公开(公告)号：WO2009037230A2

公开(公告)日：2009-03-26

申请号：PCT/EP2008062261

申请日：2008-09-15

Applicant: DSM FINE CHEM AUSTRIA GMBH ,  LUETTGEN KARSTEN ,  LASSNIG MARTIN

Inventor： LUETTGEN KARSTEN ,  LASSNIG MARTIN

IPC: C07C249/08 ,  C07C249/14 ,  C07C251/48

CPC classification number: C07C249/08 ,  C07C249/14 ,  C07C251/48

Abstract: An improved process for preparing (E)-2-(2-chloromethylphenyl)-2-alkoximinoacetic esters of Formula (I), in which R is a radical inert to the reaction, n is 0 to 4 and R1 and R5 may each independently be C1-C8-alkyl radicals, which comprises reacting a compound of Formula (II), in which n, R and R1 are each as defined above with o-methylhydroxylammonium hydrochloride (CH3ONH2-HCI) in a solvent mixture at a pH of from 0 to 7, which is established by adding an inorganic base, to give an isomer mixture of Formula (III), in which n, R, R1 and R5 are each as defined above, then extracting with cyclohexane, then isomerizing the isomer mixture by introducing gaseous hydrochloric acid, neutralizing the reaction mixture and crystallizing the compound of the formula (I) after adding a cosolvent.

Abstract translation: 制备式（I）的（E）-2-（2-氯甲基苯基）-2-肟基乙酸酯的改进方法，其中R是对反应惰性的基团，n为0至4，R 1和R 5可各自独立地 包括使式（II）化合物（其中n，R和R 1各自如上定义）与邻甲基羟基铵盐酸盐（CH 3 ONH 2 -HCl）在溶剂混合物中的pH为 通过添加无机碱而形成的0〜7，得到式（III）的异构体混合物，其中n，R，R 1和R 5各自如上所述，然后用环己烷萃取，然后异构体异构体混合物 引入气态盐酸，中和反应混合物并在加入助溶剂后使式（I）化合物结晶。

公开(公告)号：WO2009037230A3

公开(公告)日：2009-03-26

申请号：PCT/EP2008/062261

申请日：2008-09-15

Applicant: DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG ,  LUETTGEN, Karsten ,  LASSNIG, Martin

Inventor： LUETTGEN, Karsten ,  LASSNIG, Martin

IPC: C07C249/08 ,  C07C249/14 ,  C07C251/48

Abstract: An improved process for preparing (E)-2-(2-chloromethylphenyl)-2-alkoximinoacetic esters of Formula (I), in which R is a radical inert to the reaction, n is 0 to 4 and R1 and R5 may each independently be C 1 -C 8 -alkyl radicals, which comprises reacting a compound of Formula (II), in which n, R and R1 are each as defined above with o-methylhydroxylammonium hydrochloride (CH 3 ONH 2 -HCI) in a solvent mixture at a pH of from 0 to 7, which is established by adding an inorganic base, to give an isomer mixture of Formula (III), in which n, R, R1 and R5 are each as defined above, then extracting with cyclohexane, then isomerizing the isomer mixture by introducing gaseous hydrochloric acid, neutralizing the reaction mixture and crystallizing the compound of the formula (I) after adding a cosolvent.

公开(公告)号：WO2007042114A1

公开(公告)日：2007-04-19

申请号：PCT/EP2006/008906

申请日：2006-09-13

Applicant: DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG ,  JARY, Walther ,  PERNDOFER, Eduard ,  LASSNIG, Martin

Inventor： JARY, Walther ,  PERNDOFER, Eduard ,  LASSNIG, Martin

IPC: C07B41/14 ,  C07C29/48 ,  C07C33/035 ,  C07C231/14 ,  C07C233/33

CPC classification number: C07C29/48 ,  C07B41/14 ,  C07C231/14 ,  C07C233/33 ,  C07C33/035

Abstract: Process for the oxidation of organic substrates by means of singlet oxygen, in which organic substrates which react with 1 O 2 are admixed with 10-70% strength H 2 O 2 in an organic solvent in the presence of a molybdenum-based catalyst at a pH of 9 - 14 and a temperature in the range from 50 0 C to the reflux temperature, whereupon the oxidation to the corresponding oxidation products occurs subsequent to the catalytic decomposition of H 2 O 2 into water and 1 O 2 .

Abstract translation: 通过单线态氧氧化有机衬底的方法，其中与 O 2反应的有机衬底与10-70％强度H 2 在有机溶剂中，在pH为9〜14的钼系催化剂存在下，在50℃以上的温度下， 然后氧化成相应的氧化产物，随后将H 2 O 2 O 2催化分解成水和<！ - SIPO - > O _{2 。}

公开(公告)号：WO2004058698A1

公开(公告)日：2004-07-15

申请号：PCT/EP2003/013460

申请日：2003-11-28

Applicant: DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG ,  JARY, Walther ,  PÖCHLAUER, Peter ,  LASSNIG, Martin

Inventor： JARY, Walther ,  PÖCHLAUER, Peter ,  LASSNIG, Martin

IPC: C07C315/04

CPC classification number: C07C315/04 ,  C07C317/44

Abstract: Verfahren zur Oxidation von gegebenenfalls substituierten Toluolen Formel (I), in der X, Y und Z unabhängig voneinander Wasserstoff, Methylsulfonyl, Hydroxysulfonyl, Nitro, Halogen oder gegebenenfalls substituiertes Phenyl bedeuten, zu den korrespondierenden Benzoesäuren der Formel (II), in der X, Y und Z wie oben definiert sind, in Schwefelsäure bei einer Temperatur von 40-95 °C gegebenenfalls in Gegenwart eines Übergansmetallkatalysators mit Wasserstoffperoxid, Kaliumperoxodisulfat oder Kaliumperoxomonosulfat Triplesalz.

Abstract translation: 一种用于任选取代的甲苯式（I）的氧化过程，彼此独立地在X，Y和Z是氢，甲基磺酰基，羟基磺酰基，硝基，卤素或任选取代的苯基，以得到式I的相应的苯甲酸（II）其中X， Y和Z如在40-95℃下，在与过氧化氢，过氧化二硫酸钾或钾的过渡金属催化剂的存在下，温度任选如上文所定义，在硫酸peroxomonosulphate三聚盐。