公开(公告)号：WO2011049412A2

公开(公告)日：2011-04-28

申请号：PCT/KR2010/007303

申请日：2010-10-22

Applicant: HANWHA CHEMICAL CORPORATION ,  LEE, Jungtae ,  MOON, Kyungduk ,  YOON, Jiyong ,  SUNG, Byungje ,  LEE, Dongheon ,  LEE, Dongeun ,  RYU, Suyeon ,  SHIM, Hyunbo ,  KANG, Kyung Jae

Inventor： LEE, Jungtae ,  MOON, Kyungduk ,  YOON, Jiyong ,  SUNG, Byungje ,  LEE, Dongheon ,  LEE, Dongeun ,  RYU, Suyeon ,  SHIM, Hyunbo ,  KANG, Kyung Jae

IPC: C07K16/18 ,  C12N15/13 ,  G01N33/577 ,  A61K39/395 ,  A61P35/00

CPC classification number: C07K14/70542 ,  A61K2039/505 ,  C07K16/2836 ,  C07K2317/24 ,  C07K2319/30 ,  G01N33/57484 ,  G01N33/577 ,  G01N33/6893 ,  G01N33/74 ,  G01N2333/525 ,  G01N2333/70542 ,  G01N2800/24 ,  G01N2800/32 ,  Y02A50/412 ,  Y02A50/58

Abstract: The present invention relates to a human recombinant monoclonal antibody that specifically binds to human Vascular Cell Adhesion Molecule-1 (VCAM-1) to inhibit adhesion between leukocytes and activated endothelial cells and transmigration of leukocytes through the activated endothelial cells, and a prophylactic and therapeutic composition for inflammatory disease or cancer comprising the same. The human recombinant monoclonal antibody according to the present invention shows a strong affinity to VCAM-1 expressed on human endothelial cell, and effectively inhibits VCAM-1-mediated adhesion between leukocytes and activated endothelial cells and transmigration of leukocytes through the activated endothelial cells, thereby being used for the prevention and treatment of inflammatory disease such as asthma and arthritis, transplant rejection, cardiovascular disease, and cancer.

Abstract translation: 本发明涉及特异性结合人血管细胞粘附分子-1（VCAM-1）以抑制白细胞与激活的内皮细胞之间的粘附和通过活化的内皮细胞的白细胞迁移的人重组单克隆抗体，以及预防和治疗 包含其的炎性疾病或癌症的组合物。 根据本发明的人重组单克隆抗体显示出对人内皮细胞上表达的VCAM-1的强亲和力，并且有效抑制白细胞和激活的内皮细胞之间的VCAM-1介导的粘附和白细胞通过活化的内皮细胞的迁移，由此 用于预防和治疗炎性疾病如哮喘和关节炎，移植排斥反应，心血管疾病和癌症。

公开(公告)号：WO2012081921A3

公开(公告)日：2012-08-23

申请号：PCT/KR2011009686

申请日：2011-12-15

Applicant: LG ELECTRONICS INC ,  SNU R&DB FOUNDATION ,  KIM EUNSUN ,  SEOK YONGHO ,  JEON WHASOOK ,  LEE DONGHEON

Inventor： KIM EUNSUN ,  SEOK YONGHO ,  JEON WHASOOK ,  LEE DONGHEON

IPC: H04W16/14 ,  H04B7/26 ,  H04J11/00

CPC classification number: H04L5/0007 ,  H04L5/0039 ,  H04L27/0006 ,  H04W16/14 ,  H04W84/12

Abstract: A method and apparatus for transmitting channel information used by a station form among TV white space channels, and a method and apparatus for performing channel switching are disclosed. A method for transmitting information of a channel used by a station from among TV white space channels includes determining one or more channels used by the station from among channels contained in a plurality of OFDM blocks, wherein each OFDM block includes one or more contiguous channels from among the TV white space channels, generating a message including first information indicating the lowest channel number from among channels contained in a first OFDM block from among the plurality of OFDM blocks, second information indicating the lowest channel number from among channels contained in a second OFDM block, third information indicating the one or more channels used by the station as bitmap information, and fourth information indicating a total amount of bandwidth used by the station, and transmitting the generated message.

