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    NOVEL USE OF PANDURATIN DERIVATIVES OR AN EXTRACT OF BOESENBERGIA PANDURATA FOR PROMOTING MUSCLE MASS GROWTH, FIGHTING FATIGUE, AND ENHANCING EXERCISE PERFORMANCE CAPABILITY
    1.
    发明申请
    NOVEL USE OF PANDURATIN DERIVATIVES OR AN EXTRACT OF BOESENBERGIA PANDURATA FOR PROMOTING MUSCLE MASS GROWTH, FIGHTING FATIGUE, AND ENHANCING EXERCISE PERFORMANCE CAPABILITY 审中-公开
    潘多拉汀衍生物的新用途或提取物，用于促进肌肉大量生长，消除疲劳和增强锻炼性能能力

    公开(公告)号：WO2011145909A3

    公开(公告)日：2012-03-29

    申请号：PCT/KR2011003735

    申请日：2011-05-20

    Applicant: BIOCARE CO LTD ,  NEWTREE CO LTD ,  HWANG JAE-KWAN ,  KIM DO UN

    Inventor： HWANG JAE-KWAN ,  KIM DO UN

    IPC: A61K31/05 ,  A61K36/906 ,  A61P21/00 ,  A61P43/00

    CPC classification number: A61K36/906 ,  A23L33/105 ,  A61K31/12 ,  A61K36/00

    Abstract: The present invention relates to the novel use of panduratin derivatives or an extract of Boesenbergia pandurata for promoting muscle mass growth, fighting fatigue, and enhancing exercise performance capability. More particularly, the present invention relates to a composition for enhancing exercise performance capability, promoting muscle mass growth, and fighting fatigue, which comprises panduratin derivatives or salts thereof, or an extract of Boesenbergia pandurata, as active ingredients, and which promotes muscle mass growth and recovery from fatigue to improve mobility. The present invention also relates to a method for improving exercise performance capability, promoting muscle mass growth, and fighting fatigue, which involves injecting panduratin derivatives or salts thereof, or an extract of Boesenbergia pandurata, into an individual requiring same. The panduratin derivatives or the extract of Boesenbergia pandurata of the present invention can be used safely with no adverse effects, and increases the expression of PPAR d in the muscles, thus exhibiting excellent effects in promoting muscle mass growth, recovery from fatigue, and an enhancement in exercise performance capability such as an enhancement in mobility.

    Abstract translation: 本发明涉及潘多蛋白衍生物或泛黄柏提取物的新用途，用于促进肌肉生长，抗疲劳，提高运动能力。 更具体地，本发明涉及一种用于增强运动性能能力，促进肌肉量增长和抗疲劳的组合物，其包含潘多汀衍生物或其盐，或作为活性成分的Boesenbergia pandurata的提取物，并且其促进肌肉质量生长 并从疲劳中恢复，提高流动性。 本发明还涉及一种用于提高运动能力，促进肌肉量增长和抗疲劳的方法，其包括将潘多蛋白衍生物或其盐，或Boesenbergia pandurata的提取物注射到需要相同的个体中。 可以安全地使用本发明的潘氏白藜芦素衍生物或提取物，没有副作用，并且增加肌肉中PPAR d的表达，因此在促进肌肉量生长，疲劳恢复和增强方面表现出优异的效果 在运动表现能力，如增加流动性。

    USE OF LIGNAN COMPOUND FOR ANTI-WRINKLE TREATMENT
    2.
    发明申请
    USE OF LIGNAN COMPOUND FOR ANTI-WRINKLE TREATMENT 审中-公开
    LIGNAN化合物用于抗皱治疗的用途

