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    PROTEIN STABILIZED ANTIMICROBIAL COMPOSITION FORMED BY MELT PROCESSING
    1.
    发明申请
    PROTEIN STABILIZED ANTIMICROBIAL COMPOSITION FORMED BY MELT PROCESSING 审中-公开

    公开(公告)号：WO2012077006A3

    公开(公告)日：2012-06-14

    申请号：PCT/IB2011/054839

    申请日：2011-10-31

    Applicant: KIMBERLY-CLARK WORLDWIDE, INC. ,  TOPOLKARAEV, Vasily, A. ,  SCHOLL, Neil, T. ,  LEE, JaeHong ,  AMBROSE, Dianna, L. ,  KIM, YoungSook

    Inventor： TOPOLKARAEV, Vasily, A. ,  SCHOLL, Neil, T. ,  LEE, JaeHong ,  AMBROSE, Dianna, L. ,  KIM, YoungSook

    IPC: A01N65/00 ,  A01N25/02 ,  A01P1/00

    Abstract: A method for forming an antimicrobial composition that includes mixing an antimicrobially active botanical oil (e.g., thymol, carvacrol, etc.) and protein within a melt blending device (e.g., extruder) is provided. Despite the problems normally associated with melt processing proteins, the present inventors have discovered that the processing conditions and components may be selectively controlled to allow for the formation of a stable, melt-processed composition that is able to exhibit good mechanical properties. For example, the extrusion temperature(s) and shear rate employed during melt blending are relatively low to help limit polypeptide dissociation, thereby minimizing the impact of aggregation and embrittlement. While the use of such low temperature/shear conditions often tend to reduce mixing efficiency, the present inventors have discovered that a carrier fluid may be employed to enhance the ability of the botanical oil to flow into the internal structure of the protein where it can be retained in a stable manner. The composition is also typically anhydrous and generally free of solvents. In this manner, the protein will not generally disperse before use and prematurely release the botanical oil.

    PROTEIN STABILIZED ANTIMICROBIAL COMPOSITION FORMED BY MELT PROCESSING
    2.
    发明申请
    PROTEIN STABILIZED ANTIMICROBIAL COMPOSITION FORMED BY MELT PROCESSING 审中-公开
    熔融加工形成的蛋白质稳定抗菌组合物

    公开(公告)号：WO2012077006A2

    公开(公告)日：2012-06-14

    申请号：PCT/IB2011054839

    申请日：2011-10-31

    Applicant: KIMBERLY CLARK CO ,  TOPOLKARAEV VASILY A ,  SCHOLL NEIL T ,  LEE JAEHONG ,  AMBROSE DIANNA L ,  KIM YOUNGSOOK

    Inventor： TOPOLKARAEV VASILY A ,  SCHOLL NEIL T ,  LEE JAEHONG ,  AMBROSE DIANNA L ,  KIM YOUNGSOOK

    IPC: A01N65/00 ,  A01N25/02 ,  A01P1/00

    CPC classification number: A01N25/02 ,  A01N31/08 ,  A01N43/90 ,  A01N65/00 ,  B29B7/42 ,  B29C47/0004 ,  B29C47/0009 ,  B29C47/0021 ,  B29C47/0026 ,  B29C47/025 ,  B29C47/6056 ,  B29C47/92 ,  B29C2947/92514 ,  B29C2947/926 ,  B29C2947/92704 ,  B29C2947/92828 ,  B29C2947/92876 ,  A01N25/10 ,  A01N25/12 ,  A01N25/28 ,  A01N25/34 ,  A01N2300/00 ,  A01N65/20 ,  A01N65/22 ,  A01N65/44

    Abstract: A method for forming an antimicrobial composition that includes mixing an antimicrobially active botanical oil (e.g., thymol, carvacrol, etc.) and protein within a melt blending device (e.g., extruder) is provided. Despite the problems normally associated with melt processing proteins, the present inventors have discovered that the processing conditions and components may be selectively controlled to allow for the formation of a stable, melt-processed composition that is able to exhibit good mechanical properties. For example, the extrusion temperature(s) and shear rate employed during melt blending are relatively low to help limit polypeptide dissociation, thereby minimizing the impact of aggregation and embrittlement. While the use of such low temperature/shear conditions often tend to reduce mixing efficiency, the present inventors have discovered that a carrier fluid may be employed to enhance the ability of the botanical oil to flow into the internal structure of the protein where it can be retained in a stable manner. The composition is also typically anhydrous and generally free of solvents. In this manner, the protein will not generally disperse before use and prematurely release the botanical oil.

