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    PROTEIN FACTOR
    3.
    发明申请
    PROTEIN FACTOR 审中-公开
    蛋白因子

    公开(公告)号：WO1991012272A1

    公开(公告)日：1991-08-22

    申请号：PCT/GB1991000245

    申请日：1991-02-15

    Applicant: IMPERIAL CANCER RESEARCH TECHNOLOGY LTD. ,  STOKER, Michael ,  GHERARDI, Ermanno

    Inventor： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD.

    IPC: C07K13/00

    CPC classification number: C07K16/22 ,  A61K38/00 ,  C07K14/4753

    Abstract: A polypeptide or protein comprising at least five contiguous amino acid residues in a sequence corresponding to formula (I): VVNGIPTQTTVGX MVSLX YY wherein the internationally recognised 1-letter code is used to represent amino acid residues and X is any naturally occuring L-amino acid residue and X is any amino acid residue, but is preferably an L-leucine residue (L).

    Abstract translation: 包含对应于式（I）的序列中的至少五个连续氨基酸残基的多肽或蛋白质：VVNGIPTQTTVGX 1 MVSLX 2 YY其中国际公认的1个字母的代码用于表示氨基酸残基，X <1 >是任何天然存在的L-氨基酸残基，X 2是任何氨基酸残基，但优选L-亮氨酸残基（L）。

    GROWTH FACTOR RECEPTOR-LIKE PEPTIDES WITHOUT TYROSINE-KINASE ACTIVITY
    6.
    发明申请
    GROWTH FACTOR RECEPTOR-LIKE PEPTIDES WITHOUT TYROSINE-KINASE ACTIVITY 审中-公开
    不含酪氨酸激酶活性的生长因子受体样肽

    公开(公告)号：WO1990008160A1

    公开(公告)日：1990-07-26

    申请号：PCT/GB1990000083

    申请日：1990-01-19

    Applicant: IMPERIAL CANCER RESEARCH TECHNOLOGY LTD. ,  STERNBERG, Michael, Joseph, Ezra ,  GULLICK, William, John ,  CHOTHIA, Cyrus

    Inventor： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD.

    IPC: C07K07/08

    CPC classification number: C07K14/82 ,  A61K38/00 ,  C07K14/71

    Abstract: A peptide which lacks tyurosine kinase activity, having a binding portion of at least 8 contiguous amino acid residues adapted to form an intra-membrane alpha-helix and being capable of reducing tyrosine kinase activity in a target cell, the binding portion having a sequence identical to the sequence at positions P to P of a natural (wild type) or mutant growth factor receptor/tyrosine kinase portein having the motif set out below or having a sequence which differs at not more than 3 positions from the sequence at positions P to P of such a protein, wherein the motif comprises a sequence of 5 contiguous amino acid residues designated: P XXP P , wherein the residues X are the same or different and each is any naturally occurring L-amino acid residue, P is a residue selected from Ala, Gly, Ser, Thr, Pro, Val, Ile and leu, P is a residue selected from Ala, Gly, Met, Val, Ile and Leu and P is a residue selected from Ala, Gly, Thr, Pro and Val.

    Abstract translation: 缺乏酪氨酸激酶活性的肽，其具有适于形成膜内α-螺旋的至少8个连续氨基酸残基的结合部分，并且能够降低靶细胞中的酪氨酸激酶活性，所述结合部分具有相同的序列 至具有以下所示基序的天然（野生型）或突变型生长因子受体/酪氨酸激酶蛋白的位置P 0至P 7的序列，或具有不超过3个位置的序列 该蛋白质的位置P <0>至P <7>的序列，其中所述基序包含指定为：P P P P 4的5个连续氨基酸残基的序列，其中残基X为 相同或不同，并且各自是任何天然存在的L-氨基酸残基，P 0是选自Ala，Gly，Ser，Thr，Pro，Val，Ile和leu的残基，P 3是选自Ala ，Gly，Met，Val，Ile和Leu，P 4是选自Ala，Gly，Thr，Pro和Val的残基。

