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    HIV-1 NEUTRALIZING ANTIBODIES AND USES THEREOF
    1.
    发明申请
    HIV-1 NEUTRALIZING ANTIBODIES AND USES THEREOF 审中-公开
    HIV-1中和抗体及其用途

    公开(公告)号：WO2011092593A3

    公开(公告)日：2011-10-27

    申请号：PCT/IB2011000221

    申请日：2011-01-20

    Applicant: INST RESEARCH IN BIOMEDICINE ,  CORTI DAVIDE ,  LANZAVECCHIA ANTONIO

    Inventor： CORTI DAVIDE ,  LANZAVECCHIA ANTONIO

    IPC: C07K16/10 ,  A61K39/395 ,  A61P31/18

    CPC classification number: C07K16/1063 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76

    Abstract: The invention relates to antibodies and antigen binding fragments thereof that neutralize HIV-1 infection. The invention also relates to nucleic acids that encode, immortalized B cells and cultured plasma cells that produce, and to epitopes that bind to such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis, treatment and prevention of HIV-1 infection.

    Abstract translation: 本发明涉及中和HIV-1感染的抗体及其抗原结合片段。 本发明还涉及编码永生化B细胞和培养的浆细胞的核酸，所述细胞产生和结合这些抗体和抗体片段的表位。 此外，本发明涉及抗体，抗体片段和表位在筛选方法中的用途以及HIV-1感染的诊断，治疗和预防。

    DENGUE VIRUS NEUTRALIZING ANTIBODIES AND USES THEREOF
    2.
    发明申请
    DENGUE VIRUS NEUTRALIZING ANTIBODIES AND USES THEREOF 审中-公开
    登革病毒中和抗体及其用途

    公开(公告)号：WO2010043977A3

    公开(公告)日：2010-09-30

    申请号：PCT/IB2009007372

    申请日：2009-10-13

    Applicant: INST RESEARCH IN BIOMEDICINE ,  LANZAVECCHIA ANTONIO

    Inventor： LANZAVECCHIA ANTONIO

    IPC: A61P31/14 ,  C07K16/10

    CPC classification number: C07K16/1081 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2317/76

    Abstract: The invention relates to antibodies and antigen binding fragments thereof and to cocktails of antibodies and antigen binding fragments that neutralize dengue virus infection without contributing to antibody-dependent enhancement of dengue virus infection. The invention also relates to immortalized B cells that produce, and to epitopes that bind to, such antibodies and antigen binding fragments. In addition, the invention relates to the use of the antibodies, antigen binding fragments, and epitopes in screening methods as well as in the diagnosis and therapy of dengue virus infection.

    Abstract translation: 本发明涉及抗体及其抗原结合片段，以及中和登革热病毒感染的抗体和抗原结合片段的混合物，而不会导致登革热病毒感染的抗体依赖性增强。 本发明还涉及产生和结合这些抗体和抗原结合片段的表位的永生化B细胞。 此外，本发明涉及抗体，抗原结合片段和表位在筛选方法中的用途，以及登革热病毒感染的诊断和治疗。

    METHODS FOR PRODUCING ANTIBODIES FROM PLASMA CELLS
    3.
    发明申请
    METHODS FOR PRODUCING ANTIBODIES FROM PLASMA CELLS 审中-公开
    从等离子体细胞生产抗体的方法

    公开(公告)号：WO2010046775A3

    公开(公告)日：2010-06-17

    申请号：PCT/IB2009007375

    申请日：2009-10-22

    Applicant: INST RESEARCH IN BIOMEDICINE ,  LANZAVECCHIA ANTONIO ,  JARROSSAY DAVID

    Inventor： LANZAVECCHIA ANTONIO ,  JARROSSAY DAVID

    IPC: C07K16/00 ,  C07K16/10 ,  C07K16/12 ,  C12N5/0781

    CPC classification number: C12N5/0635 ,  C07K16/00 ,  C07K16/1018 ,  C07K16/1282 ,  C07K2317/21 ,  C12N2502/1394

    Abstract: The invention relates to methods of producing antibodies, including monoclonal antibodies, comprising culturing a limited number of plasma cells. It also relates to methods of identifying antibodies by performing assays on the antibodies produced by the cultured plasma cells to determine their function, binding specificity, epitope specificity, and/or their ability to neutralize a toxin or a pathogen. The invention also relates to antibodies and antibody fragments produced by the methods of the invention as well as methods of using the antibodies and antibody fragments.

    Abstract translation: 本发明涉及产生抗体的方法，包括单克隆抗体，其包括培养有限数量的浆细胞。 它还涉及通过对由培养的浆细胞产生的抗体进行测定以确定其功能，结合特异性，表位特异性和/或其中和毒素或病原体的能力来鉴定抗体的方法。 本发明还涉及通过本发明的方法产生的抗体和抗体片段以及使用抗体和抗体片段的方法。

    NEUTRALIZING ANTI-INFLUENZA A VIRUS ANTIBODIES AND USES THEREOF
    4.
    发明申请
    NEUTRALIZING ANTI-INFLUENZA A VIRUS ANTIBODIES AND USES THEREOF 审中-公开
    中毒抗流感病毒抗体及其用途

    公开(公告)号：WO2010010467A2

    公开(公告)日：2010-01-28

    申请号：PCT/IB2009006623

    申请日：2009-07-27

    Applicant: INST RESEARCH IN BIOMEDICINE ,  LANZAVECCHIA ANTONIO

    Inventor： LANZAVECCHIA ANTONIO

    IPC: A61K39/00

    CPC classification number: C07K16/1018 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76

    Abstract: The invention relates to antibodies and antigen binding fragments thereof, that bind to hemagglutinin and neutralize infection of at least two different group 1 subtypes or at least two different group 2 subtypes of influenza A virus. The invention also relates to nucleic acids that encode, immortalized B cells and cultured single plasma cells that produce, and to epitopes that bind to, such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis, treatment and prevention of influenza A virus infection.

