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1.发明申请NOVEL S. PYOGENES DNA POLYMERASE III HOLOENZYME NUCLEIC ACID MOLECULES AND PROTEINS 审中-公开新型S.PYOGENES DNA聚合酶III HOLOENZYME核酸分子和蛋白
公开(公告)号：WO0234936A9
公开(公告)日：2003-04-17
申请号：PCT/US0148396
申请日：2001-10-29
Applicant: REPLIDYNE INC , MCHENRY CHARLES S , BULLARD JAMES M , JANJIC NEBOJSA , MANHARDT ERIKA L , KERY VLADIMIR , WILLIAMS JENNIFER C
Inventor： MCHENRY CHARLES S , BULLARD JAMES M , JANJIC NEBOJSA , MANHARDT ERIKA L , KERY VLADIMIR , WILLIAMS JENNIFER C
CPC classification number: C12N9/1252
Abstract: S. pyogenes nucleic acid molecules encoding polC, dnaE, holA, holB, dnaX, dnaN, SSB, dnaG, dnaQ, dnaA and dnaB proteins, as well as nucleic acid molecules comprising oriC are provided. The encoded proteins are also provided. The nucleic acid molecules and proteins are useful for reconstituting replicases and polymerases for sequencing, amplification, and screening for compounds which modulate the function of the polymersase or replicase.
Abstract translation: 提供了编码polC，dnaE，holA，holB，dnaX，dnaN，SSB，dnaG，dnaQ，dnaA和dnaB蛋白的化脓性成瘾核酸分子以及包含oriC的核酸分子。 还提供编码的蛋白质。 核酸分子和蛋白质可用于重建复制酶和聚合酶，用于测序，扩增和筛选调节聚合酶或复制酶功能的化合物。
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Patent Agency Ranking
公开(公告)号：WO2003095619A3
公开(公告)日：2003-11-20
申请号：PCT/US2003/014511
申请日：2003-05-09
Applicant: PROLEXYS PHARMACEUTICALS, INC. , BONIFACE, John, J. , KERY, Vladimir , PELTIER, John, M. , WEIR, Lawrence , ROBBINS, Paul, B. , RODRIGUEZ, Manuel, M.
Inventor： BONIFACE, John, J. , KERY, Vladimir , PELTIER, John, M. , WEIR, Lawrence , ROBBINS, Paul, B. , RODRIGUEZ, Manuel, M.
IPC: C07K1/14
Abstract: The present invention provides a method for isolating protein complexes from a cell, a cell or tissue lysate or an whole organism by employing a combined set of affinity tags of high affinity, specificity and ease of elution. The method involves using a known protein modified to contain more than one affinity tag separated by one or more specific protease cleavage sites, as bait, to isolate any interacting proteins or fragments thereof. The proteins or fragments thereof contained in the isolated complex can then be identified and the interacting partners can be used as new targets for diagnostic tools or the basis for the development of new compounds for therapeutic drug intervention.
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3.发明申请NOVEL S. PYOGENES DNA POLYMERASE III HOLOENZYME NUCLEIC ACID MOLECULES AND PROTEINS 审中-公开NOVEL S。 PYOGENES DNA聚合酶III HOLOENZYME核酸分子和蛋白
公开(公告)号：WO0234936A2
公开(公告)日：2002-05-02
申请号：PCT/US0148396
申请日：2001-10-29
Applicant: REPLIDYNE INC , MCHENRY CHARLES S , BULLARD JAMES M , JANJIC NEBOJSA , MANHARDT ERIKA L , KERY VLADIMIR , WILLIAMS JENNIFER C
Inventor： MCHENRY CHARLES S , BULLARD JAMES M , JANJIC NEBOJSA , MANHARDT ERIKA L , KERY VLADIMIR , WILLIAMS JENNIFER C
CPC classification number: C12N9/1252
Abstract: S. pyogenes nucleic acid molecules encoding polC, dnaE, holA, holB, dnaX, dnaN, SSB, dnaG, dnaQ, dnaA and dnaB proteins, as well as nucleic acid molecules comprising oriC are provided. The encoded proteins are also provided. The nucleic acid molecules and proteins are useful for reconstituting replicases and polymerases for sequencing, amplification, and screening for compounds which modulate the function of the polymersase or replicase.
Abstract translation: 提供了编码polC，dnaE，holA，holB，dnaX，dnaN，SSB，dnaG，dnaQ，dnaA和dnaB蛋白的化脓性成瘾核酸分子以及包含oriC的核酸分子。 还提供编码的蛋白质。 核酸分子和蛋白质可用于重建复制酶和聚合酶，用于测序，扩增和筛选调节聚合酶或复制酶功能的化合物。
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4.发明申请BONE GRAFTS WITH REDUCED PROTEASE ACTIVITY AND METHODS OF SELECTION AND USE 审中-公开骨质量减少的蛋白酶活性及选择和使用方法
公开(公告)号：WO2010071857A1
公开(公告)日：2010-06-24
申请号：PCT/US2009/068873
申请日：2009-12-18
Applicant: BIOMIMETIC THERAPEUTICS, INC. , KERY, Vladimir , YOUNG, Conan, S. , SNEL, Leo, B. , HART, Charles, E.
