公开(公告)号：WO02034380A1

公开(公告)日：2002-05-02

申请号：PCT/US2001/010898

申请日：2001-04-04

IPC: B01J19/00 ,  C07B61/00 ,  C40B60/14 ,  C40B70/00

CPC classification number: B01J19/0046 ,  B01J2219/00279 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00457 ,  B01J2219/00461 ,  B01J2219/00463 ,  B01J2219/00468 ,  B01J2219/00497 ,  B01J2219/0054 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00691 ,  C07B2200/11 ,  C40B60/14 ,  C40B70/00

Abstract: An apparatus and method by which solid supports (22) may be retained in place in an array within an reaction vessel (24) but which allows easy lateral manipulation of the solid supports (22) in a defined manner to new arrays for subsequent steps in the synthesis of combinatorial chemistry libraries of compounds. According to the present invention, a pair of raks, retainers or support carriers (10,10a,10b,11a,11b) for holding solid support (22) is provided in the configuration of a solid support carrier (10,10a,10b,11a,11b) having a plurality of "fingers", tines (18) or rods (13) extending from one end (12, 15) and between which longitudinal channels (20) or spaces are defined.

Abstract translation: 固体支持物（22）可以通过其固定在反应容器（24）内的阵列中的位置，但是允许以固定的方式侧向操纵固体支持物（22），以便将新的阵列用于随后的步骤 化合物组合化学文库的合成。 根据本发明，在固体支撑载体（10,10a，10b，10b）的结构中设置有用于保持固体支撑体（22）的一对r条，保持器或支撑载体（10,10a，10b，11a， 11a，11b），具有多个“指状物”，从一个端部（12,15）延伸出来的尖齿（18）或杆（13）以及纵向通道（20）或空间之间。

公开(公告)号：WO0048735A3

公开(公告)日：2000-12-28

申请号：PCT/US0003841

申请日：2000-02-15

Applicant: PERKIN ELMER CORP ,  VANN CHARLES S ,  COX DAVID M

Inventor： VANN CHARLES S ,  COX DAVID M

IPC: A61J3/00 ,  A61J3/06 ,  A61J3/07 ,  B01J4/02 ,  B01J19/00 ,  C40B60/14 ,  C40B70/00 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

CPC classification number: B01J4/02 ,  B01J19/0046 ,  B01J2219/00274 ,  B01J2219/00306 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00322 ,  B01J2219/00333 ,  B01J2219/00351 ,  B01J2219/00409 ,  B01J2219/00459 ,  B01J2219/00461 ,  B01J2219/00463 ,  B01J2219/00466 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00547 ,  B01J2219/00596 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00693 ,  C40B60/14 ,  C40B70/00 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/026 ,  G01N35/028 ,  G01N35/1002 ,  G01N2035/00158 ,  G01N2035/00752 ,  G01N2035/042 ,  G01N2035/0425 ,  G01N2035/1041 ,  Y10T436/25375 ,  Y10T436/255 ,  Y10T436/2575

Abstract: The present invention provides a system and process providing variable access to, as well as quick and accurate dispensing of, numerous selected reagents from a mass storage arrangement. According to one embodiment, an array of reagent dispensers is supported over a movable platform assembly. The platform assembly aligns a designated receiving receptacle under a selected dispenser of the array so that a respective reagent can be dispensed therein. The dispensers in the matrix have a gate at the lower outlet region. The reagents can be in fluid or solid form, such as beads for solid phase synthesis. Advantageously, the apparatus and process can be carried out under the control of a programmed computer.

Abstract translation: 本发明提供了一种系统和方法，其提供了从大容量存储装置的多种选择的试剂的可变存取以及快速和准确的分配。 根据一个实施例，一组试剂分配器被支撑在可移动平台组件上。 平台组件将指定的接收容器对准阵列的所选择的分配器，使得可以在其中分配相应的试剂。 基体中的分配器在下部出口区域具有一个浇口。 试剂可以是流体或固体形式，例如用于固相合成的珠子。 有利的是，装置和过程可以在编程计算机的控制下进行。

公开(公告)号：WO2004004886A2

公开(公告)日：2004-01-15

申请号：PCT/US2003/020758

申请日：2003-07-02

Applicant: AVENTIS PHARMACEUTICALS INC. ,  GUILES, Joseph, W. ,  SHUTSKE, Gregory

Inventor： GUILES, Joseph, W. ,  SHUTSKE, Gregory

IPC: B01J19/00

CPC classification number: B01L3/50855 ,  B01J19/0046 ,  B01J2219/00308 ,  B01J2219/00326 ,  B01J2219/00421 ,  B01J2219/00423 ,  B01J2219/00461 ,  B01J2219/005 ,  B01J2219/0054 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/0072 ,  B01L3/5021 ,  B01L3/50255 ,  B01L9/06 ,  B01L2300/0681 ,  B01L2300/0829 ,  B01L2400/0409 ,  C40B60/14 ,  C40B70/00

Abstract: An apparatus is disclosed for use in solid-phase chemical synthesis procedures. The apparatus allows the separation of a cleaved product from the solid-phase used to make the product, and subsequent removal of the solid-phase from the apparatus. The apparatus allows the cleaved product to be concentrated within the apparatus without transfer to another device.