    Abstract translation: 本发明涉及结合血凝素并中和至少两种不同组1亚型或至少两种不同的2型亚型甲型流感病毒的感染的抗体及其抗原结合片段。 本发明还涉及编码永生化B细胞和培养的单个浆细胞的核酸，其产生与表位结合的抗体和抗体片段。 此外，本发明涉及抗体，抗体片段和表位在筛选方法中的用途以及在甲型流感病毒感染的诊断，治疗和预防中的用途。

    MONOCLONAL ANTIBODY PRODUCTION BY EBV TRANSFORMATION OF B CELLS
    5.
    发明申请
    MONOCLONAL ANTIBODY PRODUCTION BY EBV TRANSFORMATION OF B CELLS 审中-公开
    B细胞EBV转化的单克隆抗体生产

    公开(公告)号：WO2004076677A3

    公开(公告)日：2005-03-31

    申请号：PCT/IB2004001071

    申请日：2004-02-26

    Applicant: INST RESEARCH IN BIOMEDICINE ,  LANZAVECCHIA ANTONIO

    Inventor： LANZAVECCHIA ANTONIO

    IPC: A61K39/395 ,  A61P31/14 ,  C07K16/00 ,  C07K16/10 ,  C07K16/12 ,  C07K16/20 ,  C12Q20060101 ,  G01N33/49

    CPC classification number: C07K16/1027 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/10 ,  C07K16/1282 ,  C07K16/20 ,  C07K2317/21 ,  C07K2317/76

    Abstract: A method for producing a clone of an immortalised human B memory lymphocyte, comprising the step of transforming human B memory lymphocytes using Epstein Barr Virus (EBV) in the presence of a polyclonal B cell activator. The method is particularly useful in a method for producing a clone of an immortalised human B memory lymphocyte capable of producing a human monoclonal antibody with a desired antigen specificity, comprising the steps of: (i) selecting and isolating a human memory B lymphocyte subpopulation; (ii) transforming the subpopulation with Epstein Barr Virus (EBV) in the presence of a polyclonal B cell activator; (iii) screening the culture supernatant for antigen specificity; and (iv) isolating an immortalised human B memory lymphocyte clone capable of producing a human monoclonal antibody having the desired antigen specificity.

    Abstract translation: 一种生产永生化人B记忆淋巴细胞克隆的方法，包括在多克隆B细胞激活剂存在下使用爱泼斯坦巴尔病毒（EBV）转化人B记忆淋巴细胞的步骤。 该方法特别可用于生产能够产生具有所需抗原特异性的人单克隆抗体的永生化人B记忆淋巴细胞克隆的方法，包括以下步骤：（i）选择和分离人类记忆B淋巴细胞亚群; （ii）在多克隆B细胞激活剂存在下，用爱泼斯坦巴尔病毒（EBV）转化亚群; （iii）筛选培养上清液以获得抗原特异性; 和（iv）分离能够产生具有所需抗原特异性的人单克隆抗体的永生化人B记忆淋巴细胞克隆。

    NEUTRALIZING ANTI-INFLUENZA A VIRUS ANTIBODIES AND USES THEREOF
    6.
    发明申请
    NEUTRALIZING ANTI-INFLUENZA A VIRUS ANTIBODIES AND USES THEREOF 审中-公开
    中和抗流感病毒A抗体及其应用

    公开(公告)号：WO2010010466A3

    公开(公告)日：2010-07-29

    申请号：PCT/IB2009006616

    申请日：2009-07-27

    Applicant: INST RESEARCH IN BIOMEDICINE ,  LANZAVECCHIA ANTONIO

    Inventor： LANZAVECCHIA ANTONIO

    IPC: A61K39/395 ,  A61P31/16

    CPC classification number: C07K16/1018 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76

    Abstract: The invention relates to antibodies, and antigen binding fragments thereof, that bind to hemagglutinin and neutralize a group 1 subtype and a group 2 subtype of influenza A virus. The invention also relates to nucleic acids that encode, immortalized B cells and cultured single plasma cells that produce, and to epitopes that bind to such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and epitopes in screening methods as well as in the diagnosis, treatment and prevention of influenza A virus infection.

    Abstract translation: 本发明涉及与血凝素结合并中和甲型流感病毒的1族亚型和2型亚型的抗体及其抗原结合片段。 本发明还涉及编码产生永生化B细胞和培养的单个浆细胞的核酸，并且涉及与这些抗体和抗体片段结合的表位。 此外，本发明涉及抗体，抗体片段和表位在筛选方法以及诊断，治疗和预防甲型流感病毒感染中的用途。

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