公开(公告)号：WO2011103202A2

公开(公告)日：2011-08-25

申请号：PCT/US2011/025106

申请日：2011-02-16

Applicant: ARAGON PHARMACEUTICALS, INC. ,  SMITH, Nicholas, D. ,  BONNEFOUS, Celine ,  JULIEN, Jackaline, D.

Inventor： SMITH, Nicholas, D. ,  BONNEFOUS, Celine ,  JULIEN, Jackaline, D.

IPC: C07D401/04 ,  C07D487/04 ,  A61K31/4439 ,  A61K31/5025 ,  A61P5/26 ,  A61P5/28

CPC classification number: C07D401/04 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/497 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/513 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/635 ,  A61K45/06 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

Abstract: Described herein are compounds that are androgen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such androgen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon androgen receptors.

Abstract translation: 本文描述的是雄激素受体调节剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及使用这些雄激素受体调节剂单独和与其它化合物组合用于治疗介导或依赖于雄激素受体的疾病或病症的方法。

公开(公告)号：WO2012037411A3

公开(公告)日：2012-07-05

申请号：PCT/US2011051845

申请日：2011-09-15

Applicant: ARAGON PHARMACEUTICALS INC ,  SMITH NICHOLAS D ,  KAHRAMAN MEHMET ,  GOVEK STEVEN P ,  NAGASAWA JOHNNY Y ,  LAI ANDILIY G ,  JULIEN JACKALINE D ,  HERBERT MARK R ,  BONNEFOUS CELINE ,  DOUGLAS KARENSA L

Inventor： SMITH NICHOLAS D ,  KAHRAMAN MEHMET ,  GOVEK STEVEN P ,  NAGASAWA JOHNNY Y ,  LAI ANDILIY G ,  JULIEN JACKALINE D ,  HERBERT MARK R ,  BONNEFOUS CELINE ,  DOUGLAS KARENSA L

IPC: C07D231/56 ,  A61K31/416 ,  A61K31/4192 ,  A61P35/00 ,  C07D249/18 ,  C07D401/06 ,  C07D409/06

CPC classification number: C07D231/56 ,  A61K31/416 ,  A61K31/7056 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/708 ,  A61K31/7105 ,  C07C215/10 ,  C07D209/08 ,  C07D215/227 ,  C07D217/24 ,  C07D249/18 ,  C07D265/18 ,  C07D277/68 ,  C07D279/16 ,  C07D401/10 ,  C07D401/12 ,  C07D403/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  C07D471/04 ,  C07D495/04

Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

公开(公告)号：WO2012037410A2

公开(公告)日：2012-03-22

申请号：PCT/US2011051843

申请日：2011-09-15

Applicant: ARAGON PHARMACEUTICALS INC ,  SMITH NICHOLAS D ,  KAHRAMAN MEHMET ,  GOVEK STEVEN P ,  NAGASAWA JOHNNY Y ,  LAI ANDILIY G ,  BONNEFOUS CELINE ,  JULIEN JACKALINE D

Inventor： SMITH NICHOLAS D ,  KAHRAMAN MEHMET ,  GOVEK STEVEN P ,  NAGASAWA JOHNNY Y ,  LAI ANDILIY G ,  BONNEFOUS CELINE ,  JULIEN JACKALINE D

IPC: C07D231/56 ,  A61K31/416 ,  A61P35/00

CPC classification number: C07D231/56 ,  A61K31/416 ,  A61K31/7056 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/708 ,  A61K31/7105 ,  C07C215/10 ,  C07D209/08 ,  C07D215/227 ,  C07D217/24 ,  C07D249/18 ,  C07D265/18 ,  C07D277/68 ,  C07D279/16 ,  C07D401/10 ,  C07D401/12 ,  C07D403/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  C07D471/04 ,  C07D495/04

Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract translation: 本文描述的是雌激素受体调节剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及使用这种雌激素受体调节剂单独使用并与其它化合物联合用于治疗介导或依赖于雌激素受体的疾病或病症的方法。

公开(公告)号：WO2012037411A9

公开(公告)日：2012-03-22

申请号：PCT/US2011/051845

申请日：2011-09-15

Applicant: ARAGON PHARMACEUTICALS, INC. ,  SMITH, Nicholas, D. ,  KAHRAMAN, Mehmet ,  GOVEK, Steven, P. ,  NAGASAWA, Johnny, Y. ,  LAI, Andiliy, G. ,  JULIEN, Jackaline, D. ,  HERBERT, Mark R. ,  BONNEFOUS, Celine ,  DOUGLAS, Karensa L.

Inventor： SMITH, Nicholas, D. ,  KAHRAMAN, Mehmet ,  GOVEK, Steven, P. ,  NAGASAWA, Johnny, Y. ,  LAI, Andiliy, G. ,  JULIEN, Jackaline, D. ,  HERBERT, Mark R. ,  BONNEFOUS, Celine ,  DOUGLAS, Karensa L.

