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    MARKER COMPOSITIONS
    1.
    发明申请
    MARKER COMPOSITIONS 审中-公开
    标记组成

    公开(公告)号：WO1998010797A2

    公开(公告)日：1998-03-19

    申请号：PCT/GB1997002509

    申请日：1997-09-12

    Applicant: NYCOMED IMAGING AS ,  COCKBAIN, Julian ,  BRILEY-SÆBO, Karen, Catherin ,  KELLAR, Kenneth, Edmund ,  LADD, David, Lee ,  HOLLISTER, Kenneth, Robert ,  BJORNERUD, Atle

    Inventor： NYCOMED IMAGING AS ,  COCKBAIN, Julian

    IPC: A61K49/00

    CPC classification number: A61K49/128 ,  A61K49/18 ,  A61K49/1803

    Abstract: This invention relates to a set of aqueous marker compositions, each composition having a selected 1/Ti value which is substantially invariant over an at least 10 DEG C temperature range between 15 and 40 DEG C and preferably over an at least +/- 2 % magnetic field strength range about a selected field strength value between 0.01 and 5T and comprising an aqueous matrix material having a non-zero 1/Ti temperature dependence within said temperature range with distributed therein a first paramagnetic material having a Ti relaxivity which is substantially invariant within said range(s) and/or a second paramagnetic material having within said range(s) a Ti relaxivity which has a non-zero temperature dependence of opposite polarity to the temperature dependence of 1/Ti of said matrix material, said set containing a plurality of said compositions with different selected 1/Ti values preferably encompassing at least the range 1.0 to 2.5 s , said set preferably comprising at least one said composition containing said second paramagnetic material and at least one said composition containing said first paramagnetic material, where i in Ti is 1 or 2.

    Abstract translation: 本发明涉及一组水性标记组合物，每种组合物具有选择的1 / Ti值，其在15至40℃之间的至少10℃温度范围内基本上不变，优选至少为+/- 2％ 磁场强度范围大约在0.01和5T之间的选定的场强值，并且包括在所述温度范围内具有非零1 / Ti温度依赖性的水基质材料，其中分布有第一顺​​磁性材料，其具有基本上不变的Ti弛豫度 所述范围和/或第二顺磁材料具有在所述范围内的Ti弛豫度，其具有与所述基体材料的1 / Ti的温度依赖性相反极性的非零温度依赖性，所述组包含 具有不同选择的1 / Ti值的多个所述组合物优选包含至少1.0至2.5s -1的范围，所述组优选包含至少一个所述共 包含所述第二顺磁性材料和至少一种含有所述第一顺磁性材料的组合物，其中i在Ti中为1或2。

    Marker compositions
    3.
    发明申请
    Marker compositions 审中-公开
    标记成分

    公开(公告)号：WO9810797A3

    公开(公告)日：1998-06-18

    申请号：PCT/GB9702509

    申请日：1997-09-12

    Applicant: NYCOMED IMAGING AS ,  COCKBAIN JULIAN ,  BRILEY-SAEBO KAREN CATHERIN ,  KELLAR KENNETH EDMUND ,  LADD DAVID LEE ,  HOLLISTER KENNETH ROBERT ,  BJORNERUD ATLE

    Inventor： BRILEY-SAEBO KAREN CATHERIN ,  KELLAR KENNETH EDMUND ,  LADD DAVID LEE ,  HOLLISTER KENNETH ROBERT ,  BJORNERUD ATLE

    IPC: A61K49/00 ,  A61K49/12 ,  A61K49/18 ,  G01R33/58

    CPC classification number: A61K49/128 ,  A61K49/18 ,  A61K49/1803

    Abstract: This invention relates to a set of aqueous marker compositions, each composition having a selected 1/Ti value which is substantially invariant over an at least 10 °C temperature range between 15 and 40 °C and preferably over an at least ± 2 % magnetic field strength range about a selected field strength value between 0.01 and 5T and comprising an aqueous matrix material having a non-zero 1/Ti temperature dependence within said temperature range with distributed therein a first paramagnetic material having a Ti relaxivity which is substantially invariant within said range(s) and/or a second paramagnetic material having within said range(s) a Ti relaxivity which has a non-zero temperature dependence of opposite polarity to the temperature dependence of 1/Ti of said matrix material, said set containing a plurality of said compositions with different selected 1/Ti values preferably encompassing at least the range 1.0 to 2.5 s-1, said set preferably comprising at least one said composition containing said second paramagnetic material and at least one said composition containing said first paramagnetic material, where i in T¿i? is 1 or 2.

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