公开(公告)号：WO2008117943A1

公开(公告)日：2008-10-02

申请号：PCT/KR2008/001278

申请日：2008-03-07

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  JEON, Dong Ju ,  NO, Zaesung ,  SONG, Jong Hwan ,  LEE, Gehyeong ,  KIM, Ikyon ,  PARK, Chang Min ,  CHEON, Hyae Gyeong ,  CHO, Young Sik ,  SONG, Jin Sook ,  BAE, Myung Ae ,  YOO, Sung-eun

Inventor： JEON, Dong Ju ,  NO, Zaesung ,  SONG, Jong Hwan ,  LEE, Gehyeong ,  KIM, Ikyon ,  PARK, Chang Min ,  CHEON, Hyae Gyeong ,  CHO, Young Sik ,  SONG, Jin Sook ,  BAE, Myung Ae ,  YOO, Sung-eun

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: The present invention relates to novel {7-(3',4'-dialkoxyphenyl)-[1,2,4]-triazolo[1,5-a]pyrimidine compounds or pharmaceutically acceptable salts thereof, a process for preparing the same, and pharmaceutical compositions for treating or preventing inflammatory diseases including asthma and chronic obstructive pulmonary disease, arthritis, atopic dermatitis, cancers including leukemia, and degenerative brain diseases including Alzheimer's disease, depression and memory impairment, which comprises the same as an active ingredient.

Abstract translation: 本发明涉及新的{7-（3'，4'-二烷氧基苯基） - [1,2,4] - 三唑并[1,5-a]嘧啶化合物或其药学上可接受的盐，其制备方法， 以及用于治疗或预防包括哮喘和慢性阻塞性肺病，关节炎，特应性皮炎，包括白血病，包括阿尔茨海默氏病，抑郁症和记忆障碍在内的退行性脑疾病的炎症性疾病的药物组合物，其包含与活性成分相同的药物组合物。

公开(公告)号：WO2007139240A1

公开(公告)日：2007-12-06

申请号：PCT/KR2006/002058

申请日：2006-05-29

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  NO, Zae Sung ,  JEON, Dong Ju ,  SONG, Jong Hwan ,  LEE, Gehyeong ,  PARK, Chang Min ,  SO, Won Young ,  KANG, Nam Sook ,  HONG, Seok Joo ,  CHEON, Hyae Gyeong ,  CHO, Young Sik ,  KIM, Ki Young ,  BAE, Myung Ae ,  SONG, Jin Sook ,  RO, Seonggu ,  HYUN, Young-Lan ,  LEE, Woon Young ,  KIM, Yong Eun ,  KAANG, Bong-Kiun ,  LEE, Hye Ryeon ,  YOO, Sung-Eun

Inventor： NO, Zae Sung ,  JEON, Dong Ju ,  SONG, Jong Hwan ,  LEE, Gehyeong ,  PARK, Chang Min ,  SO, Won Young ,  KANG, Nam Sook ,  HONG, Seok Joo ,  CHEON, Hyae Gyeong ,  CHO, Young Sik ,  KIM, Ki Young ,  BAE, Myung Ae ,  SONG, Jin Sook ,  RO, Seonggu ,  HYUN, Young-Lan ,  LEE, Woon Young ,  KIM, Yong Eun ,  KAANG, Bong-Kiun ,  LEE, Hye Ryeon ,  YOO, Sung-Eun

IPC: C07D231/00 ,  C07D487/04 ,  C07D239/00 ,  A61K31/437 ,  A61P11/06 ,  A61P27/14 ,  A61P25/28

CPC classification number: C07D487/04

Abstract: The present invention relates to 7- (3,4- dialkoxyphenyl) -pyrazolo [1, 5 -a] pyrimidine compounds, pharmaceutically acceptable salts thereof, preparation thereof and pharmaceutical compositions comprising the same as an active ingredient for treating or preventing inflammatory diseases including asthma and chronic obstructive pulmonary disease, arthritis, atopic dermatitis, cancers including leukemia, and degenerative brain diseases such as Alzheimer disease, depression or failure of memory.

Abstract translation: 本发明涉及7-（3,4-二烷氧基苯基） - 吡唑并[1,5-a]嘧啶化合物，其药学上可接受的盐，其制备方法和药物组合物，其包含与用于治疗或预防炎症性疾病的活性成分 哮喘和慢性阻塞性肺病，关节炎，特应性皮炎，包括白血病和退行性脑疾病如阿尔茨海默病，抑郁症或记忆障碍的癌症。

公开(公告)号：WO2011053090A3

公开(公告)日：2011-11-03

申请号：PCT/KR2010007656

申请日：2010-11-02

Applicant: SNU R&DB FOUNDATION ,  KOREA RES INST CHEM TECH ,  KIM SUNGHOON ,  HAN JUNG MIN ,  KIM HYEONG RAE ,  JEON DONG JU ,  SONG JONG HWAN ,  PARK KYUNG EUN

