公开(公告)号：WO2012094623A3

公开(公告)日：2012-08-30

申请号：PCT/US2012020529

申请日：2012-01-06

Applicant: ABBOTT LAB ,  BORHANI DAVID W ,  SADHUKHAN RAMKRISHNA ,  LACY SUSAN E ,  SOUTTER HOLLY H

Inventor： BORHANI DAVID W ,  SADHUKHAN RAMKRISHNA ,  LACY SUSAN E ,  SOUTTER HOLLY H

IPC: C07K16/24 ,  A61K39/395

CPC classification number: C07K16/244 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/73

Abstract: The present invention provides antibodies, and antigen-binding portions thereof, that bind to epitopes comprising at least one amino acid residues from residues 1-197 of the p40 subunit of IL-12 and/or IL-23. The invention further provides nucleic acids encoding the antibodies, compositions, vectors and host cells comprising the antibodies, and methods of making and using the same.

Abstract translation: 本发明提供了与包含IL-12和/或IL-23的p40亚基的残基1-197的至少一个氨基酸残基的表位结合的抗体及其抗原结合部分。 本发明还提供编码抗体，组合物，载体和包含抗体的宿主细胞的核酸，以及制备和使用该抗体的方法。

公开(公告)号：WO2012024650A3

公开(公告)日：2012-05-31

申请号：PCT/US2011048518

申请日：2011-08-19

Applicant: ABBOTT LAB ,  LACY SUSAN E ,  BARBON JEFFREY A ,  CHHAYA MEHA ,  FUNG EMMA ,  HUTCHINS CHARLES W ,  LANG DIANE M ,  BARLOW EVE H ,  LEDDY MARY ,  CHARI RAVI

Inventor： LACY SUSAN E ,  BARBON JEFFREY A ,  CHHAYA MEHA ,  FUNG EMMA ,  HUTCHINS CHARLES W ,  LANG DIANE M ,  BARLOW EVE H ,  LEDDY MARY ,  CHARI RAVI

IPC: C07K16/22

CPC classification number: C07K16/22 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/50 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/60 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2317/626 ,  C07K2317/64 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/566

Abstract: The present disclosure encompasses NGF binding proteins, specifically to antibodies that are chimeric, CDR grafted and caninized antibodies, and methods of making and uses thereof. The antibodies, or antibody portions, of the disclosure are useful for detecting NGF and for inhibiting NGF activity, e.g., in a mammal subject suffering from a disorder in which NGF activity is detrimental.

Abstract translation: 本公开内容涵盖NGF结合蛋白，特别是嵌合抗体，CDR移植和可插入抗体的抗体及其制备及其用途的方法。 本公开的抗体或抗体部分可用于检测NGF和抑制NGF活性，例如在患有NGF活性有害的病症的哺乳动物受试者中。

公开(公告)号：WO2005100403A2

公开(公告)日：2005-10-27

申请号：PCT/US2005/011956

申请日：2005-04-08

Applicant: ABBOTT LABORATORIES ,  REILLY, Edward, B. ,  LACY, Susan, E. ,  FUNG, Emma ,  BELK, Jonathan, P. ,  ROGUSKA, Michael

Inventor： REILLY, Edward, B. ,  LACY, Susan, E. ,  FUNG, Emma ,  BELK, Jonathan, P. ,  ROGUSKA, Michael

IPC: C07K16/28

CPC classification number: C07K16/2863 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/74 ,  C07K2317/92

Abstract: The present invention relates to antibodies and antigen-binding portions thereof that bind to and activate an erythropoietin receptor. The invention also relates to nucleic acid sequences encoding such antibodies and antigen-binding portions. The present invention further relates to methods of activating the endogenous activity of an erythropoietin receptor in a mammal using said antibodies and antigen-binding portions, methods of treatment, as well as pharmaceutical compositions comprising said antibodies and antigen-binding portions.

