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1.SYNTHESIS OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-A]IMIDAZOLE-3-SULFONIC ACID AMIDES 审中-公开
Title translation: 6,7-二氢-5H-咪唑并[1,2-A]咪唑-3-磺酸的合成公开(公告)号:WO2007084882A2
公开(公告)日:2007-07-26
申请号:PCT/US2007/060552
申请日:2007-01-16
Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG , WIRTH, Thomas , GUTHEIL, Dieter , KROEBER, Jutta , NICOLA, Thomas , RAPP, Armin , ORLICH, Simone , WANG, Xiao-jun , KRISHNAMURTHY, Dhileepkumar
Inventor: WIRTH, Thomas , GUTHEIL, Dieter , KROEBER, Jutta , NICOLA, Thomas , RAPP, Armin , ORLICH, Simone , WANG, Xiao-jun , KRISHNAMURTHY, Dhileepkumar
IPC: C07C275/18 , C07C275/24 , C07D487/04
CPC classification number: C07D317/28 , C07C273/1836 , C07D487/04 , C07C275/24
Abstract: Disclosed is an improved multi-step process for preparing a compound of Formula I wherein R 1 to R 3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins. As a result, these compounds are useful in the treatment of inflammatory and immune cell-mediated diseases.
Abstract translation: 公开了用于制备式I化合物的改进的多步法,其中R 1至R 3如本文所定义。 式I的化合物抑制人细胞间粘附分子与白血球素结合。 结果,这些化合物可用于治疗炎性和免疫细胞介导的疾病。
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2.METHOD FOR PRODUCING ARYL-IMINOMETHYL-CARBAMIC ACID ESTERS 审中-公开
Title translation: 用于生产芳基 - 亚氨基甲基氨基公开(公告)号:WO0151457A3
公开(公告)日:2002-01-17
申请号:PCT/EP0100262
申请日:2001-01-11
Applicant: BOEHRINGER INGELHEIM PHARMA , BRANDENBURG JOERG , SOYKA RAINER , SCHMID ROLF , ANDERSKEWITZ RALF , BAUER ROLF , HAMM RAINER , KROEBER JUTTA
Inventor: BRANDENBURG JOERG , SOYKA RAINER , SCHMID ROLF , ANDERSKEWITZ RALF , BAUER ROLF , HAMM RAINER , KROEBER JUTTA
IPC: C07C269/00 , C07C271/00 , C07C271/20 , C07C271/64 , C07C255/54 , C07C271/12
CPC classification number: C07C271/00 , C07C269/00 , C07C271/20 , C07C271/64
Abstract: The invention relates to a method for producing compounds of formula (I) wherein the radicals R and R have the meanings given in the description and in the claims, which can be used on a large scale.
Abstract translation: 本发明涉及用于式(I)的化合物的制备方法在工业上适用的方法,其中的基团R <1>和R <2>可以具有在说明书和权利要求中所提及的含义。
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公开(公告)号:WO2004092203A3
公开(公告)日:2004-12-09
申请号:PCT/US2004010476
申请日:2004-04-06
Applicant: BOEHRINGER INGELHEIM INT , BOEHRINGER INGELHEIM PHARMA , DONSBACH KAI , ECKER DIETER , FRUTOS ROGELIO PEREZ , GALLOU FABRICE , GUTHEIL DIETER , HADDAD NIZAR , HAGENKOETTER ROBERT , KEMMER DIRK , KROEBER JUTTA , NICOLA THOMAS , SCHNAUBELT JUERGEN , SCHUL MICHAEL , SIMPSON ROBERT DONALD , WEI XUDONG , WINTER ERIC , XU YIBO , YEE NATHAN K , BRANDENBURG JOERG
Inventor: DONSBACH KAI , ECKER DIETER , FRUTOS ROGELIO PEREZ , GALLOU FABRICE , GUTHEIL DIETER , HADDAD NIZAR , HAGENKOETTER ROBERT , KEMMER DIRK , KROEBER JUTTA , NICOLA THOMAS , SCHNAUBELT JUERGEN , SCHUL MICHAEL , SIMPSON ROBERT DONALD , WEI XUDONG , WINTER ERIC , XU YIBO , YEE NATHAN K , BRANDENBURG JOERG
IPC: B01J31/22 , C07D491/08 , C07K1/00 , C07K1/08 , C07K5/083 , C07K5/087 , C07B37/10 , C07D207/10 , C07D265/32 , C07K5/08
CPC classification number: B01J31/2226 , B01J31/2265 , B01J31/2404 , B01J2231/543 , B01J2531/821 , C07D491/08 , C07K1/006 , C07K1/086 , C07K5/0804 , C07K5/0812
Abstract: Disclosed is a process for preparing a macrocyclic compound of the formula (I) which is carried out using an intermediate of the formula (II) wherein W, R through R , D,A and R are as defined herein. The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.
