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公开(公告)号：WO2009102966A2
公开(公告)日：2009-08-20
申请号：PCT/US2009/034069
申请日：2009-02-13
Applicant: HRUSKA, Keith , CHOI, Eric T.
Inventor： HRUSKA, Keith , CHOI, Eric T.
CPC classification number: A61K38/1875
Abstract: The present invention relates to prevention and treatment of vascular sclerosis, vascular calcification (VC) and neointimal hyperplasia using a morphogen.
Abstract translation: 本发明涉及使用形态发生剂预防和治疗血管硬化，血管钙化（VC）和新生内膜增生。
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2.发明申请CONJOINT ADMINISTRATION OF MORPHOGENS AND ACE INHIBITORS IN TREATMENT OF CHRONIC RENAL FAILURE 审中-公开多发性硬化症和ACE抑制剂治疗慢性肾功能衰竭的联合治疗
公开(公告)号：WO2004019876A3
公开(公告)日：2006-03-23
申请号：PCT/US0326923
申请日：2003-08-28
Applicant: CURIS INC , BARNES JEWISH HOSPITAL , CHARETTE MARC F , HRUSKA KEITH A , MCCARTNEY JOHN
Inventor： CHARETTE MARC F , HRUSKA KEITH A , MCCARTNEY JOHN
IPC: A01N61/00 , A01N37/18 , A61K31/00 , A61K31/401 , A61K38/00 , A61K38/04 , A61K38/17 , A61K38/18 , A61K45/06 , A61P13/00
CPC classification number: A61K45/06 , A61K31/00 , A61K31/401 , A61K38/1875 , A61K2300/00
Abstract: The present invention provides reagents and methods for the treatment, and pharmaceuticals for use in the prevention and/or treatment, of chronic renal failure and other renal disorders in subjects (particularly mammalian subjects) renal replacement therapy. The methods involve the conjoint administration of ACE (Angiotensin-Converting Enzyme) inhibitors or Angiotensin II Receptor Antagonists (AIIRAs) with one or more OP/BMP family of proteins (morphogens, or inducers of morphogens, or agonists of the corresponding morphogen receptors, etc.). The invention also provides methods for implantation of renal cells induced with the conjoint administration of ACE inhibitors or AIIRAs with those morphogens.
Abstract translation: 本发明提供用于治疗的试剂和方法，以及用于预防和/或治疗受试者（特别是哺乳动物受试者）肾脏替代疗法中的慢性肾功能衰竭和其它肾脏疾病的药物。 该方法涉及ACE（血管紧张素转换酶）抑制剂或血管紧张素II受体拮抗剂（AIIRAs）与一种或多种蛋白质（形态发生物或形态发生物诱导剂或相应的形态发生受体的激动剂等）的一个或多个OP / BMP家族 ）。 本发明还提供了用这些形态发生剂联合施用ACE抑制剂或AIIRA诱导的肾细胞植入方法。
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Patent Agency Ranking3.发明申请ACTIVIN-ACTRII ANTAGONISTS AND USES FOR TREATING BONE AND OTHER DISORDERS 审中-公开ACTIVIN-ACTRII ANTAGONISTS和用于治疗骨骼和其他疾病的用途
公开(公告)号：WO2014071158A1
公开(公告)日：2014-05-08
申请号：PCT/US2013/068009
申请日：2013-11-01
Applicant: CELGENE CORPORATION , WASHINGTON UNIVERSITY , SLOAN, Victor, Schorr , HRUSKA, Keith , FANG, Yifu
Inventor： SLOAN, Victor, Schorr , HRUSKA, Keith , FANG, Yifu , SUNG, Victoria , STEVENS, Randall , SMITH, William
CPC classification number: A61K38/1796 , A61K38/179
Abstract: Provided herein are methods for the treatment of bone disorders that are associated with kidney disease wherein the methods comprise administration of Activin-ActRIIA inhibitors to a subject in need of the treatment. Also provided herein are methods and compositions for the treatment of low turnover bone disorders wherein the methods comprise administration of Activin-ActRIIA inhibitors to a subject in need of the treatment. Further provided herein are compositions for the treatment of bone disorders that are associated with kidney disease and compositions for the treatment of low turnover bone disorders and vascular calcification.
Abstract translation: 本文提供了用于治疗与肾脏疾病相关的骨病症的方法，其中所述方法包括向需要治疗的受试者施用Activin-ActRIIA抑制剂。 本文还提供了用于治疗低周转性骨疾病的方法和组合物，其中所述方法包括向需要治疗的受试者施用Activin-ActRIIA抑制剂。 本文还提供了用于治疗与肾脏疾病相关的骨疾病的组合物和用于治疗低周转性骨病和血管钙化的组合物。
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公开(公告)号：WO2009102966A3
公开(公告)日：2010-01-28
申请号：PCT/US2009034069
申请日：2009-02-13
Applicant: HRUSKA KEITH , CHOI ERIC T
Inventor： HRUSKA KEITH , CHOI ERIC T
CPC classification number: A61K38/1875
Abstract: The present invention relates to prevention and treatment of vascular sclerosis, vascular calcification (VC) and neointimal hyperplasia using a morphogen.
