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    NOVEL NIACIN AND HMG-COA REDUCTASE INHIBITOR COMBINATION FORMULATION
    1.
    发明申请
    NOVEL NIACIN AND HMG-COA REDUCTASE INHIBITOR COMBINATION FORMULATION 审中-公开
    新型氨基酸和HMG-COA还原抑制剂组合制剂

    公开(公告)号：WO2009148245A4

    公开(公告)日：2010-04-22

    申请号：PCT/KR2009002923

    申请日：2009-06-02

    申请人： SEOUL PHARMA CO LTD ,  CHOI YOUN-WOONG ,  MIN BYUNG-GU ,  CHO SANG-MIN ,  KIM JONG-IL ,  KIM DAE-WOOK ,  JEONG YONG-MI ,  JANG JAE-SANG ,  RYOO BYUNG-HWAN

    发明人： CHOI YOUN-WOONG ,  MIN BYUNG-GU ,  CHO SANG-MIN ,  KIM JONG-IL ,  KIM DAE-WOOK ,  JEONG YONG-MI ,  JANG JAE-SANG ,  RYOO BYUNG-HWAN

    IPC分类号： A61K9/22 ,  A61K9/20 ,  A61K9/26 ,  A61K47/38

    CPC分类号： A61K9/2054

    摘要： The present invention relates to a controlled release formulation containing niacin. More specifically, the present invention relates to a controlled release-niacin formulation and a preparation method thereof, wherein the controlled release-niacin formulation comprises niacin, hydroxypropyl methylcellulose, carboxyvinyl polymers, additives, disintegrants, and lubricants, wherein the carboxyvinyl polymer and hydroxypropyl methylcellulose are included so that the weight ratio of the carboxyvinyl polymer: HPMC is 1:1 - 1:100. In addition, the present invention provides a combination formulation further containing an HMG-CoA reductase inhibitor in the controlled release-niacin formulation and a preparation method thereof.

    摘要翻译： 本发明涉及含有烟酸的控释制剂。 更具体地说，本发明涉及控释烟酸制剂及其制备方法，其中控制释放 - 烟酸配制剂包含烟酸，羟丙基甲基纤维素，羧基乙烯基聚合物，添加剂，崩解剂和润滑剂，其中羧基乙烯基聚合物和羟丙基甲基纤维素 以使得羧基乙烯基聚合物：HPMC的重量比为1:1-1:100。 此外，本发明提供了在控释硝酸配方中进一步含有HMG-CoA还原酶抑制剂的组合制剂及其制备方法。

    NOVEL NIACIN AND HMG-COA REDUCTASE INHIBITOR COMBINATION FORMULATION
    2.
    发明申请
    NOVEL NIACIN AND HMG-COA REDUCTASE INHIBITOR COMBINATION FORMULATION 审中-公开
    新型氨基酸和HMG-COA还原抑制剂组合制剂

    公开(公告)号：WO2009148245A2

    公开(公告)日：2009-12-10

    申请号：PCT/KR2009002923

    申请日：2009-06-02

    申请人： SEOUL PHARMA CO LTD ,  CHOI YOUN-WOONG ,  MIN BYUNG-GU ,  CHO SANG-MIN ,  KIM JONG-IL ,  KIM DAE-WOOK ,  JEONG YONG-MI ,  JANG JAE-SANG ,  RYOO BYUNG-HWAN

    发明人： CHOI YOUN-WOONG ,  MIN BYUNG-GU ,  CHO SANG-MIN ,  KIM JONG-IL ,  KIM DAE-WOOK ,  JEONG YONG-MI ,  JANG JAE-SANG ,  RYOO BYUNG-HWAN

    IPC分类号： A61K9/22

    CPC分类号： A61K9/2054

    摘要： The present invention relates to a controlled release formulation containing niacin. More specifically, the present invention relates to a controlled release-niacin formulation and a preparation method thereof, wherein the controlled release-niacin formulation comprises niacin, hydroxypropyl methylcellulose, carboxyvinyl polymers, additives, disintegrants, and lubricants, wherein the carboxyvinyl polymer and hydroxypropyl methylcellulose are included so that the weight ratio of the carboxyvinyl polymer: HPMC is 1:1 - 1:100. In addition, the present invention provides a combination formulation further containing an HMG-CoA reductase inhibitor in the controlled release-niacin formulation and a preparation method thereof.

    摘要翻译： 本发明涉及含有烟酸的控释制剂。 更具体地说，本发明涉及控释烟酸制剂及其制备方法，其中控制释放 - 烟酸配制剂包含烟酸，羟丙基甲基纤维素，羧基乙烯基聚合物，添加剂，崩解剂和润滑剂，其中羧基乙烯基聚合物和羟丙基甲基纤维素 以使得羧基乙烯基聚合物：HPMC的重量比为1:1-1:100。 此外，本发明提供了在控释硝酸配方中进一步含有HMG-CoA还原酶抑制剂的组合制剂及其制备方法。

    PHARMACEUTICAL COMPOSITION WITH BOTH IMMEDIATE AND EXTENDED RELEASE CHARACTERISTICS
    3.
    发明申请
    PHARMACEUTICAL COMPOSITION WITH BOTH IMMEDIATE AND EXTENDED RELEASE CHARACTERISTICS 审中-公开
    具有立即和延长释放特性的药物组合物

    公开(公告)号：WO2011049309A3

    公开(公告)日：2011-10-13

    申请号：PCT/KR2010006910

    申请日：2010-10-08

    申请人： YUNGJIN PHARM CO LTD ,  OH DONG-JOON ,  KIM BYOUNG-KI ,  MOON BYUNG-KWAN ,  YOO JI-SEOK ,  SHIN DAE-HEE ,  RYOO BYUNG-HWAN

    发明人： OH DONG-JOON ,  KIM BYOUNG-KI ,  MOON BYUNG-KWAN ,  YOO JI-SEOK ,  SHIN DAE-HEE ,  RYOO BYUNG-HWAN

    IPC分类号： A61K9/22 ,  A61K9/20 ,  A61K47/30 ,  A61K47/38

    CPC分类号： A61K9/5084

    摘要： The present invention relates to a pharmaceutical composition with both immediate and extended release characteristics, and more specifically, to a pharmaceutical composition comprising: an extended release portion comprising a pharmaceutically active ingredient, a release control material and a pharmaceutically acceptable carrier wherein a water-insoluble polymer is coated on the surface; and an immediate release portion comprising a pharmaceutically active ingredient and a pharmaceutically acceptable carrier. The pharmaceutical composition of the present invention shows independent release characteristics of an immediate release portion and an extended release portion by coating a water-insoluble polymer on the surface of the extended release portion, using a release control material and a pharmaceutically acceptable carrier to separate the extended release portion from the immediate release portion, and which can be prepared by a relatively simple process without limitation to the content or type of pharmaceutical active ingredient.

    摘要翻译： 本发明涉及具有立即释放特征和延长释放特征的药物组合物，更具体地涉及药物组合物，其包含：包含药物活性成分，释放控制物质和药学上可接受的载体的缓释部分，其中水不溶性 聚合物被涂覆在表面上; 以及包含药物活性成分和药学上可接受的载体的速释部分。 本发明的药物组合物通过使用释放控制材料和药学上可接受的载体将水不溶性聚合物涂布在缓释部分的表面上而显示立即释放部分和缓释部分的独立释放特征， 缓释部分与速释部分组合，并且可以通过相对简单的方法制备，而不限于药物活性成分的含量或类型。