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    MELT-BLENDED PROTEIN COMPOSITION
    4.
    发明申请
    MELT-BLENDED PROTEIN COMPOSITION 审中-公开
    融合蛋白组合物

    公开(公告)号：WO2012077005A2

    公开(公告)日：2012-06-14

    申请号：PCT/IB2011054838

    申请日：2011-10-31

    申请人： KIMBERLY CLARK CO ,  TOPOLKARAEV VASILY A ,  SCHOLL NEIL T

    发明人： TOPOLKARAEV VASILY A ,  SCHOLL NEIL T

    IPC分类号： C08L89/00 ,  C08B1/00 ,  C08K5/05 ,  C08K5/09 ,  C08L33/00

    CPC分类号： A61K47/42 ,  A01N25/28 ,  A61K8/0208 ,  A61K8/645 ,  A61Q17/005 ,  A61Q19/10 ,  C08K5/0016 ,  C08K5/0025 ,  C08K5/053 ,  C08K5/09 ,  C08K5/1515 ,  C08L89/00 ,  A01N25/10 ,  A01N65/00

    摘要： A melt-processed protein composition formed from a protein, plasticizer, and an electrophilic reagent is provided. The electrophilic reagent, for instance, may be selected to undergo a nucleophilic addition reaction with free sulfhydryl and/or thiyl radicals to help minimize the formation of disulfide crosslinking bonds that could otherwise lead to protein aggregation during melt processing. To enhance the degree to which the electrophilic reagent can limit crosslinking, a plasticizer is also employed that helps to mediate the adsorption of the electrophilic reagent into the internal structure of the protein, where it can be more stably retained. Furthermore, the temperature and shear rate employed during melt blending may also be selected to be relatively low to help limit polypeptide dissociation, thereby minimizing the impact of aggregation and embrittlement.

    摘要翻译： 提供由蛋白质，增塑剂和亲电子试剂形成的熔融加工的蛋白质组合物。 例如，可以选择亲电子试剂以进行与游离巯基和/或硫酰基的亲核加成反应，以帮助最小化二硫化物交联键的形成，否则所述二硫键会在熔融加工期间导致蛋白质聚集。 为了提高亲电子试剂限制交联的程度，还使用增塑剂，其帮助介导亲电试剂吸附到蛋白质的内部结构中，在那里它可以更稳定地保留。 此外，熔融共混过程中使用的温度和剪切速率也可以选择为相对较低，以帮助限制多肽解离，从而使聚集和脆化的影响最小化。

    PROTEIN STABILIZED ANTIMICROBIAL COMPOSITION FORMED BY MELT PROCESSING
    6.
    发明申请
    PROTEIN STABILIZED ANTIMICROBIAL COMPOSITION FORMED BY MELT PROCESSING 审中-公开

    公开(公告)号：WO2012077006A3

    公开(公告)日：2012-06-14

    申请号：PCT/IB2011/054839

    申请日：2011-10-31

    申请人： KIMBERLY-CLARK WORLDWIDE, INC. ,  TOPOLKARAEV, Vasily, A. ,  SCHOLL, Neil, T. ,  LEE, JaeHong ,  AMBROSE, Dianna, L. ,  KIM, YoungSook

    发明人： TOPOLKARAEV, Vasily, A. ,  SCHOLL, Neil, T. ,  LEE, JaeHong ,  AMBROSE, Dianna, L. ,  KIM, YoungSook

    IPC分类号： A01N65/00 ,  A01N25/02 ,  A01P1/00

    摘要： A method for forming an antimicrobial composition that includes mixing an antimicrobially active botanical oil (e.g., thymol, carvacrol, etc.) and protein within a melt blending device (e.g., extruder) is provided. Despite the problems normally associated with melt processing proteins, the present inventors have discovered that the processing conditions and components may be selectively controlled to allow for the formation of a stable, melt-processed composition that is able to exhibit good mechanical properties. For example, the extrusion temperature(s) and shear rate employed during melt blending are relatively low to help limit polypeptide dissociation, thereby minimizing the impact of aggregation and embrittlement. While the use of such low temperature/shear conditions often tend to reduce mixing efficiency, the present inventors have discovered that a carrier fluid may be employed to enhance the ability of the botanical oil to flow into the internal structure of the protein where it can be retained in a stable manner. The composition is also typically anhydrous and generally free of solvents. In this manner, the protein will not generally disperse before use and prematurely release the botanical oil.

