, Weol, Kyu , KLOPPROGGE, Corinna , HEROLD, Andrea , SCHRÖDER, Hartwig
Inventor： ZELDER, Oskar , JEONG, Weol, Kyu , KLOPPROGGE, Corinna , HEROLD, Andrea , SCHRÖDER, Hartwig
CPC classification number: C12P13/005 , C12N9/88 , C12P13/02
Abstract: The present invention relates to a novel method for the fermentative production of gamma-aminobutyric acid (GABA) by cultivating a recombinant micro-organism expressing an enzyme having a glutamate decarboxylase activity. The present invention also relates to corresponding recombinant hosts, recombinant vectors, expression cassettes and nucleic acids suitable for preparing such hosts as well as to a method for preparing polyamides making use of GABA as obtained fermentative production.
Abstract translation: 本发明涉及通过培养表达具有谷氨酸脱羧酶活性的酶的重组微生物来发酵γ-氨基丁酸（GABA）的新方法。 本发明还涉及适用于制备这种宿主的相应的重组宿主，重组载体，表达盒和核酸，以及使用GABA作为获得的发酵生产制备聚酰胺的方法。
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公开(公告)号：WO2008152016A9
公开(公告)日：2008-12-18
申请号：PCT/EP2008/057158
申请日：2008-06-09
Applicant: EVONIK DEGUSSA GMBH , ZELDER, Oskar , SCHRÖDER, Hartwig , KLOPPROGGE, Corinna , HEROLD, Andrea , HAEFNER, Stefan , PATTERSON, Thomas
Inventor： ZELDER, Oskar , SCHRÖDER, Hartwig , KLOPPROGGE, Corinna , HEROLD, Andrea , HAEFNER, Stefan , PATTERSON, Thomas
Abstract: The present invention relates to microorganisms with improved efficiency of vitamin B12 utilization.
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4.发明申请METHOD OF PRODUCING METHIONINE IN CORYNEBACTERIA BY OVER-EXPRESSING ENZYMES OF THE PENTOSE PHOSPHATE PATHWAY 审中-公开通过超量表达PENTOSE磷酸盐途径的酶的方法在CORYNACACATIA中生产甲硫氨酸
公开(公告)号：WO2008101850A1
公开(公告)日：2008-08-28
申请号：PCT/EP2008/051762
申请日：2008-02-13
Applicant: BASF SE , ZELDER, Oskar , SCHRÖDER, Hartwig , KLOPPROGGE, Corinna , HEROLD, Andrea
Inventor： ZELDER, Oskar , SCHRÖDER, Hartwig , KLOPPROGGE, Corinna , HEROLD, Andrea
CPC classification number: C12N9/1022 , C12N9/0006 , C12P13/12
Abstract: The present invention relates to a method of producing methionine in Coryneform bacteria in which enzymes of the pentose phosphate pathway are over - expressed. The present invention also relates to Coryneform bacteria for producing methionine in which at least two enzymes of the pentose phosphate pathway are over - expressed.
Abstract translation: 本发明涉及一种在棒状细菌中产生甲硫氨酸的方法，其中戊糖磷酸途径的酶被过度表达。 本发明还涉及用于产生甲硫氨酸的棒状细菌，其中戊糖磷酸途径的至少两种酶被过度表达。
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公开(公告)号：WO2007135188A3
公开(公告)日：2007-11-29
申请号：PCT/EP2007/055056
申请日：2007-05-24
Applicant: BASF AG , ZELDER, Oskar , HEROLD, Andrea , KLOPPROGGE, Corinna , SCHRÖDER, Hartwig , HEINZLE, Elmar , WITTMANN, Christoph , KROEMER, Jens , PERO, Janice , YOCUM, Rogers , PATTERSON, Thomas , WILLIAMS, Mark , HERMANN, Theron
Inventor： ZELDER, Oskar , HEROLD, Andrea , KLOPPROGGE, Corinna , SCHRÖDER, Hartwig , HEINZLE, Elmar , WITTMANN, Christoph , KROEMER, Jens , PERO, Janice , YOCUM, Rogers , PATTERSON, Thomas , WILLIAMS, Mark , HERMANN, Theron
Abstract: The present invention relates to microorganisms and processes for the efficient preparation of L-methionine. In particular, the present invention relates to processes in which the amount of serine available for the metabolism of the microorganism is increased.