Inventor： KIM SUNGHOON ,  HAN JUNG MIN ,  KIM HYEONG RAE ,  JEON DONG JU ,  SONG JONG HWAN ,  PARK KYUNG EUN

IPC: C07D401/12 ,  A61K31/513 ,  A61P29/00

CPC classification number: C07D239/60 ,  C07D239/52 ,  C07D401/12

Abstract: The present invention relates to novel 2, 4-pyrimidine derivatives and a use thereof, and more specifically, to pyrimidine derivatives which are effective for systemic lupus erythematosus, a composition for preventing and treating systemic lupus erythematosus comprising the same as an active ingredient and a method for screening the same. The present inventors found novel materials inhibiting surface translocation of gp96 by mimicking a function of AIMP1 which is a molecular anchor for an intracellular residence of gp96, and identified in vitro and in vivo activity of the materials for preventing and treating SLE by alleviating SLE plasma in autoimmune diseases. Therefore, the present invention provides a novel method for screening a therapeutic agent for SLE, and for preventing or treating SLE using the mechanism.

Abstract translation: 本发明涉及新的2,4-嘧啶衍生物及其用途，更具体地涉及对系统性红斑狼疮有效的嘧啶衍生物，包含其作为活性成分的系统性红斑狼疮预防和治疗用组合物和 筛选方法。 本发明人通过模拟作为gp96细胞内驻留的分子锚的AIMP1的功能，发现抑制gp96表面移位的新型材料，并通过减轻SLE血浆中的SLE血浆来鉴定用于预防和治疗SLE的材料的体外和体内活性 自身免疫性疾病。 因此，本发明提供了一种用于筛选SLE治疗剂以及使用该机制预防或治疗SLE的新方法。

公开(公告)号：WO1994003443A1

公开(公告)日：1994-02-17

申请号：PCT/KR1993000069

申请日：1993-08-06

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  RYU, Eung, Kul ,  KIM, Kyoung, Mahn ,  KIM, Hyoung, Rae ,  SONG, Jong, Hwan ,  KIM, Jae, Nyoung ,  KIM, Jin, Seog

Inventor： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

IPC: C07D307/81

CPC classification number: C07D307/79 ,  A01N43/12

Abstract: The present invention relates to novel cyclohexane-1,3-dione derivatives of formula (I) useful as herbicides and plant-growth regulants, wherein, X is selected from the group consisting of hydrogen, C1-C6 alkyl, C2-C6 alkoxy, halogen, C1-C6 haloalkyl, nitro, cyano, C1-C6 alkylthio, C1-C6 alkylsulfinyl, C1-C6 alkylsulfonyl, sulfamoyl, N-(C1-C6 alkyl)sulfamoyl and N,N-di(C1-C6 alkyl)sulfamoyl group; (X)n represents number of X substituents which may be the same or different on benzene ring, where n is 1, 2 or 3. Also, cyclohexyl moiety, one of the substituents on benzofuran ring, is substituted at 4, 5, 6 or 7 position. The (X)n cannot be filled only with hydrogens and the (X)n can substitute position where cyclohexyl moiety is not substituted; R1 is selected from hydrogen and C1-C4 alkyl group; R2 is selected from C1-C6 alkyl, C2-C6 alkenyl and C2-C6 alkynyl group; R3 is selected from hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 haloalkenyl, C2-C6 alkoxyalkyl, C2-C6 alkylthioalkyl, benzyl and C2-C6 haloalkanoyl group; R4 is selected from hydrogen, alkali metal cation, alkaline earth metal cation, C1-C4 alkanoyl, C1-C4 haloalkanoyl and benzoyl group.

Abstract translation: 本发明涉及可用作除草剂和植物生长调节剂的式（I）的新型环己烷-1,3-二酮衍生物，其中X选自氢，C 1 -C 6烷基，C 2 -C 6烷氧基， 卤素，C 1 -C 6卤代烷基，硝基，氰基，C 1 -C 6烷硫基，C 1 -C 6烷基亚磺酰基，C 1 -C 6烷基磺酰基，氨磺酰基，N-（C 1 -C 6烷基）氨磺酰基和N，N-二（C 1 -C 6烷基） 组; （X）n表示在苯环上可以相同或不同的X取代基的数目，其中n为1,2或3.此外，苯并呋喃环上的取代基之一的环己基部分在4,5,6 或7位。 （X）n不能仅用氢气填充，（X）n可以替代环己基部分未被取代的位置; R1选自氢和C1-C4烷基; R2选自C1-C6烷基，C2-C6烯基和C2-C6炔基; R 3选自氢，C 1 -C 6烷基，C 1 -C 6卤代烷基，C 2 -C 6烯基，C 2 -C 6卤代烯基，C 2 -C 6烷氧基烷基，C 2 -C 6烷硫基烷基，苄基和C 2 -C 6卤代烷酰基; R4选自氢，碱金属阳离子，碱土金属阳离子，C1-C4烷酰基，C1-C4卤代烷酰基和苯甲酰基。