    PROTEIN STABILIZED ANTIMICROBIAL COMPOSITION FORMED BY MELT PROCESSING
    7.
    发明申请
    PROTEIN STABILIZED ANTIMICROBIAL COMPOSITION FORMED BY MELT PROCESSING 审中-公开
    熔融加工形成的蛋白质稳定抗菌组合物

    公开(公告)号：WO2012077006A2

    公开(公告)日：2012-06-14

    申请号：PCT/IB2011054839

    申请日：2011-10-31

    申请人： KIMBERLY CLARK CO ,  TOPOLKARAEV VASILY A ,  SCHOLL NEIL T ,  LEE JAEHONG ,  AMBROSE DIANNA L ,  KIM YOUNGSOOK

    发明人： TOPOLKARAEV VASILY A ,  SCHOLL NEIL T ,  LEE JAEHONG ,  AMBROSE DIANNA L ,  KIM YOUNGSOOK

    IPC分类号： A01N65/00 ,  A01N25/02 ,  A01P1/00

    CPC分类号： A01N25/02 ,  A01N31/08 ,  A01N43/90 ,  A01N65/00 ,  B29B7/42 ,  B29C47/0004 ,  B29C47/0009 ,  B29C47/0021 ,  B29C47/0026 ,  B29C47/025 ,  B29C47/6056 ,  B29C47/92 ,  B29C2947/92514 ,  B29C2947/926 ,  B29C2947/92704 ,  B29C2947/92828 ,  B29C2947/92876 ,  A01N25/10 ,  A01N25/12 ,  A01N25/28 ,  A01N25/34 ,  A01N2300/00 ,  A01N65/20 ,  A01N65/22 ,  A01N65/44

    摘要： A method for forming an antimicrobial composition that includes mixing an antimicrobially active botanical oil (e.g., thymol, carvacrol, etc.) and protein within a melt blending device (e.g., extruder) is provided. Despite the problems normally associated with melt processing proteins, the present inventors have discovered that the processing conditions and components may be selectively controlled to allow for the formation of a stable, melt-processed composition that is able to exhibit good mechanical properties. For example, the extrusion temperature(s) and shear rate employed during melt blending are relatively low to help limit polypeptide dissociation, thereby minimizing the impact of aggregation and embrittlement. While the use of such low temperature/shear conditions often tend to reduce mixing efficiency, the present inventors have discovered that a carrier fluid may be employed to enhance the ability of the botanical oil to flow into the internal structure of the protein where it can be retained in a stable manner. The composition is also typically anhydrous and generally free of solvents. In this manner, the protein will not generally disperse before use and prematurely release the botanical oil.

    摘要翻译： 提供了一种形成抗微生物组合物的方法，该方法包括在熔融共混装置（例如挤出机）内混合抗微生物活性植物油（例如百里酚，香芹酚等）和蛋白质。 尽管通常与熔融加工蛋白有关的问题，本发明人已经发现可以选择性地控制加工条件和组分，以形成能够表现出良好机械性能的稳定的熔融加工组合物。 例如，在熔融共混过程中使用的挤出温度和剪切速率相对较低以帮助限制多肽解离，从而使聚集和脆化的影响最小化。 尽管使用这种低温/剪切条件常常倾向于降低混合效率，但是本发明人已经发现载体流体可以用于增强植物油流入蛋白质内部结构中的能力，其中它可以是 保持稳定。 该组合物通常也是无水的并且通常不含溶剂。 以这种方式，蛋白质在使用前通常不会分散并且过早地释放植物油。

    MELT PROCESSED ANTIMICROBIAL COMPOSITION
    9.
    发明申请
    MELT PROCESSED ANTIMICROBIAL COMPOSITION 审中-公开

    公开(公告)号：WO2012077002A3

    公开(公告)日：2012-06-14

    申请号：PCT/IB2011/054828

    申请日：2011-10-31

    申请人： KIMBERLY-CLARK WORLDWIDE, INC. ,  WANG, James, H. ,  SHI, Bo ,  LEE, JaeHong ,  TOPOLKARAEV, Vasily, A. ,  SCHOLL, Neil, T. ,  KIM, YoungSook