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Patent Agency Ranking
公开(公告)号：WO2007113127A1
公开(公告)日：2007-10-11
申请号：PCT/EP2007/052783
申请日：2007-03-23
Applicant: BASF AKTIENGESELLSCHAFT , ZELDER, Oskar , JEONG, Weol Kyu , KLOPPROGGE, Corinna , HEROLD, Andrea , SCHRÖDER, Hartwig
Inventor： ZELDER, Oskar , JEONG, Weol Kyu , KLOPPROGGE, Corinna , HEROLD, Andrea , SCHRÖDER, Hartwig
CPC classification number: C12P13/02 , C12N9/88 , C12P13/001
Abstract: Process for the production of cadaverine by constructing a recombinant microorganism which has a deregulated lysine decarboxylase gene and at least one deregulated gene selected from the group (i) which consists of aspartokinase, aspartatesemialdehyde dehydrogenase, dihydrodipicolinate synthase, dihydrodipicolinate reductase, tetrahy- drodipicolinate succinylase, succinyl-amino-ketopimelate transaminase, succinyl- diamino-pimelate desuccinylase, diaminopimelate epimerase, diaminopimelate dehy¬ drogenase, arginyl-tRNA synthetase, diaminopimelate decarboxylase, pyruvate car¬ boxylase, phosphoenolpyruvate carboxylase, glucose-6-phosphate dehydrogenase, transketolase, transaldolase, 6-phosphogluconolactonase, fructose 1 ,6-biphosphatase, homoserine dehydrogenase, phophoenolpyruvate carboxykinase, succinyl-CoA syn¬ thetase, methylmalonyl-CoA mutase, provided that if aspartokinase is deregulated as gene (i) at least a second gene (i) other than aspartokinase has to be deregulated, and cultivating said microorganism.
Abstract translation: 通过构建具有失调的赖氨酸脱羧酶基因和选自由天冬氨酸激酶，天冬氨酸二醛脱氢酶，二氢吡啶二羧酸合成酶，二氢吡啶二羧酸还原酶，四氢吡啶二羧酸琥珀酰基酶组成的组（i）中的至少一种去调节基因的重组微生物来生产尸胺的方法， 琥珀酰基 - 氨基 - 酮基庚酸酯转氨酶，琥珀酰基 - 二氨基 - 庚二酸酯去糖基酶，二氨基庚二酸差向异构酶，二氨基庚二酸脱氢酶，精氨酰-tRNA合成酶，二氨基庚二酸脱羧酶，丙酮酸酯酶，磷酸烯醇丙酮酸羧化酶，葡萄糖-6-磷酸脱氢酶，转酮醇酶，转醛醇酶 如果天冬氨酸激酶被释放为基因（i）至少第二个基因（i），除了天冬氨酸激酶以外的其他基因（i），所述第二基因（i）不是天冬氨酸激酶， 不得不放松管制，而且cul。 抚平所述微生物。
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公开(公告)号：WO2007101867A1
公开(公告)日：2007-09-13
申请号：PCT/EP2007/052138
申请日：2007-03-07
Applicant: BASF AKTIENGESELLSCHAFT , ZELDER, Oskar , JEONG, Weol Kyu , KLOPPROGGE, Corinna , HEROLD, Andrea , SCHRÖDER, Hartwig
Inventor： ZELDER, Oskar , JEONG, Weol Kyu , KLOPPROGGE, Corinna , HEROLD, Andrea , SCHRÖDER, Hartwig
CPC classification number: C12P13/08 , C12P13/005 , C12P13/02
Abstract: Process for the production of -lysine by constructing a recombinant microorganism which has a deregulated lysine 2,3-aminomutase gene and at least one deregulated gene selected from the group (i) which consists of aspartokinase, aspartatesemialdehyde dehydrogenase, dihydrodipicolinate synthase, dihydrodipicolinate reductase, tetrahydrodipicolinate succinylase, succinyl-amino-ketopimelate transaminase, succinyl-diamino-pimelate desuccinylase, diaminopimelate epimerase, diaminopimelate dehydrogenase, arginyl-tRNA synthetase, diaminopimelate decarboxylase, pyruvate carboxylase, phosphoenolpyruvate carboxylase, glucose-6-phosphate dehydrogenase, transketolase, transaldolase, 6-phosphogluconolactonase, fructose 1,6-biphosphatase, homoserine dehydrogenase, phophoenolpyruvate carboxykinase, succinyl-CoA synthetase, methylmalonyl-CoA mutase, provided that if aspartokinase is deregulated as gene (i) at least a second gene (i) other than aspartokinase has to be deregulated, and cultivating said microorganism.