Abstract translation: 公开了一种用于发送TV空白频道信道中的电台形式使用的频道信息的方法和设备，以及用于执行频道切换的方法和设备。 一种用于从TV空白频道信道中传输由站所使用的信道的信息的方法包括：从包含在多个OFDM块中的信道中确定由该站使用的一个或多个信道，其中每个OFDM块包括来自一个或多个邻近信道 在TV空白空间信道中，从多个OFDM块中的第一OFDM块中包含的信道中产生包括指示最低信道号的第一信息的消息，指示包含在第二OFDM中的信道中的最低信道号的第二信息 将表示由站使用的一个或多个信道的第三信息指定为位图信息，以及指示由站使用的带宽的总量的第四信息，并发送所生成的消息。

公开(公告)号：WO2010114312A2

公开(公告)日：2010-10-07

申请号：PCT/KR2010001988

申请日：2010-03-31

Applicant: HANWHA CHEMICAL CORP ,  LEE JUNGTAE ,  MOON KYUNGDUK ,  YOON JIYONG ,  SUNG BYUNGJE ,  LEE DONGHEON ,  LEE ILSUN ,  LEE DONGEUN ,  RYU SUYEON ,  PARK YOUNGWOO ,  CHOI SO-YOUNG ,  PARK JIHYUN ,  JANG MYEOUNGHEE

Inventor： LEE JUNGTAE ,  MOON KYUNGDUK ,  YOON JIYONG ,  SUNG BYUNGJE ,  LEE DONGHEON ,  LEE ILSUN ,  LEE DONGEUN ,  RYU SUYEON ,  PARK YOUNGWOO ,  CHOI SO-YOUNG ,  PARK JIHYUN ,  JANG MYEOUNGHEE

IPC: C07K16/18 ,  A61K39/395 ,  A61P35/00

CPC classification number: C07K16/2836 ,  A61K2039/505 ,  C07K14/70542 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/30

Abstract: The present invention relates to a human monoclonal antibody that specifically binds to VCAM-1, and a therapeutic composition for the treatment of inflammatory disease or cancer comprising the same. The human monoclonal antibody according to the present invention shows a strong affinity to VCAM-1 expressed on human or mouse endothelial cell, effectively inhibits leukocyte adhesion to activated endothelial cells expressing VCAM-1, and shows a low immunogenicity, thereby being used for the treatment of cancer or inflammatory disease such as asthma, rhinitis, arthritis, multiple sclerosis, bowel disease, arteriosclerosis, myocardial infarction and transplant rejection.

Abstract translation: 本发明涉及特异性结合VCAM-1的人单克隆抗体以及用于治疗炎症性疾病或癌症的治疗组合物。 根据本发明的人单克隆抗体对在人或小鼠内皮细胞上表达的VCAM-1显示出强亲和力，有效抑制白细胞与表达VCAM-1的活化内皮细胞粘附，并且显示出低的免疫原性，从而用于治疗 的癌症或炎性疾病如哮喘，鼻炎，关节炎，多发性硬化，肠病，动脉硬化，心肌梗死和移植排斥。

公开(公告)号：WO2012081921A2

公开(公告)日：2012-06-21

申请号：PCT/KR2011/009686

申请日：2011-12-15

Applicant: LG ELECTRONICS INC. ,  SNU R&DB FOUNDATION ,  KIM, Eunsun ,  SEOK, Yongho ,  JEON, Whasook ,  LEE, Dongheon

Inventor： KIM, Eunsun ,  SEOK, Yongho ,  JEON, Whasook ,  LEE, Dongheon

IPC: H04W16/14 ,  H04J11/00 ,  H04B7/26

CPC classification number: H04L5/0007 ,  H04L5/0039 ,  H04L27/0006 ,  H04W16/14 ,  H04W84/12

Abstract: A method and apparatus for transmitting channel information used by a station form among TV white space channels, and a method and apparatus for performing channel switching are disclosed. A method for transmitting information of a channel used by a station from among TV white space channels includes determining one or more channels used by the station from among channels contained in a plurality of OFDM blocks, wherein each OFDM block includes one or more contiguous channels from among the TV white space channels, generating a message including first information indicating the lowest channel number from among channels contained in a first OFDM block from among the plurality of OFDM blocks, second information indicating the lowest channel number from among channels contained in a second OFDM block, third information indicating the one or more channels used by the station as bitmap information, and fourth information indicating a total amount of bandwidth used by the station, and transmitting the generated message.

