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    HIGH SPEED PHARMACEUTICAL QUALITY CONTROL METROLOGY
    2.
    发明申请
    HIGH SPEED PHARMACEUTICAL QUALITY CONTROL METROLOGY 审中-公开

    公开(公告)号：WO2020106944A1

    公开(公告)日：2020-05-28

    申请号：PCT/US2019/062590

    申请日：2019-11-21

    Applicant: WEBER, Aaron ,  CHEN, Desai ,  ZENGERLE, Walter, H. III ,  VIDIMCE, Kiril ,  MATUSIK, Wojciech

    Inventor： WEBER, Aaron ,  CHEN, Desai ,  ZENGERLE, Walter, H. III ,  VIDIMCE, Kiril ,  MATUSIK, Wojciech

    IPC: G01B9/02

    Abstract: A method and apparatus are directed to characterizing a continuously moving pharmaceutical manufacture via interferometry-based scanning. The method includes forming a depth characterization of the pharmaceutical manufacture along a scan line on the surface of the pharmaceutical manufacture. During the scanning, the pharmaceutical manufacture undergoes continuous motion. The method further includes combining the determined depth characterization along the scan lines of the plurality of scan lines to form a depth map representing at least a depth of a portion associated with a location on the surface of the pharmaceutical manufacture in the third direction on a grid of locations arranged in the first and second directions. Forming the depth characterizations includes scanning a frequency dispersed pulsed optical signal in a first direction across the continuously moving pharmaceutical manufacture, the pharmaceutical manufacture moving in a second direction substantially orthogonal to the first direction. The scanned optical signal forms a scan line on a surface of the pharmaceutical manufacture in a third direction substantially orthogonal to the first direction and the second direction.

    OPTICAL APPARATUS AND METHODS FOR CHEMICAL ANALYSIS
    3.
    发明申请
    OPTICAL APPARATUS AND METHODS FOR CHEMICAL ANALYSIS 审中-公开
    光学装置和化学分析方法

    公开(公告)号：WO2008005451A2

    公开(公告)日：2008-01-10

    申请号：PCT/US2007/015385

    申请日：2007-07-02

    Applicant: HELICOS BIOSCIENCES CORPORATION ,  KEPLER, John, H. ,  WEBER, Aaron ,  WELLMAN, Parris, S.

    Inventor： KEPLER, John, H. ,  WEBER, Aaron ,  WELLMAN, Parris, S.

    IPC: G02B13/22

    CPC classification number: G02B27/0972 ,  C07C45/41 ,  C07C57/58 ,  C07C59/48 ,  C07C59/68 ,  C07C69/732 ,  C07C69/734 ,  C07C205/58 ,  C07D279/16 ,  G02B27/0994 ,  C07C47/277

    Abstract: In one aspect, the invention relates to an optical apparatus for producing light of a predetermined intensity from light sources of less than the predetermined intensity. In one embodiment the apparatus includes a first light source; a second light source; a double dove anti-Gaussian generator in optical communication with the first light source; and a compensator in optical communication with the second light source. Light from the first light source passes through the double dove anti-Gaussian generator and light from the second light source passes through the compensator, and are combined to produce a flattened Gaussian intensity distribution. In another aspect, the invention relates to a method and apparatus for separating an image into subunits and reading the separate subimages out of the detectors in parallel.

    Abstract translation: 一方面，本发明涉及一种用于从小于预定强度的光源产生预定强度的光的光学装置。 在一个实施例中，该装置包括第一光源; 第二光源; 双鸽抗反射高斯发生器与第一光源进行光通信; 以及与第二光源进行光通信的补偿器。 来自第一光源的光穿过双鸽反抗高斯发生器，并且来自第二光源的光穿过补偿器，并且被组合以产生平坦的高斯强度分布。 另一方面，本发明涉及一种用于将图像分离成子单元并且并行读取检测器中的单独子图像的方法和装置。

    LENS ASSEMBLY FOR VITREORETINAL SURGERY
    4.
    发明申请
    LENS ASSEMBLY FOR VITREORETINAL SURGERY 审中-公开
    眼镜组件用于维生素S外科手术

    公开(公告)号：WO2007095046A3

    公开(公告)日：2009-01-15

    申请号：PCT/US2007003356

    申请日：2007-02-08

    Applicant: VOLK OPTICAL INC ,  CECH STEVEN D ,  WEBER AARON V

    Inventor： CECH STEVEN D ,  WEBER AARON V

    IPC: A61B3/13

    CPC classification number: G02B7/021 ,  A61B3/1208 ,  A61B3/125 ,  A61F9/007 ,  G02B21/0012

    Abstract: This invention is directed towards ophthalmic lenses used to assist during vitreoretinal surgery. More specifically, it is directed towards Ophthalmic lenses that are constructed to generate a high-resolution image of the retinal surface during surgery while maintaining a minimal mechanical envelop all while using materials and assembly methods compatible with autoclave sterilization techniques.

