公开(公告)号：WO2004084800A2

公开(公告)日：2004-10-07

申请号：PCT/US2003/027373

申请日：2003-08-29

Applicant: PFIZER PRODUCTS INC. ,  OXFORD GLYCOSCIENCES (UK) LTD. ,  THOMPSON, John, F. ,  POTTER, David, M. ,  KNIGHT, Delvin, R., Jr. ,  GUALBERTO, Antonio ,  LANDSCHULZ, Katherine, T. ,  HERATH, Herath, Mudiyanselage, Athula, Chandrasiri ,  ROHLFF, Christian

Inventor： THOMPSON, John, F. ,  POTTER, David, M. ,  KNIGHT, Delvin, R., Jr. ,  GUALBERTO, Antonio ,  LANDSCHULZ, Katherine, T. ,  HERATH, Herath, Mudiyanselage, Athula, Chandrasiri ,  ROHLFF, Christian

IPC: A61K

CPC classification number: C07K14/47 ,  A61K38/00 ,  G01N33/6893 ,  G01N2500/04 ,  G01N2500/10 ,  G01N2500/20

Abstract: Proteins are identified that exhibit an altered expression in mammalian cardiac tissue in response to A 3 agonist infusion. These proteins are termed A 3 receptor-mediated cardioprotective proteins (A 3 Ps) and protein isoforms (A 3 PIs) and are useful as pharmaceuticals and as targets in screening methods for identifying an agent capable of modulating the expression of one or more A 3 P and/or A 3 PI.

Abstract translation: 鉴定出响应于A3激动剂输注在哺乳动物心脏组织中表现出改变的蛋白质。 这些蛋白质被称为A3受体介导的心脏保护性蛋白质（A3P）和蛋白质同种型（A3PI），并且可用作鉴定能够调节一种或多种A3P和/或A3PI的表达的试剂的筛选方法中的药物和靶标。

公开(公告)号：WO0175454A3

公开(公告)日：2003-05-08

申请号：PCT/US0110908

申请日：2001-04-03

Applicant: OXFORD GLYCOSCIENCES UK LTD ,  PFIZER ,  DURHAM KATHRYN L ,  FRIEDMAN DAVID L ,  HERATH HERATH MUDIYANSELAGE AT ,  KIMMEL LIDA H ,  PAREKH RAJESH BHIKHU ,  POTTER DAVID M ,  ROHLFF CHRISTIAN ,  SILBER B MICHAEL ,  STIGER THOMAS R ,  SUNDERLAND P TREY ,  TOWNSEND ROBERT REID ,  WHITE FROST ,  WILLIAMS STEPHEN A

Inventor： DURHAM KATHRYN L ,  FRIEDMAN DAVID L ,  HERATH HERATH MUDIYANSELAGE AT ,  KIMMEL LIDA H ,  PAREKH RAJESH BHIKHU ,  POTTER DAVID M ,  ROHLFF CHRISTIAN ,  SILBER B MICHAEL ,  STIGER THOMAS R ,  SUNDERLAND P TREY ,  TOWNSEND ROBERT REID ,  WHITE FROST ,  WILLIAMS STEPHEN A

IPC: G01N27/62 ,  A61K31/7088 ,  A61K39/395 ,  A61K48/00 ,  A61P25/28 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N15/09 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  G01N27/447 ,  G01N33/15 ,  G01N33/53 ,  G01N33/68 ,  G01N37/00 ,  C07K14/47 ,  G01N33/561

CPC classification number: G01N33/6896 ,  G01N2800/2821

Abstract: The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated Features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein Isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs, antibodies immunospecific for APIs, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same.

Abstract translation: 本发明提供了用于阿尔茨海默病筛选，诊断和预后的方法和组合物，用于监测阿尔茨海默病治疗的有效性和药物开发。 描述了通过脑脊液，血清或血浆的二维电泳可检测的阿尔茨海默氏病相关特征（AF）。 本发明还提供在脑脊液，血清或血浆中可检测的阿尔茨海默氏病相关蛋白质异构体（API），包含分离的API的制剂，针对API免疫特异性的抗体，药物组合物，诊断和治疗方法，以及包含或基于其的试剂盒。

公开(公告)号：WO2003028543A2

公开(公告)日：2003-04-10

申请号：PCT/US2002/031642

申请日：2002-10-03

Applicant: PFIZER PRODUCTS INC. ,  OXFORD GLYCOSCIENCES (UK) LTD. ,  DURHAM, L., Kathryn ,  FRIEDMAN, David, L. ,  HERATH, Herath, Mudiyanselage, Athula, Chandrasiri ,  KIMMEL, Lida, H. ,  PAREKH, Rajesh, Bhikhu ,  POTTER, David, M. ,  ROHLFF, Christian ,  SILBER, B., Michael ,  SNYDER, Peter, Jeffrey ,  SOARES, Holly, Daria ,  STIGER, Thomas, R. ,  SUNDERLAND, P., Trey ,  TOWNSEND, Robert, Reid ,  WHITE, W., Frost ,  WILLIAMS, Stephen, A.