Abstract translation: 公开了一种用于固相化学合成程序的设备。 该设备允许从用于制造产品的固相分离裂解产物，并随后从设备中除去固相。 该装置允许裂解产物在装置内集中而不转移到另一个装置。

公开(公告)号：WO2002089973A2

公开(公告)日：2002-11-14

申请号：PCT/JP2002/004531

申请日：2002-05-09

Applicant: EBARA CORPORATION ,  NAGASAWA, Hiroshi

Inventor： NAGASAWA, Hiroshi

IPC: B01J19/00

CPC classification number: G01N33/54366 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00322 ,  B01J2219/00423 ,  B01J2219/00461 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00536 ,  B01J2219/00542 ,  B01J2219/00545 ,  B01J2219/00547 ,  B01J2219/00549 ,  B01J2219/00565 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00707 ,  B01J2219/00722 ,  C07B2200/11 ,  C40B40/06 ,  C40B60/14 ,  C40B70/00

Abstract: Affinity reaction probe detection/analysis chips each comprising a retainer ring that is marked with individual identifying signals and which has a through-hole filled with or retaining a carrier having probe molecules fixed thereto. The carrier having probe molecules fixed thereto is preferably a porous membrane or nonwoven fabric stretched across the carrier to close the hole. The individual identifying signals may be written according to either a barcode system or an electronic recognition system. To establish a more convenient detection system in a chip-based affinity reaction probe assay, reaction detection/analysis chips are provided that can be used to detect DNA polymorph and diagnose various physiological functions. A detection system using such chips is also provided.

Abstract translation: 亲和力反应探针检测/分析芯片，其各自包括保持环，其被标记有单独的识别信号，并且具有填充或保持固定有探针分子的载体的通孔。 固定有探针分子的载体优选是穿过载体拉伸以闭合孔的多孔膜或非织造织物。 个体识别信号可以根据条形码系统或电子识别系统来写入。 为了在基于芯片的亲和力反应探针测定中建立更方便的检测系统，提供了可用于检测DNA多态性并诊断各种生理功能的反应检测/分析芯片。 还提供了使用这种芯片的检测系统。

公开(公告)号：WO2002081077A2

公开(公告)日：2002-10-17

申请号：PCT/US2002/010988

申请日：2002-04-05

Applicant: MILLENNIUM PHARMACEUTICALS, INC.

Inventor： READER, John, C.

IPC: B01J19/00

CPC classification number: B01J19/0046 ,  B01J2219/00299 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00313 ,  B01J2219/00319 ,  B01J2219/00461 ,  B01J2219/0047 ,  B01J2219/00472 ,  B01J2219/005 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00664 ,  B01J2219/00666 ,  B01J2219/00671 ,  B01J2219/0072 ,  C40B60/14

Abstract: Featured is an apparatus usful for preparing combinatorial libraries of compounds in a parallel fashion so that the individual compounds of the library are spatially separate and the position of each compound of the library in the apparatus is known. Moreover, the apparatus is useful for the preparation of combinatorial libraries of compounds where the library is constructed from three or more building blocks, e.g., three, four, five, six or seven building blocks, resulting in a three, four, five, six or seven dimensional combinatorial library. Also featured are related methods for the preparatons of three, four, five, six or seven dimensional combinatorial libraries of compounds using the apparatus of the present invention.

Abstract translation: 特色是用于以并行方式制备化合物组合文库的装置，使得文库的各个化合物在空间上分离，并且装置中文库的每种化合物的位置是已知的。 此外，该装置对于制备化合物的组合文库是有用的，其中文库由三个或更多个构建块构成，例如三个，四个，五个，六个或六个或七个结构单元，导致三个，四个，五个，六个 或七维组合库。 还特征在于使用本发明的装置的化合物的三，四，五，六或七维组合文库的制备方法。

公开(公告)号：WO99025470A1

公开(公告)日：1999-05-27

申请号：PCT/US1998/024519

申请日：1998-11-17

IPC: B04B1/00 ,  B01J19/00 ,  B04B5/04 ,  C07K1/04 ,  C40B60/14 ,  G01N35/00 ,  G01N35/02

CPC classification number: C07K1/045 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00421 ,  B01J2219/00461 ,  B01J2219/0049 ,  B01J2219/005 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/0072 ,  B04B5/0407 ,  C40B60/14 ,  G01N35/028 ,  G01N2035/00504 ,  Y10T436/111666 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/25375

