公开(公告)号：WO1987004434A1

公开(公告)日：1987-07-30

申请号：PCT/JP1987000021

申请日：1987-01-14

申请人： HISAMITSU PHARMACEUTICAL CO., INC. ,  TSUJI, Masayoshi ,  NAKAWAGA, Akira ,  INOUE, Hisataka ,  HACHIYA, Terumi ,  TANOUE, Yoshihiro ,  IKESUE, Koichi ,  SAITA, Masaru ,  MIZOGUCHI, Takenobu ,  AOKI, Tetsuo ,  SATO, Hironobu ,  NODA, Kanji

发明人： HISAMITSU PHARMACEUTICAL CO., INC.

IPC分类号： C07D277/60

CPC分类号： C07D277/60 ,  C07D417/12

摘要： Indenothiazole derivatives represented by general formula (Ia) (wherein X and Y, which may be the same or different, each represents hydrogen, halogen, lower alkyl or lower alkoxy, n represents an integer of 0 to 4, R1 represents hydrogen, lower alkyl or unsubstituted or substituted phenyl, R2 represents lower alkyl, cycloalkyl, lower alkoxy, unsubstituted or substituted phenoxy, unsubstituted or substituted phenyl, alkenyl, heterocyclic group or cyclic amino group, R3 represents hydrogen, lower alkyl or acyl, or R2 and R3 may be bound to each other to form a cyclic amino group), and tautomers (Ib) of general formula (Ia) (provided that R3 represents hydrogen) are disclosed.

公开(公告)号：WO1990003373A1

公开(公告)日：1990-04-05

申请号：PCT/JP1989000932

申请日：1989-09-12

申请人： HISAMITSU PHARMACEUTICAL CO., INC. ,  SAITA, Masaru ,  INOUE, Hisataka ,  HACHIYA, Terumi ,  NAKASHIMA, Mikio ,  YAHIRO, Shigenori ,  TANIGUCHI, Yasuaki ,  DEGUCHI, Yoshiki ,  HAMANAKA, Shoji ,  TSUJI, Masayoshi ,  NODA, Kanji

发明人： HISAMITSU PHARMACEUTICAL CO., INC.

IPC分类号： C07D313/12

CPC分类号： C07D417/12 ,  C07D313/12

摘要： The invention provides dibenz[b,e]oxepin derivatives represented by general formula (I), wherein R?1 and R2¿ each represent a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group, one of R?3 and R4¿ is a group represented by general formula (II), [wherein R5 represents a hydrogen atom or a lower alkyl group, A represents a hydroxy group, -O(CH¿2)m-R?6 (wherein m represents an integer of 1 to 6 and R6 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a 5- or 6-membered cyclic amino group or a lower alkoxycarbonyl group), a 5- or 6-membered cyclic amino group, a di(lower alkyl)-amino group or -NH(CH¿2)n-R?7 (wherein n represents an integer of 0 to 3, and R7 represents a hydrogen atom, a hydroxy group, a phenyl group, a thiazole group or a 5- or 6-membered cyclic amino group)] and the other represents a lower alkoxy group.

公开(公告)号：WO1987006226A2

公开(公告)日：1987-10-22

申请号：PCT/JP1987000086

申请日：1987-02-10

申请人： HISAMITSU PHARMACEUTICAL CO., INC. ,  TSUJI, Masayoshi ,  INOUE, Hisataka ,  HACHIYA, Terumi ,  NAKASHIMA, Mikio ,  SAITA, Masaru ,  SHIMOZONO, Yuji ,  NAKAGAWA, Akira ,  SAKAI, Michinori

发明人： HISAMITSU PHARMACEUTICAL CO., INC.

IPC分类号： C07D207/27

CPC分类号： C07D207/267 ,  C07D207/27 ,  C07D211/76 ,  C07D223/10 ,  C07D263/18 ,  C07D265/32 ,  C07D277/14 ,  C07D279/12 ,  C07D281/06 ,  Y10S514/946

摘要： An azacycloalkane derivative useful for promoting the absorption of a medicine, an absorption promoting agent comprising at least one of the azacycloalkane derivatives as the effective ingredient for promoting the absorption and an external preparation containing the absorption promoting agent, the derivative being represented by formula (I), wherein A is -CH2- or -S- for example, B is sulfur or oxygen, R is -SR'' in which R'' is an alkyl group or alkylthioalkyl group for example, or -OR'' in which R'' is as defined above, an alkyl group or substituted amino group, R' is a hydrogen atom, alkyl group or alkyloxy group for example, m is an integer of 0-5 and n is an integer of 1-15.

