公开(公告)号：WO2007083978A1

公开(公告)日：2007-07-26

申请号：PCT/KR2007/000393

申请日：2007-01-23

Applicant: CRYSTALGENOMICS, INC. ,  LEE, Seung Chul ,  CHOI, Jin Seok ,  OH, Jung Hoon ,  PARK, Boonsaeng ,  KIM, Yong Eun ,  LEE, Jun Hee ,  SHIN, Dongkyu ,  KIM, Cheol Min ,  HYUN, Young-Lan ,  LEE, Cheol Soon ,  CHO, Joong-Myung ,  RO, Seonggu

Inventor： LEE, Seung Chul ,  CHOI, Jin Seok ,  OH, Jung Hoon ,  PARK, Boonsaeng ,  KIM, Yong Eun ,  LEE, Jun Hee ,  SHIN, Dongkyu ,  KIM, Cheol Min ,  HYUN, Young-Lan ,  LEE, Cheol Soon ,  CHO, Joong-Myung ,  RO, Seonggu

IPC: C07D487/04

CPC classification number: C07D471/04

Abstract: The inventive imidazopyridine derivative can be used in a pharmaceutical composition for preventing or treating diseases such as diabetes, obesity, dementia, cancer, and inflammation, since it can efficiently inhibit the activities of several protein kinases including glycogen synthase kinase-3 (GSK-3), aurora kinase, extracellular signal-regulated kinase (ERK), protein kinase B (AKT), and the likes, to control signal transductions thereof.

Abstract translation: 本发明的咪唑并吡啶衍生物可用于预防或治疗诸如糖尿病，肥胖症，痴呆，癌症和炎症等疾病的药物组合物中，因为它能有效抑制几种蛋白激酶（包括糖原合酶激酶-3（GSK-3 ），极光激酶，细胞外信号调节激酶（ERK），蛋白激酶B（AKT）等，以控制其信号转导。

公开(公告)号：WO2007052938A1

公开(公告)日：2007-05-10

申请号：PCT/KR2006/004482

申请日：2006-10-31

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  CRYSTALGENOMICS, INC. ,  LEE, Cheol Hae ,  JUNG, Hee Jung ,  KIM, Jae Hak ,  JEONG, Won Jang ,  CHO, Joong Myung ,  RO, Seonggu ,  HYUN, Young Lan ,  SHIN, Dongkyu ,  LEE, Cheol Soon

Inventor： LEE, Cheol Hae ,  JUNG, Hee Jung ,  KIM, Jae Hak ,  JEONG, Won Jang ,  CHO, Joong Myung ,  RO, Seonggu ,  HYUN, Young Lan ,  SHIN, Dongkyu ,  LEE, Cheol Soon

IPC: C07C237/32

CPC classification number: C07C259/06 ,  C07C2601/14 ,  C07C2601/16 ,  C07D207/12 ,  C07D207/14 ,  C07D211/58 ,  C07D213/75 ,  C07D233/54 ,  C07D233/61 ,  C07D295/185 ,  C07D307/66 ,  C07D333/20

Abstract: This invention discloses a novel alkylcarbamoyl naphthalenyloxy octenoylhydroxyamide derivative of formula (1) useful for inhibiting the enzyme activity of histone deacetylase, which leads to effective suppression of the cancer cell proliferation, a method for preparing same and a pharmaceutical composition comprising same.

Abstract translation: 本发明公开了一种新颖的式（1）的烷基氨基甲酰基萘基氧基辛烯酰基羟基酰胺衍生物，其可用于抑制组蛋白脱乙酰酶的酶活性，从而有效抑制癌细胞增殖，其制备方法和含有该组合物的药物组合物。