Abstract translation: 本发明涉及结合并激活促红细胞生成素受体的抗体及其抗原结合部分。 本发明还涉及编码这种抗体和抗原结合部分的核酸序列。 本发明还涉及使用所述抗体和抗原结合部分，治疗方法以及包含所述抗体和抗原结合部分的药物组合物来激活哺乳动物中促红细胞生成素受体的内源性活性的方法。

公开(公告)号：WO2009029123A1

公开(公告)日：2009-03-05

申请号：PCT/US2007/087514

申请日：2007-12-14

Applicant: ABBOTT LABORATORIES ,  REILLY, Edward, B. ,  LACY, Susan, E. ,  FUNG, Emma ,  BELK, Jonathan, P. ,  ROGUSKA, Michael ,  STOLL, Vincent, S. ,  JAKOB, Clarissa

Inventor： REILLY, Edward, B. ,  LACY, Susan, E. ,  FUNG, Emma ,  BELK, Jonathan, P. ,  ROGUSKA, Michael ,  STOLL, Vincent, S. ,  JAKOB, Clarissa

IPC: C07K16/28

CPC classification number: C07K16/2863 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/74 ,  C07K2317/92

Abstract: The present invention relates to antibodies and antigen-binding portions thereof that bind to and activate an erythropoietin receptor. The invention also relates to nucleic acid sequences encoding such antibodies and antigen-binding portions. The present invention further relates to methods of activating the endogenous activity of an erythropoietin receptor in a mammal using said antibodies and antigen-binding portions, methods of treatment, as well as pharmaceutical compositions comprising said antibodies and antigen-binding portions. The invention further provides compositions and crystals of an erythropoietin receptor in complex with an anti-erythropoietin receptor antibody. Specifically, the high-resolution structure provides binding sites defined by the structure coordinated determined herein.

Abstract translation: 本发明涉及结合并激活促红细胞生成素受体的抗体及其抗原结合部分。 本发明还涉及编码这种抗体和抗原结合部分的核酸序列。 本发明还涉及使用所述抗体和抗原结合部分，治疗方法以及包含所述抗体和抗原结合部分的药物组合物来激活哺乳动物中促红细胞生成素受体的内源性活性的方法。 本发明还提供与抗促红细胞生成素受体抗体复合的促红细胞生成素受体的组合物和晶体。 具体地，高分辨率结构提供由本文确定的结构所定义的结合位点。

公开(公告)号：WO2007005608A3

公开(公告)日：2008-10-09

申请号：PCT/US2006025584

申请日：2006-06-29

Applicant: ABBOTT LAB ,  LACY SUSAN E ,  FUNG EMMA ,  BELK JONATHAN P ,  DIXON RICHARD W ,  ROGUSKA MICHAEL ,  HINTON PAUL R ,  KUMAR SHANKAR

Inventor： LACY SUSAN E ,  FUNG EMMA ,  BELK JONATHAN P ,  DIXON RICHARD W ,  ROGUSKA MICHAEL ,  HINTON PAUL R ,  KUMAR SHANKAR

IPC: C07K16/00

CPC classification number: C07K16/244 ,  A61K39/3955 ,  A61K45/06 ,  C07K2317/24 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6869

Abstract: The present invention encompasses IL-12p40 binding proteins, particularly antibodies that bind human interleukin-12 (hIL-12) and/or human IL-23 (hIL-23). Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-12 and/or hIL-23 and neutralize h IL-12 and/or hIL-23 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and/or hIL-23 and for inhibiting hIL-12 and/or hIL-23 activity, e.g., in a human subject suffering from a disorder in which hIL-12 and/or hIL-23 activity is detrimental.

Abstract translation: 本发明包括IL-12p40结合蛋白，特别是结合人白细胞介素-12（hIL-12）和/或人IL-23（hIL-23）的抗体。 具体地，本发明涉及作为嵌合，CDR移植和人源化抗体的抗体。 优选的抗体对hIL-12和/或hIL-23具有高亲和力，并在体外和体内中和h IL-12和/或hIL-23活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测hIL-12和/或hIL-23和用于抑制hIL-12和/或hIL-23活性，例如在患有hIL -12和/或hIL-23活性是有害的。

公开(公告)号：WO2012094623A2

公开(公告)日：2012-07-12

申请号：PCT/US2012/020529

申请日：2012-01-06

Applicant: ABBOTT LABORATORIES ,  BORHANI, David, W. ,  SADHUKHAN, Ramkrishna ,  LACY, Susan, E. ,  SOUTTER, Holly, H.

