公开(公告)号：WO2004084800A2

公开(公告)日：2004-10-07

申请号：PCT/US2003/027373

申请日：2003-08-29

Applicant: PFIZER PRODUCTS INC. ,  OXFORD GLYCOSCIENCES (UK) LTD. ,  THOMPSON, John, F. ,  POTTER, David, M. ,  KNIGHT, Delvin, R., Jr. ,  GUALBERTO, Antonio ,  LANDSCHULZ, Katherine, T. ,  HERATH, Herath, Mudiyanselage, Athula, Chandrasiri ,  ROHLFF, Christian

Inventor： THOMPSON, John, F. ,  POTTER, David, M. ,  KNIGHT, Delvin, R., Jr. ,  GUALBERTO, Antonio ,  LANDSCHULZ, Katherine, T. ,  HERATH, Herath, Mudiyanselage, Athula, Chandrasiri ,  ROHLFF, Christian

IPC: A61K

CPC classification number: C07K14/47 ,  A61K38/00 ,  G01N33/6893 ,  G01N2500/04 ,  G01N2500/10 ,  G01N2500/20

Abstract: Proteins are identified that exhibit an altered expression in mammalian cardiac tissue in response to A 3 agonist infusion. These proteins are termed A 3 receptor-mediated cardioprotective proteins (A 3 Ps) and protein isoforms (A 3 PIs) and are useful as pharmaceuticals and as targets in screening methods for identifying an agent capable of modulating the expression of one or more A 3 P and/or A 3 PI.

Abstract translation: 鉴定出响应于A3激动剂输注在哺乳动物心脏组织中表现出改变的蛋白质。 这些蛋白质被称为A3受体介导的心脏保护性蛋白质（A3P）和蛋白质同种型（A3PI），并且可用作鉴定能够调节一种或多种A3P和/或A3PI的表达的试剂的筛选方法中的药物和靶标。

公开(公告)号：WO2004084800A3

公开(公告)日：2005-10-06

申请号：PCT/US0327373

申请日：2003-08-29

Applicant: PFIZER PROD INC ,  OXFORD GLYCOSCIENCES UK LTD ,  THOMPSON JOHN F ,  POTTER DAVID M ,  KNIGHT DELVIN R JR ,  GUALBERTO ANTONIO ,  LANDSCHULZ KATHERINE T ,  HERATH HERATH MUDIYANSELAGE AT ,  ROHLFF CHRISTIAN

Inventor： THOMPSON JOHN F ,  POTTER DAVID M ,  KNIGHT DELVIN R JR ,  GUALBERTO ANTONIO ,  LANDSCHULZ KATHERINE T ,  HERATH HERATH MUDIYANSELAGE AT ,  ROHLFF CHRISTIAN

IPC: A61K20060101 ,  A61K38/00 ,  A61K38/08 ,  A61K38/10 ,  A61K38/17 ,  C07K7/06 ,  C07K7/08 ,  C07K14/47 ,  G01N33/68

CPC classification number: C07K14/47 ,  A61K38/00 ,  G01N33/6893 ,  G01N2500/04 ,  G01N2500/10 ,  G01N2500/20

Abstract: Proteins are identified that exhibit an altered expression in mammalian cardiac tissue in response to A3 agonist infusion. These proteins are termed A3 receptor-mediated cardioprotective proteins (A3Ps) and protein isoforms (A3PIs) and are useful as pharmaceuticals and as targets in screening methods for identifying an agent capable of modulating the expression of one or more A3P and/or A3PI.

Abstract translation: 鉴定出响应于A3激动剂输注在哺乳动物心脏组织中表现出改变的蛋白质。 这些蛋白质被称为A3受体介导的心脏保护性蛋白质（A3P）和蛋白质同种型（A3PI），并且可用作鉴定能够调节一种或多种A3P和/或A3PI的表达的试剂的筛选方法中的药物和靶标。