公开(公告)号：WO2008069500A1

公开(公告)日：2008-06-12

申请号：PCT/KR2007/006136

申请日：2007-11-30

Applicant: AMOREPACIFIC CORPORATION ,  INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY ,  CRYSTALGENOMICS, INC. ,  HONG, Yong Deog ,  KANG, Seung-hyun ,  KIM, Yeonjoon ,  BYOUN, Kyoung Hee ,  WOO, Byoung Young ,  PARK, Miyoung ,  JOO, Yung Hyup ,  KIM, Jung Ju ,  JANG, Doo Ok ,  TAE, Jinsung ,  SHIN, Dongkyu ,  KIM, Yong Eun ,  CHEON, Younghoon ,  LEE, Jae Il ,  HYUN, Young-Lan ,  RO, Seonggu ,  CHO, Joong Myung

Inventor： HONG, Yong Deog ,  KANG, Seung-hyun ,  KIM, Yeonjoon ,  BYOUN, Kyoung Hee ,  WOO, Byoung Young ,  PARK, Miyoung ,  JOO, Yung Hyup ,  KIM, Jung Ju ,  JANG, Doo Ok ,  TAE, Jinsung ,  SHIN, Dongkyu ,  KIM, Yong Eun ,  CHEON, Younghoon ,  LEE, Jae Il ,  HYUN, Young-Lan ,  RO, Seonggu ,  CHO, Joong Myung

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: The present invention relates to a novel triazolopyridazine derivative or a pharmaceutically acceptable salt thereof, and an Acetyl-CoA Carboxylase2 (ACC2) comprising same as an active ingredient. The triazolopyridazine derivative of the present invention effectively inhibits the activity of ACC2 and it may be used for preventing or treating obesity, diabetes, dyslipidemia and diseases related to metabolic syndrome.

Abstract translation: 本发明涉及一种新的三唑并哒嗪衍生物或其药学上可接受的盐，以及含有作为活性成分的乙酰辅酶A羧化酶2（ACC2）。 本发明的三唑并哒嗪衍生物有效抑制ACC2的活性，可用于预防或治疗肥胖症，糖尿病，血脂异常和与代谢综合征有关的疾病。

公开(公告)号：WO2008054154A1

公开(公告)日：2008-05-08

申请号：PCT/KR2007/005491

申请日：2007-11-01

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  CRYSTALGENOMICS, INC. ,  LEE, Cheol Hae ,  JUNG, Hee Jung ,  KIM, Jae Hak ,  JEONG, Won Jang ,  CHO, Joong Myung ,  RO, Seong Gu ,  HYUN, Young Lan ,  LEE, Cheol Soon

Inventor： LEE, Cheol Hae ,  JUNG, Hee Jung ,  KIM, Jae Hak ,  JEONG, Won Jang ,  CHO, Joong Myung ,  RO, Seong Gu ,  HYUN, Young Lan ,  LEE, Cheol Soon

IPC: C07C233/22 ,  C07C233/16 ,  C07C217/18 ,  C07C217/16

CPC classification number: C07C259/10 ,  C07C259/06 ,  C07C2601/14 ,  C07C2601/16 ,  C07D207/27 ,  C07D207/335 ,  C07D211/10 ,  C07D211/58 ,  C07D233/64 ,  C07D295/13 ,  C07D307/14 ,  C07D307/52 ,  C07D333/20

Abstract: The present invention discloses novel naphthalenyloxypropenyl derivatives useful for inhibiting the enzyme activity of histone deacetylase, leading effective suppression of cancer cell proliferation.

Abstract translation: 本发明公开了可用于抑制组蛋白脱乙酰酶的酶活性的新型萘氧基丙烯基衍生物，有效抑制癌细胞增殖。

公开(公告)号：WO2007139240A1

公开(公告)日：2007-12-06

申请号：PCT/KR2006/002058

申请日：2006-05-29

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  NO, Zae Sung ,  JEON, Dong Ju ,  SONG, Jong Hwan ,  LEE, Gehyeong ,  PARK, Chang Min ,  SO, Won Young ,  KANG, Nam Sook ,  HONG, Seok Joo ,  CHEON, Hyae Gyeong ,  CHO, Young Sik ,  KIM, Ki Young ,  BAE, Myung Ae ,  SONG, Jin Sook ,  RO, Seonggu ,  HYUN, Young-Lan ,  LEE, Woon Young ,  KIM, Yong Eun ,  KAANG, Bong-Kiun ,  LEE, Hye Ryeon ,  YOO, Sung-Eun

