公开(公告)号：WO2011099730A3

公开(公告)日：2012-01-12

申请号：PCT/KR2011000790

申请日：2011-02-08

Applicant: MEDISCOV INC ,  KIM DAE JOONG

Inventor： KIM DAE JOONG

IPC: G01N33/483 ,  G01N27/00 ,  G01N33/48 ,  G06T7/60

CPC classification number: G01N33/502 ,  G01N33/54326 ,  G01N33/582

Abstract: The present invention provides a method for identifying modulators that modulate physiological functions of intracellular components within a cell. The method for identifying modulators that modulate physiological functions of intracellular components according to the invention, comprises: imaging a pattern of a magnetic substance that is magnetized in the direction of the magnetic flux as well as a pattern of a tracer that is coupled with the cellular component; and then determining whether there is a competing reaction between a reference substance and a modifier in the cell. One advantage of the present invention is that since the reaction in a cellular component for the modifier such as a drug and the reference substance occurs in a living cell, the competing reaction between the modifier and the reference substance represents actual intracellular metabolism. Also, the present invention is advantageous in that a plurality of modifiers can be screened using a small number of reference substances, and that the function of a modifier in cells, i.e., pharmaceutical efficacy, can be searched without changing the modifier with introduction of a reference substance.

Abstract translation: 本发明提供了一种用于鉴定调节细胞内细胞内组分的生理功能的调节剂的方法。 用于鉴定调节根据本发明的细胞内组分的生理功能的调节剂的方法包括：对在磁通方向上磁化的磁性物质的图案以及与细胞结合的示踪剂的图案进行成像 零件; 然后确定细胞中参考物质和修饰剂之间是否存在竞争性反应。 本发明的一个优点是，由于用于改性剂如药物和参考物质的细胞成分中的反应发生在活细胞中，改性剂与参照物质之间的竞争反应代表实际的细胞内代谢。 此外，本发明的优点在于可以使用少量参考物质来筛选多个改性剂，并且可以在不改变改性剂的情况下搜索细胞中修饰剂的功能，即药物功效，而不改变改性剂 参考物质。

公开(公告)号：WO2010053323A3

公开(公告)日：2010-08-26

申请号：PCT/KR2009006539

申请日：2009-11-09

Applicant: MEDISCOV INC ,  KIM DAE JOONG ,  KIM JIN HWAN

Inventor： KIM DAE JOONG ,  KIM JIN HWAN

IPC: C07C39/16 ,  C01C1/16 ,  C07C47/04 ,  C07D207/448

CPC classification number: C07D207/448 ,  C07C29/94 ,  C07C45/90 ,  C07C31/04 ,  C07C31/08 ,  C07C47/04

Abstract: The present invention provides a method for exposing particles to cytoplasm, comprising the steps of delivering particles into live cells, enabling a cytoplasm exposure additive to contact the cells for exposing the particles to cytoplasm from endocytic vesicles when the physiological, biochemical, or biological environments of the cells are kept intact, and enabling the particles to be exposed to the cytoplasm from the endocytic vesicles. The present invention is advantageous in that particles delivered into cells can be effectively exposed to cytoplasm from endocytic vesicles in intact cells when the physiological, biochemical, or biological environments of the cells are kept intact.

Abstract translation: 本发明提供了一种将颗粒暴露于细胞质的方法，其包括将颗粒递送至活细胞中的步骤，使细胞质暴露添加剂与细胞接触，以使细胞暴露于来自内吞囊泡的细胞质中，当生理学，生物化学或生物学环境 细胞保持完整，并使颗粒从细胞内囊泡暴露于细胞质。 本发明的优点在于，当细胞的生理，生物化学或生物学环境保持完整时，递送到细胞中的颗粒可以有效地从完整细胞中的内吞囊泡暴露于细胞质。

公开(公告)号：WO2007035039A1

公开(公告)日：2007-03-29

申请号：PCT/KR2006/003737

申请日：2006-09-20

Applicant: SAMSUNG CORPORATION ,  ICHINOHE, Hideo ,  KIM, Dae-Joong ,  PARK, Seong-Hwa

