公开(公告)号：WO2008065199A1

公开(公告)日：2008-06-05

申请号：PCT/EP2007/063108

申请日：2007-11-30

Applicant: GALAPAGOS N.V. ,  EDWARDS, Paul John ,  MARTINA, Sébastien Laurent Xavier ,  ANDREWS, Martin James Inglis ,  BAR, Grégory Louis Joseph ,  ALLART, Brigitte ,  BURRITT, Andrew ,  TAO, Xueliang ,  KROLL, Friedrich Erich Karl

Inventor： EDWARDS, Paul John ,  MARTINA, Sébastien Laurent Xavier ,  ANDREWS, Martin James Inglis ,  BAR, Grégory Louis Joseph ,  ALLART, Brigitte ,  BURRITT, Andrew ,  TAO, Xueliang ,  KROLL, Friedrich Erich Karl

IPC: C07D471/04 ,  A61K31/437 ,  A61P29/00 ,  A61P19/02

CPC classification number: C07D471/04

Abstract: Novel imidazolopyridine compounds are disclosed that have a formula represented by Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, ECM degradation, joint degradation and/or inflammation, and others.

Abstract translation: 公开了具有由式（I）表示的式的新型咪唑并吡啶化合物。 化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的各种病症，包括作为非限制性实例的ECM降解，关节降解和/或炎症等。

公开(公告)号：WO1997030784A1

公开(公告)日：1997-08-28

申请号：PCT/GB1997000496

申请日：1997-02-24

Applicant: THE UNIVERSITY COURT OF THE UNIVERSITY OF ST. ANDREWS ,  GANI, David ,  AKHTAR, Mahmoud ,  KROLL, Friedrich, Erich, Karl ,  SMITH, Colin, Forbes, MacDonald

Inventor： THE UNIVERSITY COURT OF THE UNIVERSITY OF ST. ANDREWS

IPC: B01J19/00

CPC classification number: C07K1/045 ,  B01J19/0046 ,  B01J2219/00299 ,  B01J2219/00461 ,  B01J2219/005 ,  B01J2219/00542 ,  B01J2219/00545 ,  B01J2219/00547 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  C40B60/14 ,  C40B70/00

Abstract: A microreactor (20) for the synthesis of chemical compounds includes a container having a body section (21). Entry pores are provided to permit fluid to enter the container and a visual identification device is provided to enable visual identification of the microreactor (20).

Abstract translation: 用于合成化合物的微反应器（20）包括具有主体部分（21）的容器。 提供入口孔以允许流体进入容器，并且提供视觉识别装置以使得能够目视识别微反应器（20）。

公开(公告)号：WO2008065198A1

公开(公告)日：2008-06-05

申请号：PCT/EP2007/063106

申请日：2007-11-30

Applicant: GALAPAGOS N.V. ,  BURRITT, Andrew ,  EDWARDS, Paul John ,  SCHMIDT, Wolfgang ,  BIRAULT, Veronique ,  KROLL, Friedrich Erich Karl ,  TAO, Xueliang ,  ANDREWS, Martin James Inglis ,  MARTINA, Sébastien Laurent Xavier

Inventor： BURRITT, Andrew ,  EDWARDS, Paul John ,  SCHMIDT, Wolfgang ,  BIRAULT, Veronique ,  KROLL, Friedrich Erich Karl ,  TAO, Xueliang ,  ANDREWS, Martin James Inglis ,  MARTINA, Sébastien Laurent Xavier

IPC: A61K31/437 ,  C07D471/04 ,  A61P29/00

CPC classification number: C07D471/04

Abstract: Novel triazolopyridine compounds are disclosed that have a formula represented by Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non- limiting example, ECM degradation, joint degradation and/or inflammation, and others.

Abstract translation: 公开了具有式（I）表示的式的新型三唑并吡啶化合物。 化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的各种病症，包括通过非限制性实例，ECM降解，关节降解和/或炎症等。