Inventor： NO, Zae Sung ,  JEON, Dong Ju ,  SONG, Jong Hwan ,  LEE, Gehyeong ,  PARK, Chang Min ,  SO, Won Young ,  KANG, Nam Sook ,  HONG, Seok Joo ,  CHEON, Hyae Gyeong ,  CHO, Young Sik ,  KIM, Ki Young ,  BAE, Myung Ae ,  SONG, Jin Sook ,  RO, Seonggu ,  HYUN, Young-Lan ,  LEE, Woon Young ,  KIM, Yong Eun ,  KAANG, Bong-Kiun ,  LEE, Hye Ryeon ,  YOO, Sung-Eun

IPC: C07D231/00 ,  C07D487/04 ,  C07D239/00 ,  A61K31/437 ,  A61P11/06 ,  A61P27/14 ,  A61P25/28

CPC classification number: C07D487/04

Abstract: The present invention relates to 7- (3,4- dialkoxyphenyl) -pyrazolo [1, 5 -a] pyrimidine compounds, pharmaceutically acceptable salts thereof, preparation thereof and pharmaceutical compositions comprising the same as an active ingredient for treating or preventing inflammatory diseases including asthma and chronic obstructive pulmonary disease, arthritis, atopic dermatitis, cancers including leukemia, and degenerative brain diseases such as Alzheimer disease, depression or failure of memory.

Abstract translation: 本发明涉及7-（3,4-二烷氧基苯基） - 吡唑并[1,5-a]嘧啶化合物，其药学上可接受的盐，其制备方法和药物组合物，其包含与用于治疗或预防炎症性疾病的活性成分 哮喘和慢性阻塞性肺病，关节炎，特应性皮炎，包括白血病和退行性脑疾病如阿尔茨海默病，抑郁症或记忆障碍的癌症。

公开(公告)号：WO2010067980A3

公开(公告)日：2010-09-23

申请号：PCT/KR2009007162

申请日：2009-12-02

Applicant: KOREA CT FOR DISEASE CONTROL A ,  HONG KEE JONG ,  CHOI BYEONG SUN ,  KIM SUNG SOON ,  LEE HAK SUNG ,  RO SUNG GU ,  HYUN YOUNG LAN

Inventor： HONG KEE JONG ,  CHOI BYEONG SUN ,  KIM SUNG SOON ,  LEE HAK SUNG ,  RO SUNG GU ,  HYUN YOUNG LAN

IPC: A61K31/16 ,  A61P31/18

CPC classification number: A61K31/16

Abstract: The present invention relates to a histone deacetylase (HDAC) inhibitor represented by chemical formula 1 that enables reactivation of HIV-1 proviruses from latently HIV-infected cells, and a method for reactivating HIV-1 provirus from latently HIV-infected cells using the inhibitor. The HDAC inhibitor exhibits low cytotoxicity and high stability, and thus can effectively reactivate latent HIV-1 proviruses from a CD4+ T cell reservoir. Accordingly, the HDAC inhibitor is processed together with an HAART cocktail therapeutic drug such as a reverse transcriptase inhibitor AZT, thereby efficiently reducing or removing the latent HIV reservoir.