    Abstract translation: 提供了一种形成抗微生物组合物的方法，该方法包括在熔融共混装置（例如挤出机）内混合抗微生物活性植物油（例如百里酚，香芹酚等）和蛋白质。 尽管通常与熔融加工蛋白有关的问题，本发明人已经发现可以选择性地控制加工条件和组分，以形成能够表现出良好机械性能的稳定的熔融加工组合物。 例如，在熔融共混过程中使用的挤出温度和剪切速率相对较低以帮助限制多肽解离，从而使聚集和脆化的影响最小化。 尽管使用这种低温/剪切条件常常倾向于降低混合效率，但是本发明人已经发现载体流体可以用于增强植物油流入蛋白质内部结构中的能力，其中它可以是 保持稳定。 该组合物通常也是无水的并且通常不含溶剂。 以这种方式，蛋白质在使用前通常不会分散并且过早地释放植物油。

    WIPE COATED WITH A BOTANICAL EMULSION HAVING ANITMICROBIAL PROPERTIES
    3.
    发明申请
    WIPE COATED WITH A BOTANICAL EMULSION HAVING ANITMICROBIAL PROPERTIES 审中-公开
    用具有抗微生物特性的植物乳液涂布的擦拭物

    公开(公告)号：WO2012077001A2

    公开(公告)日：2012-06-14

    申请号：PCT/IB2011054787

    申请日：2011-10-26

    Applicant: KIMBERLY CLARK CO ,  LEE JAEHONG ,  TOPOLKARAEV VASILY A ,  KOENIG DAVID W ,  SCHOLL NEIL T ,  KIM YOUNGSOOK ,  WANG JAMES H

    Inventor： LEE JAEHONG ,  TOPOLKARAEV VASILY A ,  KOENIG DAVID W ,  SCHOLL NEIL T ,  KIM YOUNGSOOK ,  WANG JAMES H

    IPC: A01N25/34 ,  A01N65/00 ,  A01P1/00 ,  A47K7/02 ,  A47L13/17 ,  A61K9/70 ,  C09G1/04 ,  C11D17/04

    CPC classification number: A01N65/00 ,  A01N31/08 ,  A01N2300/00 ,  A01N25/04 ,  A01N25/10 ,  A01N25/22 ,  A01N25/34 ,  A01N65/22

    Abstract: An oil-in-water emulsion that is environmentally friendly and also exhibits antimicrobial activity is provided. More specifically, the oil phase of the emulsion includes a botanical oil derived from a plant (e.g., thymol, carvacrol, etc.). Because the botanical oil tends to leach out of the emulsion during storage and before it is used in the desired application, a water-dispersible polymer is also employed in the aqueous phase of the emulsion to enhance long term stability of the oil and, in turn, antimicrobial efficacy. Without intending to be limited by theory, it is believed that the water-dispersible polymer can effectively encapsulate the botanical oil within the emulsion and inhibit its premature release. Once the emulsion is formed, water can then be removed so that it becomes a substantially anhydrous concentrate. In this manner, the water-dispersible polymer will not generally disperse before use and prematurely release the botanical oil. When it is desired, moisture may simply be re-applied to the concentrate to disperse the polymer and activate the release of the botanical oil. Of course, to provide the optimum degree of biocompatibility, the water-dispersible polymer is also a "biopolymer" that is biodegradable and/or renewable.

    Abstract translation: 提供对环境友好并且还显示出抗微生物活性的水包油乳液。 更具体地说，乳剂的油相包括来源于植物的植物油（例如百里酚，香芹酚等）。 由于植物油倾向于在储存过程中以及在用于所需应用之前浸出乳液，因此在乳液的水相中也使用水分散性聚合物以增强油的长期稳定性，并且反过来 ，抗菌功效。 不受理论限制，认为水分散性聚合物可以有效地将植物油包封在乳液中并且抑制其过早释放。 一旦形成乳液，就可以除去水，使其变成基本上无水的浓缩物。 以这种方式，水分散性聚合物在使用前通常不会分散并过早地释放植物油。 当需要时，可以简单地将水分重新施加到浓缩物上以分散聚合物并激活植物油的释放。 当然，为了提供最佳的生物相容性，水分散性聚合物也是可生物降解和/或可再生的“生物聚合物”。

