公开(公告)号：WO2003046256A1

公开(公告)日：2003-06-05

申请号：PCT/US2002/038056

申请日：2002-11-26

Applicant: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK ,  HUA, Zonglu, Susan ,  CHOPRA, Harsh, Deep ,  SACHS, Frederick

Inventor： HUA, Zonglu, Susan ,  CHOPRA, Harsh, Deep ,  SACHS, Frederick

IPC: C25B1/00

CPC classification number: F16K99/0001 ,  F15C5/00 ,  F16K99/0019 ,  F16K99/0042 ,  F16K2099/0074 ,  F16K2099/008 ,  F16K2099/0084

Abstract: A microfluidic system and method, suitable for "lab-on-a-chip" applications, by which a bubble is inflated in fluid flowing through a microfluidic channel at a predetermined location along the channel and the bubble is maintained at that location to stop flow through the channel in the manner of a valve. The microfluidic channel is formed on a semiconductor chip and a pair of electrodes is formed one on each side of the channel, whereby a bubble is electrochemically inflated between the electrodes and held in fixed position by the channel wall when a voltage is applied across the fluid incident to connecting the electrodes to a voltage source. When the voltage is removed, deflation of the bubble valve rapidly occurs to restore flow. The present invention provides flow control in a microfluidic system regardless of channel cross-sectional geometry and with no moving parts and low power consumption. Moreover, the present invention may be practiced using existing fabrication techniques.

Abstract translation: 适用于“芯片实验室”应用的微流体系统和方法，通过该微流体系统和方法，气体在沿着通道的预定位置流过微流体通道的流体中膨胀，气泡保持在该位置以停止流动 通过通道以阀的方式。 微流体通道形成在半导体芯片上，并且一对电极形成在通道的每一侧上，从而在电极之间电化学膨胀气泡，并且当跨过流体施加电压时通过通道壁将其保持在固定位置 将电极连接到电压源的事件。 当去除电压时，快速发生气泡阀的放气以恢复流量。 本发明提供微流体系统中的流量控制，而不管通道截面几何形状如何，并且没有移动部件和低功耗。 此外，本发明可以使用现有的制造技术来实施。

公开(公告)号：WO2010138904A2

公开(公告)日：2010-12-02

申请号：PCT/US2010/036714

申请日：2010-05-28

Applicant: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK ,  CHOPRA, Harsh, Deep ,  ARMSTRONG, Jason, N. ,  HUA, Zonglu

Inventor： CHOPRA, Harsh, Deep ,  ARMSTRONG, Jason, N. ,  HUA, Zonglu

IPC: G01Q70/08 ,  G01Q60/38 ,  G01N27/04 ,  B82B1/00

CPC classification number: G01Q10/02 ,  G01Q10/04 ,  G01Q70/02

Abstract: A metrology probe capable of measurements of a broad range of physical properties of individual samples of nano- or sub-nanometer dimensions is provided. The probe comprises a probe body, a substrate connected to the probe body, and a tip proximate the substrate. The probe further comprises a coarse piezoelectric actuator having an electrical input. The coarse piezo is configured to cause the tip and/or the substrate to move relative to each other when a first electrical signal is provided to the electrical input. The probe further comprises a low- pass filter in electrical communication with the electrical input of the coarse piezo. The probe further comprises a fine piezoelectric actuator having an electrical input configured to cause the tip and/or the substrate to move relative to each other when a second electrical signal is provided to the electrical input.

Abstract translation: 提供了能够测量纳米或亚纳米尺寸的单个样品的宽范围物理性质的计量探针。 探针包括探针体，连接到探针体的基底和靠近基底的尖端。 探头还包括具有电输入的粗压电致动器。 粗电压被配置为当第一电信号被提供给电输入端时，尖端和/或衬底相对于彼此移动。 探头还包括与粗压电体的电输入端电连通的低通滤波器。 所述探头还包括精细的压电致动器，其具有电输入，所述电输入被配置成当向所述电输入提供第二电信号时使所述尖端和/或所述基板相对于彼此移动。