Abstract: A simple, efficient apparatus and method for separation of solid and liquid phases useful in methods of high-throughput combinatorial organic synthesis of large libraries or megaarrays of organic compounds is disclosed. The method for separating a liquid phase from a solid phase during a solid phase organic synthetic process comprises: (1) positioning a reaction vessel or one or more arrays of reaction vessels, such as one or more microtiter plates, said vessels containing a slurry of solid phase particles or beads in a liquid, on the perimeter of a centrifuge rotor in a tilted or not tilted position; and (2) spinning the rotor of the centrifuge at a speed so that the solid phase particles sediment in a "pocket" of the vessels and the liquid phase is expelled from the vessels. The apparatus and method are useful, whether as part of an automated, robotic or manual system for combinatorial organic synthesis. In a preferred embodiment, an apparatus and method of removal of liquid phase from solid phase compatible with microtiter plate type array(s) of reaction vessels is disclosed.

Abstract translation: 公开了一种用于分离固相和液相的简单有效的装置和方法，其用于大量文库或大型有机化合物的高通量组合有机合成方法。 在固相有机合成方法中从固相中分离液相的方法包括：（1）将反应容器或一个或多个反应容器阵列放置在一个或多个微量滴定板中，所述容器含有 固相颗粒或珠粒在液体中，在离心机转子的周边处于倾斜或不倾斜的位置; 和（2）以一定的速度旋转离心机的转子，使得固相颗粒沉积在容器的“口袋”中，液相从容器中排出。 该装置和方法无论作为组合有机合成的自动机器人手动系统的一部分是有用的。 在一个优选的实施方案中，公开了一种从微量滴定板型反应容器阵列相容的固相中除去液相的装置和方法。

公开(公告)号：WO1997049653A2

公开(公告)日：1997-12-31

申请号：PCT/US1997011035

申请日：1997-06-24

Applicant: IRORI ,  XIAO, Xiao-Yi ,  SHI, Shuhao ,  PARANDOOSH, Zahra ,  NOVA, Michael, P.

Inventor： IRORI

IPC: C07B61/00

CPC classification number: G01N35/00732 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00295 ,  B01J2219/00299 ,  B01J2219/00308 ,  B01J2219/00333 ,  B01J2219/00344 ,  B01J2219/00461 ,  B01J2219/00463 ,  B01J2219/005 ,  B01J2219/00542 ,  B01J2219/00547 ,  B01J2219/00549 ,  B01J2219/00551 ,  B01J2219/00554 ,  B01J2219/00563 ,  B01J2219/00567 ,  B01J2219/00569 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00948 ,  B01L2300/0609 ,  C07H21/00 ,  C07K1/047 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  C40B70/00 ,  G01N35/00871 ,  G01N2015/149 ,  G01N2035/00782 ,  G01N2333/9121 ,  G01N2500/00

Abstract: Combinations, called matrices with memories, of matrix materials with memories that are remotely addressable or remotely programmable recording devices or are associated with imprinted symbology are provided. In particular, combinations of matrix materials, memories, and linked molecules that are tyrphostin analogs are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix materials may additionally include fluophors or other luminescent moieties to produce luminescing matrices with memories. The memories include electronic and optical storage media and also include optical memories, such as bar codes and other machine-readable codes. By virtue of this combination, molecules and biological particles, such as the tyrphostin compounds, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. The tyrphostin compounds, as well as methods of preparing the compounds, are also provided.

Abstract translation: 提供了具有存储器的组合，具有可远程寻址的存储器或远程可编程记录装置或与压印符号系统相关联的矩阵材料。 特别地，提供了酪氨酸磷酸酯类似物的基质材料，记忆和连接分子的组合。 基质材料是在固相化学和生物化学合成，免疫测定和杂交反应中用作载体的基质材料。 基质材料还可以包括荧光体或其它发光部分以产生具有记忆的发光基质。 存储器包括电子和光学存储介质，并且还包括诸如条形码和其他机器可读代码的光学存储器。 通过这种组合，可以通过用识别信息对存储器进行编程来标记与基质组合接近或物理接触的分子和生物颗粒，例如酪氨酸磷酸化合物，并且可以通过检索所存储的信息来鉴定。 还提供了酪氨酸磷酸酯化合物，以及制备化合物的方法。

