公开(公告)号：WO2007037791A2

公开(公告)日：2007-04-05

申请号：PCT/US2006/022462

申请日：2006-06-09

Applicant: FLORIDA ATLANTIC UNIVERSITY ,  KERR, Russell, G. ,  BRUECK, Thomas

Inventor： KERR, Russell, G. ,  BRUECK, Thomas

IPC: C12P21/04

CPC classification number: C12P1/04 ,  C12P5/007 ,  C12P7/02 ,  C12P7/04 ,  C12P7/22 ,  C12P7/24

Abstract: The identification and characterization of the sources of terpenes from the soft corals Leptogorgia minimata (LM, formerly Lophogorgia spp., Family: Gorgoniidae), Swifita exertia (SE, Family: Plexauridae), Iciligorgia schrammi (IS, Family: Anthothelidae), Eunicea fusca, Eiythropodium caribaeorum or Plexaurella sp. through direct culture of microbial populations derived from coral homogenates.

Abstract translation: 来自软珊瑚Leptogorgia minimata（LM，以前的Lophogorgia spp。，Family：Gorgoniidae），Swifita exertia（SE，Family：Plexauridae），Iciligorgia schrammi（IS，Family：Anthothelidae），Eunicea fusca的萜烯来源的鉴定和表征 ，Eiythropodium caribaeorum或Plexaurella sp。 通过直接培养来自珊瑚匀浆的微生物群落。

公开(公告)号：WO1998004676A2

公开(公告)日：1998-02-05

申请号：PCT/US1997013155

申请日：1997-07-25

Applicant: FLORIDA ATLANTIC UNIVERSITY RESEARCH CORPORATION ,  KERR, Russell, G.

Inventor： FLORIDA ATLANTIC UNIVERSITY RESEARCH CORPORATION

IPC: C12N00/00

CPC classification number: C12P33/00 ,  C12N9/00 ,  C12P19/56 ,  C40B40/00

Abstract: A fortified enzyme preparation of the gorgonian Pseudopterogorgia americana or Pseudopterogorgia elisabethae has been developed which efficiently transforms a variety of precursor molecules, e.g., sterols, to their corresponding metabolites, e.g., 9(11)-secosteroid in high yield. NAD, NADP, and glutamate dehydrogenase can be used as additives in this enzymatic conversion. In addition to naturally-occurring metabolites, novel secosteroids have been prepared.

Abstract translation: 已经开发了美国红假单胞菌（Pseudopterogorgia americana）或伪猕猴桃（Pseudopterogorgia elisabethae）的强化酶制剂，其高效率地将多种前体分子（例如甾醇）转化成其相应的代谢物，例如9（11） - 类固醇。 NAD，NADP和谷氨酸脱氢酶可用作该酶转化中的添加剂。 除天然存在的代谢物外，还制备了新的类固醇。

公开(公告)号：WO2007037791A3

公开(公告)日：2009-04-30

申请号：PCT/US2006022462

申请日：2006-06-09

Applicant: UNIV FLORIDA ATLANTIC ,  KERR RUSSELL G ,  BRUECK THOMAS

Inventor： KERR RUSSELL G ,  BRUECK THOMAS

IPC: C12P23/00 ,  C07C403/00 ,  C12P7/02

CPC classification number: C12P1/04 ,  C12P5/007 ,  C12P7/02 ,  C12P7/04 ,  C12P7/22 ,  C12P7/24

Abstract: The identification and characterization of the sources of terpenes from the soft corals Leptogorgia minimata (LM, formerly Lophogorgia spp., Family: Gorgoniidae), Swifita exertia (SE, Family: Plexauridae), Iciligorgia schrammi (IS, Family: Anthothelidae), Eunicea fusca, Eiythropodium caribaeorum or Plexaurella sp. through direct culture of microbial populations derived from coral homogenates.

