ATTENUATED SALMONELLA MUTANTS WHEREIN ADHESIN OF BOVINE PATHOGENIC ESCHERICHIA COLI IS TRANSFORMED, AND VACCINE COMPOSITION FOR PREVENTING AND TREATING BOVINE COLIBACILLOSIS AND SALMONELLOSIS COMPRISING SAME
    4.
    发明申请
    ATTENUATED SALMONELLA MUTANTS WHEREIN ADHESIN OF BOVINE PATHOGENIC ESCHERICHIA COLI IS TRANSFORMED, AND VACCINE COMPOSITION FOR PREVENTING AND TREATING BOVINE COLIBACILLOSIS AND SALMONELLOSIS COMPRISING SAME 审中-公开
    减毒沙门氏菌突变体,其中牛病原性大肠杆菌大肠杆菌的粘附素被转化,以及用于预防和治疗牛布鲁氏菌病和包含该病的沙门氏菌病的疫苗组合物

    公开(公告)号:WO2011025344A3

    公开(公告)日:2011-08-25

    申请号:PCT/KR2010005895

    申请日:2010-08-31

    CPC classification number: C12N15/74 C07K14/245 C07K14/255

    Abstract: The present invention provides Salmonella mutants which comprise an adhesin gene of bovine pathogenic Escherichia coli, and are transformed into attenuated Salmonella mutants wherein asd, lon and cpxR genes are deleted; and a vaccine composition for preventing and treating bovine Colibacillosis and Salmonellosis comprising the same. The Salmonella mutants of the present invention efficiently deliver an antigen derived from Escherichia coli into bovine mucosa lymphoid tissues and induce powerful mucosal immunity, and enable the production of the associated vaccine and mass innoculation. In addition, the Salmonella mutants of the present invention allow the innoculation cost and the side effects such as pain, inflammation or the like to be reduced. The production and storage of the Salmonella mutants of the present invention are easy and thus economical. Therefore, the Salmonella mutants of the present invention prevent infections by inducing immune responses against Salmonella and can be used as a polyvalent vaccine due to the inducement of immune responses against expressing exogenous antigens.

    Abstract translation: 本发明提供了含有牛致病性大肠杆菌粘附素基因的沙门氏菌突变体,并将其转化为减毒沙门氏菌突变体,其中asd,lon和cpxR基因缺失; 以及用于预防和治疗牛大肠杆菌病和沙门氏菌病的疫苗组合物。 本发明的沙门氏菌突变体将来源于大肠杆菌的抗原有效地递送到牛粘膜淋巴组织中并诱导强大的粘膜免疫,并且能够产生相关疫苗和大量接种。 另外,本发明的沙门氏菌突变体允许降低接种成本和诸如疼痛,炎症等的副作用。 本发明的沙门氏菌突变体的生产和储存容易并且因此经济。 因此,本发明的沙门氏菌突变体通过诱导针对沙门氏菌的免疫应答来预防感染,并且由于诱导针对表达外源抗原的免疫应答而可以用作多价疫苗。

    VACCINE COMPOSITION INCLUDING SALMONELLA MICROORGANISM VARIANTS FOR PREVENTING FOWL TYPHOID
    5.
    发明申请
    VACCINE COMPOSITION INCLUDING SALMONELLA MICROORGANISM VARIANTS FOR PREVENTING FOWL TYPHOID 审中-公开
    疫苗组合物,包括沙门氏菌微生物变种,用于预防粪便类型

    公开(公告)号:WO2011019134A3

    公开(公告)日:2011-04-21

    申请号:PCT/KR2010003233

    申请日:2010-05-24

    CPC classification number: A61K39/0275 A61K2039/522

    Abstract: The present invention relates to a vaccine composition including salmonella microorganism variants, the lon and cpxR genes of which are deleted from the DNA in the chromosomes thereof, for preventing fowl typhoid. The attenuated salmonella vaccine according to the present invention is a live vaccine rendering production and storage convenient and cost-effective. Being free of the risk of recurring pathogenicity, the vaccine is safe to administer to fowls. In addition, the protective strength of the vaccine against field strains is superior to that of conventional vaccines.

    Abstract translation: 本发明涉及包含沙门氏菌微生物变体的疫苗组合物,所述沙门氏菌微生物变体的lon和cpxR基因从其染色体的DNA中缺失,用于预防家禽伤寒。 根据本发明的减毒沙门氏菌疫苗是使得生产和储存方便且成本有效的活疫苗。 由于没有重复致病的风险,该疫苗对家禽是安全的。 此外,针对田间菌株的疫苗的保护强度优于传统疫苗。

    SPRAY-COATED BODY, METHOD OF COATING AN OBJECT BY A SPRAY COATING PROCESS AND APPARATUS FOR PERFORMING THE SAME
    9.
    发明申请
    SPRAY-COATED BODY, METHOD OF COATING AN OBJECT BY A SPRAY COATING PROCESS AND APPARATUS FOR PERFORMING THE SAME 审中-公开
    喷涂体,通过喷涂工艺涂覆对象的方法及其实施方法

    公开(公告)号:WO2009078516A1

    公开(公告)日:2009-06-25

    申请号:PCT/KR2008/003239

    申请日:2008-06-11

    CPC classification number: C09D1/00 C23C4/11

    Abstract: In a spray-coated body and apparatus and method of forming a spray-coating layer, the spray- coating layer is positioned on a surface of a object body and has a volume resistivity in a range of about 10 10 Ω-cm to about 10 14 Ω-cm. Accordingly, the spray-coating layer has an optimized volume resistivity and the chemical or plasma damage to the spray-coating layer may be minimized in the spray coating process, to thereby improve the characteristics of the spray- coating layer and the reliability of the spray coating process.

    Abstract translation: 在喷涂体中,形成喷涂层的装置和方法中,喷涂层位于物体的表面上,体积电阻率范围为约1010O-cm至约1014O -厘米。 因此,喷涂层具有优化的体积电阻率,并且在喷涂过程中可以使喷涂层的化学或等离子体损伤最小化,从而改善喷涂层的特性和喷涂的可靠性 涂层工艺。

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