公开(公告)号：WO2006136461A3

公开(公告)日：2007-03-15

申请号：PCT/EP2006006531

申请日：2006-06-22

Applicant: SCHERING AG ,  HILLISCH ALEXANDER ,  BOTHE ULRICH ,  KAUFMANN GUENTER ,  SOBEK LOTHAR ,  FUHRMANN ULRIKE ,  DROESCHER PETER ,  SCHMEES NORBERT ,  SCHWEDE WOLFGANG ,  MOELLER CARSTEN ,  SCHMIDT ANJA

Inventor： HILLISCH ALEXANDER ,  BOTHE ULRICH ,  KAUFMANN GUENTER ,  SOBEK LOTHAR ,  FUHRMANN ULRIKE ,  DROESCHER PETER ,  SCHMEES NORBERT ,  SCHWEDE WOLFGANG ,  MOELLER CARSTEN ,  SCHMIDT ANJA

IPC: C07D413/12 ,  A61K31/536 ,  A61P5/34 ,  C07D265/02

CPC classification number: C07D413/12 ,  C07D265/02

Abstract: The present invention relates to non-steroidal progesterone receptor modulators of the general formula (I), a process for their preparation, the use of the progesterone receptor modulators for producing medicaments, and pharmaceutical compositions comprising these compounds. The compounds according to the invention are suitable for the therapy and prophylaxis of gynaecological disorders such as endometriosis, leiomyomas of the uterus, dysfunctional (bleeding )and dysmenorrhoea, and for the therapy and prophylaxis of hormone-dependent tumours and for use for female fertility control and for hormone replacement therapy.

Abstract translation: 本发明涉及通式（I）的非甾体孕激素受体调节剂，其制备方法，孕酮受体调节剂用于生产药物的用途，以及包含这些化合物的药物组合物。 根据本发明的化合物适用于治疗和预防妇科疾病如子宫内膜异位症，子宫平滑肌瘤，功能障碍（出血）和痛经，以及用于治疗和预防激素依赖性肿瘤并用于女性生育控制 并用于激素替代疗法。

公开(公告)号：WO2006136461A2

公开(公告)日：2006-12-28

申请号：PCT/EP2006/006531

申请日：2006-06-22

Applicant: SCHERING AKTIENGESELLSCHAFT ,  HILLISCH, Alexander ,  BOTHE, Ulrich ,  KAUFMANN, Guenter ,  SOBEK, Lothar ,  FUHRMANN, Ulrike ,  DROESCHER, Peter ,  SCHMEES, Norbert ,  SCHWEDE, Wolfgang ,  MOELLER, Carsten ,  SCHMIDT, Anja

Inventor： HILLISCH, Alexander ,  BOTHE, Ulrich ,  KAUFMANN, Guenter ,  SOBEK, Lothar ,  FUHRMANN, Ulrike ,  DROESCHER, Peter ,  SCHMEES, Norbert ,  SCHWEDE, Wolfgang ,  MOELLER, Carsten ,  SCHMIDT, Anja

IPC: C07D413/12 ,  C07D265/02 ,  A61K31/536 ,  A61P5/34

CPC classification number: C07D413/12 ,  C07D265/02

Abstract: The present invention relates to non-steroidal progesterone receptor modulators of the general formula (I), a process for their preparation, the use of the progesterone receptor modulators for producing medicaments, and pharmaceutical compositions comprising these compounds. The compounds according to the invention are suitable for the therapy and prophylaxis of gynaecological disorders such as endometriosis, leiomyomas of the uterus, dysfunctional (bleeding )and dysmenorrhoea, and for the therapy and prophylaxis of hormone-dependent tumours and for use for female fertility control and for hormone replacement therapy.