Inventor： ICHINOHE, Hideo ,  KIM, Dae-Joong ,  PARK, Seong-Hwa

IPC: E04H5/02 ,  E04B1/24 ,  E04B1/14 ,  E04B1/30 ,  E04C3/293

CPC classification number: E04C3/293

Abstract: The present invention relates to a high strength mega-truss structure, which is adapted to be effective to the vibration by constructing steel-concrete sandwich beams with the advantage of construction efficiency of a steel structure and the advantage of high strength and high damping capacity of an RC structure by means of the synthetic action of steel member and concrete, as upper and lower floor beams, and disposing web members between the upper and lower floor portions to thereby make the upper and lower floor beams move concurrently, and a factory building accomplished as an anti-vibration building by applying such mega-truss structure to it. The high strength mega-truss structure of the present invention, comprises an upper floor beam constructed by a steel-concrete sandwich beam; a lower floor beam constructed by a steel- concrete sandwich beam; a primary web member disposed to define a wave shape between the upper floor beam and the lower floor beam; and a secondary web member disposed to define a wave shape between the upper floor beam and the lower floor beam and disposed to be spaced apart from the primary web member, wherein the filled concrete of the upper floor beam is constructed integrally with slab concrete above the upper floor beam, and the filled concrete of the lower floor beam is constructed integrally with slab concrete above the lower floor beam.

Abstract translation: 高强度桁架结构本发明涉及一种高强度桁架结构，该结构适用于通过构造钢混凝土夹层梁对振动有效，具有钢结构的施工效率和高强度和高阻尼能力的优点 通过钢构件和混凝土的合成作用的RC结构，作为上下地板梁，并且在上下地板部分之间设置腹板构件，从而使上下地板梁同时移动，并且完成工厂建筑 作为抗震建筑物，通过应用这种大型桁架结构。 本发明的高强度桁架结构包括由钢筋混凝土夹心梁构成的上层梁; 由钢筋混凝土夹心梁构成的下部地板梁; 被设置为在所述上部地板梁和所述下部地板梁之间限定波浪形状的主网状构件; 以及第二腹板构件，其设置成在上地板梁和下地板梁之间限定波形，并且设置成与主腹板构件间隔开，其中上地板梁的填充混凝土与上面的梁上的板混凝土一体地构成 上层梁和下层梁的混凝土与下层地板梁上方的板坯混凝土一体成型。

公开(公告)号：WO2012148190A2

公开(公告)日：2012-11-01

申请号：PCT/KR2012003240

申请日：2012-04-26

Applicant: KOLON BENIT CO LTD ,  KOLON INC ,  NOH JUNGMIN ,  KIM DAE JOONG ,  PARK DONG-EUL ,  LEE AH REUM ,  SHIN YONG-CHEOL ,  LEE KWANG-JIN

Inventor： NOH JUNGMIN ,  KIM DAE JOONG ,  PARK DONG-EUL ,  LEE AH REUM ,  SHIN YONG-CHEOL ,  LEE KWANG-JIN

IPC: B01D63/04 ,  B01D61/14 ,  B01D63/02 ,  B01D65/00

CPC classification number: B01D63/02 ,  B01D61/14 ,  B01D61/18 ,  B01D61/20 ,  B01D2311/20 ,  B01D2313/18 ,  B01D2313/24 ,  B01D2313/243 ,  B01D2315/06 ,  C02F1/444 ,  C02F2103/007 ,  C02F2103/42 ,  Y02W10/33 ,  Y02W10/37

Abstract: Disclosed is an energy-saving and environmentally-friendly filtering system which minimizes energy consumption during a filtering process so as to dramatically reduce water treatment costs. According to the present invention, an inter-membrane pressure difference higher than a threshold membrane pressure is naturally generated by a head pressure of raw water and/or by water pressure of filtered water based on the siphon principle, and thus the amount of energy consumed during the filtering process is minimized.

Abstract translation: 公开了一种节能环保的过滤系统，其最小化过滤过程中的能量消耗，从而显着降低水处理成本。 根据本发明，通过原水的头部压力和/或基于虹吸原理的过滤水的水压自然产生高于阈值膜压力的膜间压差，因此消耗的能量量 在过滤过程中最小化。

公开(公告)号：WO2010053324A3

公开(公告)日：2010-08-05

申请号：PCT/KR2009006541

申请日：2009-11-09

Applicant: MEDISCOV INC ,  KIM DAE JOONG ,  KIM JIN HWAN

Inventor： KIM DAE JOONG ,  KIM JIN HWAN

IPC: C12M1/42 ,  C12M1/00 ,  C12N13/00

CPC classification number: C12N13/00

Abstract: The present invention provides a method for patterning magnetic materials in live cells, comprising the steps of preparing a plurality of nanoencapsulated and surface-modified magnetic materials which are magnetized in a magnetic line of force by a magnetic field, providing the magnetic materials into live cells in such a manner that the plurality of magnetic materials can be provided to one live cell, applying a focused magnetic field onto the live cells to enable bundles of magnetic lines of force to pass through the live cells in a predetermined direction, enabling the plurality of magnetic materials to be arranged in the magnetic line of force of the magnetic field in the live cells, and checking the pattern of the arrangement of the magnetic materials.