Inventor： DURHAM, L., Kathryn ,  FRIEDMAN, David, L. ,  HERATH, Herath, Mudiyanselage, Athula, Chandrasiri ,  KIMMEL, Lida, H. ,  PAREKH, Rajesh, Bhikhu ,  POTTER, David, M. ,  ROHLFF, Christian ,  SILBER, B., Michael ,  SNYDER, Peter, Jeffrey ,  SOARES, Holly, Daria ,  STIGER, Thomas, R. ,  SUNDERLAND, P., Trey ,  TOWNSEND, Robert, Reid ,  WHITE, W., Frost ,  WILLIAMS, Stephen, A.

IPC: A61B

CPC classification number: G01N33/6896 ,  C07K14/4711 ,  C07K16/18 ,  G01N2333/4709 ,  G01N2500/00 ,  G01N2800/2821 ,  G01N2800/52

Abstract: The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein Isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs antibodies immunospecific for APIs, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same.

Abstract translation: 本发明提供了用于阿尔茨海默病筛选，诊断和预后的方法和组合物，用于监测阿尔茨海默病治疗的有效性和药物开发。 描述了通过脑脊液，血清或血浆的二维电泳可检测的阿尔茨海默病相关特征（AF）。 本发明进一步提供在脑脊液，血清或血浆中可检测的阿尔茨海默病相关蛋白质异构体（API），包含针对API免疫特异性的分离的API抗体的制剂，药物组合物，诊断和治疗方法以及包含或基于其的试剂盒。

公开(公告)号：WO2003028543A3

公开(公告)日：2003-04-10

申请号：PCT/US2002/031642

申请日：2002-10-03

Applicant: PFIZER PRODUCTS INC. ,  OXFORD GLYCOSCIENCES (UK) LTD. ,  DURHAM, L., Kathryn ,  FRIEDMAN, David, L. ,  HERATH, Herath, Mudiyanselage, Athula, Chandrasiri ,  KIMMEL, Lida, H. ,  PAREKH, Rajesh, Bhikhu ,  POTTER, David, M. ,  ROHLFF, Christian ,  SILBER, B., Michael ,  SNYDER, Peter, Jeffrey ,  SOARES, Holly, Daria ,  STIGER, Thomas, R. ,  SUNDERLAND, P., Trey ,  TOWNSEND, Robert, Reid ,  WHITE, W., Frost ,  WILLIAMS, Stephen, A.

Inventor： DURHAM, L., Kathryn ,  FRIEDMAN, David, L. ,  HERATH, Herath, Mudiyanselage, Athula, Chandrasiri ,  KIMMEL, Lida, H. ,  PAREKH, Rajesh, Bhikhu ,  POTTER, David, M. ,  ROHLFF, Christian ,  SILBER, B., Michael ,  SNYDER, Peter, Jeffrey ,  SOARES, Holly, Daria ,  STIGER, Thomas, R. ,  SUNDERLAND, P., Trey ,  TOWNSEND, Robert, Reid ,  WHITE, W., Frost ,  WILLIAMS, Stephen, A.

IPC: C07K5/00

Abstract: The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein Isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs antibodies immunospecific for APIs, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same.

公开(公告)号：WO2004084800A3

公开(公告)日：2005-10-06

申请号：PCT/US0327373

申请日：2003-08-29

Applicant: PFIZER PROD INC ,  OXFORD GLYCOSCIENCES UK LTD ,  THOMPSON JOHN F ,  POTTER DAVID M ,  KNIGHT DELVIN R JR ,  GUALBERTO ANTONIO ,  LANDSCHULZ KATHERINE T ,  HERATH HERATH MUDIYANSELAGE AT ,  ROHLFF CHRISTIAN

Inventor： THOMPSON JOHN F ,  POTTER DAVID M ,  KNIGHT DELVIN R JR ,  GUALBERTO ANTONIO ,  LANDSCHULZ KATHERINE T ,  HERATH HERATH MUDIYANSELAGE AT ,  ROHLFF CHRISTIAN

IPC: A61K20060101 ,  A61K38/00 ,  A61K38/08 ,  A61K38/10 ,  A61K38/17 ,  C07K7/06 ,  C07K7/08 ,  C07K14/47 ,  G01N33/68

CPC classification number: C07K14/47 ,  A61K38/00 ,  G01N33/6893 ,  G01N2500/04 ,  G01N2500/10 ,  G01N2500/20

Abstract: Proteins are identified that exhibit an altered expression in mammalian cardiac tissue in response to A3 agonist infusion. These proteins are termed A3 receptor-mediated cardioprotective proteins (A3Ps) and protein isoforms (A3PIs) and are useful as pharmaceuticals and as targets in screening methods for identifying an agent capable of modulating the expression of one or more A3P and/or A3PI.

Abstract translation: 鉴定出响应于A3激动剂输注在哺乳动物心脏组织中表现出改变的蛋白质。 这些蛋白质被称为A3受体介导的心脏保护性蛋白质（A3P）和蛋白质同种型（A3PI），并且可用作鉴定能够调节一种或多种A3P和/或A3PI的表达的试剂的筛选方法中的药物和靶标。