公开(公告)号：WO2008087560A9

公开(公告)日：2008-07-24

申请号：PCT/IB2008/000773

申请日：2008-01-16

Applicant: KAINOS MEDICINE, INC., ,  KOREAN RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  YUNGJIN PHARM. Co Ltd., ,  KIM, Sung Soo ,  AHN, Jin Hee ,  CHEON, Hyae Gyeong ,  RHEE, Sang Dal ,  KANG, Nam Sook ,  KIM, Ki Young ,  KANG, Seung Kyu ,  JUNG, Won Hoon ,  KIM, Sung Gyu ,  KIM, Sun Young ,  KWEON, Jae Hong ,  SOHN, Sang Kwon ,  SHIN, Min Ki ,  HA, Ni Na

Inventor： KIM, Sung Soo ,  AHN, Jin Hee ,  CHEON, Hyae Gyeong ,  RHEE, Sang Dal ,  KANG, Nam Sook ,  KIM, Ki Young ,  KANG, Seung Kyu ,  JUNG, Won Hoon ,  KIM, Sung Gyu ,  KIM, Sun Young ,  KWEON, Jae Hong ,  SOHN, Sang Kwon ,  SHIN, Min Ki ,  HA, Ni Na

IPC: C07D277/22 ,  C07D277/24 ,  C07D277/04 ,  A61P3/04 ,  A61P3/10 ,  A61P19/10

Abstract: The present invention relates to novel 2-carbonyl-3-acyl-1,3-thiazolidines having a β-amino group on the acyl chain, in free, prodrug form or pharmaceutically acceptable salt thereof, including their enantiomers, diastereomers and racemates, as efficient inhibitors against DPP-IV. The invention further relates to the pharmaceutical compositions comprising the disclosed compounds. The present invention also relates to methods for preparing the disclosed compounds and for treating DPP-IV-mediated diseases.

公开(公告)号：WO2012134233A3

公开(公告)日：2013-01-10

申请号：PCT/KR2012002407

申请日：2012-03-30

Applicant: KOREA RES INST CHEM TECH ,  SK BIOPHARMACEUTICALS CO LTD ,  KIM KI YOUNG ,  AHN JIN HEE ,  KANG SEUNG KYU ,  RHEE SANG DAL ,  BAE MYUNG AE ,  AHN SUNG HOON ,  KIM HEE YOUN ,  JUNG WON HOON ,  KANG NAM SOOK

Inventor： KIM KI YOUNG ,  AHN JIN HEE ,  KANG SEUNG KYU ,  BAE MYUNG AE ,  AHN SUNG HOON ,  KIM HEE YOUN ,  JUNG WON HOON ,  KANG NAM SOOK

IPC: C07C307/06 ,  A61K31/18 ,  A61P3/10

CPC classification number: C07D417/04 ,  A61K31/18 ,  C07C307/10 ,  C07C2603/74 ,  C07D285/10 ,  C07D285/14 ,  C07D285/15 ,  C07D285/16 ,  C07D285/36 ,  C07D417/10 ,  C07D417/12

Abstract: Provided is a sulphamide derivative having an adamantyl group, represented by the accompanying chemical formula 1, or a pharmaceutically acceptable salt thereof. The sulphamide derivative suppresses the activity of 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1), and is useful in the treatment of various diseases that are mediated by 11ß-HSD1.

Abstract translation: 提供具有金刚烷基的磺酰胺衍生物，由所附化学式1表示，或其药学上可接受的盐。 磺酰胺衍生物抑制11β-羟基类固醇脱氢酶1型（11β-HSD1）的活性，可用于治疗由11β-HSD1介导的各种疾病。

公开(公告)号：WO2008087560A3

公开(公告)日：2008-09-12

申请号：PCT/IB2008000773

申请日：2008-01-16

Applicant: KAINOS MEDICINE INC ,  KOREAN RES INST OF CHEMICAL TE ,  YUNGJIN PHARM CO LTD ,  KIM SUNG SOO ,  AHN JIN HEE ,  CHEON HYAE GYEONG ,  RHEE SANG DAL ,  KANG NAM SOOK ,  KIM KI YOUNG ,  KANG SEUNG KYU ,  JUNG WON HOON ,  KIM SUNG GYU ,  KIM SUN YOUNG ,  KWEON JAE HONG ,  SOHN SANG KWON ,  SHIN MIN KI ,  HA NI NA

Inventor： KIM SUNG SOO ,  AHN JIN HEE ,  CHEON HYAE GYEONG ,  RHEE SANG DAL ,  KANG NAM SOOK ,  KIM KI YOUNG ,  KANG SEUNG KYU ,  JUNG WON HOON ,  KIM SUNG GYU ,  KIM SUN YOUNG ,  KWEON JAE HONG ,  SOHN SANG KWON ,  SHIN MIN KI ,  HA NI NA

IPC: C07D277/06 ,  A61K31/427 ,  A61P3/10 ,  C07D417/12

CPC classification number: C07D277/06 ,  C07D417/12 ,  Y02P20/55

Abstract: The present invention relates to novel 2-carbonyl-3-acyl-1,3-thiazolidines having a ß-amino group on the acyl chain, in free, prodrug form or pharmaceutically acceptable salt thereof, including their enantiomers, diastereomers and racemates, as efficient inhibitors against DPP-IV. The invention further relates to the pharmaceutical compositions comprising the disclosed compounds. The present invention also relates to methods for preparing the disclosed compounds and for treating DPP-IV-mediated diseases.