公开(公告)号：WO1993002999A1

公开(公告)日：1993-02-18

申请号：PCT/JP1992000995

申请日：1992-08-04

申请人： HISAMITSU PHARMACEUTICAL CO., INC. ,  SAITA, Masaru ,  INOUE, Hisataka ,  BEPPU, Koichi ,  HACHIYA, Terumi ,  SHINOHARA, Ikuo ,  TANIGUCHI, Yasuaki ,  DEGUCHI, Yoshiki ,  HAMAGUCHI, Yoshihiro

发明人： HISAMITSU PHARMACEUTICAL CO., INC.

IPC分类号： C07C59/54

CPC分类号： C07C205/56 ,  C07C45/562 ,  C07C45/63 ,  C07C49/697 ,  C07C49/747 ,  C07C59/54 ,  C07C59/56 ,  C07C59/72 ,  C07C59/88 ,  C07C59/90 ,  C07C69/732 ,  C07C69/738

摘要： A novel phenylalkanoic acid derivative represented by general formulae (I) or (II), a process for the production thereof, a method of separating optical isomers thereof, and an anti-inflammatory, analgesic or external preparation containing the same. In the said formulae, n represents an integer of 1 or 2; X represents halogen, alkoxy or nitro; R represents hydrogen or alkyl; and Z represents hydrogen or acyl.

摘要翻译： 一种由通式（I）或（II）表示的新型苯基链烷酸衍生物，其制备方法，分离其旋光异构体的方法，以及含有它们的抗炎止痛剂或外用制剂。 在所述式中，n表示1或2的整数; X表示卤素，烷氧基或硝基; R代表氢或烷基; Z表示氢或酰基。

公开(公告)号：WO1992007827A1

公开(公告)日：1992-05-14

申请号：PCT/JP1991001451

申请日：1991-10-23

申请人： HISAMITSU PHARMACEUTICAL CO., INC. ,  SAITA, Masaru ,  INOUE, Hisataka ,  HACHIYA, Terumi ,  YAHIRO, Shigenori ,  NODA, Kanji

发明人： HISAMITSU PHARMACEUTICAL CO., INC.

IPC分类号： C07D207/27

CPC分类号： C07D207/27 ,  C07D211/76 ,  C07D223/10

摘要： A process for producing an azacycloalkane derivative represented by general formula (II), wherein m represents an integer of 1 to 3, n2 represents an integer of 2 to 10, and R represents C3 to C12 alkyl, which comprises reacting 1-(n-alkenyl)azacycloalkan-2-one represented by general formula (I) wherein, m is as defined above and n1 represents an integer of 0 to 8, with an alkyl mercaptan in the presence of a radical initiator in an organic solvent, treating the reaction product with a reducing agent in a watery organic solvent, followed by purification through distillation.

公开(公告)号：WO1992015570A1

公开(公告)日：1992-09-17

申请号：PCT/JP1991000310

申请日：1991-03-07

申请人： HISAMITSU PHARMACEUTICAL CO., INC. ,  SAITA, Masaru ,  INOUE, Hisataka ,  IKESUE, Kouichi ,  FUJIMOTO, Noriyuki ,  SHINOHARA, Ikuo ,  TANIGUCHI, Yasuaki ,  DEGUCHI, Yoshiki ,  MINAMI, Hidenao ,  NODA, Kanji

发明人： HISAMITSU PHARMACEUTICAL CO., INC.

