公开(公告)号：WO2011147319A1

公开(公告)日：2011-12-01

申请号：PCT/CN2011/074678

申请日：2011-05-25

申请人： GENERON (SHANGHAI) CORPORATION LTD. ,  YAN, Xiaoqiang ,  HUANG, Zhihua ,  YANG, Hongzhou ,  SUN, Bill N.C. ,  HUANG, Yuliang

发明人： YAN, Xiaoqiang ,  HUANG, Zhihua ,  YANG, Hongzhou ,  SUN, Bill N.C. ,  HUANG, Yuliang

IPC分类号： C07K19/00 ,  C12N15/62 ,  C12N15/63 ,  A61K38/19 ,  A61P25/00 ,  C07K14/535

CPC分类号： C07K14/535 ,  A61K38/193 ,  C07K2319/00 ,  C07K2319/30

摘要： Provided is a recombinant human G-CSF (rhG-CSF) dimer having prolonged serum half-life and increased biological activity of G-CSF, wherein the dimer is produced by two G-CSF-Fc complexes through the pairing of two Fc fragments via disulfide bonds, and the G-CSF-Fc complex comprises a G-CSF monomer, an Fc fragment of human IgG2, and a peptide connecting the G-CSF monomer and the Fc fragment. The rhG-CSF can be used for the treatment of neurological diseases.

摘要翻译： 提供了具有延长的血清半衰期和增加的G-CSF的生物学活性的重组人G-CSF（rhG-CSF）二聚体，其中二聚体是由两个G-CSF-Fc复合物通过两个Fc片段的配对通过 二硫键，并且G-CSF-Fc复合物包含G-CSF单体，人IgG2的Fc片段和连接G-CSF单体和Fc片段的肽。 rhG-CSF可用于治疗神经系统疾病。

公开(公告)号：WO2005038497A3

公开(公告)日：2005-12-15

申请号：PCT/US2004034017

申请日：2004-10-14

申请人： OPTIMER PHOTONICS INC ,  RISSER STEVEN M ,  MCGINNISS VINCENT D ,  SPAHR KEVIN B ,  HIGGINS RICHARD J ,  RIDGEWAY RICHARD W ,  HUANG ZHIHUA ,  JIANG EDWARD

发明人： RISSER STEVEN M ,  MCGINNISS VINCENT D ,  SPAHR KEVIN B ,  HIGGINS RICHARD J ,  RIDGEWAY RICHARD W ,  HUANG ZHIHUA ,  JIANG EDWARD

IPC分类号： C09K19/54 ,  G02B20060101 ,  G02B6/02 ,  G02B6/12 ,  G02B6/122 ,  G02F1/01 ,  G02F1/1333 ,  G02F1/1334 ,  G02F1/225

CPC分类号： C09K19/544 ,  G02B6/1221 ,  G02B2006/12142 ,  G02B2006/12159 ,  G02F1/011 ,  G02F1/0118 ,  G02F1/1326 ,  G02F1/1334 ,  G02F1/225 ,  G02F2203/50

摘要： Broadly, then, one aspect of the present invention is a functional optical material composed of a liquid crystal (LC) evidencing a pair of refractive indices (RI's) and a polymer in which the LC is dispersed. The refractive index (RI) of said polymer may be outside of the L C RI's by at least about 0.03. Another aspect of the present invention is a functional optical material composed of a liquid crystal (LC) and a polymer in which the LC is dispersed, wherein said LC is less than about 5% miscible in said polymer. A further aspect of the present invention is a functional optical material composed of a liquid crystal (LC) and a polymer in which the LC is dispersed, wherein the cladding contains not more than about 20wt% LC. In all of these embodiments, the functional optical material can be clad to an optical waveguide and can optionally contain a chromophore. In yet another aspect of the present invention, a functional optical waveguide is composed of a polymer having a refractive index, RIP and an optical waveguide clad having a refractive index, RIWG, wherein RIP is at least about 0.3% lower than RIWG under operating conditions of said clad optical waveguide.