Abstract translation: 本发明涉及由化学式1表示的组蛋白脱乙酰酶（HDAC）抑制剂，其可使来自潜在HIV感染细胞的HIV-1原病毒能够再活化，以及使用抑制剂从潜伏HIV感染细胞再次激活HIV-1前病毒的方法 。 HDAC抑制剂表现出低细胞毒性和高稳定性，因此可以有效地重新激活CD4 + T细胞储库中潜伏的HIV-1前病毒。 因此，HDAC抑制剂与HAART鸡尾酒治疗药物如逆转录酶抑制剂AZT一起加工，从而有效地减少或去除潜伏的HIV储存器。

公开(公告)号：WO2006025683A1

公开(公告)日：2006-03-09

申请号：PCT/KR2005/002864

申请日：2005-08-30

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  CRYSTALGENOMICS, INC. ,  LEE, Cheol Hae ,  JUNG, Hee Jung ,  KIM, Jae Hak ,  CHO, Joong Myung ,  RO, Seong Gu ,  LEE, Tae Gyu ,  HYUN, Young-Lan ,  SHIN, Dong Kyu

Inventor： LEE, Cheol Hae ,  JUNG, Hee Jung ,  KIM, Jae Hak ,  CHO, Joong Myung ,  RO, Seong Gu ,  LEE, Tae Gyu ,  HYUN, Young-Lan ,  SHIN, Dong Kyu

IPC: C07C239/14

CPC classification number: C07C259/10 ,  C07D207/27 ,  C07D207/452 ,  C07D209/34 ,  C07D209/38 ,  C07D209/48 ,  C07D209/88 ,  C07D213/74 ,  C07D215/38 ,  C07D215/40 ,  C07D217/04 ,  C07D231/38 ,  C07D249/14 ,  C07D275/06 ,  C07D277/44 ,  C07D277/68 ,  C07D277/82 ,  C07D285/14 ,  C07D295/135 ,  C07D295/155 ,  C07D307/91 ,  C07D311/58 ,  C07D401/12 ,  C07D417/12

Abstract: This invention discloses a novel arylaminomethyl propenyl benzhydroxyamide derivative of formula (I) useful for preventing or treating various diseases induced by histone deacetylase, a method for preparing same and a pharmaceutical composition comprising same.

Abstract translation: 本发明公开了一种可用于预防或治疗由组蛋白脱乙酰酶诱导的各种疾病的式（I）的新型芳基氨基甲基丙烯基苯并羟基酰胺衍生物，其制备方法和含有该组合物的药物组合物。

公开(公告)号：WO2008117982A1

公开(公告)日：2008-10-02

申请号：PCT/KR2008/001682

申请日：2008-03-26

Applicant: CRYSTAL GENOMICS, INC. ,  KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  CHO, Joong Myung ,  RO, Seonggu ,  SHIN, Dongkyu ,  HYUN, Young-Lan ,  LEE, Jun Hee ,  YON, Gyu Hwan ,  CHOI, Eun Bok ,  LEE, Hyeon Kyu ,  PAK, Chwang Siek ,  CHEON, Hyae Gyeong ,  RHEE, Sang Dal ,  JUNG, Won Hoon ,  YANG, Heui Cheol ,  JO, So Hee ,  LEE, Eunsil ,  IM, Jung Hee

Inventor： CHO, Joong Myung ,  RO, Seonggu ,  SHIN, Dongkyu ,  HYUN, Young-Lan ,  LEE, Jun Hee ,  YON, Gyu Hwan ,  CHOI, Eun Bok ,  LEE, Hyeon Kyu ,  PAK, Chwang Siek ,  CHEON, Hyae Gyeong ,  RHEE, Sang Dal ,  JUNG, Won Hoon ,  YANG, Heui Cheol ,  JO, So Hee ,  LEE, Eunsil ,  IM, Jung Hee

IPC: C07D413/12 ,  C07D417/12 ,  A61P3/04

CPC classification number: C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

Abstract: The present invention relates to a novel heterocyclic carboxylic acid derivative, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an active ingredient for inhibiting the accumulation of lipids in the body.

