公开(公告)号：WO2011152652A2

公开(公告)日：2011-12-08

申请号：PCT/KR2011003989

申请日：2011-06-01

Applicant: KOREA UNITED PHARM INC ,  LEE BEOM JIN ,  JUNG WON-TAE ,  CHOI YOUN WOONG ,  NAM KYU YEOL ,  CHO SANG-MIN ,  JANG JAE SANG ,  CHOI MINJI

Inventor： LEE BEOM JIN ,  JUNG WON-TAE ,  CHOI YOUN WOONG ,  NAM KYU YEOL ,  CHO SANG-MIN ,  JANG JAE SANG ,  CHOI MINJI

IPC: A61K9/22 ,  A61K9/20 ,  A61K31/216 ,  A61K47/38

CPC classification number: A61K9/209 ,  A61K31/216

Abstract: The present invention relates to a controlled-release preparation administered orally once a day that exhibits an optimum pharmacological clinical effect, featuring two-layer tablets, dual tablets and multilayered tablets having a fast-release layer comprising aceclofenac, a water-soluble additive, a non-soluble additive, a solubilizer, a disintegrator and a filler, and a slow-release layer comprising aceclofenac, a slow-release base, a disintegrator, a binder, a filler, a fluidizer, a solubilizer and a lubricant.

Abstract translation: 本发明涉及具有最佳药理临床效果的一天一次口服的控释制剂，其特征在于具有快速释放层的双层片剂，双片剂和多层片剂，其包含醋氯芬酸，水溶性添加剂， 不溶性添加剂，增溶剂，崩解剂和填料，以及包含醋氯芬酸，缓释碱，崩解剂，粘合剂，填料，流化剂，增溶剂和润滑剂的缓释层。

公开(公告)号：WO2009148245A4

公开(公告)日：2010-04-22

申请号：PCT/KR2009002923

申请日：2009-06-02

Applicant: SEOUL PHARMA CO LTD ,  CHOI YOUN-WOONG ,  MIN BYUNG-GU ,  CHO SANG-MIN ,  KIM JONG-IL ,  KIM DAE-WOOK ,  JEONG YONG-MI ,  JANG JAE-SANG ,  RYOO BYUNG-HWAN

Inventor： CHOI YOUN-WOONG ,  MIN BYUNG-GU ,  CHO SANG-MIN ,  KIM JONG-IL ,  KIM DAE-WOOK ,  JEONG YONG-MI ,  JANG JAE-SANG ,  RYOO BYUNG-HWAN

IPC: A61K9/22 ,  A61K9/20 ,  A61K9/26 ,  A61K47/38

CPC classification number: A61K9/2054

Abstract: The present invention relates to a controlled release formulation containing niacin. More specifically, the present invention relates to a controlled release-niacin formulation and a preparation method thereof, wherein the controlled release-niacin formulation comprises niacin, hydroxypropyl methylcellulose, carboxyvinyl polymers, additives, disintegrants, and lubricants, wherein the carboxyvinyl polymer and hydroxypropyl methylcellulose are included so that the weight ratio of the carboxyvinyl polymer: HPMC is 1:1 - 1:100. In addition, the present invention provides a combination formulation further containing an HMG-CoA reductase inhibitor in the controlled release-niacin formulation and a preparation method thereof.

Abstract translation: 本发明涉及含有烟酸的控释制剂。 更具体地说，本发明涉及控释烟酸制剂及其制备方法，其中控制释放 - 烟酸配制剂包含烟酸，羟丙基甲基纤维素，羧基乙烯基聚合物，添加剂，崩解剂和润滑剂，其中羧基乙烯基聚合物和羟丙基甲基纤维素 以使得羧基乙烯基聚合物：HPMC的重量比为1:1-1:100。 此外，本发明提供了在控释硝酸配方中进一步含有HMG-CoA还原酶抑制剂的组合制剂及其制备方法。

公开(公告)号：WO2009148245A2

公开(公告)日：2009-12-10

申请号：PCT/KR2009002923

申请日：2009-06-02

Applicant: SEOUL PHARMA CO LTD ,  CHOI YOUN-WOONG ,  MIN BYUNG-GU ,  CHO SANG-MIN ,  KIM JONG-IL ,  KIM DAE-WOOK ,  JEONG YONG-MI ,  JANG JAE-SANG ,  RYOO BYUNG-HWAN

Inventor： CHOI YOUN-WOONG ,  MIN BYUNG-GU ,  CHO SANG-MIN ,  KIM JONG-IL ,  KIM DAE-WOOK ,  JEONG YONG-MI ,  JANG JAE-SANG ,  RYOO BYUNG-HWAN

IPC: A61K9/22

CPC classification number: A61K9/2054

Abstract: The present invention relates to a controlled release formulation containing niacin. More specifically, the present invention relates to a controlled release-niacin formulation and a preparation method thereof, wherein the controlled release-niacin formulation comprises niacin, hydroxypropyl methylcellulose, carboxyvinyl polymers, additives, disintegrants, and lubricants, wherein the carboxyvinyl polymer and hydroxypropyl methylcellulose are included so that the weight ratio of the carboxyvinyl polymer: HPMC is 1:1 - 1:100. In addition, the present invention provides a combination formulation further containing an HMG-CoA reductase inhibitor in the controlled release-niacin formulation and a preparation method thereof.

Abstract translation: 本发明涉及含有烟酸的控释制剂。 更具体地说，本发明涉及控释烟酸制剂及其制备方法，其中控制释放 - 烟酸配制剂包含烟酸，羟丙基甲基纤维素，羧基乙烯基聚合物，添加剂，崩解剂和润滑剂，其中羧基乙烯基聚合物和羟丙基甲基纤维素 以使得羧基乙烯基聚合物：HPMC的重量比为1:1-1:100。 此外，本发明提供了在控释硝酸配方中进一步含有HMG-CoA还原酶抑制剂的组合制剂及其制备方法。