    公开(公告)号：WO2008156345A3

    公开(公告)日：2009-03-12

    申请号：PCT/KR2008003547

    申请日：2008-06-20

    Applicant: BIOCARE CO LTD ,  HWANG JAE-KWAN ,  LEE HAE JI ,  LEE JAE YOUNG ,  SHIM JAE-SEOK ,  KIM JEONG HWAN

    Inventor： HWANG JAE-KWAN ,  LEE HAE JI ,  LEE JAE YOUNG ,  SHIM JAE-SEOK ,  KIM JEONG HWAN

    IPC: A61K8/34

    CPC classification number: A61K8/97 ,  A61K8/347 ,  A61K8/498 ,  A61Q19/08

    Abstract: The present invention relates to a novel use of lignan compounds, which are isolated and purified from nutmeg or the aril of nutmeg for anti-wrinkle, and more particularly, the present invention relates to a novel use for anti-wrinkle of an extract of the nutmeg or an extract of the aril of the nutmeg, fragrin A, austobailignan 7, licarin E, and macelignan. The extracts and lignan compounds of the present invention have activities in suppressing collagen degradation enzyme- 1(MMP-I, matrix metalloprotei-nase-1) and formation of new collagen (type-1 procollagen), thereby having effect on inhibitng wrinkle caused by photoaging. Accordingly, the extracts and lignan compounds of the present invention may be useful for preventing or treating wrinkle caused by photoaging.

    Abstract translation: 本发明涉及木糖素化合物的新用途，其从肉豆蔻或肉豆蔻的肠道中分离和纯化用于抗皱，更具体地，本发明涉及用于抗皱的提取物的抗皱纹的新用途 肉豆蔻或肉豆蔻，fragrin A，奥维菌素7，licarin E和肉豆蔻衣木脂的提取物。 本发明的提取物和木脂素化合物具有抑制胶原降解酶-1（MMP-1，基质金属蛋白酶-1）和新型胶原（1型前胶原）的形成的作用，从而具有抑制由 光老化。 因此，本发明的提取物和木酚素化合物可用于预防或治疗由光老化引起的皱纹。

    NOVEL USE OF LIGNAN COMPOUNDS
    3.
    发明申请
    NOVEL USE OF LIGNAN COMPOUNDS 审中-公开
    使用LIGNAN化合物的新用途

    公开(公告)号：WO2006104369A1

    公开(公告)日：2006-10-05

    申请号：PCT/KR2006/001212

    申请日：2006-03-31

    Applicant: INJE UNIVERSITY ,  HWANG, Jae-Kwan ,  HAN, Jung-Soo ,  LIM, Chol-Seung ,  JIN, Daqing ,  LEE, Sun-Hee ,  HAN, Kyu-Lee

    Inventor： HWANG, Jae-Kwan ,  HAN, Jung-Soo ,  LIM, Chol-Seung ,  JIN, Daqing ,  LEE, Sun-Hee ,  HAN, Kyu-Lee

    IPC: A61K31/357

    CPC classification number: A61K36/185 ,  A61K31/357

    Abstract: The present invention relates to the novel use of lignan compounds represented by Formula I. More particularly, the present invention relates to a pharmaceutical composition for treating or preventing a brain disease, comprising a lignan compound represented by Formula I or a Myristica fragrans extract as an active ingredient, as well as the method and use for treating or preventing a brain disease using the lignan compound. The lignan compound represented by Formula I has the effects of antioxidation, brain cell protection and antiinflammation. Accordingly, said lignan compound will be highly useful for treating or preventing a brain disease.

    Abstract translation: 本发明涉及由式I表示的木酚素化合物的新用途。更具体地，本发明涉及用于治疗或预防脑疾病的药物组合物，其包含由式I表示的木酚素化合物或肉豆蔻酸提取物作为 活性成分，以及用于使用木脂素化合物治疗或预防脑部疾病的方法和用途。 由式I表示的木酚素化合物具有抗氧化，脑细胞保护和抗炎的作用。 因此，所述木脂素化合物对于治疗或预防脑部疾病是非常有用的。

    COMPOSITION FOR ENHANCING ORAL HEALTH
    5.
    发明申请
    COMPOSITION FOR ENHANCING ORAL HEALTH 审中-公开
    用于增强口腔健康的组合物

    公开(公告)号：WO2003097000A1

    公开(公告)日：2003-11-27

    申请号：PCT/KR2003/000979

    申请日：2003-05-16

    Applicant: LG HOUSEHOLD & HEALTHCARE CO., LTD. ,  HWANG, Jae-Kwan ,  KIM, Hyung-Jin ,  KIM, Sang-Nyun ,  KIM, Hoo-Deok ,  KIM, Young-Ho ,  KIM, Moon-Moo ,  PARK, Hyoung-Kook

    Inventor： KIM, Hoo-Deok ,  KIM, Young-Ho ,  KIM, Moon-Moo ,  PARK, Hyoung-Kook

    IPC: A61K7/16

    CPC classification number: A61K8/97 ,  A61K8/347 ,  A61K8/42 ,  A61K8/44 ,  A61K8/463 ,  A61K8/466 ,  A61K36/9066 ,  A61K45/06 ,  A61Q11/00 ,  A61K2300/00

