公开(公告)号：WO2010114312A2

公开(公告)日：2010-10-07

申请号：PCT/KR2010001988

申请日：2010-03-31

Applicant: HANWHA CHEMICAL CORP ,  LEE JUNGTAE ,  MOON KYUNGDUK ,  YOON JIYONG ,  SUNG BYUNGJE ,  LEE DONGHEON ,  LEE ILSUN ,  LEE DONGEUN ,  RYU SUYEON ,  PARK YOUNGWOO ,  CHOI SO-YOUNG ,  PARK JIHYUN ,  JANG MYEOUNGHEE

Inventor： LEE JUNGTAE ,  MOON KYUNGDUK ,  YOON JIYONG ,  SUNG BYUNGJE ,  LEE DONGHEON ,  LEE ILSUN ,  LEE DONGEUN ,  RYU SUYEON ,  PARK YOUNGWOO ,  CHOI SO-YOUNG ,  PARK JIHYUN ,  JANG MYEOUNGHEE

IPC: C07K16/18 ,  A61K39/395 ,  A61P35/00

CPC classification number: C07K16/2836 ,  A61K2039/505 ,  C07K14/70542 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/30

Abstract: The present invention relates to a human monoclonal antibody that specifically binds to VCAM-1, and a therapeutic composition for the treatment of inflammatory disease or cancer comprising the same. The human monoclonal antibody according to the present invention shows a strong affinity to VCAM-1 expressed on human or mouse endothelial cell, effectively inhibits leukocyte adhesion to activated endothelial cells expressing VCAM-1, and shows a low immunogenicity, thereby being used for the treatment of cancer or inflammatory disease such as asthma, rhinitis, arthritis, multiple sclerosis, bowel disease, arteriosclerosis, myocardial infarction and transplant rejection.

Abstract translation: 本发明涉及特异性结合VCAM-1的人单克隆抗体以及用于治疗炎症性疾病或癌症的治疗组合物。 根据本发明的人单克隆抗体对在人或小鼠内皮细胞上表达的VCAM-1显示出强亲和力，有效抑制白细胞与表达VCAM-1的活化内皮细胞粘附，并且显示出低的免疫原性，从而用于治疗 的癌症或炎性疾病如哮喘，鼻炎，关节炎，多发性硬化，肠病，动脉硬化，心肌梗死和移植排斥。

公开(公告)号：WO2010114312A3

公开(公告)日：2010-10-07

申请号：PCT/KR2010/001988

申请日：2010-03-31

Applicant: HANWHA CHEMICAL CORPORATION ,  LEE, Jungtae ,  MOON, Kyungduk ,  YOON, Jiyong ,  SUNG, Byungje ,  LEE, Dongheon ,  LEE, Ilsun ,  LEE, Dongeun ,  RYU, Suyeon ,  PARK, Youngwoo ,  CHOI, So-Young ,  PARK, Jihyun ,  JANG, Myeounghee

Inventor： LEE, Jungtae ,  MOON, Kyungduk ,  YOON, Jiyong ,  SUNG, Byungje ,  LEE, Dongheon ,  LEE, Ilsun ,  LEE, Dongeun ,  RYU, Suyeon ,  PARK, Youngwoo ,  CHOI, So-Young ,  PARK, Jihyun ,  JANG, Myeounghee

IPC: C07K16/18 ,  A61K39/395 ,  A61P35/00

Abstract: The present invention relates to a human monoclonal antibody that specifically binds to VCAM-1, and a therapeutic composition for the treatment of inflammatory disease or cancer comprising the same. The human monoclonal antibody according to the present invention shows a strong affinity to VCAM-1 expressed on human or mouse endothelial cell, effectively inhibits leukocyte adhesion to activated endothelial cells expressing VCAM-1, and shows a low immunogenicity, thereby being used for the treatment of cancer or inflammatory disease such as asthma, rhinitis, arthritis, multiple sclerosis, bowel disease, arteriosclerosis, myocardial infarction and transplant rejection.