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    UNIFORM DEPOSITION OF MATERIAL
    4.
    发明申请
    UNIFORM DEPOSITION OF MATERIAL 审中-公开
    均质沉积材料

    公开(公告)号：WO2015161148A1

    公开(公告)日：2015-10-22

    申请号：PCT/US2015/026292

    申请日：2015-04-17

    Applicant: IBIS BIOSCIENCES, INC.

    Inventor： CHIESL, Thomas N.

    IPC: B32B5/00

    CPC classification number: B32B5/00 ,  B01J19/0046 ,  B01J2219/00466 ,  B01J2219/005 ,  B01J2219/00527 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01L3/0241 ,  G01N1/00 ,  G01N27/3278 ,  H01L2224/00

    Abstract: Provided herein is technology relating to depositing a material uniformly onto a surface and particularly, but not exclusively, to compositions comprising polymers near their entanglement concentrations and related methods and uses for depositing a material onto a surface uniformly. Accordingly, provided herein is technology that is general, aqueous-based, and does not require re-engineering or chemistry changes to the materials (e.g., beads and/or macromolecules) being deposited. In some embodiments, conventional spotting buffers are modified by dissolving one or more polymers in solution (e.g., aqueous or organic) to provide an even distribution of material (e.g., beads, macromolecules, etc.).

    Abstract translation: 本文提供了涉及将材料均匀地沉积到表面上的技术，特别地但不排他地涉及包含聚合物在其缠结浓度附近的组合物，以及用于将材料均匀沉积到表面上的相关方法和用途。 因此，本文提供的技术是一般的，基于水性的，并且不需要对被沉积的材料（例如珠和/或大分子）进行重新设计或化学改变。 在一些实施方案中，通过将一种或多种聚合物溶解在溶液（例如水性或有机的）中来提供常规的点样缓冲液，以提供均匀分布的材料（例如珠，大分子等）。

    METHOD AND APPARATUS FOR PRODUCING SEQUENCE VERIFIED DNA
    6.
    发明申请
    METHOD AND APPARATUS FOR PRODUCING SEQUENCE VERIFIED DNA 审中-公开
    用于产生序列验证的DNA的方法和装置

    公开(公告)号：WO2014179735A1

    公开(公告)日：2014-11-06

    申请号：PCT/US2014/036645

    申请日：2014-05-02

    Applicant: CAMBRIAN GENOMICS, INC.

    Inventor： HEINZ, Austen ,  LEVSKAYA, Anselm ,  MULLIGAN, John

    IPC: C40B20/08 ,  C40B40/06 ,  C12M1/34 ,  C12Q1/68

    CPC classification number: C12N15/1065 ,  B01J2219/005 ,  B01J2219/00572 ,  B01J2219/00596 ,  C40B20/08 ,  C40B50/14

    Abstract: A method of retrieving a subset of polynuceotide molecules from a mixture of polynucleotide molecules includes receiving a mixture of nucleotide sequences comprising one or more polynucleotide molecules, synthesizing one or more identifier (ID) regions onto the one or more polynucleotide molecules. The method also includes generating a bead-bound library of one or more beads comprising subsets of identical polynucleotide molecules. Each bead is identified by the ID Sequence of the associated Polynucleotide Sequence. The method further includes sequencing the one or more ID regions of each bead to generate ID Sequence information for each bead, combining the Polynucleotide Sequence information, the one or more ID Sequences, and coordinates of each bead to identify the Polynucleotide Sequence on the bead, and retrieving the bead with its associated Polynucleotide Sequence from the flow cell based on the absolute coordinate position of the bead.

    Abstract translation: 从多核苷酸分子的混合物中检索多肽核苷酸分子子集的方法包括接收包含一个或多个多核苷酸分子的核苷酸序列的混合物，在一个或多个多核苷酸分子上合成一个或多个标识符（ID）区域。 该方法还包括产生包含相同多核苷酸分子亚组的一个或多个珠的珠结合文库。 每个珠粒由相关多核苷酸序列的ID序列鉴定。 该方法还包括对每个珠粒的一个或多个ID区域进行排序以产生每个珠粒的ID序列信息，组合多核苷酸序列信息，一个或多个ID序列和每个珠粒的坐标以鉴定珠粒上的多核苷酸序列， 并且基于珠的绝对坐标位置从流动池中取出具有其相关多核苷酸序列的珠粒。

    APPARATUS AND METHOD FOR SOLID PHASE SYNTHESIS
    8.
    发明申请
    APPARATUS AND METHOD FOR SOLID PHASE SYNTHESIS 审中-公开
    用于固相合成的装置和方法

    公开(公告)号：WO2014033297A1

    公开(公告)日：2014-03-06

    申请号：PCT/EP2013/068097

    申请日：2013-09-02

    Applicant: BIOTAGE AB

    Inventor： WESSMAN, Anders ,  STRANDELL, Axel

    IPC: B01F9/10 ,  B01F11/00 ,  B01J19/12 ,  B01J19/28

    CPC classification number: C07K1/045 ,  B01F11/0002 ,  B01J8/10 ,  B01J19/0046 ,  B01J19/126 ,  B01J19/28 ,  B01J2208/00442 ,  B01J2208/00858 ,  B01J2219/00141 ,  B01J2219/00286 ,  B01J2219/00423 ,  B01J2219/00495 ,  B01J2219/005 ,  B01J2219/00596 ,  B01J2219/00725

    Abstract: An apparatus for microwave assisted solid phase synthesis using solid-phase resin beads mixed with a liquid solvent comprises: - a generally cylindrical reactor (1) made of microwave transparent material and having a central axis, the reactor (1) having an inlet (5) and an outlet (6); - a porous frit associated with the outlet (6) of the reactor (1), the porous frit preventing discharge of beads and allowing discharge of the solvent from the reactor; and - means (4) for concentric rotation of the reactor (1) around the central axis in alternating clockwise and anti-clockwise directions. A method for microwave assisted solid phase synthesis using the apparatus is also disclosed.

    Abstract translation: 使用与液体溶剂混合的固相树脂珠的微波辅助固相合成装置包括： - 由微波透明材料制成并具有中心轴的大致圆柱形反应器（1），反应器（1）具有入口（5） ）和出口（6）; - 与反应器（1）的出口（6）相关联的多孔玻璃料，多孔玻璃料防止珠粒排出并允许溶剂从反应器排出; 以及 - 用于在交替的顺时针和逆时针方向上使反应器（1）围绕中心轴同心旋转的装置（4）。 还公开了使用该装置的微波辅助固相合成方法。

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