IPC分类号： C07D277/44

CPC分类号： C07D277/46 ,  C07D277/52

摘要： A novel diphenylthiazole derivative which is effectively used as a medicine with an anti-inflammaory, analgesic, antiallergic, uric acid excretion stimulating, or platelet aggregation inhibiting action and is represented by general formula (I), wherein m and n are each 1 or 2; R?1 and R2¿ each represents hydrogen, lower alkyl, lower alkoxy, lower alkylsulfonyl, nitro, amino, methanesulfonyloxy, or halogen; A1 represents lower alkanesulfonyl, halogenated lower alkanesulfonyl, substituted bezenesulfonyl, lower acyl, or halogenated lower acyl; and A2 represents hydrogen, lower alkanesulfonyl, halogenated lower alkanesulfonyl, or lower alkyl.

公开(公告)号：WO1989008110A1

公开(公告)日：1989-09-08

申请号：PCT/JP1989000143

申请日：1989-02-13

申请人： HISAMITSU PHARMACEUTICAL CO., INC. ,  TSUJI, Masayoshi ,  INOUE, Hisataka ,  TANOUE, Yoshihiro ,  BEPPU, Kouichi ,  SHINOHARA, Ikuo ,  SAITA, Masaru ,  TANIGUCHI, Yasuaki ,  FURUTA, Kenichi ,  DEGUCHI, Yoshiki ,  HAMANAKA, Shoji ,  HORI, Masaaki ,  NODA, Kanji

发明人： HISAMITSU PHARMACEUTICAL CO., INC.

IPC分类号： C07D487/04

CPC分类号： C07D487/04

摘要： 5,6-Diphenyl-1,2-dihydroxy-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives represented by general formula (I) (wherein m and n each represents an integer of 0 to 3, X and Y may be the same or different and each represents a halogen atom, a trihalomethyl group, an alkyl group, an alkoxy group, an alkylthio group, a hydroxy group, a mercapto group, a nitro group or an amino group, R1 represents a hydrogen atom, a halogen atom, an alkyl group, a carboxyl group or its alkyl ester group, and R2 represents a hydroxy group, an alkoxy group or an amino group) are disclosed.

公开(公告)号：WO8706226A3

公开(公告)日：1988-04-07

申请号：PCT/JP8700086

申请日：1987-02-10

申请人： HISAMITSU PHARMACEUTICAL CO ,  TSUJI MASAYOSHI ,  INOUE HISATAKA ,  HACHIYA TERUMI ,  NAKASHIMA MIKIO ,  SAITA MASARU ,  SHIMOZONO YUJI ,  NAKAGAWA AKIRA ,  SAKAI MICHINORI

发明人： TSUJI MASAYOSHI ,  INOUE HISATAKA ,  HACHIYA TERUMI ,  NAKASHIMA MIKIO ,  SAITA MASARU ,  SHIMOZONO YUJI ,  NAKAGAWA AKIRA ,  SAKAI MICHINORI

IPC分类号： C07D207/12 ,  A61K31/395 ,  A61K31/4015 ,  A61K31/435 ,  A61K31/55 ,  A61K47/00 ,  A61K47/22 ,  A61P43/00 ,  C07D207/26 ,  C07D207/267 ,  C07D207/27 ,  C07D211/76 ,  C07D223/10 ,  C07D227/087 ,  C07D263/18 ,  C07D265/32 ,  C07D277/14 ,  C07D279/12 ,  C07D281/06 ,  A01N25/32 ,  C07D265/30 ,  C07D267/10 ,  C07D281/08

CPC分类号： C07D207/267 ,  C07D207/27 ,  C07D211/76 ,  C07D223/10 ,  C07D263/18 ,  C07D265/32 ,  C07D277/14 ,  C07D279/12 ,  C07D281/06 ,  Y10S514/946

摘要： An azacycloalkane derivative useful for promoting the absorption of a medicine, an absorption promoting agent comprising at least one of the azacycloalkane derivatives as the effective ingredient for promoting the absorption and an external preparation containing the absorption promoting agent, the derivative being represented by formula (I), wherein A is -CH2- or -S- for example, B is sulfur or oxygen, R is -SR'' in which R'' is an alkyl group or alkylthioalkyl group for example, or -OR'' in which R'' is as defined above, an alkyl group or substituted amino group, R' is a hydrogen atom, alkyl group or alkyloxy group for example, m is an integer of 0-5 and n is an integer of 1-15.