摘要:
The invention relates to pharmaceutical agents containing leptin antagonists for treating Type II diabetes. One leptin antagonist is based on a murine leptin fragment and comprises amino acids 116 to 167 or 116 to 166. Methods of treating Type II diabetes are also disclosed.
摘要:
The invention relates to the extensive removal of butadiene from vinyl chloride. The object of the invention is attained when a low-boiling, high hydrogen-chloride fraction is conveyed, while the pyrolysis product is being separated off, on a catalyst which converts the acetylene contained as a by-product with hydrogen-chloride to form vinyl chloride.
摘要:
The invention relates to a catalyst containing rhodium and a compound of the general formula (I), in which R , R and R are identical or different and independently of each other are hydrogen, an alkyl group or alkoxy group with 1 to 4 carbon atoms, an alkenyl group with 2 to 4 carbon atoms, or R and R including the carbon atoms connected therewith in each case form a ring with 6 carbon atoms, m and n independently of each other are 0 or 1, and (m+n) is equal to 1 or 2, and R is an unsubstituted phenyl radical or naphthyl radical or a phenyl radical or naphthyl radical substituted by an alkyl group with 1 to 4 carbon atoms, an amino group or dialkyl amino group with a total of 2 to 8 carbon atoms. The invention also relates to a process for preparation of aldehydes by reaction of an olefinic compound having 2 to 20 carbon atoms with carbon monoxide and hydrogen in the presence of said catalyst.
摘要:
The invention relates to compounds of the formula (I), in which the radicals R , R , R and A have the meaning given in the description. The invention also relates to a process for the preparation of the compounds of the formula (I) by solid phase synthesis, and use of said compounds as drugs.
摘要:
The active substances identified as inhibitors of the cellular Na /H exchanger (NHE) are used to prepare a medicament for normalizing serum lipids. They are used in the preparation of a medicament which reduces lipid levels in the blood and can be administered for treating diseases caused by lipid levels which are too high, and for alleviating the endothelial dysfunctional syndrome and for treating diseases caused thereby.
摘要翻译:作为细胞Na <+> / H <+>的抑制剂 - 器(NHE)用于血清脂质的正常化的药物中的用途鉴定的活性化合物。 以下是用于治疗降低血脂水平,并由此引起的疾病和内皮功能障碍综合征,和由此引起的疾病用的制备。
摘要:
A sensor element for determining ozone concentrations is characterised in that it contains at least one dye with conjugated double bonds contained in a polymer layer with at least one polymer. Also disclosed are a sensor that contains at least one sensor element of this type and a process for determining ozone concentrations.
摘要:
The invention relates to the production of enzyme pre-granules with stable activity which can be incorporated in particles of a granular fodder. The invention also relates to pre-granules with stable activity which are obtained according to said production process and can be made into granular fodder.
摘要:
The invention relates to novel peptides, i.e. texenomycines, from Scleroderma texense, a process for their production and their use as medicaments, especially as antimycotics. The texenomycines of this invention are distinguished in particular by the amino acid sequence (I) FS-Pro-Aib-Aib-Aib-Aib-Ala-Ala-Aib-ssAla-Leu-Aib-ssAla-Ala-Aib-ssAla-Ala-Aib-Aib-Aib-Ala-Arg-ol, in which FS is an ox-fatty acid radical, Aib is aminoisobutyric acid and Arg-ol is argininol.
摘要:
The invention concerns a process for preparing heterocyclic carbenes of general formula (I) in which R1, R2, R3 and R4 are identical or different and mean saturated or unsaturated, straight-chain, branched or cyclic, unsubstituted or substituted Ci-Ci alkyl, C2-C5 alkylidene, C2-C5 alkylidine, C7-C19 aralkyl or C6-C14 alkyl groups, R3 and R4 can also stand for hydrogen or form jointly anellated, substituted or unsubstituted groups with between 3 and 7 carbon atoms and X stands for carbon or nitrogen, R3 being dropped if X is nitrogen. The process is carried out by reacting azolium salts with a deprotonizing reagent in pure liquid ammonia or in pure organic amine or a mixture of liquid ammonia or an organic amine and an organic polar-aprotic solvent. This process enables a plurality of in particular temperature-sensitive carbenes to be produced under mild reaction conditions at temperatures of between -75 and 0°C.