公开(公告)号：WO2008058089A3

公开(公告)日：2008-07-17

申请号：PCT/US2007083672

申请日：2007-11-05

Applicant: NORTH AMERICAN SCIENTIFIC INC ,  CUTRER L MICHAEL ,  WINTCH FREDRICK ,  TERWILLIGER RICHARD A ,  ZHANG JOHN ,  BOSSI DAVID

Inventor： CUTRER L MICHAEL ,  WINTCH FREDRICK ,  TERWILLIGER RICHARD A ,  ZHANG JOHN ,  BOSSI DAVID

IPC: A61M5/00

CPC classification number: A61N5/1015 ,  A61N2005/1018

Abstract: A brachytherapy device may include a plurality of rods, each configured to move between a straightened position and a bowed position, the plurality of rods configured to collectively form a shaft while each rod is in the straightened position and to collectively form at least one cage while at least some of the rods are in the bowed position, at least some of the rods having lumens that are configured to receive and hold radioactive material. A brachytherapy device may further include a rotatable mechanism configured to cause at least some of the plurality of rods to move between the straightened position and the bowed position upon rotation of the rotatable mechanism.

Abstract translation: 近程放射治疗装置可以包括多个杆，每个杆被构造成在矫直位置和弯曲位置之间移动，多个杆构造成在每个杆处于矫直位置时共同形成轴，并且共同形成至少一个笼，而 杆中的至少一些处于弯曲位置，至少一些杆具有被配置为容纳和保持放射性材料的腔。 近程放射治疗装置还可以包括可旋转机构，其被配置为当可旋转机构旋转时使多个杆中的至少一些杆在矫正位置和弯曲位置之间移动。

公开(公告)号：WO2007084365A2

公开(公告)日：2007-07-26

申请号：PCT/US2007000827

申请日：2007-01-12

Applicant: NORTH AMERICAN SCIENTIFIC INC ,  TERWILLIGER RICHARD A ,  CUTRER L MICHAEL

Inventor： TERWILLIGER RICHARD A ,  CUTRER L MICHAEL

IPC: G21K1/04

CPC classification number: G21K1/04 ,  G21K1/046

Abstract: A variable stop collimator for use in a radiation therapy machine having a radiation source for producing a radiation beam directed toward a patient. The variable stop collimator includes a plurality of radiation attenuating leaves, with each leaf having an opposing leaf to collimate a ray of the radiation beam. For each leaf, the collimator includes a pneumatic cylinder configured to independently move each leaf between the open and closed state and at points between the open and closed states. Each pneumatic cylinder is connected at one end to the leaf and, at the other end, to a variable stop. The. stop may include a raised spiral projection that permits a smooth stop at any point deemed appropriate for the motor. The collimator includes a support configured to guide the plurality of radiation attenuating leaves transverse to the beam plane.

Abstract translation: 一种用于放射治疗机的可变停止准直器，其具有用于产生朝向患者的辐射束的辐射源。 可变停止准直器包括多个辐射衰减叶片，每个叶片具有相对的叶片以准直辐射束的射线。 对于每个叶片，准直器包括气缸，其被构造成在打开和关闭状态之间以及在打开和关闭状态之间的点处独立地移动每个叶片。 每个气缸的一端连接到叶片，另一端连接到可变挡块。 的。 止动件可以包括凸起的螺旋突起，其允许在被认为适合于电动机的任何点处平稳地停止。 准直器包括被配置为引导横向于光束平面的多个辐射衰减叶片的支撑件。

公开(公告)号：WO03039655A3

公开(公告)日：2003-10-16

申请号：PCT/US0235236

申请日：2002-11-01

Applicant: TERWILLIGER RICHARD A ,  LAMOUREUX GARY A

Inventor： TERWILLIGER RICHARD A ,  LAMOUREUX GARY A

IPC: A61M36/12 ,  A61N5/10 ,  B29C47/02 ,  G21G4/08

CPC classification number: A61N5/1027 ,  A61N5/1007 ,  A61N2005/1023 ,  A61N2005/1024 ,  B29C47/0009 ,  B29C47/021 ,  B29C47/028 ,  G21G4/08

Abstract: A delivery system and method for interstitial radiation therapy having a substantially axially stiff and longitudinally flexible elongated member (12) carrying radioactive seeds (14).