Abstract translation: 本发明涉及在游离的前体药物形式或其药学上可接受的盐，包括它们的对映异构体，非对映异构体和外消旋体的酰基链上具有β-氨基的新的2-羰基-3-酰基-1,3-噻唑烷， 有效的抗DPP-IV抑制剂。 本发明进一步涉及包含所公开的化合物的药物组合物。 本发明还涉及制备所公开的化合物和用于治疗DPP-IV介导的疾病的方法。

公开(公告)号：WO2007139240A1

公开(公告)日：2007-12-06

申请号：PCT/KR2006/002058

申请日：2006-05-29

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  NO, Zae Sung ,  JEON, Dong Ju ,  SONG, Jong Hwan ,  LEE, Gehyeong ,  PARK, Chang Min ,  SO, Won Young ,  KANG, Nam Sook ,  HONG, Seok Joo ,  CHEON, Hyae Gyeong ,  CHO, Young Sik ,  KIM, Ki Young ,  BAE, Myung Ae ,  SONG, Jin Sook ,  RO, Seonggu ,  HYUN, Young-Lan ,  LEE, Woon Young ,  KIM, Yong Eun ,  KAANG, Bong-Kiun ,  LEE, Hye Ryeon ,  YOO, Sung-Eun

Inventor： NO, Zae Sung ,  JEON, Dong Ju ,  SONG, Jong Hwan ,  LEE, Gehyeong ,  PARK, Chang Min ,  SO, Won Young ,  KANG, Nam Sook ,  HONG, Seok Joo ,  CHEON, Hyae Gyeong ,  CHO, Young Sik ,  KIM, Ki Young ,  BAE, Myung Ae ,  SONG, Jin Sook ,  RO, Seonggu ,  HYUN, Young-Lan ,  LEE, Woon Young ,  KIM, Yong Eun ,  KAANG, Bong-Kiun ,  LEE, Hye Ryeon ,  YOO, Sung-Eun

IPC: C07D231/00 ,  C07D487/04 ,  C07D239/00 ,  A61K31/437 ,  A61P11/06 ,  A61P27/14 ,  A61P25/28

CPC classification number: C07D487/04

Abstract: The present invention relates to 7- (3,4- dialkoxyphenyl) -pyrazolo [1, 5 -a] pyrimidine compounds, pharmaceutically acceptable salts thereof, preparation thereof and pharmaceutical compositions comprising the same as an active ingredient for treating or preventing inflammatory diseases including asthma and chronic obstructive pulmonary disease, arthritis, atopic dermatitis, cancers including leukemia, and degenerative brain diseases such as Alzheimer disease, depression or failure of memory.

Abstract translation: 本发明涉及7-（3,4-二烷氧基苯基） - 吡唑并[1,5-a]嘧啶化合物，其药学上可接受的盐，其制备方法和药物组合物，其包含与用于治疗或预防炎症性疾病的活性成分 哮喘和慢性阻塞性肺病，关节炎，特应性皮炎，包括白血病和退行性脑疾病如阿尔茨海默病，抑郁症或记忆障碍的癌症。

公开(公告)号：WO2008087560A2

公开(公告)日：2008-07-24

申请号：PCT/IB2008000773

申请日：2008-01-16

Applicant: KAINOS MEDICINE INC ,  KOREAN RES INST OF CHEMICAL TE ,  YUNGJIN PHARM CO LTD ,  KIM SUNG SOO ,  AHN JIN HEE ,  CHEON HYAE GYEONG ,  RHEE SANG DAL ,  KANG NAM SOOK ,  KIM KI YOUNG ,  KANG SEUNG KYU ,  JUNG WON HOON ,  KIM SUNG GYU ,  KIM SUN YOUNG ,  KWEON JAE HONG ,  SOHN SANG KWON ,  SHIN MIN KI ,  HA NI NA

Inventor： KIM SUNG SOO ,  AHN JIN HEE ,  CHEON HYAE GYEONG ,  RHEE SANG DAL ,  KANG NAM SOOK ,  KIM KI YOUNG ,  KANG SEUNG KYU ,  JUNG WON HOON ,  KIM SUNG GYU ,  KIM SUN YOUNG ,  KWEON JAE HONG ,  SOHN SANG KWON ,  SHIN MIN KI ,  HA NI NA

CPC classification number: C07D277/06 ,  C07D417/12 ,  Y02P20/55

Abstract: The present invention relates to novel 2-carbonyl-3-acyl-1,3-thiazolidines having a ß-amino group on the acyl chain, in free, prodrug form or pharmaceutically acceptable salt thereof, including their enantiomers, diastereomers and racemates, as efficient inhibitors against DPP-IV. The invention further relates to the pharmaceutical compositions comprising the disclosed compounds. The present invention also relates to methods for preparing the disclosed compounds and for treating DPP-IV-mediated diseases.

Abstract translation: 本发明涉及在酰基链上具有游离前药形式或其药学上可接受的盐中的β-氨基的新的2-羰基-3-酰基-1,3-噻唑烷，包括其对映异构体，非对映异构体和外消旋体，如 有效的DPP-IV抑制剂。 本发明还涉及包含所公开的化合物的药物组合物。 本发明还涉及制备所公开化合物和用于治疗DPP-IV介导的疾病的方法。