公开(公告)号：WO2021058602A1

公开(公告)日：2021-04-01

申请号：PCT/EP2020/076624

申请日：2020-09-23

Applicant: INSTITUT QUÍMIC DE SARRIÀ CETS FUNDACIÓ PRIVADA ,  HOSPITAL CLÍNIC DE BARCELONA

Inventor： GIL, Alejandro Aranda ,  GRANADA, Andrés-Amador García ,  LÓPEZ, Jordi Martorell ,  ALONSO, Vicente Riambau

IPC: A61B17/00

Abstract: The present invention provides a patch deployment device, the device comprising a pusher wire having a proximal end and a distal end; a plurality of deployment wires, wherein each deployment wire: has a first end and a second end, and the first end and the second end are connected to the distal end of the pusher wire; and is configured to be in an unexpanded state when positioned and constrained within a catheter, and configured to self-expand into an expanded state when positioned beyond a distal end of the catheter and not constrained, wherein in the expanded state at least a portion of the wire is positioned substantially within a plane that is substantially perpendicular to the longitudinal axis of the pusher wire and has an asymmetric form when viewed along a direction parallel to the longitudinal axis of the pusher wire.

公开(公告)号：WO2021009184A1

公开(公告)日：2021-01-21

申请号：PCT/EP2020/069918

申请日：2020-07-14

Applicant: INSTITUT D'INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER (IDIBAPS) ,  HOSPITAL CLÍNIC DE BARCELONA ,  CONSORCIO CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED, M.P. ,  UNIVERSITAT DE BARCELONA

Inventor： CASTELLS GARANGOU, Antoni ,  GIRONELLA COS, Meritxell ,  DURAN SANCHON, Saray

IPC: C12Q1/6886

Abstract: Non-invasive method for the diagnosis or screening of colorectal cancer and/or pre-cancerous stage thereof. The present invention refers to an in vitro method for the diagnosis of colorectal cancer and/or pre-cancerous stage thereof.

公开(公告)号：WO2020254072A1

公开(公告)日：2020-12-24

申请号：PCT/EP2020/064523

申请日：2020-05-26

Applicant: FUNDACIÓ CELLEX ,  HOSPITAL SANT JOAN DE DEU ,  INSTITUT QUÍMIC DE SARRIÀ CETS FUNDACIÓ PRIVADA ,  HOSPITAL CLÍNIC DE BARCELONA ,  INSTITUT D'INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER (IDIBAPS) ,  UNIVERSITAT DE BARCELONA

Inventor： GRATACOS SOLSONA, Eduard ,  EIXARCH ROCA, Elisenda ,  FEBAS BOSOMBA, German ,  BORRÓS GÓMEZ, Salvador ,  MICHELETTI HELFER, Talita

IPC: A61B17/00 ,  A61B17/42

Abstract: Patch (1) for sealing an amniotic membrane, wherein the patch (1) comprises a support (11) and an adhesive (12) that is activated in presence of amniotic liquid or a wet environment. Device for placing said patch (1) comprising a cannula (2) for inserting said patch (1) in a rolled-up position, said cannula (2) being provided with a handle (3); and a dipstick (4) provided with a pusher (5), said dipstick (4) being inserted inside the cannula (2) in the use position. The patch adheres efficiently on the amniotic membrane, adapts to the elastic properties of this membrane, and by attaching only to the amnion it does not interfere with the natural sliding movements of one membrane against each other, together with the device to ensure that the patch is placed in the proper position without damaging the membrane.

公开(公告)号：WO2014195306A1

公开(公告)日：2014-12-11

申请号：PCT/EP2014/061470

申请日：2014-06-03

Applicant: UNIVERSITAT DE BARCELONA ,  INSTITUT D'INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER ,  HOSPITAL CLÍNIC DE BARCELONA

Inventor： GOMIS BARBARÀ, Ramón ,  CANIVELL FUSTÉ, Silvia

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q2600/154

Abstract: The invention relates to methods for diagnosing type 2 diabetes as well as antidiabetic agents for use in the treatment of type 2 diabetes. The invention relates as well to kits and nucleic acids for carrying out the diagnostic methods.

Abstract translation: 本发明涉及用于诊断2型糖尿病的方法以及用于治疗2型糖尿病的抗糖尿病药。 本发明还涉及用于进行诊断方法的试剂盒和核酸。

公开(公告)号：WO2014096498A1

公开(公告)日：2014-06-26

申请号：PCT/ES2013/070905

申请日：2013-12-20

Applicant: UNIVERSITAT DE BARCELONA ,  HOSPITAL CLÍNIC DE BARCELONA ,  INSTITUT D'INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER ,  CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED (CIBER)

Inventor： DÍAZ RICART, M. Isabel ,  PINO FERRER, Marcos ,  ESCOLAR ALBALADEJO, Ginés ,  GOMIS DE BARBERÀ, Ramon ,  FERNÁNDEZ RUIZ, Rebeca

IPC: A61K33/24 ,  A61P7/02

CPC classification number: A61K33/24

Abstract: Las sales de tungstatode metales farmacéuticamente aceptables, o sus solvatos,son útiles para reducir la reactividad de las plaquetas en un mamífero, incluido un humano, y se pueden utilizar para tratar a sujetos que padecen una condición o enfermedad vascular asociada a plaquetas.

