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    STRUCTURE, MANUFACTURING AND USES OF HUMAN-DERIVED CELL-PERMEABLE PEPTIDES CONJUGATED WITH SPECIFIC BIOLOGICALLY ACTIVE CARGO PEPTIDES
    4.
    发明申请
    STRUCTURE, MANUFACTURING AND USES OF HUMAN-DERIVED CELL-PERMEABLE PEPTIDES CONJUGATED WITH SPECIFIC BIOLOGICALLY ACTIVE CARGO PEPTIDES 审中-公开

    公开(公告)号：WO2015025217A4

    公开(公告)日：2015-02-26

    申请号：PCT/IB2014/002029

    申请日：2014-06-11

    Applicant: PORTAGE PHARMACEUTICALS LTD. ,  LITTMAN, Bruce, H. ,  THOMPSON, John, F. ,  MARCOUX, Frank, W.

    Inventor： LITTMAN, Bruce, H. ,  THOMPSON, John, F. ,  MARCOUX, Frank, W.

    IPC: A61K47/48

    Abstract: Embodiments disclosed herein provide compositions for conjugates, including fusion proteins, and methods of using them to treat a variety of conditions. In some embodiments, the conjugates and/or fusion proteins incorporate a 60-amino acid human homeodomain (e.g., peptides derived from human HOX genes), to translocate functional and regulatory peptides and proteins or other biologically active molecules such as nucleic acids, which are not naturally associated with the human homeodomain, across cell and nuclear membranes to intended sites of action without provoking an unwanted immune response that may reduce exposure to the conjugate and/or result in a clinical adverse event. In further embodiments, disclosed conjugates and fusion proteins can pass through the blood-brain barrier to allow entry into the CNS. In various embodiments, the disclosed compositions are suitable for delivery into a cell (i) the expression product of a gene of interest and/or (ii) novel peptides or polynucleotides to regulate gene function.

    METHODS FOR DETECTING FETAL NUCLEIC ACIDS AND DIAGNOSING FETAL ABNORMALITIES
    5.
    发明申请
    METHODS FOR DETECTING FETAL NUCLEIC ACIDS AND DIAGNOSING FETAL ABNORMALITIES 审中-公开
    用于检测天然核酸的方法和诊断宫颈异常

    公开(公告)号：WO2011102998A2

    公开(公告)日：2011-08-25

    申请号：PCT/US2011024132

    申请日：2011-02-09

    Applicant: HELICOS BIOSCIENCES CORP ,  LAPIDUS STANLEY N ,  THOMPSON JOHN F ,  LIPSON DORON ,  MILOS PATRICE M ,  EFCAVITCH J WILLIAM ,  LETOVSKY STANLEY

    Inventor： LAPIDUS STANLEY N ,  THOMPSON JOHN F ,  LIPSON DORON ,  MILOS PATRICE M ,  EFCAVITCH J WILLIAM ,  LETOVSKY STANLEY

    IPC: C12Q1/68

    CPC classification number: C12Q1/6869 ,  C12Q1/6809 ,  C12Q1/6883 ,  C12Q2600/156 ,  G06F19/18 ,  C12Q2535/122 ,  C12Q2537/16 ,  C12Q2537/165 ,  C12Q2563/159

    Abstract: The invention generally relates to methods for detecting fetal nucleic acids and methods for diagnosing fetal abnormalities. In certain embodiments, the invention provides methods for determining whether fetal nucleic acid is present in a maternal sample including obtaining a maternal sample suspected to include fetal nucleic acids, and performing a sequencing reaction on the sample to determine presence of at least a portion of a Y chromosome in the sample, thereby determining that fetal nucleic acid is present in the sample. In other embodiments, the invention provides methods for quantitative or qualitative analysis to detect fetal nucleic acid in a maternal sample, regardless of the ability to detect the Y chromosome, particularly for samples including normal nucleic acids from a female fetus.

    Abstract translation: 本发明一般涉及用于检测胎儿核酸的方法和用于诊断胎儿异常的方法。 在某些实施方案中，本发明提供了用于确定胎儿核酸是否存在于母体样品中的方法，包括获得怀疑包括胎儿核酸的母体样品，并对样品进行测序反应以确定至少部分 Y染色体，从而确定胎儿核酸存在于样品中。 在其它实施方案中，本发明提供用于定量或定性分析以检测母体样品中的胎儿核酸的方法，而不管检测Y染色体的能力，特别是对于包括来自雌性胎儿的正常核酸的样品的检测能力。

    METHODS FOR SEQUENCING DEGRADED OR MODIFIED NUCLEIC ACIDS
    6.
    发明申请
    METHODS FOR SEQUENCING DEGRADED OR MODIFIED NUCLEIC ACIDS 审中-公开
    用于测序降解或修饰的核酸的方法

    公开(公告)号：WO2010039189A3

    公开(公告)日：2011-03-03

    申请号：PCT/US2009005287

    申请日：2009-09-23

    Applicant: HELICOS BIOSCIENCES CORP ,  THOMPSON JOHN F

    Inventor： THOMPSON JOHN F

    IPC: G01N33/48 ,  C12P19/34

    CPC classification number: C12Q1/6869

    Abstract: The invention provides methods and compositions for sequencing DNA or RNA samples that would be impossible to do via standard means. Samples that are part of mixtures or are degraded or modified may be sequenced so that the individual from whom the sample originated can be determined or useful biological information can be associated with the sample. Methods are described that allow high efficiency sequencing of degraded nucleic acid samples such as are typically found with FFPE. Samples from severely degraded sources or that have been treated with preservatives such as formalin may be sequenced. In addition to permitting identification of samples, information about disease or treatment status may also be determined.

    Abstract translation: 本发明提供了用于测序DNA或RNA样品的方法和组合物，其通过标准方法是不可能的。 作为混合物的一部分或被降解或修饰的样品可以被测序，使得来自样品的个体可以被确定或有用的生物信息可以与样品相关联。 描述了允许对通常用FFPE发现的降解的核酸样品进行高效测序的方法。 来自严重降解来源或已用防腐剂如福尔马林处理的样品可以进行测序。 除了允许样品的鉴定之外，还可以确定关于疾病或治疗状态的信息。

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