Abstract translation: 本发明提供了一种用于对活细胞中的磁性材料进行图案化的方法，包括以下步骤：制备多个纳米囊封和表面改性的磁性材料，所述磁性材料通过磁场在磁力线中磁化，将所述磁性材料提供到活细胞中 使得可以将多个磁性材料提供给一个活细胞，将聚焦的磁场施加到活细胞上以使得磁力线束能够在预定方向上穿过活细胞，使得多个 将磁性材料布置在活细胞中的磁场的磁力线中，并检查磁性材料的布置的图案。

公开(公告)号：WO2010077006A2

公开(公告)日：2010-07-08

申请号：PCT/KR2009007705

申请日：2009-12-23

Applicant: SAMSUNG ELECTRONICS CO LTD ,  KIM DAE JOONG

Inventor： KIM DAE JOONG

IPC: H04W4/02 ,  H04W64/00

CPC classification number: H04W4/02 ,  H04L67/02 ,  H04L67/18

Abstract: A location information tagging method and system for location-based services in a wireless communication system are provided. In the method, if it is determined that a service request message received from a device is being sent to an application server for providing a service based on a location of the device, location information about a base station is tagged to the service request message. The service request message with the tagged location information is transmitted to the application server. Therefore, the application server can obtain location information about the device by merely depending on the message received from the device without referring to a conventional location service server. This reduces a service response time and also rapidly offers a location-based service.

Abstract translation: 提供了一种用于无线通信系统中的基于位置的服务的位置信息标记方法和系统。 在该方法中，如果确定从设备接收的服务请求消息正被发送到应用服务器以基于设备的位置提供服务，则关于基站的位置信息被标记为服务请求消息。 具有标记的位置信息的服务请求消息被发送到应用服务器。 因此，应用服务器可以仅通过取决于从设备接收到的消息而不参考传统的位置服务服务器来获得关于设备的位置信息。 这减少了服务响应时间，并且还迅速提供基于位置的服务。

公开(公告)号：WO2010053320A2

公开(公告)日：2010-05-14

申请号：PCT/KR2009006533

申请日：2009-11-09

Applicant: MEDISCOV INC ,  KIM DAE JOONG ,  KIM JIN HWAN

Inventor： KIM DAE JOONG ,  KIM JIN HWAN

IPC: C07K14/00

CPC classification number: C07K7/08 ,  C07K7/06 ,  C07K2319/01

Abstract: The present invention provides a peptide for delivering cargoes into cells, wherein the peptide contains an intracellular transduction domain. Said intracellular transduction domain is a peptide containing a hydrophilic domain for improving the interaction between charged materials and/or the solubility of the intracellular transduction domain and the cargoes, and a hydrophobic domain which can be used in a hydrophobic interaction and/or an interaction with cell membranes. Said intracellular transduction domain delivers the cargoes into cells when the intracellular transduction domain is not conjugated to the cargoes. The present invention provides a method for delivering cargoes into cells that comprises the steps of preparing an intracellular transduction domain, preparing cargoes to be delivered into cells, treating cells with the cargoes and the intracellular transduction domain when the cargoes and the intracellular transduction domains are not conjugated to each other, and delivering the cargoes into cells.

Abstract translation: 本发明提供了用于将货物递送到细胞中的肽，其中所述肽含有细胞内转导结构域。 所述细胞内转导结构域是含有用于改善带电物质之间的相互作用和/或细胞内转导结构域与货物的溶解性的亲水结构域的肽，以及可以用于疏水性相互作用和/或与疏水性相互作用的疏水性结构域 细胞膜。 当细胞内转导结构域不与货物缀合时，所述细胞内转导结构域将货物递送到细胞中。 本发明提供了一种将货物运送到细胞中的方法，其包括制备细胞内转导结构域，制备待运送到细胞中的货物，当货物和细胞内转导结构域不是货物和细胞内转导结构域时用货物和细胞内转导结构域处理细胞的步骤 相互缀合，并将货物运送到细胞中。

公开(公告)号：WO2005120396A1

公开(公告)日：2005-12-22

申请号：PCT/KR2005/001633

申请日：2005-06-01

Applicant: ACCESS PLUS CO., LTD ,  KIM, Dae, Joong ,  GIM, Chul, Soo ,  KO, Jai, Young ,  PARK, Jong, Sang ,  KWON, Tae, Gun ,  LEE, Byung, Ha ,  LEE, Woo, Kyoung ,  JEONG, Sang, Ho