Abstract translation: 用于间质放射治疗的递送系统和方法，其具有携带放射性种子（14）的基本上轴向刚性且纵向柔性的细长构件（12）。

公开(公告)号：WO2003039806A1

公开(公告)日：2003-05-15

申请号：PCT/US2002/035237

申请日：2002-11-01

Applicant: TERWILLIGER, Richard, A. ,  LAMOUREUX, Gary, A.

Inventor： TERWILLIGER, Richard, A. ,  LAMOUREUX, Gary, A.

IPC: B23P15/00

CPC classification number: B29C47/028 ,  A61N5/1027 ,  A61N2005/1023 ,  B29C47/0023 ,  B29C47/021 ,  G21G4/08

Abstract: A system and method for making radiation therapy seed strands (422) comprises extruding an elongate hollow member (440) with a bore and inserting radioactive seed elements (408) into the bore.

Abstract translation: 用于制造辐射治疗种子股422的系统和方法包括用孔填充细长的中空构件440并将放射性种子元件408插入孔中。

公开(公告)号：WO03039653A2

公开(公告)日：2003-05-15

申请号：PCT/US0234967

申请日：2002-11-01

Applicant: TERWILLIGER RICHARD A ,  LAMOUREUX GARY A

Inventor： TERWILLIGER RICHARD A ,  LAMOUREUX GARY A

IPC: A61N5/10 ,  B29C47/02 ,  G21G4/08 ,  A61N

CPC classification number: A61N5/1027 ,  A61N2005/1023 ,  B29C47/0014 ,  B29C47/021 ,  B29C47/028 ,  G21G4/08 ,  Y10T29/49885 ,  Y10T29/49982 ,  Y10T29/53013

Abstract: A delivery system and method for interstitial radiation therapy comprising substantially axially stiff and longitudinally flexible elongated members made of material which is bioabsorbable in living tissue and a plurality of radioactive seeds dispersed in a predetermined array within the elongate member. The radioactive seeds can be dispersed within assembled half-shells made of the same material. The housing for the radiation seeds can also be manufactured from extruded material. A system for manufacturing the interstitial radiation therapy seed strands that automatically makes the seed strands at the patient's bedside. The delivery system and method further customize the member based on a prescription.

Abstract translation: 一种用于间质放射治疗的输送系统和方法，包括由活体组织中可生物吸收的材料制成的基本上轴向刚性和纵向柔性的细长构件，以及以预定阵列分散在细长构件内的多个放射性种子。 放射性种子可以分散在由相同材料制成的组装的半壳内。 用于辐射种子的外壳也可以由挤压材料制成。 用于制造间质放射治疗种子股的系统，其自动使种子股在病人的床边。 递送系统和方法基于处方进一步定制成员。

公开(公告)号：WO1996027329A1

公开(公告)日：1996-09-12

申请号：PCT/US1996002082

申请日：1996-02-14

Applicant: TERWILLIGER, Richard, A.

IPC: A61B08/14

CPC classification number: A61B17/3403 ,  A61B8/0833 ,  A61B90/39 ,  A61B2090/3925

Abstract: An echogenic cannula (7) includes a hole (5) provided at the distal end (17). Preferably the hole (5) is positioned through a centerline (8) which is spaced from the centerline (6) of the stylet (9) in order to form a concave surface (11) from which sound waves (10) are reflected in order to locate the distal tip end (17). An echogenic needle (410) includes a hole (42) provided at the distal tip end. Preferably, the hole (42) is positioned through a centerline (413) which is spaced from the centerline (414) of the stylet (411) in order to form a concave surface (43) from which sound waves are reflected in order to locate the distal tip end.