    Abstract: Disclosed is composition for enhancing oral health, which includes 0.0001∼10 wt % of Xanthorrhizol on the basis of the total weight of the composition, and 0.01∼10 wt % of at least one antibacterial activity enhancer selected form the group consisting of alkyl sodium sulfate, sodium lauroyl sarcocinate and sodium methylcocoyltaurate. The antibacterial activity enhancer contained in the composition more effectively enhances antibacterial activity of Xanthorrhizol against causative bacterial of a decayed tooth or a peridental disease existing in the mouth, so the composition is very helpful for enhancing the oral health, for example the prevention or relief of a decayed tooth or a peridental disease or the restraint of foul breath.

    Abstract translation: 公开了用于提高口腔健康的组合物，其包含基于组合物总重量的0.0001〜10重量％的Xanthorrhizol，以及选自烷基硫酸钠的0.01〜10重量％的至少一种抗菌活性增强剂 月桂酰肌氨酸钠和甲基胆甾烯酸月桂酸钠。 组合物中所含的抗菌活性增强剂更有效地提高了Xanthorrhizol对存在于口腔中的腐烂性牙齿或外来疾病的致病菌的抗菌活性，因此该组合物对于提高口腔健康状况非常有帮助，例如预防或缓解 蛀牙或外伤性疾病或窒息呼吸的限制。

    NOVEL USE OF FLAVONE-BASED COMPOUND
    6.
    发明申请
    NOVEL USE OF FLAVONE-BASED COMPOUND 审中-公开
    使用基于FLAVONE的化合物的新用途

    公开(公告)号：WO2012099449A3

    公开(公告)日：2012-12-06

    申请号：PCT/KR2012000601

    申请日：2012-01-25

    Applicant: INDUSTRY ACADEMIC COOPERATION ,  HWANG JAE-KWAN ,  KIM JAEKYUNG

    Inventor： HWANG JAE-KWAN ,  KIM JAEKYUNG

    IPC: A61K8/49 ,  A61K8/97 ,  A61K31/352 ,  A61Q19/00

    CPC classification number: A61K8/498 ,  A23G3/48 ,  A23G4/068 ,  A23L2/52 ,  A23L33/105 ,  A61K8/97 ,  A61K31/352 ,  A61Q19/007 ,  A61Q19/08

    Abstract: The present invention relates to a novel use of a flavone-based compound or Kaempferia parviflora extract, and more particularly, to a composition for anti-wrinkle, anti-aging and improvement of skin elasticity, comprising a flavone-based compound or Kaempferia parviflora extract, as an active ingredient. The composition of the present invention has superior effects of inhibiting collagenases and promoting collagen production, and therefore, may be effective in preventing skin wrinkles and aging and improving skin elasticity, and has superior effects of inhibiting loss of skin moisture and thus is effective in skin moisturizing.

    Abstract translation: 本发明涉及一种黄酮类化合物或小叶草提取物的新用途，更具体地说，涉及一种抗皱，抗衰老，改善皮肤弹性的组合物，其含有黄酮类化合物或小叶草（Kaempferia parviflora extract） ，作为活性成分。 本发明的组合物具有抑制胶原酶和促进胶原蛋白生成的优异效果，因此可以有效地防止皮肤皱纹和老化并改善皮肤弹性，并且具有抑制皮肤水分损失的优异效果，因此在皮肤中有效 保湿。

    USE OF LIGNAN COMPOUND FOR ANTI-WRINKLE TREATMENT
    8.
    发明申请
    USE OF LIGNAN COMPOUND FOR ANTI-WRINKLE TREATMENT 审中-公开
    LIGNAN化合物用于抗皱治疗的用途

    公开(公告)号：WO2008156345A2

    公开(公告)日：2008-12-24

    申请号：PCT/KR2008/003547

    申请日：2008-06-20

    Applicant: BIOCARE CO., LTD. ,  HWANG, Jae-Kwan ,  LEE, Hae Ji ,  LEE, Jae Young ,  SHIM, Jae-Seok ,  KIM, Jeong Hwan

    Inventor： HWANG, Jae-Kwan ,  LEE, Hae Ji ,  LEE, Jae Young ,  SHIM, Jae-Seok ,  KIM, Jeong Hwan