摘要翻译： 广义地说，本发明的一个方面是由表现出一对折射率（RI）的液晶（LC）和其中分散有LC的聚合物组成的功能光学材料。 所述聚合物的折射率（RI）可以在L C RI之外至少约0.03。 本发明的另一方面是由液晶（LC）和其中分散有LC的聚合物组成的功能性光学材料，其中所述聚合物中所述LC小于约5％。 本发明的另一方面是一种由液晶（LC）和其中分散有LC的聚合物组成的功能光学材料，其中包层含有不超过约20wt％的LC。 在所有这些实施例中，功能光学材料可以被包覆到光波导并且可以可选地包含发色团。 在本发明的另一方面，功能性光波导由具有折射率的聚合物RIP和包含折射率RIWG的光波导包层组成，其中RIP在工作条件下比RIWG低至少约0.3％ 的所述包层光波导。

公开(公告)号：WO0035998A2

公开(公告)日：2000-06-22

申请号：PCT/US9929574

申请日：1999-12-15

申请人： UNIV YALE ,  BECKMAN ERIC J ,  HAMILTON ANDREW D ,  HUANG ZHIHUA ,  CARR ANDREW ,  ENICK ROBERT M

发明人： BECKMAN ERIC J ,  HAMILTON ANDREW D ,  HUANG ZHIHUA ,  CARR ANDREW ,  ENICK ROBERT M

IPC分类号： C07C233/63 ,  C07C233/83 ,  C07C235/12 ,  C07C271/16 ,  C07C271/22 ,  C07C271/52 ,  C07C275/16 ,  C07C275/18 ,  C07C275/24 ,  C08G18/08 ,  C08G18/28 ,  C08G18/38 ,  C08J9/12 ,  C08J9/00

CPC分类号： C08J9/122 ,  C07C233/63 ,  C07C233/83 ,  C07C235/12 ,  C07C271/16 ,  C07C271/22 ,  C07C271/52 ,  C07C275/16 ,  C07C275/18 ,  C07C275/24 ,  C07C2601/14 ,  C08G18/0852 ,  C08G18/2885 ,  C08G18/3821 ,  C08G2101/00 ,  C08J2203/08 ,  C08J2375/04

摘要： The invention relates to a method of increasing the viscosity of supercritical CO2 by combining a compound having a CO2-philic functional group and an aggregating functional group which enables the compound to form a supramolecular network in solution with supercritical CO2 to form a solution. The compound is then aggregated in solution to form a supramolecular network such that the viscosity of the supercritical CO2 with the supramolecular network is greater than that of the starting supercritical CO2. The invention also relates to a method of making a microcellular foam by combining a compound having a CO2-philic functional group and an aggregating functional group which enables the compound to form a supramolecular network in solution, with supercritical CO2 to form a solution. The compound is aggregated to form a supramolecular network in solution. Then the CO2 is removed under conditions sufficient to form a microcellular foam.

摘要翻译： 本发明涉及通过组合具有亲CO 2官能团和聚合官能团的化合物来增加超临界CO 2的粘度的方法，所述聚集官能团使得所述化合物能够与超临界CO 2在溶液中形成超分子网络以形成溶液。 然后该化合物在溶液中聚集形成超分子网络，使超临界二氧化碳具有超分子网络的粘度大于起始超临界二氧化碳的粘度。 本发明还涉及通过将具有亲CO 2官能团和使聚合物在溶液中形成超分子网络的聚集官能团的化合物与超临界CO 2组合以形成溶液来制备微孔泡沫的方法。 该化合物聚集形成溶液中的超分子网络。 然后在足以形成微孔泡沫的条件下除去CO 2。

公开(公告)号：WO2005038497A2

公开(公告)日：2005-04-28

申请号：PCT/US2004/034017

申请日：2004-10-14

申请人： OPTIMER PHOTONICS, INC. ,  RISSER, Steven, M. ,  MCGINNISS, Vincent, D. ,  SPAHR, Kevin, B. ,  HIGGINS, Richard, J. ,  RIDGEWAY, Richard, W. ,  HUANG, Zhihua ,  JIANG, Edward

发明人： RISSER, Steven, M. ,  MCGINNISS, Vincent, D. ,  SPAHR, Kevin, B. ,  HIGGINS, Richard, J. ,  RIDGEWAY, Richard, W. ,  HUANG, Zhihua ,  JIANG, Edward

IPC分类号： G02B

CPC分类号： C09K19/544 ,  G02B6/1221 ,  G02B2006/12142 ,  G02B2006/12159 ,  G02F1/011 ,  G02F1/0118 ,  G02F1/1326 ,  G02F1/1334 ,  G02F1/225 ,  G02F2203/50

