公开(公告)号：WO2003045351A1

公开(公告)日：2003-06-05

申请号：PCT/IB2002/004965

申请日：2002-11-20

Applicant: PFIZER INC. ,  DUMONT, Francis ,  KORSMEYER, Richard, Wilker ,  LI, Mei ,  PARALKAR, Vishwas, Madhav ,  DUNN, Richard, Lee ,  JEFFERS, Scott, Alexander ,  ZHOU, Mingxing

Inventor： DUMONT, Francis ,  KORSMEYER, Richard, Wilker ,  LI, Mei ,  PARALKAR, Vishwas, Madhav ,  DUNN, Richard, Lee ,  JEFFERS, Scott, Alexander ,  ZHOU, Mingxing

IPC: A61K9/00

CPC classification number: A61K9/0024 ,  A61K31/20 ,  A61K31/44

Abstract: The present invention is directed to an improved system for controlled release of a bone growth promoting compound and to a flowable composition for its formation. The flowable composition is composed of a bone growth promoting compound, a thermoplastic polymer and an organic solvent. The flowable composition is capable of forming a biodegradable and/or bioerodible microporous, solid polymer matrix. The matrix is useful as an implant in patients (humans and animals) for delivery of a bone growth promoting compound to certain tissues.

Abstract translation: 本发明涉及一种用于骨生长促进化合物和用于其形成的可流动组合物的控制释放的改进系统。 可流动组合物由骨生长促进化合物，热塑性聚合物和有机溶剂组成。 可流动组合物能够形成可生物降解和/或生物腐蚀性微孔固体聚合物基质。 该基质可用作用于将骨生长促进化合物递送至某些组织的患者（人和动物）中的植入物。

公开(公告)号：WO1992002212A2

公开(公告)日：1992-02-20

申请号：PCT/US1991005337

申请日：1991-08-01

Applicant: PFIZER INC. ,  HERBIG, Scott, Max ,  KORSMEYER, Richard, Wilker ,  THOMBRE, Avinash, Govind

Inventor： PFIZER INC.

IPC: A61K09/32

CPC classification number: A61K9/2886 ,  A61K9/0004 ,  A61K9/4891 ,  A61K9/5073

Abstract: Devices for controlled release of active substances in the form of tablets, capsules and beads comprised of a porous substructure surrounded by one or more interfacial membranes.

Abstract translation: 用于控制释放片剂，胶囊和珠粒形式的活性物质的装置，其由一个或多个界面膜包围的多孔亚结构组成。

公开(公告)号：WO2003045371A1

公开(公告)日：2003-06-05

申请号：PCT/IB2002/004368

申请日：2002-10-21

Applicant: PFIZER PRODUCTS INC. ,  DUMONT, Francis ,  HONG, Jinyang ,  KIM, Yesook ,  KORSMEYER, Richard, Wilker ,  LI, Mei ,  PARALKAR, Vishwas, Madhav ,  THOMPSON, David, Duane

Inventor： DUMONT, Francis ,  HONG, Jinyang ,  KIM, Yesook ,  KORSMEYER, Richard, Wilker ,  LI, Mei ,  PARALKAR, Vishwas, Madhav ,  THOMPSON, David, Duane

IPC: A61K31/195

CPC classification number: A61K31/195 ,  A61K9/1647 ,  A61K31/4406

Abstract: This invention is directed to pharmaceutical compositions and methods comprising prostglandin agonists, specifically EP 2 receptor selective agonists, which are useful to enhance bone repair and healing and restore or augment bone mass in vertebrates, particularly mammals. The EP 2 receptor selective agonists of the present invention are effective in the treatment of conditions such as those in which the patient has delayed or non-union fracture, bone defect, spinal fusion, bone in-growth, cranial facial reconstruction or bone sites at risk for fracture.

Abstract translation: 本发明涉及包含前列腺素激动剂，特别是EP2受体选择性激动剂的药物组合物和方法，其可用于增强脊椎动物，特别是哺乳动物中的骨修复和愈合并恢复或增加骨量。 本发明的EP2受体选择性激动剂在治疗诸如患者具有延迟或非并发骨折，骨缺损，脊柱融合，骨生长增长，颅面重建或具有风险的骨骼部位的病症方面是有效的 用于骨折。