    MELT PROCESSED ANTIMICROBIAL COMPOSITION
    6.
    发明申请
    MELT PROCESSED ANTIMICROBIAL COMPOSITION 审中-公开

    公开(公告)号：WO2012077002A3

    公开(公告)日：2012-06-14

    申请号：PCT/IB2011/054828

    申请日：2011-10-31

    Applicant: KIMBERLY-CLARK WORLDWIDE, INC. ,  WANG, James, H. ,  SHI, Bo ,  LEE, JaeHong ,  TOPOLKARAEV, Vasily, A. ,  SCHOLL, Neil, T. ,  KIM, YoungSook

    Inventor： WANG, James, H. ,  SHI, Bo ,  LEE, JaeHong ,  TOPOLKARAEV, Vasily, A. ,  SCHOLL, Neil, T. ,  KIM, YoungSook

    IPC: A01N65/00 ,  A01N43/04 ,  A61K31/70 ,  A01P1/00

    Abstract: A method for forming a composition that includes mixing an antimicrobially active botanical oil (e.g., thymol, carvacrol, etc.) and a modified starch polymer within a melt blending device (e.g., extruder) is provided. Unlike the problems associated with proteins, the use of starch polymers allows for a greater degree of flexibility in the processing conditions and is still able to achieve good properties in the resulting composition. The present inventors have also discovered that a plasticizer may be employed to facilitate melt processing of the starch, as well as to enhance the ability of the botanical oil to flow into the internal structure of the starch where it can be retained in a stable manner. The composition is also typically generally free of solvents. In this manner, the starch will not generally disperse before use and prematurely release the botanical oil. Due to the water sensitivity of the modified starch, however, it may be subsequently dispersed by moisture when it is desired to release the botanical oil.

    MELT PROCESSED ANTIMICROBIAL COMPOSITION
    7.
    发明申请
    MELT PROCESSED ANTIMICROBIAL COMPOSITION 审中-公开
    熔融加工抗微生物组合物

    公开(公告)号：WO2012077002A2

    公开(公告)日：2012-06-14

    申请号：PCT/IB2011054828

    申请日：2011-10-31

    Applicant: KIMBERLY CLARK CO ,  WANG JAMES H ,  SHI BO ,  LEE JAEHONG ,  TOPOLKARAEV VASILY A ,  SCHOLL NEIL T ,  KIM YOUNGSOOK

    Inventor： WANG JAMES H ,  SHI BO ,  LEE JAEHONG ,  TOPOLKARAEV VASILY A ,  SCHOLL NEIL T ,  KIM YOUNGSOOK

    IPC: A01N65/00 ,  A01N43/04 ,  A01P1/00 ,  A61K31/70

    CPC classification number: A01N31/08 ,  A01N65/00 ,  B29B7/10 ,  B29B7/38 ,  B29B9/06 ,  B29B9/12 ,  B29B9/16 ,  B29C47/00 ,  B29C47/6087 ,  A01N25/10 ,  A01N25/12 ,  A01N25/28 ,  A01N25/34 ,  A01N2300/00 ,  A01N65/08 ,  A01N65/20 ,  A01N65/24 ,  A01N65/28 ,  A01N65/38

    Abstract: A method for forming a composition that includes mixing an antimicrobially active botanical oil (e.g., thymol, carvacrol, etc.) and a modified starch polymer within a melt blending device (e.g., extruder) is provided. Unlike the problems associated with proteins, the use of starch polymers allows for a greater degree of flexibility in the processing conditions and is still able to achieve good properties in the resulting composition. The present inventors have also discovered that a plasticizer may be employed to facilitate melt processing of the starch, as well as to enhance the ability of the botanical oil to flow into the internal structure of the starch where it can be retained in a stable manner. The composition is also typically generally free of solvents. In this manner, the starch will not generally disperse before use and prematurely release the botanical oil. Due to the water sensitivity of the modified starch, however, it may be subsequently dispersed by moisture when it is desired to release the botanical oil.

    Abstract translation: 提供了一种形成组合物的方法，其包括在熔融共混装置（例如挤出机）中混合抗微生物活性植物油（例如百里酚，香芹酚等）和改性淀粉聚合物。 与蛋白质相关的问题不同，淀粉聚合物的使用允许在加工条件下具有更大程度的柔性，并且仍能在所得组合物中获得良好的性能。 本发明人还发现，可以使用增塑剂来促进淀粉的熔融加工，以及提高植物油流入淀粉内部结构的能力，其中它可以以稳定的方式保留。 组合物通常通常也不含溶剂。 以这种方式，淀粉通常不会在使用前分散并且过早地释放植物油。 然而，由于改性淀粉的水敏感性，当需要释放植物油时，随后可以通过水分分散。

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