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公开(公告)号：WO2008065542A3
公开(公告)日：2008-06-05
申请号：PCT/IB2007/004344
申请日：2007-09-24
Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LTD. , RAO, Siripragada, Mahender , ARULMOLI, Thangavel , LAKSHMIPATHI, Venu, Sanjeevi , JAGANNATH, Vasanthakumar
Inventor： RAO, Siripragada, Mahender , ARULMOLI, Thangavel , LAKSHMIPATHI, Venu, Sanjeevi , JAGANNATH, Vasanthakumar
IPC: C07F9/38
Abstract: The present invention relates to an improved process for the preparation of pure hydrate forms of Risedronate monosodium, which is used for the treatment of osteoporosis.
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2.发明申请IMPROVED PROCESS FOR THE PREPARATION OF (-) TRANS-N-METHYL PAROXETINE 审中-公开（ - ）反式-N-甲基PAROXETINE的改进方法
公开(公告)号：WO2007034270A2
公开(公告)日：2007-03-29
申请号：PCT/IB2006002470
申请日：2006-09-07
Applicant: ORCHID CHEMICALS & PHARM LTD , RAO SIRIPRAGADA MAHENDER , ARULMOLI THANGAVEL , LAKSHMIPATHI VENU SANJEEVI , SELVAMUTHU KALIYAPPAN BALU
Inventor： RAO SIRIPRAGADA MAHENDER , ARULMOLI THANGAVEL , LAKSHMIPATHI VENU SANJEEVI , SELVAMUTHU KALIYAPPAN BALU
CPC classification number: C07D405/12
Abstract: The present invention relates to an improved process for the preparation of (-) Trans-N-methyl paroxetine of formula (I), which is an intermediate in the synthesis of Paroxetine of formula (II). (-) Trans-N-methyl paroxetine is prepared by reacting (-) trans sulphonate compound of formula (III) with 3,4-methylenedioxyphenol ("sesamol") of formula (IV) in the presence of base potassium carbonate using Methyl isobutyl ketone (MIBK) as solvent.
Abstract translation: 本发明涉及用于制备式（I）的（ - ）反式-N-甲基帕罗西汀的改进方法，其为式（II）的帕罗西汀合成中的中间体。 （ - ）反式-N-甲基帕罗西汀通过式（III）的反式磺酸酯化合物与式（IV）的3,4-亚甲二氧基苯酚（“芝麻酚”）在碱式碳酸钾存在下反应制备，使用甲基异丁基 酮（MIBK）作为溶剂。
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公开(公告)号：WO2008035131A1
公开(公告)日：2008-03-27
申请号：PCT/IB2006/002588
申请日：2006-09-19
Applicant: ORCHID CHEMICALS AND PHARMACEUTICALS LIMITED , SENTHILKUMAR, Udayampalayam, Palanisamy , ARULMOLI, Thangavel , LAKSHMIPATHI, Venu, Sanjeevi , RAO, Siripragada, Mahender
Inventor： SENTHILKUMAR, Udayampalayam, Palanisamy , ARULMOLI, Thangavel , LAKSHMIPATHI, Venu, Sanjeevi , RAO, Siripragada, Mahender
IPC: C07F9/38
CPC classification number: C07F9/3873 , C07F9/582 , C07F9/65061 , C07F9/6561
Abstract: The present invention is to relate an improved process using anisole as solvent for the preparation of compound of formula (I) and its pharmaceutically acceptable salts thereof. wherein R represents-NR 1 R 2 , or formula (II), a group n = 1,2,3,4 and 5, where R 1 and R2 may be same or different and independently represents hydrogen, or C 1-6 alkyl;
Abstract translation: 本发明涉及使用苯甲醚作为制备式（I）化合物及其药学上可接受的盐的溶剂的改进方法。 其中R表示-NR 1 R 2 R 2或式（II），n = 1,2,3,4和5组，其中R 1， / SUB和R 2可以相同或不同，并且独立地表示氢或C 1-6烷基;
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Patent Agency Ranking4.发明申请
公开(公告)号：WO2008065542A2
公开(公告)日：2008-06-05
申请号：PCT/IB2007004344
申请日：2007-09-24
Applicant: ORCHID CHEMICALS & PHARM LTD , RAO SIRIPRAGADA MAHENDER , ARULMOLI THANGAVEL , LAKSHMIPATHI VENU SANJEEVI , JAGANNATH VASANTHAKUMAR
Inventor： RAO SIRIPRAGADA MAHENDER , ARULMOLI THANGAVEL , LAKSHMIPATHI VENU SANJEEVI , JAGANNATH VASANTHAKUMAR
CPC classification number: C07F9/582
Abstract: The present invention relates to an improved process for the preparation of pure hydrate forms of Risedronate monosodium, which is used for the treatment of osteoporosis.