Abstract translation: 公开了制备式(I)的大环化合物的方法,其中使用式(II)的中间体其中W,R 1至R 4,D,A和R 12为 如本文所定义的。 式(I)化合物是治疗丙型肝炎病毒(HCV)感染的有效活性剂。
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4.PROCESS FOR THE PREPARATION OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-A]IMIDAZOLE-3-SULFONIC ACID AMIDES AND INTERMEDIATES USED THEREIN 审中-公开
Title translation: 制备6,7-二氢-5H-咪唑并[1,2-A]咪唑-3-磺酸的方法及其使用的中间体公开(公告)号:WO2007084882A3
公开(公告)日:2007-11-29
申请号:PCT/US2007060552
申请日:2007-01-16
Applicant: BOEHRINGER INGELHEIM INT , BOEHRINGER INGELHEIM PHARMA , WIRTH THOMAS , GUTHEIL DIETER , KROEBER JUTTA , NICOLA THOMAS , RAPP ARMIN , ORLICH SIMONE , WANG XIAO-JUN , KRISHNAMURTHY DHILEEPKUMAR
Inventor: WIRTH THOMAS , GUTHEIL DIETER , KROEBER JUTTA , NICOLA THOMAS , RAPP ARMIN , ORLICH SIMONE , WANG XIAO-JUN , KRISHNAMURTHY DHILEEPKUMAR
IPC: C07C275/18 , C07C275/24 , C07D487/04
CPC classification number: C07D317/28 , C07C273/1836 , C07D487/04 , C07C275/24
Abstract: Disclosed is an improved multi-step process for preparing a compound of Formula I and intermediates used therein: (I) wherein R 1 to R 3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins. As a result, these compounds are useful in the treatment of inflammatory and immune cell-mediated diseases.
Abstract translation: 公开了用于制备式I化合物和其中使用的中间体的改进的多步法:其中R 1至R 3中的R 1如本文所定义。 式I的化合物抑制人细胞间粘附分子与白血球素结合。 结果,这些化合物可用于治疗炎性和免疫细胞介导的疾病。
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5.SYNTHESIS OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-A]IMIDAZOLE-3-SULFONIC ACID AMIDES 审中-公开
Title translation: 6,7-二氢-5H-咪唑并[1,2-A]咪唑-3-磺酸的合成公开(公告)号:WO2006014828A1
公开(公告)日:2006-02-09
申请号:PCT/US2005/026148
申请日:2005-07-25
Applicant: BOEHRINGER INGELHEIM INTERNATIONAL, GMBH , BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. , BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG , WANG, Xiao-jun , WIRTH, Thomas , NICOLA, Thomas , ZHANG, Li , FRUTOS, Rogelio, Perez , XU, Yibo , KRISHNAMURTHY, Dhileepkumar , NUMMY, Laurence, John , VARSOLONA, Richard, J. , KROEBER, Jutta , SENANAYAKE, Chris, Hugh
Inventor: WANG, Xiao-jun , WIRTH, Thomas , NICOLA, Thomas , ZHANG, Li , FRUTOS, Rogelio, Perez , XU, Yibo , KRISHNAMURTHY, Dhileepkumar , NUMMY, Laurence, John , VARSOLONA, Richard, J. , KROEBER, Jutta , SENANAYAKE, Chris, Hugh
IPC: C07D487/04 , A61P29/00 , A61K31/4188
CPC classification number: C07D487/04 , C07C275/24 , C07D239/06
Abstract: Disclosed is a multi-step process for preparing a compound of Formula I wherein R¿1? to R¿3? are as defined herein. The compounds of Formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins. As a result, these compounds are useful in the treatment of inflammatory and immune cell-mediated diseases.
Abstract translation: 公开了一种制备式I化合物的多步法,其中R 1, 到R¿3? 如本文所定义。 式I的化合物抑制人细胞间粘附分子与白血球素结合。 结果,这些化合物可用于治疗炎症和免疫细胞介导的疾病。
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公开(公告)号:WO2004092203A2
公开(公告)日:2004-10-28
申请号:PCT/US2004/010476
申请日:2004-04-06
Applicant: BOEHRINGER INGELHEIM INTERNATIONAL, GMBH , BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG , DONSBACH, Kai , ECKER, Dieter , FRUTOS, Rogelio, Perez , GALLOU, Fabrice , GUTHEIL, Dieter , HADDAD, Nizar , HAGENKOETTER, Robert , KEMMER, Dirk , KROEBER, Jutta , NICOLA, Thomas , SCHNAUBELT, Juergen , SCHUL, Michael , SIMPSON, Robert, Donald , WEI, Xudong , WINTER, Eric , XU, Yibo , YEE, Nathan, K. , BRANDENBURG, Joerg
Inventor: DONSBACH, Kai , ECKER, Dieter , FRUTOS, Rogelio, Perez , GALLOU, Fabrice , GUTHEIL, Dieter , HADDAD, Nizar , HAGENKOETTER, Robert , KEMMER, Dirk , KROEBER, Jutta , NICOLA, Thomas , SCHNAUBELT, Juergen , SCHUL, Michael , SIMPSON, Robert, Donald , WEI, Xudong , WINTER, Eric , XU, Yibo , YEE, Nathan, K. , BRANDENBURG, Joerg
IPC: C07K5/00
CPC classification number: B01J31/2226 , B01J31/2265 , B01J31/2404 , B01J2231/543 , B01J2531/821 , C07D491/08 , C07K1/006 , C07K1/086 , C07K5/0804 , C07K5/0812
Abstract: Disclosed is a process for preparing a macrocyclic compound of the formula (I) which is carried out using an intermediate of the formula (II) wherein W, R 1 through R 4 , D,A and R 12 are as defined herein. The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.
Abstract translation: 公开了一种制备式(I)的大环化合物的方法,其使用式(II)的中间体进行,其中W,R 1至R 4,D,A和R 12为 如本文所定义。 式(I)化合物是用于治疗丙型肝炎病毒(HCV)感染的有效活性剂。
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