    IPC: A61K8/34

    CPC classification number: A61K8/97 ,  A61K8/347 ,  A61K8/498 ,  A61Q19/08

    Abstract: The present invention relates to a novel use of lignan compounds, which are isolated and purified from nutmeg or the aril of nutmeg for anti-wrinkle, and more particularly, the present invention relates to a novel use for anti-wrinkle of an extract of the nutmeg or an extract of the aril of the nutmeg, fragrin A, austobailignan 7, licarin E, and macelignan. The extracts and lignan compounds of the present invention have activities in suppressing collagen degradation enzyme- 1(MMP-I, matrix metalloprotei-nase-1) and formation of new collagen (type-1 procollagen), thereby having effect on inhibitng wrinkle caused by photoaging. Accordingly, the extracts and lignan compounds of the present invention may be useful for preventing or treating wrinkle caused by photoaging.

    Abstract translation: 本发明涉及木糖素化合物的新用途，其从肉豆蔻或肉豆蔻的肠道中分离和纯化用于抗皱，更具体地，本发明涉及用于抗皱的提取物的抗皱纹的新用途 肉豆蔻或肉豆蔻，fragrin A，奥维菌素7，licarin E和肉豆蔻衣木脂的提取物。 本发明的提取物和木脂素化合物具有抑制胶原降解酶-1（MMP-1，基质金属蛋白酶-1）和新型胶原（1型前胶原）的形成的作用，从而具有抑制由 光老化。 因此，本发明的提取物和木酚素化合物可用于预防或治疗由光老化引起的皱纹。

    IMMUNOSTIMULATING POLYSACCHARIDES ISOLATED FROM CURCUMA XANTHORRHIZA AND MANUFACTURING METHOD THEREOF
    9.
    发明申请
    IMMUNOSTIMULATING POLYSACCHARIDES ISOLATED FROM CURCUMA XANTHORRHIZA AND MANUFACTURING METHOD THEREOF 审中-公开
    免疫球蛋白分离多糖和其制备方法

    公开(公告)号：WO2006135197A1

    公开(公告)日：2006-12-21

    申请号：PCT/KR2006/002282

    申请日：2006-06-14

    Applicant: HWANG, Jae-Kwan ,  KIM, Ah-Jin ,  SOHN, Jong-Hee ,  HAN, Kyu-Lee ,  LEE, Sun-Hee ,  CHOO, Jeong-Han

    Inventor： HWANG, Jae-Kwan ,  KIM, Ah-Jin ,  SOHN, Jong-Hee ,  HAN, Kyu-Lee ,  LEE, Sun-Hee ,  CHOO, Jeong-Han

    IPC: C08B37/00

    CPC classification number: C08B37/006 ,  C12P19/04

    Abstract: The present invention provides a method for manufacturing polysaccharides isolated from Curcuma xanthorrhiza , including steps of: (S1) preparing a powder of Curcuma xanthorrhiza Roxb .; (S2) extracting the powder with an organic solvent, and then filtering or centrifuging to obtain a residue; (S3) extracting the residue to prepare a solution containing polysaccharides; (S4) removing starch by adding starch-hydrolyzing enzyme to the polysaccharides-containing solution; (S5) precipitating the polysaccharides after the step (S4); and (S6) purifying the polysaccharides after the step (S5), polysaccharides obtained according to the manufacturing method, and a pharmaceutical composition in eluding the polysaccharides as effective component. The polysaccharides according to the present invention may be very effectively used in drugs and functional foods for stimulating macrophage activity, preventing and treating immunological diseases including cancer, and enhancing immunity after the treatment of the immunological diseases.

    Abstract translation: 本发明提供了从姜黄分离的多糖的制造方法，包括以下步骤：（S1）制备姜黄黄酮粉末; （S2）用有机溶剂萃取粉末，然后过滤或离心得到残留物; （S3）提取残渣以制备含有多糖的溶液; （S4）通过向含多糖溶液中加入淀粉水解酶除去淀粉; （S5）在步骤（S4）后沉淀多糖; 和（S6）步骤（S5）后的多糖的纯化，根据制造方法得到的多糖，以及除了多糖作为有效成分的药物组合物。 本发明的多糖可以非常有效地用于药物和功能性食品中，用于刺激巨噬细胞活性，预防和治疗免疫疾病，包括癌症，以及增强免疫疾病治疗后的免疫力。

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