Abstract translation: 本发明涉及一种新的杂环羧酸衍生物或其药学上可接受的盐，以及包含其作为抑制脂质在体内积聚的活性成分的药物组合物。

公开(公告)号：WO2008072850A1

公开(公告)日：2008-06-19

申请号：PCT/KR2007/006192

申请日：2007-12-03

Applicant: AMOREPACIFIC CORPORATION ,  CRYSTALGENOMICS, INC. ,  INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY of Yonsei University ,  JOO, Yung Hyup ,  KANG, Seung-hyun ,  HONG, Yong Deog ,  KIM, Yeonjoon ,  BYOUN, KyoungHee ,  WOO, Byoung Young ,  PARK, Miyoung ,  HA, Jun Yong ,  KOH, Hyunju ,  LIM, Kyung Min ,  KIM, Chae-wook ,  LEE, Byoung-seok ,  KIM, Jung Ju ,  JANG, Doo Ok ,  TAE, Jinsung ,  SHIN, Dongkyu ,  KIM, Yong Eun ,  LEE, Kyung Ho ,  LEE, Jae Il ,  HYUN, Young-Lan ,  RO, Seonggu ,  CHO, Joong Myung

Inventor： JOO, Yung Hyup ,  KANG, Seung-hyun ,  HONG, Yong Deog ,  KIM, Yeonjoon ,  BYOUN, KyoungHee ,  WOO, Byoung Young ,  PARK, Miyoung ,  HA, Jun Yong ,  KOH, Hyunju ,  LIM, Kyung Min ,  KIM, Chae-wook ,  LEE, Byoung-seok ,  KIM, Jung Ju ,  JANG, Doo Ok ,  TAE, Jinsung ,  SHIN, Dongkyu ,  KIM, Yong Eun ,  LEE, Kyung Ho ,  LEE, Jae Il ,  HYUN, Young-Lan ,  RO, Seonggu ,  CHO, Joong Myung

IPC: C07D413/14 ,  C07D251/72 ,  C07D251/02 ,  C07D215/00 ,  C07D265/00 ,  C07D207/00 ,  C07D221/00 ,  A61K31/47 ,  A61K31/53 ,  A61P7/00

CPC classification number: C07D405/14 ,  C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention relates to a novel triazine derivative or a pharmaceutically acceptable salt thereof, and an Acetyl-CoA Carboxylase (ACC) comprising same as an active ingredient. The triazine derivative of the present invention effectively inhibits the activity of ACC and it may be used for preventing or treating obesity, diabetes, dyslipidemia and diseases related to metabolic syndrome.

Abstract translation: 本发明涉及一种新型的三嗪衍生物或其药学上可接受的盐，以及含有作为活性成分的乙酰辅酶A羧化酶（ACC）。 本发明的三嗪衍生物有效抑制ACC的活性，可用于预防或治疗肥胖症，糖尿病，血脂异常和与代谢综合征有关的疾病。

公开(公告)号：WO2006006832A1

公开(公告)日：2006-01-19

申请号：PCT/KR2005/002266

申请日：2005-07-14

Applicant: CRYSTALGENOMICS, INC. ,  KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  CHO, Joong Myung ,  LEE, Tae Gyu ,  RO, Seonggu ,  KIM, Jin Hwan ,  JEON, Young Ho ,  SHIN, Dong Kyu ,  HYUN, Young-Lan ,  YON, Gyu Hwan ,  YOON, Young-Gwi ,  CHOI, Eun Bok ,  LEE, Hyeon Kyu ,  PAK, Chwang Siek

Inventor： CHO, Joong Myung ,  LEE, Tae Gyu ,  RO, Seonggu ,  KIM, Jin Hwan ,  JEON, Young Ho ,  SHIN, Dong Kyu ,  HYUN, Young-Lan ,  YON, Gyu Hwan ,  YOON, Young-Gwi ,  CHOI, Eun Bok ,  LEE, Hyeon Kyu ,  PAK, Chwang Siek

IPC: C07D263/32

CPC classification number: C07D263/32 ,  C07D409/04 ,  C07D413/12

Abstract: The present invention relates to a novel sulfamide derivative, a pharmaceutically acceptable salt thereof and a pharmaceutical composition for upregulation of lipid metabolism comprising same as an active ingredient.

Abstract translation: 本发明涉及一种新型的磺酰胺衍生物，其药学上可接受的盐和用于上调脂质代谢的药物组合物，其包含其作为活性成分。