    Abstract translation: 本发明涉及用于在玻璃体视网膜手术期间辅助的眼科镜片。 更具体地，针对眼科镜片被构造成在手术期间产生视网膜表面的高分辨率图像，同时在使用与高压灭菌技术相容的材料和装配方法的同时保持最小的机械包封。

    SYSTEMS AND METHODS FOR REDUCING DETECTED INTENSITY NON-UNIFORMITY IN A LASER BEAM
    5.
    发明申请
    SYSTEMS AND METHODS FOR REDUCING DETECTED INTENSITY NON-UNIFORMITY IN A LASER BEAM 审中-公开

    公开(公告)号：WO2007103465A3

    公开(公告)日：2007-09-13

    申请号：PCT/US2007/005876

    申请日：2007-03-07

    Applicant: HELICOS BIOSCIENCES CORPORATION ,  WEBER, Aaron ,  TRACY, David

    Inventor： WEBER, Aaron ,  TRACY, David

    IPC: H01S3/00

    Abstract: A method of increasing the spatial uniformity of the detected intensity of a beam of light from a laser in a system including the laser (34) and a light detector (74). In one embodiment the method includes the steps of generating a beam of light (30) with the laser; and moving the beam of light and the light detector relative to each other, such that the detector averages the spatial intensity of the beam of light over time. In another embodiment the invention relates to a system for increasing the detected spatial uniformity of the intensity of a beam of light. In one embodiment the system comprises a light detector; a laser source for generating the beam of light; and a means (10) for moving the beam of light and the detector relative to one another such that the detector averages the intensity of the light beam over time.

    SYSTEMS AND METHODS FOR REDUCING DETECTED INTENSITY NON-UNIFORMITY IN A LASER BEAM
    6.
    发明申请
    SYSTEMS AND METHODS FOR REDUCING DETECTED INTENSITY NON-UNIFORMITY IN A LASER BEAM 审中-公开
    用于减少激光束中检测强度非均匀性的系统和方法

    公开(公告)号：WO2007103465A2

    公开(公告)日：2007-09-13

    申请号：PCT/US2007005876

    申请日：2007-03-07

    Applicant: HELICOS BIOSCIENCES CORP ,  WEBER AARON ,  TRACY DAVID

    Inventor： WEBER AARON ,  TRACY DAVID

    CPC classification number: G01J1/4257 ,  G01J1/04 ,  G01J1/0407 ,  G01J1/0414 ,  G01J1/0437 ,  G01J2001/4261

    Abstract: A method of increasing the spatial uniformity of the detected intensity of a beam of light from a laser in a system including the laser and a light detector. In one embodiment the method includes the steps of generating a beam of light with the laser; and moving the beam of light and the light detector relative to each other, such that the detector averages the spatial intensity of the beam of light over time. In another embodiment the invention relates to a system for increasing the detected spatial uniformity of the intensity of a beam of light. In one embodiment the system comprises a light detector; a laser source for generating the beam of light; and a means for moving the beam of light and the detector relative to one another such that the detector averages the intensity of the light beam over time

    Abstract translation: 一种增加在包括激光器和光检测器的系统中来自激光器的光束的检测强度的空间均匀性的方法。 在一个实施例中，该方法包括以下步骤：用激光产生光束; 并且相对于彼此移动光束和光检测器，使得检测器随时间平均光束的空间强度。 在另一个实施例中，本发明涉及一种用于增加检测到的光束的强度的空间均匀性的系统。 在一个实施例中，系统包括光检测器; 用于产生光束的激光源; 以及用于相对于彼此移动光束和检测器的装置，使得检测器随着时间平均光束的强度

    LENS ASSEMBLY FOR VITREORETINAL SURGERY
    9.
    发明申请
    LENS ASSEMBLY FOR VITREORETINAL SURGERY 审中-公开
    眼镜组件用于维生素S外科手术

    公开(公告)号：WO2007095046A2

    公开(公告)日：2007-08-23

    申请号：PCT/US2007/003356

    申请日：2007-02-08

    Applicant: VOLK OPTICAL INC. ,  CECH, Steven, D. ,  WEBER, Aaron, V.

    Inventor： CECH, Steven, D. ,  WEBER, Aaron, V.

    CPC classification number: G02B7/021 ,  A61B3/1208 ,  A61B3/125 ,  A61F9/007 ,  G02B21/0012

    Abstract: This invention is directed towards ophthalmic lenses used to assist during vitreoretinal surgery. More specifically, it is directed towards Ophthalmic lenses that are constructed to generate a high-resolution image of the retinal surface during surgery while maintaining a minimal mechanical envelop all while using materials and assembly methods compatible with autoclave sterilization techniques.

    Abstract translation: 本发明涉及用于在玻璃体视网膜手术期间辅助的眼科镜片。 更具体地，针对眼科镜片被构造成在手术期间产生视网膜表面的高分辨率图像，同时在使用与高压灭菌技术相容的材料和装配方法的同时保持最小的机械包封。

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