Abstract translation: 回声插管（7）包括设置在远端（17）处的孔（5）。 优选地，孔（5）定位成穿过与探针（9）的中心线（6）间隔开的中心线（8），以形成凹面（11），声波（10）从该表面顺序反射 以定位远侧末端（17）。 回声针（410）包括设置在远侧末端的孔（42）。 优选地，孔（42）定位成穿过与探针（411）的中心线（414）间隔开的中心线（413），以形成凹面（43），从而从中反射声波以便定位 远端尖端。

公开(公告)号：WO2007078453A2

公开(公告)日：2007-07-12

申请号：PCT/US2006/045081

申请日：2006-11-21

Applicant: NORTH AMERICAN SCIENTIFIC, INC. ,  CUTRER, L., Michael ,  TERWILLIGER, Richard, A. ,  WINCH, Fredrick ,  ZHANG, John ,  HIGGINS, Wayne ,  ELLARD, Terence, R. ,  BOSSI, David

Inventor： CUTRER, L., Michael ,  TERWILLIGER, Richard, A. ,  WINCH, Fredrick ,  ZHANG, John ,  HIGGINS, Wayne ,  ELLARD, Terence, R. ,  BOSSI, David

IPC: A61N5/00 ,  A61M36/00

CPC classification number: A61N5/1015 ,  A61N2005/1018

Abstract: The present disclosure provides a brachytherapy apparatus, system and method that delivers partial breast irradiation treatment for post-lumpectomy patients via introduction of a catheter-like device through a trocar. The apparatus may be introduced post-surgically with local anesthesia under image guidance into the previous excision site and into a cavity by a surgeon. The brachytherapy apparatus includes one or more thin-walled tubes, each of said thin-walled tubes being configured to contain one or more radioactive sources, at least one radiation source configured to deliver a prescribed dose of radiation, a whisk adjuster configured to permit adjustment of each of the one or more thin-walled tubes so that the tubes substantially conform to a size of the body cavity; and an expansion element configured to expand outwardly said one or more thin-walled tubes within the cavity so that the thin-walled tubes substantially conform to a shape and/or size of the body cavity.

Abstract translation: 本公开提供了一种近距离放射治疗装置，系统和方法，其通过经由套管针引入导管状装置来递送部分乳房外照射治疗肿瘤后切除术患者。 该装置可以在图像引导下用手术后的局部麻醉引入先前的切除部位并由外科医生进入腔中。 近距离放射治疗装置包括一个或多个薄壁管，每个所述薄壁管被构造成容纳一个或多个放射源，至少一个辐射源被配置为传送规定剂量的辐射，构造成允许调节的搅拌器调节器 所述一个或多个薄壁管中的每一个使得所述管基本上符合所述体腔的尺寸; 以及膨胀元件，其构造成向外扩张所述空腔内的所述一个或多个薄壁管，使得所述薄壁管基本上符合所述体腔的形状和/或尺寸。

公开(公告)号：WO2007075241A1

公开(公告)日：2007-07-05

申请号：PCT/US2006/045117

申请日：2006-11-21

Applicant: NORTH AMERICAN SCIENTIFIC, INC. ,  CUTRER, L., Michael ,  TERWILLIGER, Richard, A. ,  WINCH, Fredrick ,  ZHANG, John ,  HIGGINS, Wayne ,  ELLARD, Terence, R. ,  BOSSI, David

Inventor： CUTRER, L., Michael ,  TERWILLIGER, Richard, A. ,  WINCH, Fredrick ,  ZHANG, John ,  HIGGINS, Wayne ,  ELLARD, Terence, R. ,  BOSSI, David

