公开(公告)号：WO2003046256A1

公开(公告)日：2003-06-05

申请号：PCT/US2002/038056

申请日：2002-11-26

Applicant: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK ,  HUA, Zonglu, Susan ,  CHOPRA, Harsh, Deep ,  SACHS, Frederick

Inventor： HUA, Zonglu, Susan ,  CHOPRA, Harsh, Deep ,  SACHS, Frederick

IPC: C25B1/00

CPC classification number: F16K99/0001 ,  F15C5/00 ,  F16K99/0019 ,  F16K99/0042 ,  F16K2099/0074 ,  F16K2099/008 ,  F16K2099/0084

Abstract: A microfluidic system and method, suitable for "lab-on-a-chip" applications, by which a bubble is inflated in fluid flowing through a microfluidic channel at a predetermined location along the channel and the bubble is maintained at that location to stop flow through the channel in the manner of a valve. The microfluidic channel is formed on a semiconductor chip and a pair of electrodes is formed one on each side of the channel, whereby a bubble is electrochemically inflated between the electrodes and held in fixed position by the channel wall when a voltage is applied across the fluid incident to connecting the electrodes to a voltage source. When the voltage is removed, deflation of the bubble valve rapidly occurs to restore flow. The present invention provides flow control in a microfluidic system regardless of channel cross-sectional geometry and with no moving parts and low power consumption. Moreover, the present invention may be practiced using existing fabrication techniques.

Abstract translation: 适用于“芯片实验室”应用的微流体系统和方法，通过该微流体系统和方法，气体在沿着通道的预定位置流过微流体通道的流体中膨胀，气泡保持在该位置以停止流动 通过通道以阀的方式。 微流体通道形成在半导体芯片上，并且一对电极形成在通道的每一侧上，从而在电极之间电化学膨胀气泡，并且当跨过流体施加电压时通过通道壁将其保持在固定位置 将电极连接到电压源的事件。 当去除电压时，快速发生气泡阀的放气以恢复流量。 本发明提供微流体系统中的流量控制，而不管通道截面几何形状如何，并且没有移动部件和低功耗。 此外，本发明可以使用现有的制造技术来实施。