公开(公告)号：WO2018081470A1

公开(公告)日：2018-05-03

申请号：PCT/US2017/058605

申请日：2017-10-26

Applicant: INTIMA BIOSCIENCE, INC. ,  REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： HENLEY, Thomas ,  RHODES, Eric ,  CHOUDHRY, Modassir ,  MORIARITY, Branden ,  WEBBER, Beau

IPC: A61K35/12 ,  A61K48/00 ,  C12N15/64 ,  C12N15/86 ,  C12N15/90

Abstract: The present disclosure provides methods of producing a population of genetically modified cells using viral or non-viral vectors. Also disclosed are modified viruses for producing a population of genetically modified cells and/or for the treatment of cancer.

Abstract translation: 本公开提供了使用病毒或非病毒载体产生遗传修饰细胞群体的方法。 还公开了用于产生遗传修饰细胞群和/或用于治疗癌症的修饰病毒。

公开(公告)号：WO2019006418A3

公开(公告)日：2019-01-03

申请号：PCT/US2018/040480

申请日：2018-06-29

Applicant: INTIMA BIOSCIENCE, INC.

Inventor： HENLEY, Thomas ,  AGBANDJE-MCKENNA, Mavis ,  BUERCKSTUEMMER, Tilmann ,  VINEY, Lydia ,  CHOUDHRY, Modassir

IPC: A61K35/17 ,  C12N5/0783 ,  C12N15/63 ,  C12N15/74 ,  C12N15/113 ,  C12N15/861 ,  C12N15/864 ,  C07H21/04

Abstract: Genetically modified compositions, such as adeno-associated viral vectors and primary cells, for treating various conditions and diseases. Disclosed are also modified adeno-associated viruses for the treatment of cancer. Also disclosed are the methods of making and using the genetically modified compositions in treating various diseases, conditions, and cancer.

公开(公告)号：WO2017023801A1

公开(公告)日：2017-02-09

申请号：PCT/US2016/044856

申请日：2016-07-29

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  INTIMA BIOSCIENCE, INC.

Inventor： MORIARITY, Branden ,  WEBBER, Beau ,  MCIVOR, R., Scott ,  CHOUDHRY, Modassir

IPC: A61K35/17 ,  C12N1/15 ,  C12N15/09 ,  C12N15/85 ,  C12Q1/68

CPC classification number: A61K35/17 ,  C07K14/4718 ,  C07K14/70503 ,  C07K14/7051 ,  C07K14/70521 ,  C07K14/7158 ,  C12N5/0636 ,  C12N9/22 ,  C12N9/96 ,  C12N15/113 ,  C12N15/87 ,  C12N15/907 ,  C12N2310/20 ,  C12N2510/00 ,  C12N2800/80 ,  Y02A50/463

Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.

Abstract translation: 公开了用于治疗癌症的转基因组合物，例如非病毒载体和T细胞。 还公开了制备和使用转基因组合物治疗癌症的方法。

公开(公告)号：WO2021216738A2

公开(公告)日：2021-10-28

申请号：PCT/US2021/028436

申请日：2021-04-21

Applicant: INTIMA BIOSCIENCE, INC.

Inventor： HENLEY, Thomas ,  CHOUDHRY, Modassir

IPC: A61K39/44 ,  A61K39/395 ,  A61K35/17 ,  A61K35/14 ,  C12N5/071

Abstract: Provided herein are compositions and methods for use in generating an immune response against a target peptide antigen. Also included, are methods for stabilizing, treating, and eliminating various diseases and conditions associated with target peptide expression.

公开(公告)号：WO2021216729A1

公开(公告)日：2021-10-28

申请号：PCT/US2021/028427

申请日：2021-04-21

Applicant: INTIMA BIOSCIENCE, INC.

Inventor： CHOUDHRY, Modassir ,  HENLEY, Thomas

IPC: A61K39/02 ,  A61K39/12 ,  C07K14/705 ,  C12N5/00

Abstract: Cellular vaccine platforms, such as vaccine immune viral opsonization platforms, for eliciting host immune responses are disclosed. Also disclosed are the methods of making and using the cellular vaccine platforms in stimulating host immune responses.

公开(公告)号：WO2018075664A1

公开(公告)日：2018-04-26

申请号：PCT/US2017/057228

申请日：2017-10-18

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  INTIMA BIOSCIENCE, INC. ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

Inventor： MORIARITY, Branden ,  WEBBER, Beau ,  CHOUDHRY, Modassir ,  ROSENBERG, Steven A. ,  PALMER, Douglas C. ,  RESTIFO, Nicholas P.