Inventor： KIM, Dae, Joong ,  GIM, Chul, Soo ,  KO, Jai, Young ,  PARK, Jong, Sang ,  KWON, Tae, Gun ,  LEE, Byung, Ha ,  LEE, Woo, Kyoung ,  JEONG, Sang, Ho

IPC: A61F2/06

CPC classification number: A61L29/041 ,  A61F2/06 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/608 ,  A61M1/3655 ,  C08L27/18

Abstract: Disclosed herein is a hemodialysis tube treated with a medicament on the surface thereof, which provides stable communication between the artery and the vein of the patient under hemodialysis and can greatly reduce stenosis at arteriovenous connections. As a base material of the hemodialysis tube, expanded polytetrafluoroethylene is used while the medicament is paclitaxel or rapamycin.

Abstract translation: 本文公开了一种在其表面上用药物处理的血液透析管，其在血液透析下在患者的动脉和静脉之间提供稳定的连通性，并且可以大大减少动静脉连接处的狭窄。 作为血液透析管的基材，使用发泡聚四氟乙烯，而药物是紫杉醇或雷帕霉素。

公开(公告)号：WO2012169750A3

公开(公告)日：2013-03-07

申请号：PCT/KR2012004376

申请日：2012-06-04

Applicant: UNIV SOGANG IND UNIV COOP FOUN ,  KIM DAE JOONG

Inventor： KIM DAE JOONG

IPC: F21V29/00 ,  B03C3/41

CPC classification number: F21V29/503 ,  F21S8/08 ,  F21V29/63 ,  F21V29/70 ,  F21V29/763 ,  F21V29/80 ,  F21V29/83 ,  F21Y2105/16 ,  F21Y2115/10

Abstract: A lighting apparatus for broadcasting can comprise an ionic wind generator further comprising: a plate-shaped lighting portion, on an upper surface of which a plurality of light sources are arranged; a heat dissipation portion, which is coupled to a lower surface of the lighting portion, for dissipating heat from the lighting portion to the exterior; and first and second electrodes, which are in contact with the lighting portion and the heat dissipation portion and are arranged so as to be separated away from each other; and an ionic wind generator for generating the ionic wind from between the first and second electrodes by means of a potential difference of a voltage which is applied to the first and second electrodes, and for transferring the heat from the lighting portion and the heat dissipation portion to the exterior by using the ionic wind.

Abstract translation: 用于广播的照明装置可以包括离子风发生器，还包括：板状照明部分，其上表面上布置有多个光源; 散热部分，其耦合到照明部分的下表面，用于将热量从照明部分散发到外部; 以及第一和第二电极，它们与照明部分和散热部分接触并被布置成彼此分开; 以及离子风发生器，用于通过施加到第一和第二电极的电压的电位差产生来自第一和第二电极之间的离子风，并且用于从照明部分和散热部分传递热量 通过使用离子风到外部。

公开(公告)号：WO2007058399A1

公开(公告)日：2007-05-24

申请号：PCT/KR2005/003906

申请日：2005-11-17

Applicant: ACCESS PLUS CO., LTD ,  KIM, Dae-joong ,  GIM, Chul-soo ,  KO, Jai-young ,  PARK, Jong-sang ,  KWON, Tae-gun ,  LEE, Byung-ha ,  LEE, Woo-kyung ,  NAM, Hye-yeong ,  LIM, Hyun-jung

Inventor： KIM, Dae-joong ,  GIM, Chul-soo ,  KO, Jai-young ,  PARK, Jong-sang ,  KWON, Tae-gun ,  LEE, Byung-ha ,  LEE, Woo-kyung ,  NAM, Hye-yeong ,  LIM, Hyun-jung

IPC: A61F2/06

CPC classification number: A61L31/16 ,  A61F2/06 ,  A61L29/16 ,  A61L2300/416

Abstract: Disclosed herein are a tube for arteriovenous anastomosis useful in hemodialysis patients and an insert for use in medicinal operation in the body. The tube or the insert are repetitively treated with a medicament on the surface thereof, which provides stable communication between an artery and a vein of a patient under hemodialysis and can greatly reduce stenosis at arteriovenous connections by releasing the medicament at a suitable rate over a prolonged period of time.

Abstract translation: 本文公开了用于血液透析患者的动静脉吻合管和用于体内药物操作的插入物。 管或插入物在其表面上用药物重复地处理，其在血液透析下提供患者的动脉和静脉之间的稳定连通，并且可以通过在延长的时间内以合适的速率释放药物来大大减少动静脉连接处的狭窄 一段的时间。