摘要： Broadly, then, one aspect of the present invention is a functional optical material composed of a liquid crystal (LC) evidencing a pair of refractive indices (RI’s) and a polymer in which the LC is dispersed. The refractive index (RI) of said polymer may be outside of the L C RI’s by at least about 0.03. Another aspect of the present invention is a functional optical material composed of a liquid crystal (LC) and a polymer in which the LC is dispersed, wherein said LC is less than about 5% miscible in said polymer. A further aspect of the present invention is a functional optical material composed of a liquid crystal (LC) and a polymer in which the LC is dispersed, wherein the cladding contains not more than about 20wt% LC. In all of these embodiments, the functional optical material can be clad to an optical waveguide and can optionally contain a chromophore. In yet another aspect of the present invention, a functional optical waveguide is composed of a polymer having a refractive index, RI P and an optical waveguide clad having a refractive index, RI WG , wherein RI P is at least about 0.3% lower than RI WG under operating conditions of said clad optical waveguide.

摘要翻译： 因此，广泛地说，本发明的一个方面是由液晶（LC）构成的功能性光学材料，该液晶（LC）表示一对折射率（RI）和分散有LC的聚合物。 所述聚合物的折射率（RI）可以在L C RI之外至少约0.03。 本发明的另一方面是由液晶（LC）和其中分散有LC的聚合物组成的功能光学材料，其中所述LC小于约5％在所述聚合物中混溶。 本发明的另一方面是由液晶（LC）和其中分散有LC的聚合物组成的功能光学材料，其中包层含有不超过约20重量％的LC。 在所有这些实施例中，功能性光学材料可以包覆到光波导并且可以任选地包含发色团。 在本发明的另一方面，功能光波导由具有折射率的聚合物RIP和具有折射率的光波导包围RIWG组成，其中RIP在操作条件下比RIWG低至少约0.3％ 的所述包层光波导。

公开(公告)号：WO0035998B1

公开(公告)日：2000-11-16

申请号：PCT/US9929574

申请日：1999-12-15

申请人： UNIV YALE ,  BECKMAN ERIC J ,  HAMILTON ANDREW D ,  HUANG ZHIHUA ,  CARR ANDREW ,  ENICK ROBERT M

发明人： BECKMAN ERIC J ,  HAMILTON ANDREW D ,  HUANG ZHIHUA ,  CARR ANDREW ,  ENICK ROBERT M

IPC分类号： C07C233/63 ,  C07C233/83 ,  C07C235/12 ,  C07C271/16 ,  C07C271/22 ,  C07C271/52 ,  C07C275/16 ,  C07C275/18 ,  C07C275/24 ,  C08G18/08 ,  C08G18/28 ,  C08G18/38 ,  C08J9/12 ,  E21B43/26

CPC分类号： C08J9/122 ,  C07C233/63 ,  C07C233/83 ,  C07C235/12 ,  C07C271/16 ,  C07C271/22 ,  C07C271/52 ,  C07C275/16 ,  C07C275/18 ,  C07C275/24 ,  C07C2601/14 ,  C08G18/0852 ,  C08G18/2885 ,  C08G18/3821 ,  C08G2101/00 ,  C08J2203/08 ,  C08J2375/04

摘要： The invention relates to a method of increasing the viscosity of supercritical CO2 by combining a compound having a CO2-philic functional group and an aggregating functional group which enables the compound to form a supramolecular network in solution with supercritical CO2 to form a solution. The compound is then aggregated in solution to form a supramolecular network such that the viscosity of the supercritical CO2 with the supramolecular network is greater than that of the starting supercritical CO2. The invention also relates to a method of making a microcellular foam by combining a compound having a CO2-philic functional group and an aggregating functional group which enables the compound to form a supramolecular network in solution, with supercritical CO2 to form a solution. The compound is aggregated to form a supramolecular network in solution. Then the CO2 is removed under conditions sufficient to form a microcellular foam.

摘要翻译： 本发明涉及通过组合具有CO 2亲水官能团的化合物和聚集官能团来提高超临界CO 2的粘度的方法，该方法使化合物能够在超临界CO 2溶液中形成超分子网络以形成溶液。 然后将化合物在溶液中聚合以形成超分子网络，使得超超临界CO 2与超分子网络的粘度大于起始超临界CO 2的粘度。 本发明还涉及通过组合具有CO 2亲水官能团的化合物和能够使化合物在溶液中形成超分子网络的聚集官能团，通过超临界CO 2形成溶液来制备微孔泡沫的方法。 该化合物被聚集以形成溶液中的超分子网络。 然后在足以形成微孔泡沫的条件下除去CO 2。