公开(公告)号：WO2008005451A2

公开(公告)日：2008-01-10

申请号：PCT/US2007/015385

申请日：2007-07-02

Applicant: HELICOS BIOSCIENCES CORPORATION ,  KEPLER, John, H. ,  WEBER, Aaron ,  WELLMAN, Parris, S.

Inventor： KEPLER, John, H. ,  WEBER, Aaron ,  WELLMAN, Parris, S.

IPC: G02B13/22

CPC classification number: G02B27/0972 ,  C07C45/41 ,  C07C57/58 ,  C07C59/48 ,  C07C59/68 ,  C07C69/732 ,  C07C69/734 ,  C07C205/58 ,  C07D279/16 ,  G02B27/0994 ,  C07C47/277

Abstract: In one aspect, the invention relates to an optical apparatus for producing light of a predetermined intensity from light sources of less than the predetermined intensity. In one embodiment the apparatus includes a first light source; a second light source; a double dove anti-Gaussian generator in optical communication with the first light source; and a compensator in optical communication with the second light source. Light from the first light source passes through the double dove anti-Gaussian generator and light from the second light source passes through the compensator, and are combined to produce a flattened Gaussian intensity distribution. In another aspect, the invention relates to a method and apparatus for separating an image into subunits and reading the separate subimages out of the detectors in parallel.

Abstract translation: 一方面，本发明涉及一种用于从小于预定强度的光源产生预定强度的光的光学装置。 在一个实施例中，该装置包括第一光源; 第二光源; 双鸽抗反射高斯发生器与第一光源进行光通信; 以及与第二光源进行光通信的补偿器。 来自第一光源的光穿过双鸽反抗高斯发生器，并且来自第二光源的光穿过补偿器，并且被组合以产生平坦的高斯强度分布。 另一方面，本发明涉及一种用于将图像分离成子单元并且并行读取检测器中的单独子图像的方法和装置。

公开(公告)号：WO2008005451A3

公开(公告)日：2009-04-02

申请号：PCT/US2007015385

申请日：2007-07-02

Applicant: HELICOS BIOSCIENCES CORP ,  KEPLER JOHN H ,  WEBER AARON ,  WELLMAN PARRIS S

Inventor： KEPLER JOHN H ,  WEBER AARON ,  WELLMAN PARRIS S

IPC: A61K31/5415 ,  A61P29/00 ,  A61P43/00 ,  C07C45/41 ,  C07C57/58 ,  C07C59/48 ,  C07C59/64 ,  C07C59/68 ,  C07C69/732 ,  C07C69/734 ,  C07C205/56 ,  C07C205/58 ,  C07D279/16 ,  G02B13/22

CPC classification number: G02B27/0972 ,  C07C45/41 ,  C07C57/58 ,  C07C59/48 ,  C07C59/68 ,  C07C69/732 ,  C07C69/734 ,  C07C205/58 ,  C07D279/16 ,  G02B27/0994 ,  C07C47/277

Abstract: An optical apparatus (fig. 1) for producing light of a predetermined intensity from light sources of less than the predetermined intensity includes a first light source; a second light source; a double dove anti-Gaussian generator in optical communication with the first light source; and a compensator in optical communication with the second light source. Light from the first light source passes through the double dove anti-Gaussian generator and light from the second light source passes through the compensator, and are combined to produce a flattened Gaussian intensity distribution.

Abstract translation: 用于从小于预定强度的光源产生预定强度的光的光学装置（图1）包括第一光源; 第二光源; 双鸽抗反射高斯发生器与第一光源进行光通信; 以及与第二光源进行光通信的补偿器。 来自第一光源的光穿过双鸽反抗高斯发生器，并且来自第二光源的光穿过补偿器，并且被组合以产生平坦的高斯强度分布。