Inventor： KERY, Vladimir , YOUNG, Conan, S. , SNEL, Leo, B. , HART, Charles, E.
CPC classification number: A61K35/32 , A61K38/1858 , A61L27/22 , A61L2430/02 , A61K2300/00
Abstract: The invention features bone grafts (such as bone allografts) with reduced protease activity. These bone grafts are useful, for example, in conjunction with a polypeptide of interest (such as platelet derived growth factor) for treating, stabilizing, preventing, and/or delaying a bone, periodontium, ligament, cartilage, or tendon condition in an individual (such as a human). Additionally, the invention provides methods of measuring the protease activity associated with a bone graft, reducing the level of protease activity associated with a bone graft, selecting a bone graft with an acceptable level of protease activity, and methods of administering a bone graft and a polypeptide of interest to an individual.
Abstract translation: 本发明具有蛋白酶活性降低的骨移植物（例如骨同种异体移植物）。 这些骨移植物例如与用于治疗，稳定，预防和/或延迟个体中的骨，牙周，韧带，软骨或腱状况的感兴趣的多肽（例如血小板衍生的生长因子）联用是有用的 （如人）。 此外，本发明提供了测量与骨移植相关的蛋白酶活性的方法，降低与骨移植相关的蛋白酶活性的水平，选择具有可接受水平的蛋白酶活性的骨移植物，以及施用骨移植物和 个体感兴趣的多肽。
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公开(公告)号：WO03095619A2
公开(公告)日：2003-11-20
申请号：PCT/US0314511
申请日：2003-05-09
Applicant: MYRIAD PROTEOMICS INC , BONIFACE JOHN J , KERY VLADIMIR , PELTIER JOHN M , WEIR LAWRENCE , ROBBINS PAUL B , RODRIGUEZ MANUEL M
Inventor： BONIFACE JOHN J , KERY VLADIMIR , PELTIER JOHN M , WEIR LAWRENCE , ROBBINS PAUL B , RODRIGUEZ MANUEL M
CPC classification number: G01N33/6842 , C07K1/22 , C07K1/36 , C07K5/101 , C07K5/1021 , G01N33/68 , G01N2500/00
Abstract: The present invention provides a method for isolating protein complexes from a cell, a cell or tissue lysate or an whole organism by employing a combined set of affinity tags of high affinity, specificity and ease of elution. The method involves using a known protein modified to contain more than one affinity tag separated by one or more specific protease cleavage sites, as bait, to isolate any interacting proteins or fragments thereof. The proteins or fragments thereof contained in the isolated complex can then be identified and the interacting partners can be used as new targets for diagnostic tools or the basis for the development of new compounds for therapeutic drug intervention.
Abstract translation: 本发明提供了通过使用高亲和力，特异性和易于洗脱的组合的一组亲和标签从细胞，细胞或组织裂解物或整个生物体分离蛋白质复合物的方法。 该方法包括使用已知的已被修饰的蛋白质包含一个或多个特异性蛋白酶切割位点分离的多于一个的亲和标签作为诱饵，以分离任何相互作用的蛋白质或其片段。 然后可以鉴定分离的复合物中包含的蛋白质或其片段，并且相互作用的配偶体可以用作诊断工具的新靶标或用于开发用于治疗性药物干预的新化合物的基础。
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公开(公告)号：WO2002034936A3
公开(公告)日：2002-05-02
申请号：PCT/US2001/048396
申请日：2001-10-29
Applicant: REPLIDYNE, INC. , MCHENRY, Charles, S. , BULLARD, James, M. , JANJIC, Nebojsa , MANHARDT, Erika, L. , KERY, Vladimir , WILLIAMS, Jennifer, C.
Inventor： MCHENRY, Charles, S. , BULLARD, James, M. , JANJIC, Nebojsa , MANHARDT, Erika, L. , KERY, Vladimir , WILLIAMS, Jennifer, C.
IPC: C12N9/12
Abstract: S. pyogenes nucleic acid molecules encoding polC, dnaE, holA, holB, dnaX, dnaN, SSB, dnaG, dnaQ, dnaA and dnaB proteins, as well as nucleic acid molecules comprising oriC are provided. The encoded proteins are also provided. The nucleic acid molecules and proteins are useful for reconstituting replicases and polymerases for sequencing, amplification, and screening for compounds which modulate the function of the polymersase or replicase.
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