Abstract translation: 来自软珊瑚Leptogorgia minimata（LM，以前的Lophogorgia spp。，Family：Gorgoniidae），Swifita exertia（SE，Family：Plexauridae），Iciligorgia schrammi（IS，Family：Anthothelidae），Eunicea fusca的萜烯来源的鉴定和表征 ，Eiythropodium caribaeorum或Plexaurella sp。 通过直接培养来自珊瑚匀浆的微生物群落。

公开(公告)号：WO2012139212A1

公开(公告)日：2012-10-18

申请号：PCT/CA2012/000367

申请日：2012-04-13

Applicant: NAUTILUS BIOSCIENCES CANADA, INC. ,  UNIVERSITY OF PRINCE EDWARD ISLAND ,  KERR, Russell G. ,  MCCULLOCH, Malcolm W. B.

Inventor： KERR, Russell G. ,  MCCULLOCH, Malcolm W. B.

IPC: C07D263/52 ,  A61K31/122 ,  A61K31/27 ,  A61K31/423 ,  A61L2/16 ,  C07C215/88 ,  C07C49/747 ,  C07D235/02 ,  C07D241/38

CPC classification number: C07C43/23 ,  C07B2200/07 ,  C07C39/11 ,  C07C39/23 ,  C07C43/215 ,  C07C49/737 ,  C07C215/88 ,  C07C2603/28 ,  C07D241/38 ,  C07D263/52

Abstract: New methods of converting pseudopterosins to pseudopteroxazoles have been developed and used to make several new non-natural pseudopteroxazole analogs. These as well as pseudopterosins and derivatives thereof and prenylated aromatic structural mimics of pseudopterosins/pseudopteroxazoles are shown to display anti-bacterial activity including that against non-replicating mycobacteria, with some exhibiting no or limited toxicity against mammalian cells.

Abstract translation: 已经开发出新的将拟蝶呤转化为假opter唑的方法，并用于制备几种新的非天然假opter azole唑类似物。 这些以及假飞蝶素及其衍生物和假飞虱素/假opter and唑的异戊烯基化芳族结构模拟物显示出显示出抗细菌活性，包括针对非复制性分枝杆菌的抗菌活性，其中一些对哺乳动物细胞表现出无毒性或有限性。

公开(公告)号：WO0244191A3

公开(公告)日：2003-04-17

申请号：PCT/US0144334

申请日：2001-11-27

Applicant: UNIV CALIFORNIA ,  JACOBS ROBERT S ,  KERR RUSSELL G

Inventor： JACOBS ROBERT S ,  KERR RUSSELL G

IPC: A61P29/00 ,  C07H15/24 ,  A61K31/704 ,  C07C13/48 ,  C07C39/17 ,  C07C49/737 ,  C07C49/753 ,  C07C50/14 ,  C07C50/32 ,  C07C69/14 ,  C07H15/203

CPC classification number: C07H15/24

Abstract: Methods for treating, preventing, or inhibiting diseases and disorders associated with inflammation, cell-proliferation, and pain comprising the administration of a compound having the structural formula (I) wherein R1 is a hydrogen, alkyl, aryl, hydroxyalkyl, cycloalkyl, cycloalkenyl, carboxylic acid, alkylamino or amide group having from 2 to 20 carbon atoms, R2, R3, and R4 are each independently hydrogen or an acyl residue having from 1 to 6 carbon atoms, R5 is hydrogen, CH3, or CH2OH, and R6 is an organo group such as a hydrocarbon having from 1 to 10 carbon atoms are disclosed. Other seco-pseudopterosins and compounds related to pseudopterosins are disclosed.

Abstract translation: 用于治疗，预防或抑制与炎症，细胞增殖和疼痛相关的疾病和病症的方法，包括施用具有结构式（I）的化合物，其中R 1是氢，烷基，芳基，羟基烷基，环烷基，环烯基， 羧酸，具有2至20个碳原子的烷基氨基或酰胺基，R 2，R 3和R 4各自独立地为氢或具有1至6个碳原子的酰基，R 5为氢，CH 3或CH 2 OH，并且R 6为 公开了具有1至10个碳原子的有机基团。 公开了其他与假飞虱相关的鳞翅目和化合物。