公开(公告)号：WO2022087433A8

公开(公告)日：2022-04-28

申请号：PCT/US2021/056280

申请日：2021-10-22

申请人： DANA-FARBER CANCER INSTITUTE, INC. ,  GRAY, Nathanael, S. ,  CHOUCHANI, Edward ,  ZHANG, Tinghu ,  DARABEDIAN, Narek ,  JI, Wenzhi ,  CHE, Jianwei

发明人： GRAY, Nathanael, S. ,  CHOUCHANI, Edward ,  ZHANG, Tinghu ,  DARABEDIAN, Narek ,  JI, Wenzhi ,  CHE, Jianwei

IPC分类号： A61P35/00 ,  C07D265/36 ,  C07D413/04 ,  A61K31/538

摘要： The present disclosure relates to compounds of formula I that are capable of inhibiting creatine kinase. The present disclosure also relates to methods of treating cancer, such as hematological malignancies.

公开(公告)号：WO2022140554A1

公开(公告)日：2022-06-30

申请号：PCT/US2021/064880

申请日：2021-12-22

申请人： DANA-FARBER CANCER INSTITUTE, INC. ,  CORNELL UNIVERSITY ,  GRAY, Nathanael S. ,  ZHANG, Tinghu ,  CANTLEY, Lewis C. ,  SIVAKUMAREN, Carmen ,  MANZ, Theresa ,  WANG, Eric ,  JI, Wenzhi ,  FISCHER, Eric S. ,  DONOVAN, Katherine

发明人： GRAY, Nathanael S. ,  ZHANG, Tinghu ,  CANTLEY, Lewis C. ,  SIVAKUMAREN, Carmen ,  MANZ, Theresa ,  WANG, Eric ,  JI, Wenzhi ,  FISCHER, Eric S. ,  DONOVAN, Katherine

IPC分类号： A61K31/495 ,  A61K31/4965 ,  A61K31/497 ,  C07D239/42 ,  C07D403/02 ,  C07D403/04

摘要： The present invention relates to bifunctional compounds, compositions, and methods for treating diseases or conditions by modulating (e.g., reducing) the level or activity of at least one of PIP4K2A, PIP4K2B, and PIP4K2C.