公开(公告)号：WO2008093222A1

公开(公告)日：2008-08-07

申请号：PCT/IB2008/000218

申请日：2008-01-31

Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  LAVALLE, Philippe ,  HEMMERLE, Joseph ,  MERTZ, Damien ,  SCHAAF, Pierre ,  VOEGEL, Jean-Claude

Inventor： LAVALLE, Philippe ,  HEMMERLE, Joseph ,  MERTZ, Damien ,  SCHAAF, Pierre ,  VOEGEL, Jean-Claude

IPC: B05D7/04 ,  B05D1/18 ,  B05D1/36 ,  A61K9/70 ,  C08J7/04

CPC classification number: B05D7/56 ,  A61K9/7007 ,  A61L27/34 ,  A61L27/54 ,  A61L2300/00 ,  A61L2420/08 ,  B05D7/52

Abstract: The invention concerns a mechanically responsive supported polyelectrolyte multilayer film, comprising: - an elastic substrate, on which are alternately coated : - at least one exponentially growing film; and - at least one mechanically responsive barrier film. It further concerns a process for its preparation and the use of such films notably for mechanically responsive mixing or delivery of active substances. It further concerns dosage forms of a drug, biosensors and implants comprising such films.

Abstract translation: 本发明涉及一种机械响应的负载聚电解质多层膜，其包括： - 弹性基材，其上交替地涂覆有：至少一个指数生长膜; 和 - 至少一个机械响应阻挡膜。 它还涉及其制备和使用这种膜的方法，特别是用于机械响应的混合或递送活性物质。 它还涉及药物，生物传感器和包含这种膜的植入物的剂型。

公开(公告)号：WO2006079928A2

公开(公告)日：2006-08-03

申请号：PCT/IB2006000378

申请日：2006-01-31

Applicant: INST NAT SANTE RECH MED ,  CENTRE NAT RECH SCIENT ,  SCHAAF PIERRE ,  JESSEL NADIA ,  OGIER-DIRRIG JOELLE ,  LAVALLE PHILIPPE ,  VOEGEL JEAN-CLAUDE ,  SENGER BERNARD

Inventor： SCHAAF PIERRE ,  JESSEL NADIA ,  OGIER-DIRRIG JOELLE ,  LAVALLE PHILIPPE ,  VOEGEL JEAN-CLAUDE ,  SENGER BERNARD

CPC classification number: A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/80 ,  C08L89/00 ,  C08L77/04

Abstract: The invention relates to polyelectrolyte multilayer films presenting a tunable biological activity and methods for preparing the same. The invention further relates to surfaces presenting such films and uses thereof, such as for the controlled delivery of biologically active agents.

Abstract translation: 本发明涉及具有可调节生物活性的聚电解质多层膜及其制备方法。 本发明还涉及呈现这种膜的表面及其用途，例如用于控制递送生物活性剂。

公开(公告)号：WO2006079928A3

公开(公告)日：2006-08-03

申请号：PCT/IB2006/000378

申请日：2006-01-31

Applicant: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  SCHAAF, Pierre ,  JESSEL, Nadia ,  OGIER-DIRRIG, Joëlle ,  LAVALLE, Philippe ,  VOEGEL, Jean-Claude ,  SENGER, Bernard

Inventor： SCHAAF, Pierre ,  JESSEL, Nadia ,  OGIER-DIRRIG, Joëlle ,  LAVALLE, Philippe ,  VOEGEL, Jean-Claude ,  SENGER, Bernard

IPC: A61L27/34 ,  A61L31/10

Abstract: The invention relates to polyelectrolyte multilayer films presenting a tunable biological activity and methods for preparing the same. The invention further relates to surfaces presenting such films and uses thereof, such as for the controlled delivery of biologically active agents.