    NUCLEOTIDE AND PROTEIN SEQUENCES OF VERTEBRATE DELTA GENES AND METHODS BASED THEREON
    8.
    发明申请
    NUCLEOTIDE AND PROTEIN SEQUENCES OF VERTEBRATE DELTA GENES AND METHODS BASED THEREON 审中-公开
    VERTEBRATE DELTA基因的核苷酸和蛋白质序列及其方法

    公开(公告)号：WO1997001571A1

    公开(公告)日：1997-01-16

    申请号：PCT/US1996011178

    申请日：1996-06-28

    Applicant: IMPERIAL CANCER RESEARCH TECHNOLOGY, LTD. ,  YALE UNIVERSITY ,  ISH-HOROWICZ, David ,  HENRIQUE, Domingo, M., P. ,  LEWIS, Julian, H. ,  ARTAVANIS-TSAKONAS, Spyridon ,  GRAY, Grace, E.

    Inventor： IMPERIAL CANCER RESEARCH TECHNOLOGY, LTD. ,  YALE UNIVERSITY

    IPC: C07H17/00

    CPC classification number: C07K14/47 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/00

    Abstract: The present invention relates to nucleotide sequences of vertebrate Delta genes, and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof. In a specific embodiment, the vertebrate Delta protein is a human protein. The invention further relates to fragments (and derivatives and analogs thereof) of Delta which comprise one or more domains of the Delta protein, including but not limited to the intracellular domain, extracellular domain, DSL domain, domain amino-terminal to the DSL domain, transmembrane region, or one or more EGF-like repeats of a Delta protein, or any combination of the foregoing. Antobidies to Delta, its derivatives and analogs, are additionally provided. Methods of production of the Delta proteins, derivatives and analogs, e.g., by recombinant means, are also provided. Therapeutic and diagnostic methods and pharmaceutical compositions are provided. In specific examples, isolated Delta genes, from Xenopus, chick, mouse, and human, are provided.

    Abstract translation: 本发明涉及脊椎动物Delta基因的核苷酸序列及其编码的蛋白质的氨基酸序列以及衍生物（例如片段）及其类似物。 在具体实施方案中，脊椎动物Delta蛋白是人蛋白质。 本发明还涉及包含Delta蛋白的一个或多个结构域的Delta的片段（及其衍生物和类似物），包括但不限于细胞内结构域，细胞外结构域，DSL结构域，DSL结构域的氨基末端， 跨膜区域，或一种或多种Delta蛋白质的EGF样重复序列，或上述的任何组合。 另外提供了对三角洲，其衍生物和类似物的安慰剂。 还提供了通过重组方法生产Delta蛋白质，衍生物和类似物的方法。 提供了治疗和诊断方法和药物组合物。 在具体实例中，提供了来自爪蟾，小鸡，小鼠和人的孤立的Delta基因。

    ANTIGEN PROCESSING
    9.
    发明申请
    ANTIGEN PROCESSING 审中-公开
    抗原加工

    公开(公告)号：WO1992011289A1

    公开(公告)日：1992-07-09

    申请号：PCT/GB1991002278

    申请日：1991-12-19

    Applicant: IMPERIAL CANCER RESEARCH TECHNOLOGY LTD. ,  TROWSDALE, John ,  KELLY, Adrian, Paul ,  GLYNNE, Richards ,  POWIS, Stephen, Hugh

    Inventor： IMPERIAL CANCER RESEARCH TECHNOLOGY LTD.

    IPC: C07K13/00

    CPC classification number: C07K14/70539 ,  A61K38/00

    Abstract: Genes encoding protein subunits involved in the processing and presentation, in association with MHC class I molecules, of peptide antigens and designated RING4, RING10, RING11 and RING12 are described and claimed together with related proteins and peptides, antibodies, nucleic acids, vectors and other products which are useful in diagnosis and therapy of immune-system disorders and associated diseases.

    Abstract translation: 编码参与与MHC I类分子相关的肽抗原和命名为RING4，RING10，RING11和RING12的加工和呈递的蛋白质亚基的基因与相关蛋白质和肽，抗体，核酸，载体和其他物质一起被描述和要求 可用于诊断和治疗免疫系统疾病及相关疾病的产品。

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