    发明人： WANG, James, H. ,  SHI, Bo ,  LEE, JaeHong ,  TOPOLKARAEV, Vasily, A. ,  SCHOLL, Neil, T. ,  KIM, YoungSook

    IPC分类号： A01N65/00 ,  A01N43/04 ,  A61K31/70 ,  A01P1/00

    摘要： A method for forming a composition that includes mixing an antimicrobially active botanical oil (e.g., thymol, carvacrol, etc.) and a modified starch polymer within a melt blending device (e.g., extruder) is provided. Unlike the problems associated with proteins, the use of starch polymers allows for a greater degree of flexibility in the processing conditions and is still able to achieve good properties in the resulting composition. The present inventors have also discovered that a plasticizer may be employed to facilitate melt processing of the starch, as well as to enhance the ability of the botanical oil to flow into the internal structure of the starch where it can be retained in a stable manner. The composition is also typically generally free of solvents. In this manner, the starch will not generally disperse before use and prematurely release the botanical oil. Due to the water sensitivity of the modified starch, however, it may be subsequently dispersed by moisture when it is desired to release the botanical oil.

    MELT PROCESSED ANTIMICROBIAL COMPOSITION
    10.
    发明申请
    MELT PROCESSED ANTIMICROBIAL COMPOSITION 审中-公开
    熔融加工抗微生物组合物

    公开(公告)号：WO2012077002A2

    公开(公告)日：2012-06-14

    申请号：PCT/IB2011054828

    申请日：2011-10-31

    申请人： KIMBERLY CLARK CO ,  WANG JAMES H ,  SHI BO ,  LEE JAEHONG ,  TOPOLKARAEV VASILY A ,  SCHOLL NEIL T ,  KIM YOUNGSOOK

    发明人： WANG JAMES H ,  SHI BO ,  LEE JAEHONG ,  TOPOLKARAEV VASILY A ,  SCHOLL NEIL T ,  KIM YOUNGSOOK

    IPC分类号： A01N65/00 ,  A01N43/04 ,  A01P1/00 ,  A61K31/70

    CPC分类号： A01N31/08 ,  A01N65/00 ,  B29B7/10 ,  B29B7/38 ,  B29B9/06 ,  B29B9/12 ,  B29B9/16 ,  B29C47/00 ,  B29C47/6087 ,  A01N25/10 ,  A01N25/12 ,  A01N25/28 ,  A01N25/34 ,  A01N2300/00 ,  A01N65/08 ,  A01N65/20 ,  A01N65/24 ,  A01N65/28 ,  A01N65/38

    摘要： A method for forming a composition that includes mixing an antimicrobially active botanical oil (e.g., thymol, carvacrol, etc.) and a modified starch polymer within a melt blending device (e.g., extruder) is provided. Unlike the problems associated with proteins, the use of starch polymers allows for a greater degree of flexibility in the processing conditions and is still able to achieve good properties in the resulting composition. The present inventors have also discovered that a plasticizer may be employed to facilitate melt processing of the starch, as well as to enhance the ability of the botanical oil to flow into the internal structure of the starch where it can be retained in a stable manner. The composition is also typically generally free of solvents. In this manner, the starch will not generally disperse before use and prematurely release the botanical oil. Due to the water sensitivity of the modified starch, however, it may be subsequently dispersed by moisture when it is desired to release the botanical oil.

    摘要翻译： 提供了一种形成组合物的方法，其包括在熔融共混装置（例如挤出机）中混合抗微生物活性植物油（例如百里酚，香芹酚等）和改性淀粉聚合物。 与蛋白质相关的问题不同，淀粉聚合物的使用允许在加工条件下具有更大程度的柔性，并且仍能在所得组合物中获得良好的性能。 本发明人还发现，可以使用增塑剂来促进淀粉的熔融加工，以及提高植物油流入淀粉内部结构的能力，其中它可以以稳定的方式保留。 组合物通常通常也不含溶剂。 以这种方式，淀粉通常不会在使用前分散并且过早地释放植物油。 然而，由于改性淀粉的水敏感性，当需要释放植物油时，随后可以通过水分分散。