Inventor： BORHANI, David, W. ,  SADHUKHAN, Ramkrishna ,  LACY, Susan, E. ,  SOUTTER, Holly, H.

IPC: A61K39/395

CPC classification number: C07K16/244 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/73

Abstract: The present invention provides antibodies, and antigen-binding portions thereof, that bind to epitopes comprising at least one amino acid residues from residues 1-197 of the p40 subunit of IL-12 and/or IL-23. The invention further provides nucleic acids encoding the antibodies, compositions, vectors and host cells comprising the antibodies, and methods of making and using the same.

Abstract translation: 本发明提供了结合表位的抗体及其抗原结合部分，所述表位包含IL-12和/或IL-12的p40亚基的残基1-197的至少一个氨基酸残基， 23。 本发明进一步提供编码包含抗体的抗体，组合物，载体和宿主细胞的核酸，以及制备和使用它们的方法。

公开(公告)号：WO2007005608A2

公开(公告)日：2007-01-11

申请号：PCT/US2006/025584

申请日：2006-06-29

Applicant: ABBOTT LABORATORIES ,  LACY, Susan E. ,  FUNG, Emma ,  BELK, Jonathan P. ,  DIXON, Richard W. ,  ROGUSKA, Michael ,  HINTON, Paul R. ,  KUMAR, Shankar

Inventor： LACY, Susan E. ,  FUNG, Emma ,  BELK, Jonathan P. ,  DIXON, Richard W. ,  ROGUSKA, Michael ,  HINTON, Paul R. ,  KUMAR, Shankar

IPC: C07K14/715

CPC classification number: C07K16/244 ,  A61K39/3955 ,  A61K45/06 ,  C07K2317/24 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6869

Abstract: The present invention encompasses IL-12p40 binding proteins, particularly antibodies that bind human interleukin-12 (hIL-12) and/or human IL-23 (hIL-23). Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-12 and/or hIL-23 and neutralize h IL-12 and/or hIL-23 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and/or hIL-23 and for inhibiting hIL-12 and/or hIL-23 activity, e.g., in a human subject suffering from a disorder in which hIL-12 and/or hIL-23 activity is detrimental.

Abstract translation: 本发明包括IL-12p40结合蛋白，特别是结合人白细胞介素-12（hIL-12）和/或人IL-23（hIL-23）的抗体。 具体地，本发明涉及作为嵌合，CDR移植和人源化抗体的抗体。 优选的抗体对hIL-12和/或hIL-23具有高亲和力，并在体外和体内中和h IL-12和/或hIL-23活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测hIL-12和/或hIL-23和用于抑制hIL-12和/或hIL-23活性，例如在患有hIL -12和/或hIL-23活性是有害的。

公开(公告)号：WO2005100403A3

公开(公告)日：2006-07-13

申请号：PCT/US2005011956

申请日：2005-04-08

Applicant: ABBOTT LAB ,  REILLY EDWARD B ,  LACY SUSAN E ,  FUNG EMMA ,  BELK JONATHAN P ,  ROGUSKA MICHAEL

Inventor： REILLY EDWARD B ,  LACY SUSAN E ,  FUNG EMMA ,  BELK JONATHAN P ,  ROGUSKA MICHAEL

IPC: C07K16/28 ,  A61K39/395 ,  C12N5/10 ,  C12N15/13 ,  C12N15/63 ,  C12Q1/70 ,  G01N33/53

CPC classification number: C07K16/2863 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/74 ,  C07K2317/92

Abstract: The present invention relates to antibodies and antigen-binding portions thereof that bind to and activate an erythropoietin receptor. The invention also relates to nucleic acid sequences encoding such antibodies and antigen-binding portions. The present invention further relates to methods of activating the endogenous activity of an erythropoietin receptor in a mammal using said antibodies and antigen-binding portions, methods of treatment, as well as pharmaceutical compositions comprising said antibodies and antigen-binding portions.

Abstract translation: 本发明涉及结合并激活促红细胞生成素受体的抗体及其抗原结合部分。 本发明还涉及编码这种抗体和抗原结合部分的核酸序列。 本发明还涉及使用所述抗体和抗原结合部分，治疗方法以及包含所述抗体和抗原结合部分的药物组合物来激活哺乳动物中促红细胞生成素受体的内源性活性的方法。