IPC: C12N15/11 ,  C12N9/10 ,  C12N5/0783 ,  A61K35/17

Abstract: Genetically modified compositions, such as non-viral vectors and tumor infiltrating lymphocytes, for the treatment of gastrointestinal cancer are disclosed. Disclosed are methods of utilizing a CRISPR system to generate genetically modified compositions. Also disclosed are the methods of making and using the genetically modified compositions for the treatment of gastrointestinal cancer.

Abstract translation: 公开了用于治疗胃肠癌的基因修饰组合物，如非病毒载体和肿瘤浸润淋巴细胞。 公开了利用CRISPR系统产生遗传修饰组合物的方法。 还公开了制造和使用经遗传修饰的组合物用于治疗胃肠癌的方法。

公开(公告)号：WO2017023803A1

公开(公告)日：2017-02-09

申请号：PCT/US2016/044858

申请日：2016-07-29

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  INTIMA BIOSCIENCE, INC.

Inventor： MORIARITY, Branden ,  WEBBER, Beau ,  MCIVOR, Scott, R. ,  LARGAESPADA, David ,  CHOUDHRY, Modassir

IPC: A61K35/00 ,  A61K35/17 ,  A61K35/28 ,  A61K38/00 ,  C07H21/04 ,  C07K14/725

CPC classification number: A61K35/17 ,  C07K14/4718 ,  C07K14/70503 ,  C07K14/7051 ,  C07K14/70521 ,  C07K14/7158 ,  C12N5/0636 ,  C12N9/22 ,  C12N9/96 ,  C12N15/113 ,  C12N15/87 ,  C12N15/907 ,  C12N2310/20 ,  C12N2510/00 ,  C12N2800/80 ,  Y02A50/463

Abstract: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.

Abstract translation: 公开了用于治疗癌症的转基因组合物，例如非病毒载体和T细胞。 还公开了制备和使用转基因组合物治疗癌症的方法。

公开(公告)号：WO2021067640A1

公开(公告)日：2021-04-08

申请号：PCT/US2020/053865

申请日：2020-10-01

Applicant: INTIMA BIOSCIENCE, INC.

Inventor： HENLEY, Thomas ,  CHOUDHRY, Modassir ,  FERNANDEZ-GOMEZ, Jose

IPC: C07K14/415 ,  C12N15/82 ,  C12N9/02

Abstract: Provided herein are compositions comprising genetically modified cells, organisms, or plants described herein or extracts and products thereof and methods for making and using the same. Also provided are therapeutics derived from genetically modified cells, organisms, or plants described herein or extracts and products thereof for use in preventing, treating, or stabilizing disease and conditions.

公开(公告)号：WO2020181072A1

公开(公告)日：2020-09-10

申请号：PCT/US2020/021163

申请日：2020-03-05

Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY ,  INTIMA BIOSCIENCE, INC.

Inventor： QI, Lei S. ,  CHOUDHRY, Modassir ,  LIN, Xueqiu ,  COLLINGWOOD, Trevor N. ,  HENLEY, Thomas ,  KLAPHOLZ, Benjamin ,  BUERCKSTUEMMER, Tilmann ,  SALIC, Sejla

IPC: C12N15/10 ,  C12N9/22 ,  C07K14/33 ,  C12N15/63 ,  C12N15/09 ,  C12P19/34

Abstract: Constructs comprising Argonautes and neighboring genes are disclosed for use in gene editing. Disclosed are also compositions and methods utilizing these Argonautes and neighboring genes. Also disclosed are the methods of making and using the Argonautes and neighboring genes in treating various diseases, conditions, and cancer.

公开(公告)号：WO2020112860A1

公开(公告)日：2020-06-04

申请号：PCT/US2019/063383

申请日：2019-11-26

Applicant: INTIMA BIOSCIENCE, INC.

Inventor： HENLEY, Thomas ,  CHOUDHRY, Modassir ,  VINEY, Lydia

IPC: C07K14/705 ,  C12N5/00 ,  C12N9/22 ,  C12N15/113

Abstract: Disclosed herein are methods for identifying immunomodulatory genes. In some embodiments, the method comprises of screening a candidate gene comprising: a) expressing an exogenous cellular receptor, or a functional portion thereof, in a plurality of immune cells; b) introducing into said plurality of immune cells: i. a guiding polynucleic acid, or a nucleic acid encoding said guiding polynucleic acid, wherein said guiding polynucleic acid targets said candidate gene; and ii. an exogenous nuclease, or a nucleic acid encoding said exogenous nuclease; thereby generating a plurality of engineered immune cells comprising a genomic disruption in said candidate gene; c) contacting said plurality of engineered immune cells with a plurality of cells expressing a cognate antigen of said exogenous cellular receptor or a functional portion thereof, thereby performing an in vitro assay; and d) determining a readout of said in vitro assay.