Abstract translation: 通过构建具有失调的赖氨酸2,3-氨基变位酶基因的重组微生物和选自由天冬氨酸激酶，天冬氨酸二甲二醇脱氢酶，二氢吡啶二羧酸合酶，二氢吡啶二羧酸还原酶，二氢吡啶二羧酸还原酶组成的组中的至少一种去调节基因的生产赖氨酸的方法， 四氢吡啶二羧酸琥珀酰基酶，琥珀酰 - 氨基 - 酮基庚酸酯转氨酶，琥珀酰 - 二氨基 - 庚二酸二琥珀酰酶，二氨基庚酸酯差向异构酶，二氨基庚二酸脱氢酶，精氨酰-tRNA合成酶，二氨基庚二酸脱羧酶，丙酮酸羧化酶，磷酸烯醇丙酮酸羧化酶，葡萄糖-6-磷酸脱氢酶，转酮酶，转醛醇酶， 磷酸葡糖糖苷酶，果糖1,6-二磷酸酶，高丝氨酸脱氢酶，磷酸烯醇丙酮酸羧激酶，琥珀酰辅酶A合成酶，甲基丙二酰-CoA变位酶，条件是如果天冬氨酸激酶被解除调控为基因（i）至少第二个基因（i）除了天冬氨酸激酶必须 放松管制，培养说 微生物。
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公开(公告)号：WO2006069711A1
公开(公告)日：2006-07-06
申请号：PCT/EP2005/013809
申请日：2005-12-21
Applicant: BASF AKTIENGESELLSCHAFT , HAEFNER, Stefan , SCHRÖDER, Hartwig , ZELDER, Oskar , KLOPPROGGE, Corinna , HEROLD, Andrea
Inventor： HAEFNER, Stefan , SCHRÖDER, Hartwig , ZELDER, Oskar , KLOPPROGGE, Corinna , HEROLD, Andrea
Abstract: Die vorliegende Erfindung betrifft Mehrfachpromotoren und diese enthaltende Expressionseinheiten; deren Verwendung zur Regulation der Transkription und Expression von Genen; Expressionskassetten, die solche Mehrfachpromotoren oder Expressionseinheiten umfassen; Vektoren, welche solche Expressionskassetten enthalten; genetisch veränderte Mikroorganismen, welche solche Vektoren und/oder Expressionseinheiten enthalten; sowie Verfahren zur Herstellung von biosynthetischen Produkten durch Kultivierung der genetisch veränderten Mikroorganismen.
Abstract translation: 本发明涉及多个启动子和含有这些表达单位; 其转录和基因表达的调节使用; 表达盒包含这样的多个启动子或表达单位; 含有这样的表达盒的载体; 遗传修饰的含有这样的载体和/或表达单位的微生物; 并通过培养遗传修饰的微生物的制备生物合成产物的过程。
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9.发明申请PRODUCTION PROCESS FOR METHIONINE USING MICROORGANISMS WITH REDUCED ISOCITRATE DEHYDROGENASE ACTIVITY 审中-公开使用具有降低的异烟酸脱氢酶活性的微生物的甲磺酸的生产方法
公开(公告)号：WO2009133063A2
公开(公告)日：2009-11-05
申请号：PCT/EP2009/055051
申请日：2009-04-27
Applicant: EVONIK DEGUSSA GMBH , ZELDER, Oskar , SCHRÖDER, Hartwig , KLOPPROGGE, Corinna , HEROLD, Andrea , HAEFNER, Stefan
Inventor： ZELDER, Oskar , SCHRÖDER, Hartwig , KLOPPROGGE, Corinna , HEROLD, Andrea , HAEFNER, Stefan
IPC: C12P13/12
CPC classification number: C12P13/12
Abstract: The present invention is directed to a method utilizing a microorganism with reduced isocitrate dehydrogenase activity for the production of methionine.
Abstract translation: 本发明涉及利用具有降低的异柠檬酸脱氢酶活性的微生物来生产甲硫氨酸的方法。
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公开(公告)号：WO2008080900A2
公开(公告)日：2008-07-10
申请号：PCT/EP2007/064471
申请日：2007-12-21
Applicant: BASF SE , ZELDER, Oskar , GRABARSE, Wolfgang , KLOPPROGGE, Corinna , SCHRÖDER, Hartwig , HAEFNER, Stefan , KNIETSCH, Anja , HEROLD, Andrea
Inventor： ZELDER, Oskar , GRABARSE, Wolfgang , KLOPPROGGE, Corinna , SCHRÖDER, Hartwig , HAEFNER, Stefan , KNIETSCH, Anja , HEROLD, Andrea
IPC: C07K14/43
CPC classification number: C12N9/0091 , C12P13/12
Abstract: The present invention relates to nulceotide sequences encoding enzymatically active cobalamin-methionine synthase and functional fragments thereof being modified in comparison to the respective wild-type enzyme such that said enzymes show reduced product inhibition by methionine. The present invention also relates to polypeptides being encoded by such nucleotide sequences and host cells comprising such nucleotide sequences. Furthermore, the present invention relates to methods for producing methionine in host organisms by making use of suchnucleotide sequences.
Abstract translation: 本发明涉及编码酶促活性钴胺素 - 甲硫氨酸合成酶的核糖核酸序列及其功能片段，其与相应的野生型酶相比被修饰，使得所述酶显示产品抑制蛋氨酸的产物减少。 本发明还涉及由该核苷酸序列编码的多肽和包含该核苷酸序列的宿主细胞。 此外，本发明涉及通过利用这种核苷酸序列在宿主生物体中产生甲硫氨酸的方法。
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