Abstract translation: 本发明涉及通式（I）的非甾体孕激素受体调节剂，其制备方法，孕酮受体调节剂用于生产药物的用途，以及包含这些化合物的药物组合物。 根据本发明的化合物适用于治疗和预防妇科疾病如子宫内膜异位症，子宫平滑肌瘤，功能障碍（出血）和痛经，以及用于治疗和预防激素依赖性肿瘤并用于女性生育控制 并用于激素替代疗法。

公开(公告)号：WO0219971A9

公开(公告)日：2002-08-08

申请号：PCT/EP0109943

申请日：2001-08-29

Applicant: JENAPHARM GMBH ,  MENZENBACH BERND ,  ELGER WALTER ,  DROESCHER PETER ,  HILLISCH ALEXANDER ,  KAUFMANN GUENTER ,  SCHWEIKERT HANS-UDO ,  MUELLER GERD

Inventor： MENZENBACH BERND ,  ELGER WALTER ,  DROESCHER PETER ,  HILLISCH ALEXANDER ,  KAUFMANN GUENTER ,  SCHWEIKERT HANS-UDO ,  MUELLER GERD

IPC: A61K31/569 ,  A61K31/57 ,  A61P5/24 ,  A61P5/28 ,  A61P5/34 ,  A61P13/08 ,  A61P15/16 ,  A61P15/18 ,  A61P17/10 ,  A61P17/14 ,  A61P43/00 ,  C07J13/00 ,  C07J17/00 ,  A61K31/56

CPC classification number: C07J13/007

Abstract: The invention relates to 17-Methylene steroids. Method for the production thereof and pharmaceutical compositions containing these compounds. The inventive compounds have an active profile with a hybrid character of such that they act as inhibitors of the 5 alpha -reductase and, at the same time, as gestagens. Said compounds are thus suited for treating medical disorders that, in men and women, are a result of an increased androgen level in certain organs and tissues. The inventive compounds combined with other hormonal substances such as estrogen, testosterone or a potent androgen are suited as contraceptives for women and men.

Abstract translation: 本发明涉及17-亚甲基甾类，处理用于含有这些化合物和药物组合物及其制备。 本发明的化合物具有与在它们用作5α还原酶的抑制剂，并在同一时间作为孕激素的方式混合字符的有效简表。 因此，它们适用于治疗男性疾病和女性在某些器官和组织，从而提高雄激素水平。 与其它激素物质如雌激素，睾甾酮或强雄激素结合，本发明的化合物适合作为避孕药的妇女和男性。

公开(公告)号：WO0226759A3

公开(公告)日：2002-06-20

申请号：PCT/DE0103732

申请日：2001-09-28

Applicant: JENAPHARM GMBH ,  RING SVEN ,  KAUFMANN GUENTER ,  WYRWA RALF ,  ELGER WALTER

Inventor： RING SVEN ,  KAUFMANN GUENTER ,  WYRWA RALF ,  ELGER WALTER

IPC: A61K31/569 ,  A61K31/58 ,  A61P5/26 ,  A61P15/00 ,  A61P15/10 ,  A61P15/16 ,  A61P35/00 ,  C07J1/00 ,  C07J11/00 ,  C07J43/00 ,  C07J71/00 ,  A61K31/565

CPC classification number: C07J71/0047 ,  C07J1/0037 ,  C07J1/0085 ,  C07J11/00 ,  C07J71/0063 ,  C07J71/0084

Abstract: The invention relates to 17 alpha fluoroalkyl steroids of the general formula (I), STEROID (I), wherein R3 represents a group of the formula CnFmHo, wherein n = 1, 2, 3, 4, 5 or 6, m > 1 and m+o = 2n+1. The invention further relates to methods for producing the same and to compositions that contain said compounds. The inventive composition of the general formula (I) possess androgenic activity.

Abstract translation: 本发明涉及17阿尔法-Fluoraklylsteroide通式（I）其中R 3是下式基团的CnFmHo，其中n = 1，2，3，4，5或6，M> 1，且m + O = 2N + 1 其制备方法和含有这些化合物的药物组合物。 根据本发明的通式（I）的化合物具有雄激素活性。