Abstract translation: 一种用于在TV空白信道中发送站形式使用的信道信息的方法和装置，以及用于执行信道切换的方法和装置。 一种用于从TV空白信道中发送由站使用的信道的信息的方法包括：从包含在多个OFDM块中的信道中确定该站使用的一个或多个信道，其中每个OFDM块包括一个或多个邻接信道 在TV空白信道中，从多个OFDM块中的包含在第一OFDM块中的信道中生成指示最低信道号的第一信息的消息，指示包含在第二OFDM中的信道中的最低信道号的第二信息 指示站所使用的一个或多个信道作为位图信息的第三信息，以及指示站使用的带宽总量的第四信息，以及发送生成的消息。

公开(公告)号：WO2011049412A3

公开(公告)日：2011-10-13

申请号：PCT/KR2010007303

申请日：2010-10-22

Applicant: HANWHA CHEMICAL CORP ,  LEE JUNGTAE ,  MOON KYUNGDUK ,  YOON JIYONG ,  SUNG BYUNGJE ,  LEE DONGHEON ,  LEE DONGEUN ,  RYU SUYEON ,  SHIM HYUNBO ,  KANG KYUNG JAE

Inventor： LEE JUNGTAE ,  MOON KYUNGDUK ,  YOON JIYONG ,  SUNG BYUNGJE ,  LEE DONGHEON ,  LEE DONGEUN ,  RYU SUYEON ,  SHIM HYUNBO ,  KANG KYUNG JAE

IPC: C07K16/18 ,  A61K39/395 ,  A61P35/00 ,  C12N15/13 ,  G01N33/577

CPC classification number: C07K14/70542 ,  A61K2039/505 ,  C07K16/2836 ,  C07K2317/24 ,  C07K2319/30 ,  G01N33/57484 ,  G01N33/577 ,  G01N33/6893 ,  G01N33/74 ,  G01N2333/525 ,  G01N2333/70542 ,  G01N2800/24 ,  G01N2800/32

Abstract: The present invention relates to a human recombinant monoclonal antibody that specifically binds to human Vascular Cell Adhesion Molecule-1 (VCAM-1) to inhibit adhesion between leukocytes and activated endothelial cells and transmigration of leukocytes through the activated endothelial cells, and a prophylactic and therapeutic composition for inflammatory disease or cancer comprising the same. The human recombinant monoclonal antibody according to the present invention shows a strong affinity to VCAM-1 expressed on human endothelial cell, and effectively inhibits VCAM-1-mediated adhesion between leukocytes and activated endothelial cells and transmigration of leukocytes through the activated endothelial cells, thereby being used for the prevention and treatment of inflammatory disease such as asthma and arthritis, transplant rejection, cardiovascular disease, and cancer.

Abstract translation: 本发明涉及与人血管细胞粘附分子-1（VCAM-1）特异性结合以抑制白细胞与活化内皮细胞之间的粘附和白细胞通过活化内皮细胞的迁移的人重组单克隆抗体，以及预防性和治疗性 用于炎性疾病的组合物或包含其的癌症。 根据本发明的人重组单克隆抗体显示出对人内皮细胞上表达的VCAM-1具有强亲和力，并且有效地抑制了VCAM-1介导的白细胞和激活的内皮细胞之间的粘附和白细胞通过激活的内皮细胞的迁移，由此 用于预防和治疗炎症性疾病，例如哮喘和关节炎，移植排斥反应，心血管疾病和癌症。

公开(公告)号：WO2010114312A3

公开(公告)日：2010-10-07

申请号：PCT/KR2010/001988

申请日：2010-03-31

Applicant: HANWHA CHEMICAL CORPORATION ,  LEE, Jungtae ,  MOON, Kyungduk ,  YOON, Jiyong ,  SUNG, Byungje ,  LEE, Dongheon ,  LEE, Ilsun ,  LEE, Dongeun ,  RYU, Suyeon ,  PARK, Youngwoo ,  CHOI, So-Young ,  PARK, Jihyun ,  JANG, Myeounghee

Inventor： LEE, Jungtae ,  MOON, Kyungduk ,  YOON, Jiyong ,  SUNG, Byungje ,  LEE, Dongheon ,  LEE, Ilsun ,  LEE, Dongeun ,  RYU, Suyeon ,  PARK, Youngwoo ,  CHOI, So-Young ,  PARK, Jihyun ,  JANG, Myeounghee

IPC: C07K16/18 ,  A61K39/395 ,  A61P35/00

Abstract: The present invention relates to a human monoclonal antibody that specifically binds to VCAM-1, and a therapeutic composition for the treatment of inflammatory disease or cancer comprising the same. The human monoclonal antibody according to the present invention shows a strong affinity to VCAM-1 expressed on human or mouse endothelial cell, effectively inhibits leukocyte adhesion to activated endothelial cells expressing VCAM-1, and shows a low immunogenicity, thereby being used for the treatment of cancer or inflammatory disease such as asthma, rhinitis, arthritis, multiple sclerosis, bowel disease, arteriosclerosis, myocardial infarction and transplant rejection.