公开(公告)号：WO1997030784A1

公开(公告)日：1997-08-28

申请号：PCT/GB1997000496

申请日：1997-02-24

Applicant: THE UNIVERSITY COURT OF THE UNIVERSITY OF ST. ANDREWS ,  GANI, David ,  AKHTAR, Mahmoud ,  KROLL, Friedrich, Erich, Karl ,  SMITH, Colin, Forbes, MacDonald

Inventor： THE UNIVERSITY COURT OF THE UNIVERSITY OF ST. ANDREWS

IPC: B01J19/00

CPC classification number: C07K1/045 ,  B01J19/0046 ,  B01J2219/00299 ,  B01J2219/00461 ,  B01J2219/005 ,  B01J2219/00542 ,  B01J2219/00545 ,  B01J2219/00547 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  C40B60/14 ,  C40B70/00

Abstract: A microreactor (20) for the synthesis of chemical compounds includes a container having a body section (21). Entry pores are provided to permit fluid to enter the container and a visual identification device is provided to enable visual identification of the microreactor (20).

Abstract translation: 用于合成化合物的微反应器（20）包括具有主体部分（21）的容器。 提供入口孔以允许流体进入容器，并且提供视觉识别装置以使得能够目视识别微反应器（20）。

公开(公告)号：WO1992009300A1

公开(公告)日：1992-06-11

申请号：PCT/US1991008694

申请日：1991-11-20

Applicant: ITEREX PHARMACEUTICALS LTD. PARTNERSHIP

Inventor： ITEREX PHARMACEUTICALS LTD. PARTNERSHIP ,  HOUGHTEN, Richard, A. ,  CUERVO, Julio, Hernan ,  PINILLA, Clemencia ,  APPEL, Jon, R., Jr. ,  BLONDELLE, Silvie

IPC: A61K37/02

CPC classification number: C07K7/06 ,  B01J19/0046 ,  B01J2219/00297 ,  B01J2219/00461 ,  B01J2219/005 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00725 ,  C07K1/047 ,  C40B40/10 ,  C40B60/14

Abstract: A process for the synthesis of a complex mixture pool of solid support-coupled monomeric repeating unit compounds such as amino acid derivatives is disclosed in which the mixture pool contains an equimolar representation of reacted monomeric repeating unit compounds coupled. Also disclosed is a process for the stepwise synthesis of a complex mixture of coupled or free, unsupported oligomers such as oligopeptides. A set of self-solubilizing, unsupported mixed oligopeptides having one or more predetermined amino acid residues at one or more of the same, predetermined positions in the oligopeptide chain in which the set contains equimolar amounts of a plurality of different amino acid residues, preferably at least six different residues, at one or more of the same predetermined positions of the oligopeptide chain is also disclosed, as are methods of making and using the same.

Abstract translation: 公开了一种用于合成固体支持偶联单体重复单元化合物如氨基酸衍生物的复合混合物池的方法，其中混合物池包含偶联反应的单体重复单元化合物的等摩尔表示。 还公开了逐步合成偶联或游离的，未负载的寡聚物如寡肽的复合混合物的方法。 在寡肽链中的一个或多个相同的预定位置上具有一个或多个预定氨基酸残基的一组自溶解的，未支撑的混合寡肽，其中该组含有等摩尔量的多个不同氨基酸残基，优选在 还公开了在寡肽链的一个或多个相同的预定位置处的至少六个不同的残基，以及制备和使用寡肽链的方法。

公开(公告)号：WO03047742A8

公开(公告)日：2003-10-30

申请号：PCT/EP0212850

申请日：2002-11-15

Applicant: HTE AG THE HIGH THROUGHPUT EXP ,  SCHUNK STEPHAN ANDREAS ,  ZECH TORSTEN ,  CROSS ALEXANDER ,  VIETZE UWE ,  KLEIN JENS ,  SUNDERMANN ANDREAS ,  STICHERT WOLFRAM

Inventor： SCHUNK STEPHAN ANDREAS ,  ZECH TORSTEN ,  CROSS ALEXANDER ,  VIETZE UWE ,  KLEIN JENS ,  SUNDERMANN ANDREAS ,  STICHERT WOLFRAM

IPC: B01J19/00 ,  C40B30/08 ,  C40B40/18 ,  C40B60/14 ,  G01N35/00

CPC classification number: B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00326 ,  B01J2219/00328 ,  B01J2219/00416 ,  B01J2219/00418 ,  B01J2219/00459 ,  B01J2219/00461 ,  B01J2219/00468 ,  B01J2219/00495 ,  B01J2219/005 ,  B01J2219/00502 ,  B01J2219/00587 ,  B01J2219/0059 ,  B01J2219/00689 ,  B01J2219/00693 ,  B01J2219/00695 ,  B01J2219/00702 ,  B01J2219/00745 ,  B01J2219/00747 ,  C40B30/08 ,  C40B40/18 ,  C40B60/14