Abstract translation: 本发明涉及使用形态发生剂预防和治疗血管硬化，血管钙化（VC）和新生内膜增生。
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公开(公告)号：WO2004043385A2
公开(公告)日：2004-05-27
申请号：PCT/US2003/035637
申请日：2003-11-07
Applicant: BARNES-JEWISH HOSPITAL , HRUSKA, Keith, A. , CHAUDHARY, Lala, R.
Inventor： HRUSKA, Keith, A. , CHAUDHARY, Lala, R.
IPC: A61K
CPC classification number: G01N33/57434 , A61K38/18 , G01N2333/52 , G01N2333/96438
Abstract: Methods and compositions for treating prostate cancer by promoting prostate epithelial cell differentiation are described. Treatment methods involve administration of an active form of prostate-derived factor (PDF), or of an inactive PDF precursor, or of a combination of a proprotein convertase (PC) with a PDF precursor, to increase the biological activity of PDF in the subject and promote prostate epithelial cell differentiation.
Abstract translation: 描述了通过促进前列腺上皮细胞分化来治疗前列腺癌的方法和组合物。 治疗方法包括施用活性形式的前列腺衍生因子（PDF）或非活性PDF前体或前体蛋白转化酶（PC）与PDF前体的组合，以增加受试者中的PDF的生物学活性 并促进前列腺上皮细胞分化。
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6.发明申请CONJOINT ADMINISTRATION OF MORPHOGENS AND ACE INHIBITORS IN TREATMENT OF CHRONIC RENAL FAILURE 审中-公开多发性硬化症和ACE抑制剂治疗慢性肾功能衰竭的联合治疗
公开(公告)号：WO2004019876A2
公开(公告)日：2004-03-11
申请号：PCT/US2003/026923
申请日：2003-08-28
Applicant: CURIS, INC. , WASHINGTON UNIVERSITY IN ST. LOUIS , CHARETTE, Marc, F. , HRUSKA, Keith, A. , MCCARTNEY, John
Inventor： CHARETTE, Marc, F. , HRUSKA, Keith, A. , MCCARTNEY, John
IPC: A61K
CPC classification number: A61K45/06 , A61K31/00 , A61K31/401 , A61K38/1875 , A61K2300/00
Abstract: The present invention provides reagents and methods for the treatment, and pharmaceuticals for use in the prevention and/or treatment, of chronic renal failure and other renal disorders in subjects (particularly mammalian subjects) renal replacement therapy. The methods involve the conjoint administration of ACE (Angiotensin-Converting Enzyme) inhibitors or Angiotensin II Receptor Antagonists (AIIRAs) with one or more OP/BMP family of proteins (morphogens, or inducers of morphogens, or agonists of the corresponding morphogen receptors, etc.). The invention also provides methods for implantation of renal cells induced with the conjoint administration of ACE inhibitors or AIIRAs with those morphogens.
Abstract translation: 本发明提供用于治疗的试剂和方法，以及用于预防和/或治疗受试者（特别是哺乳动物受试者）肾脏替代疗法中的慢性肾功能衰竭和其它肾脏疾病的药物。 该方法涉及ACE（血管紧张素转换酶）抑制剂或血管紧张素II受体拮抗剂（AIIRAs）与一种或多种蛋白质（形态发生物或形态发生物诱导剂或相应的形态发生受体的激动剂等）的一个或多个OP / BMP家族 ）。 本发明还提供了用这些形态发生剂联合施用ACE抑制剂或AIIRA诱导的肾细胞植入方法。
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公开(公告)号：WO2004043385A3
公开(公告)日：2005-09-29
申请号：PCT/US0335637
申请日：2003-11-07
Applicant: BARNES JEWISH HOSPITAL , HRUSKA KEITH A , CHAUDHARY LALA R
Inventor： HRUSKA KEITH A , CHAUDHARY LALA R
CPC classification number: G01N33/57434 , A61K38/18 , G01N2333/52 , G01N2333/96438
Abstract: Methods and compositions for treating prostate cancer by promoting prostate epithelial cell differentiation are described. Treatment methods involve administration of an active form of prostate-derived factor (PDF), or of an inactive PDF precursor, or of a combination of a proprotein convertase (PC) with a PDF precursor, to increase the biological activity of PDF in the subject and promote prostate epithelial cell differentiation.
Abstract translation: 描述了通过促进前列腺上皮细胞分化来治疗前列腺癌的方法和组合物。 治疗方法包括施用活性形式的前列腺衍生因子（PDF）或非活性PDF前体或前体蛋白转化酶（PC）与PDF前体的组合，以增加受试者中的PDF的生物学活性 并促进前列腺上皮细胞分化。
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