公开(公告)号：WO2006089040A3

公开(公告)日：2009-04-16

申请号：PCT/US2006005503

申请日：2006-02-16

Applicant: UNIV NEW YORK STATE RES FOUND ,  CHOPRA HARSH DEEP ,  HUA ZONGLU ,  SULLIVAN MATTHEW R ,  ARMSTRONG JASON N

Inventor： CHOPRA HARSH DEEP ,  HUA ZONGLU ,  SULLIVAN MATTHEW R ,  ARMSTRONG JASON N

IPC: G01R33/02 ,  G01R33/12

CPC classification number: G01R33/093 ,  B82Y25/00 ,  G01R33/09

Abstract: The invention includes a conductor (13) with a first side (16) and a second side (19). The conductor (13) may be sized to have a cros section diameter substantially similar to a Fermi wavelength of electrons in the conductor, the cross-section diameter being taken substantially perpendicular to a primary direction in which current could flow (28) through the conductor (13). The conductor size be selected so that when a magnetic field less than a threshold value is applied to the conductor (13), the first side (16) of the conductor has a first magnetic state and the second side (19) of the conductor has a second magnetic state. However, when a magnetic field of sufficient strength is applied to the magnetic conductor (13) the first side (16) and the second side (19) will be caused to have the same magnetic state. The material of the conductor (13) may be selected from those for which magnetoresistance magnitude of the material oscillates as a function of the material's cross-sectional area, and the cross-sectional area of the conductor may be selected to correspond to a peak of the function.

Abstract translation: 本发明包括具有第一侧（16）和第二侧（19）的导体（13）。 导体（13）的尺寸可以具有与导体中的电子的费米波长基本相似的交叉截面直径，其截面直径基本上垂直于电流可通过导体（28）流动的主要方向（28） （13）。 选择导体尺寸，使得当小于阈值的磁场被施加到导体（13）时，导体的第一侧（16）具有第一磁状态，并且导体的第二侧（19）具有 第二磁状态。 然而，当对磁导体（13）施加足够强度的磁场时，使第一侧（16）和第二侧（19）具有相同的磁状态。 导体（13）的材料可以选自材料的磁阻大小作为材料的横截面积的函数振荡的材料，并且导体的横截面面积可以被选择为对应于 功能。

公开(公告)号：WO2005086784A3

公开(公告)日：2005-09-22

申请号：PCT/US2005/007461

申请日：2005-03-04

Applicant: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK ,  SACHS, Frederick ,  HUA, Zonglu ,  BESCH, Stephen ,  CHOPRA, Harsh, Deep ,  AUERBACH, Anthony ,  GOTTLIEB, Philip ,  ATEYA, Daniel, A.

Inventor： SACHS, Frederick ,  HUA, Zonglu ,  BESCH, Stephen ,  CHOPRA, Harsh, Deep ,  AUERBACH, Anthony ,  GOTTLIEB, Philip ,  ATEYA, Daniel, A.

IPC: C12Q1/02

Abstract: A method and apparatus for measuring changes in cell volume generally includes introducing cells into a chamber having a volume between 2 and 100 times the volume of the introduced cell. A first electrically conductive extracellular fluid is introduced into the chamber and a current is applied. The current flow is measured. The first fluid is exchanged with a second electrically conductive extracellular fluid and a current is applied. The current flow is measured. The first current flow result and the second current flow result are used in conjunction with known current flows to monitor changes in the volume corresponding to fluid flow between the cell and an extracellular fluid.

公开(公告)号：WO2010138904A3

公开(公告)日：2011-03-10

申请号：PCT/US2010036714

申请日：2010-05-28

Applicant: UNIV NEW YORK STATE RES FOUND ,  CHOPRA HARSH DEEP ,  ARMSTRONG JASON N ,  HUA ZONGLU

Inventor： CHOPRA HARSH DEEP ,  ARMSTRONG JASON N ,  HUA ZONGLU

IPC: G01Q70/08 ,  B82B1/00 ,  G01N27/04 ,  G01Q60/38

CPC classification number: G01Q10/02 ,  G01Q10/04 ,  G01Q70/02

Abstract: A metrology probe capable of measurements of a broad range of physical properties of individual samples of nano- or sub-nanometer dimensions is provided. The probe comprises a probe body, a substrate connected to the probe body, and a tip proximate the substrate. The probe further comprises a coarse piezoelectric actuator having an electrical input. The coarse piezo is configured to cause the tip and/or the substrate to move relative to each other when a first electrical signal is provided to the electrical input. The probe further comprises a low- pass filter in electrical communication with the electrical input of the coarse piezo. The probe further comprises a fine piezoelectric actuator having an electrical input configured to cause the tip and/or the substrate to move relative to each other when a second electrical signal is provided to the electrical input.

