公开(公告)号：WO2007053526A1

公开(公告)日：2007-05-10

申请号：PCT/US2006/042241

申请日：2006-10-30

Applicant: JANSSEN PHARMACEUTICA N.V. ,  QIN, Ning ,  LIU, Yi ,  FLORES, Christopher, M. ,  HUTCHINSON, Tasha ,  NEEPER, Michael, P.

Inventor： QIN, Ning ,  LIU, Yi ,  FLORES, Christopher, M. ,  HUTCHINSON, Tasha ,  NEEPER, Michael, P.

IPC: G01N33/68 ,  A61P39/00 ,  A61K31/352 ,  A61K31/05

CPC classification number: G01N33/6872 ,  A61K31/05 ,  A61K31/352 ,  G01N33/5058 ,  G01N33/948 ,  G01N2500/02

Abstract: It has now been discovered that certain cannabinoids specifically activate TRPV2 channel activity. Based on the discovery, novel compositions and methods for screening, identifying and characterizing compounds that increase or decrease the biological activity of a TRPV2.

Abstract translation: 现在已经发现某些大麻素特异性地激活TRPV2通道活性。 基于发现，用于筛选，鉴定和表征增加或降低TRPV2生物活性的化合物的新型组合物和方法。