IPC: A61N5/00

CPC classification number: A61N5/1015 ,  A61N2005/1018

Abstract: The present disclosure provides a brachytherapy apparatus that delivers a low dose, partial breast irradiation treatment for post-lumpectomy patients via introduction of a catheter-like device through a cannula. The apparatus may be introduced post- surgically with local anesthesia under image guidance into the previous excision site and into a cavity by a surgeon. The brachytherapy apparatus includes a seed containment device configured to contain a plurality of low-dose radioactive seeds therein. The seed containment device may be one or more thin-walled tubes. The apparatus is further configured to expand so that at least a portion of the seed containment device is positioned against the remaining tissue and the plurality of radioactive seeds are disposed at the perimeter of the seed containment device. Also described are various clamps for the apparatus, and sleeves for adjusting the size of the device to fit a cavity when the apparatus is in use.

Abstract translation: 本公开提供了一种近距离放射治疗装置，其通过经由插管引入导管状装置来递送针对后肿瘤切除术患者的低剂量部分乳房照射治疗。 该装置可以在手术前通过局部麻醉在图像引导下引入先前的切除部位并由外科医生进入腔中。 近程放射治疗装置包括种子容纳装置，其构造成在其中容纳多个低剂量放射性种子。 种子容纳装置可以是一个或多个薄壁管。 该装置进一步构造成扩张，使得种子容纳装置的至少一部分抵靠剩余的组织定位，并且多个放射性种子设置在种子容纳装置的周边。 还描述了用于装置的各种夹具以及用于在装置使用时调节装置的尺寸以配合空腔的套筒。

公开(公告)号：WO2004101026A2

公开(公告)日：2004-11-25

申请号：PCT/US2004/014732

申请日：2004-05-12

Applicant: IDEAMATRIX, INC. ,  TERWILLIGER, Richard, A. ,  LAMOUREUX, Gary, A.

Inventor： TERWILLIGER, Richard, A. ,  LAMOUREUX, Gary, A.

IPC: A61M

CPC classification number: A61M37/0069 ,  A61B17/3468 ,  A61B2017/3407 ,  A61B2017/3411 ,  A61N5/1027 ,  A61N2005/1012 ,  A61N2005/1023

Abstract: A delivery system and method for interstitial radiation therapy comprising a substantially axially stiff and longitudinally flexible elongated strand made of material, which is bio-absorbable in living tissue and a plurality of radioactive seeds dispersed in a predeterrnined array within the strand. The delivery system and method further customize the strand based on a prescription. The strands can have custom end spacings, which allow the optimal placing of seeds within the treatment tissue by implanting a plurality of strands to the same depth. A plurality of these strands can be implanted at the same time by the use of a guiding device.

Abstract translation: 一种用于间质放射治疗的递送系统和方法，包括在生物体组织中可生物吸收的基本上轴向刚性和纵向柔性的细长股线，所述细长股线由分散在股线内的预定阵列中的多个放射性种子组成。 递送系统和方法基于处方进一步定制链。 股线可以具有定制的端部间隔，其允许通过将多个股线植入同一深度来最佳地将种子放置在处理组织内。 可以通过使用引导装置同时植入多个这些线。

公开(公告)号：WO2003028808A3

公开(公告)日：2003-04-10

申请号：PCT/US2001/027780

申请日：2001-10-24

Applicant: LAMOUREUX, Gary, A. ,  TERWILLIGER, Richard, A.

Inventor： LAMOUREUX, Gary, A. ,  TERWILLIGER, Richard, A.

IPC: A61N5/10

Abstract: A needle assembly (10) including a cannula (12) having a sharpened distal end (20a), a line of elements (28) n the cannula (12) extending reward from the distal end (20a). A yieldable positioner (32) positions the elements (28) more proximate the distal end (20a). The positioner (32) may be in various forms including a plug (32), a tab (214) in the cannula (12) and a distortion (364). A stylet (22) engages the line of elements (28).