Abstract translation: 本发明涉及用于制备用于治疗骨质疏松症的利塞膦酸单钠的纯水合物形式的改进方法。
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5.发明申请NEWS DIAMINE SALTS OF CEPHALOSPORIN ANTIBIOTICS AND THEIR PREPARATION 审中-公开新西兰CEPHALOSPORIN抗生素的DIAMINE SALTS及其制备
公开(公告)号：WO2006006040A3
公开(公告)日：2006-09-21
申请号：PCT/IB2005001888
申请日：2005-07-04
Applicant: ORCHID CHEMICALS & PHARM LTD , SENTHILKUMAR UDAYAMPALAYAM PAL , LAKSHMIPATHI VENU SANJEEVI , ANDREW GNANAPRAKASAM , CHANDRASEKARAN RAMASUBBU , NAGENDER RAO DINDIGALA , OM REDDY GADDAM
Inventor： SENTHILKUMAR UDAYAMPALAYAM PAL , LAKSHMIPATHI VENU SANJEEVI , ANDREW GNANAPRAKASAM , CHANDRASEKARAN RAMASUBBU , NAGENDER RAO DINDIGALA , OM REDDY GADDAM
IPC: C07D501/20 , C07D501/06
CPC classification number: C07D501/00
Abstract: The present invention relates to an improved process for the preparation of cephalosporin antibiotics of formula (I). The present invention also provides new salts of compound of formula (II) and a process for the preparation of these new salts, where n = 0.5 to 2. The present invention also provides a process for the preparation of compound of formula (I) using the new salts of formula (II).
Abstract translation: 本发明涉及制备式（I）的头孢菌素抗生素的改进方法。 本发明还提供了式（II）化合物的新盐和制备这些新盐的方法，其中n = 0.5至2.本发明还提供了一种制备式（I）化合物的方法，其使用 式（II）的新盐。
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公开(公告)号：WO2007034270A3
公开(公告)日：2007-03-29
申请号：PCT/IB2006/002470
申请日：2006-09-07
Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LIMITED , RAO, Siripragada, Mahender , ARULMOLI, Thangavel , LAKSHMIPATHI, Venu, Sanjeevi , SELVAMUTHU, Kaliyappan, Balu
Inventor： RAO, Siripragada, Mahender , ARULMOLI, Thangavel , LAKSHMIPATHI, Venu, Sanjeevi , SELVAMUTHU, Kaliyappan, Balu
IPC: C07D405/12
Abstract: The present invention relates to an improved process for the preparation of (-) Trans-N-methyl paroxetine of formula (I), which is an intermediate in the synthesis of Paroxetine of formula (II). (-) Trans-N-methyl paroxetine is prepared by reacting (-) trans sulphonate compound of formula (III) with 3,4-methylenedioxyphenol ("sesamol") of formula (IV) in the presence of base potassium carbonate using Methyl isobutyl ketone (MIBK) as solvent.
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7.发明申请
公开(公告)号：WO2006006040B1
公开(公告)日：2006-11-02
申请号：PCT/IB2005001888
申请日：2005-07-04
Applicant: ORCHID CHEMICALS & PHARM LTD , SENTHILKUMAR UDAYAMPALAYAM PAL , LAKSHMIPATHI VENU SANJEEVI , ANDREW GNANAPRAKASAM , CHANDRASEKARAN RAMASUBBU , NAGENDER RAO DINDIGALA , OM REDDY GADDAM
Inventor： SENTHILKUMAR UDAYAMPALAYAM PAL , LAKSHMIPATHI VENU SANJEEVI , ANDREW GNANAPRAKASAM , CHANDRASEKARAN RAMASUBBU , NAGENDER RAO DINDIGALA , OM REDDY GADDAM
IPC: C07D501/20 , C07D501/06
CPC classification number: C07D501/00
Abstract: The present invention relates to an improved process for the preparation of cephalosporin antibiotics of formula (I). The present invention also provides new salts of compound of formula (II) and a process for the preparation of these new salts, where n = 0.5 to 2. The present invention also provides a process for the preparation of compound of formula (I) using the new salts of formula (II).
Abstract translation: 本发明涉及制备式（I）的头孢菌素抗生素的改进方法。 本发明还提供了式（II）化合物的新盐和制备这些新盐的方法，其中n = 0.5至2.本发明还提供了一种制备式（I）化合物的方法，其中使用 式（II）的新盐。
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公开(公告)号：WO2006006040A2
公开(公告)日：2006-01-19
申请号：PCT/IB2005/001888
申请日：2005-07-04
Applicant: ORCHID CHEMICALS & PHARMACEUTICALS LIMITED , SENTHILKUMAR, Udayampalayam, Palanisamy , LAKSHMIPATHI, Venu, Sanjeevi , ANDREW, Gnanaprakasam , CHANDRASEKARAN, Ramasubbu , NAGENDER RAO, Dindigala , OM REDDY, Gaddam
Inventor： SENTHILKUMAR, Udayampalayam, Palanisamy , LAKSHMIPATHI, Venu, Sanjeevi , ANDREW, Gnanaprakasam , CHANDRASEKARAN, Ramasubbu , NAGENDER RAO, Dindigala , OM REDDY, Gaddam
IPC: C07D501/20
CPC classification number: C07D501/00
Abstract: The present invention relates to an improved process for the preparation of cephalosporin antibiotics of formula (I). The present invention also provides new salts of compound of formula (II) and a process for the preparation of these new salts, where n = 0.5 to 2. The present invention also provides a process for the preparation of compound of formula (I) using the new salts of formula (II).
Abstract translation: 本发明涉及制备式（I）的头孢菌素抗生素的改进方法。 本发明还提供了式（II）化合物的新盐和制备这些新盐的方法，其中n = 0.5至2.本发明还提供了一种制备式（I）化合物的方法，其使用 式（II）的新盐。
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