Abstract translation: 提供了能够测量纳米或亚纳米尺寸的单个样品的宽范围物理性质的计量探针。 探针包括探针体，连接到探针体的基底和靠近基底的尖端。 探头还包括具有电输入的粗压电致动器。 粗电压被配置为当第一电信号被提供给电输入端时，尖端和/或衬底相对于彼此移动。 探头还包括与粗压电体的电输入端电连通的低通滤波器。 该探头还包括精细的压电致动器，其具有电输入，该电输入被配置成当向电输入提供第二电信号时使尖端和/或基板相对于彼此移动。

公开(公告)号：WO2006089040A2

公开(公告)日：2006-08-24

申请号：PCT/US2006/005503

申请日：2006-02-16

Applicant: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK AT BUFFALO ,  CHOPRA, Harsh, Deep ,  HUA, Zonglu ,  SULLIVAN, Matthew, R. ,  ARMSTRONG, Jason, N.

Inventor： CHOPRA, Harsh, Deep ,  HUA, Zonglu ,  SULLIVAN, Matthew, R. ,  ARMSTRONG, Jason, N.

IPC: G01R1/067

CPC classification number: G01R33/093 ,  B82Y25/00 ,  G01R33/09

Abstract: The invention includes a conductor with a first side and a second side. The conductor may be sized to have a cross-section diameter substantially similar to a Fermi wavelength of electrons in the conductor, the cross-section diameter being taken substantially perpendicular to a primary direction in which current could flow through the conductor. The conductor size may be selected so that when a magnetic field less than a threshold value is applied to the conductor, the first side of the conductor has a first magnetic state and the second side of the conductor has a second magnetic state. However, when a magnetic field of sufficient strength is applied to the magnetic conductor the first side and the second side will be caused to have the same magnetic state. The material of the conductor may be selected from those for which magnetoresistance magnitude of the material oscillates as a function of the material's cross-sectional area, and the cross-sectional area of the conductor may be selected to correspond to a peak of the function.

Abstract translation: 本发明包括具有第一侧和第二侧的导体。 导体的尺寸可以具有与导体中的电子的费米波长基本相似的截面直径，其截面直径基本上垂直于电流可以流过导体的主要方向。 可以选择导体尺寸，使得当将小于阈值的磁场施加到导体时，导体的第一侧具有第一磁状态，并且导体的第二侧具有第二磁状态。 然而，当对磁导体施加足够强度的磁场时，将使第一侧和第二侧具有相同的磁状态。 导体的材料可以选自材料的磁阻大小作为材料的横截面积的函数振荡的材料，并且可以选择导体的横截面面积以对应于功能的峰值。

公开(公告)号：WO2005086784A2

公开(公告)日：2005-09-22

申请号：PCT/US2005007461

申请日：2005-03-04

Applicant: UNIV NEW YORK STATE RES FOUND ,  SACHS FREDERICK ,  HUA ZONGLU ,  BESCH STEPHEN ,  CHOPRA HARSH DEEP ,  AUERBACH ANTHONY ,  GOTTLIEB PHILIP ,  ATEYA DANIEL A

Inventor： SACHS FREDERICK ,  HUA ZONGLU ,  BESCH STEPHEN ,  CHOPRA HARSH DEEP ,  AUERBACH ANTHONY ,  GOTTLIEB PHILIP ,  ATEYA DANIEL A

IPC: C12Q1/00 ,  C12Q1/02 ,  G01N15/02 ,  G01N33/487 ,  G01N33/50 ,  G01N33/569

CPC classification number: G01N15/0266 ,  G01N33/5026 ,  G01N33/569

Abstract: A method and apparatus for measuring changes in cell volume generally includes introducing cells into a chamber having a volume between 2 and 100 times the volume of the introduced cell. A first electrically conductive extracellular fluid is introduced into the chamber and a current is applied. The current flow is measured. The first fluid is exchanged with a second electrically conductive extracellular fluid and a current is applied. The current flow is measured. The first current flow result and the second current flow result are used in conjunction with known current flows to monitor changes in the volume corresponding to fluid flow between the cell and an extracellular fluid.

Abstract translation: 用于测量细胞体积变化的方法和装置通常包括将细胞引入具有介入细胞的体积的2至100倍之间的体积的室中。 将第一导电细胞外液引入腔室并施加电流。 测量电流。 将第一流体与第二导电细胞外液相互交换并施加电流。 测量电流。 第一电流流动结果和第二电流流动结果与已知电流一起使用以监测对应于细胞和细胞外液体之间的流体流动的体积变化。