IPC: C07D231/56 ,  C07D249/18 ,  C07D409/06 ,  C07D401/06 ,  A61K31/416 ,  A61K31/4192 ,  A61P35/00

Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

公开(公告)号：WO2012037411A2

公开(公告)日：2012-03-22

申请号：PCT/US2011051845

申请日：2011-09-15

Applicant: ARAGON PHARMACEUTICALS INC ,  SMITH NICHOLAS D ,  KAHRAMAN MEHMET ,  GOVEK STEVEN P ,  NAGASAWA JOHNNY Y ,  LAI ANDILIY G ,  JULIEN JACKALINE D ,  HERBERT MARK R ,  BONNEFOUS CELINE ,  DOUGLAS KARENSA L

Inventor： SMITH NICHOLAS D ,  KAHRAMAN MEHMET ,  GOVEK STEVEN P ,  NAGASAWA JOHNNY Y ,  LAI ANDILIY G ,  JULIEN JACKALINE D ,  HERBERT MARK R ,  BONNEFOUS CELINE ,  DOUGLAS KARENSA L

IPC: C07D231/56 ,  A61K31/416 ,  A61K31/4192 ,  A61P35/00 ,  C07D249/18 ,  C07D401/06 ,  C07D409/06

CPC classification number: C07D231/56 ,  A61K31/416 ,  A61K31/7056 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/708 ,  A61K31/7105 ,  C07C215/10 ,  C07D209/08 ,  C07D215/227 ,  C07D217/24 ,  C07D249/18 ,  C07D265/18 ,  C07D277/68 ,  C07D279/16 ,  C07D401/10 ,  C07D401/12 ,  C07D403/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  C07D471/04 ,  C07D495/04

Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

公开(公告)号：WO2012037410A3

公开(公告)日：2012-06-28

申请号：PCT/US2011051843

申请日：2011-09-15

Applicant: ARAGON PHARMACEUTICALS INC ,  SMITH NICHOLAS D ,  KAHRAMAN MEHMET ,  GOVEK STEVEN P ,  NAGASAWA JOHNNY Y ,  LAI ANDILIY G ,  BONNEFOUS CELINE ,  JULIEN JACKALINE D

Inventor： SMITH NICHOLAS D ,  KAHRAMAN MEHMET ,  GOVEK STEVEN P ,  NAGASAWA JOHNNY Y ,  LAI ANDILIY G ,  BONNEFOUS CELINE ,  JULIEN JACKALINE D

IPC: C07D231/56 ,  A61K31/416 ,  A61P35/00

CPC classification number: C07D231/56 ,  A61K31/416 ,  A61K31/7056 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/708 ,  A61K31/7105 ,  C07C215/10 ,  C07D209/08 ,  C07D215/227 ,  C07D217/24 ,  C07D249/18 ,  C07D265/18 ,  C07D277/68 ,  C07D279/16 ,  C07D401/10 ,  C07D401/12 ,  C07D403/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  C07D471/04 ,  C07D495/04

Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

公开(公告)号：WO2012037410A9

公开(公告)日：2012-03-22

申请号：PCT/US2011/051843

申请日：2011-09-15

Applicant: ARAGON PHARMACEUTICALS, INC. ,  SMITH, Nicholas, D. ,  KAHRAMAN, Mehmet ,  GOVEK, Steven, P. ,  NAGASAWA, Johnny, Y. ,  LAI, Andiliy, G. ,  BONNEFOUS, Celine ,  JULIEN, Jackaline D.

Inventor： SMITH, Nicholas, D. ,  KAHRAMAN, Mehmet ,  GOVEK, Steven, P. ,  NAGASAWA, Johnny, Y. ,  LAI, Andiliy, G. ,  BONNEFOUS, Celine ,  JULIEN, Jackaline D.

IPC: C07D231/56 ,  A61K31/416 ,  A61P35/00

Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

公开(公告)号：WO2011103202A3

公开(公告)日：2012-01-12

申请号：PCT/US2011025106

申请日：2011-02-16

Applicant: ARAGON PHARMACEUTICALS INC ,  SMITH NICHOLAS D ,  BONNEFOUS CELINE ,  JULIEN JACKALINE D

Inventor： SMITH NICHOLAS D ,  BONNEFOUS CELINE ,  JULIEN JACKALINE D

IPC: C07D401/04 ,  A61K31/4439 ,  A61K31/5025 ,  A61P5/26 ,  A61P5/28 ,  C07D487/04

CPC classification number: C07D401/04 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/497 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/513 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/635 ,  A61K45/06 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

Abstract: Described herein are compounds that are androgen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such androgen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon androgen receptors.

Abstract translation: 本文描述的是雄激素受体调节剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及使用这些雄激素受体调节剂单独和与其它化合物组合用于治疗介导或依赖于雄激素受体的疾病或病症的方法。