Abstract translation: 药学上可接受的金属的钨酸盐或其溶剂化物可用于降低哺乳动物（包括人）中血小板的反应性，并且可用于治疗患有血小板相关性血管疾病或疾病的患者。

公开(公告)号：WO2022234134A1

公开(公告)日：2022-11-10

申请号：PCT/EP2022/062374

申请日：2022-05-06

Applicant: INSTITUT D'INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER (IDIBAPS) ,  HOSPITAL CLÍNIC DE BARCELONA ,  UNIVERSITAT DE BARCELONA

Inventor： JUAN OTERO, Manel ,  URBANO ISPIZUA, Álvaro ,  PASCAL CAPDEVILA, Mariona ,  YAGÜE RIBES, Jordi ,  DELGADO GONZÁLEZ, Julio ,  ESTEVE REYNER, Jordi

IPC: C07K16/28 ,  A61K39/00 ,  A61K35/17 ,  A61K2039/5156 ,  A61K39/001112 ,  C07K16/2803 ,  C07K2317/622 ,  C07K2319/00 ,  C12N2510/00

Abstract: The present invention refers to a CD19-specific chimeric antigen receptor (CAR) T-cell therapy and to its use for treating CD19+ malignancies.

公开(公告)号：WO2022069200A1

公开(公告)日：2022-04-07

申请号：PCT/EP2021/075075

申请日：2021-09-13

Applicant: UNIVERSITAT POLITECNICA DE CATALUNYA ,  FUNDACIÓ CLÍNIC PER A LA RECERCA BIOMÈDICA ,  HOSPITAL CLÍNIC DE BARCELONA ,  INSTITUT D'INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER (IDIBAPS)

Inventor： MASIP BRUIN, Xavier ,  PASCUAL SALDAÑA, Heribert ,  PRIETO GONZÁLEZ, Andrés ,  BLANCO VICH, Isabel ,  ALONSO BELTRAN, Albert

IPC: G16H20/40 ,  G16H50/20 ,  A61M16/00 ,  A61M16/10 ,  A61B5/083 ,  A61B5/00 ,  A61M16/06 ,  A61B5/1455

Abstract: A method and a system for determining the amount of oxygen required by a user with respiratory problems are disclosed. First data about several users with respiratory problems is stored in a database. The method a) collects second data from a monitored user while (s)he is performing a test at a first location; b) computes a user's behavioral model executing a first algorithm on the first and second data; c) collects, every period of time t1, third data of the user while (s)he is performing an activity at a second location; d) adjusts, every period of time t2, the computed user's behavioral model using the first algorithm, providing a customized user's behavioral model as a result; and e) computes an estimator of the quantity of oxygen to be delivered to the user by executing a second algorithm on the customized user's behavioral model.

公开(公告)号：WO2020016402A1

公开(公告)日：2020-01-23

申请号：PCT/EP2019/069478

申请日：2019-07-19

Applicant: HOSPITAL CLÍNIC DE BARCELONA ,  FUNDACIÓ PRIVADA INSTITUT DE SALUT GLOBAL BARCELONA ,  FUNDACIÓ INSTITUT D'LNVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS I PUJOL (IGTP)

Inventor： FERNANDEZ BECERRA, Maria del Carmen ,  GASCON BRUSTENGA, Joaquim ,  PINAZO DELGADO, Maria Jesus

IPC: G01N33/569

Abstract: A method for predicting the therapeutic response and/or prognosis in a subject suffering Chagas disease and uses thereof are disclosed. The method comprises the analysis of an isolated biological sample, wherein it is detected at least one protein expression product comprising human and/or T. cruzi parasite proteins, said human proteins including at least one of: the group of mannose-binding lectin-associated serine proteins 2, MASP2, the group of angiopoietin-related proteins, the group of collagen alpha-2 chain, VI, and the group of myosin regulatory light chain 12A, and said T. cruzi parasite protein including pyruvate phosphate dikinase, such that the detected protein expression product can serve as potential biomarker in the context of the therapeutic response and prognosis of the disease during chronic infection.

公开(公告)号：WO2018206826A1

公开(公告)日：2018-11-15

申请号：PCT/ES2017/070290

申请日：2017-05-09

Applicant: HOSPITAL CLÍNIC DE BARCELONA ,  INSTITUT D'INVESTIGACIONS BIOMÈDIQUES AUGUSTI PI I SUNYER (IDIBAPS)

Inventor： CHAMORRO SÁNCHEZ, Ángel

IPC: A61K31/522 ,  A61P25/00

Abstract: La presente invención se refiere a una composición que comprende ácido úrico para su uso en el tratamiento de infarto cerebral en un paciente tratado también mediante trombectomía mecánica.

公开(公告)号：WO2016015779A1

公开(公告)日：2016-02-04

申请号：PCT/EP2014/066604

申请日：2014-08-01

Applicant: FUNDACIÓ HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA ,  HOSPITAL CLÍNIC DE BARCELONA

Inventor： MARSAL BARRIL, Sara ,  JULIA CANO, Antonio ,  CAÑETE CRESPILLO, Juan De Dios

IPC: C12Q1/68 ,  G01N33/53

CPC classification number: C12Q1/485 ,  C07K16/241 ,  C07K2317/73 ,  C12Q1/005 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/577 ,  G01N33/6893 ,  G01N2500/00 ,  G01N2800/102 ,  G01N2800/52

Abstract: The invention provides methods for predicting response to anti-TNFα biological agent treatment in a rheumatoid arthritis patient and methods for selecting a treatment for a rheumatoid arthritis patient, the methods comprising determining the level of expression of PIK3CD as a biomarker, and optionally also determining the level of expression of CX3CL1 as a second biomarker. The invention additionally provides kits for carrying out the methods described.

Abstract translation: 本发明提供了预测类风湿关节炎患者抗TNFα生物制剂治疗反应的方法以及用于选择类风湿关节炎患者治疗的方法，所述方法包括测定作为生物标志物的PIK3CD的表达水平，以及任选地也可以确定 CX3CL1作为第二生物标志物的表达水平。 本发明另外提供用于实施所述方法的套件。