公开(公告)号：WO2010102251A2

公开(公告)日：2010-09-10

申请号：PCT/US2010/026424

申请日：2010-03-05

Applicant: ABBOTT LABORATORIES ,  HSIEH, Chung-Ming ,  HUGUNIN, Margaret ,  MURTAZA, Anwar ,  McRAE, Bradford, L. ,  KUTSKOVA, Yuliya ,  MEMMOTT, John, E. ,  PEREZ, Jennifer, M. ,  ZHONG, Suju ,  TARCSA, Edit ,  CLABBERS, Anca ,  WALLACE, Craig ,  BRYANT, Shaughn, H. ,  LEDDY, Mary, R.

Inventor： HSIEH, Chung-Ming ,  HUGUNIN, Margaret ,  MURTAZA, Anwar ,  McRAE, Bradford, L. ,  KUTSKOVA, Yuliya ,  MEMMOTT, John, E. ,  PEREZ, Jennifer, M. ,  ZHONG, Suju ,  TARCSA, Edit ,  CLABBERS, Anca ,  WALLACE, Craig ,  BRYANT, Shaughn, H. ,  LEDDY, Mary, R.

IPC: A61K39/395

CPC classification number: C07K16/468 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2300/00 ,  C07K16/241 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/50 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/386 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/466

Abstract: Proteins that bind IL- 17 and/or IL- 17F are described along with there use in composition and methods for treating, preventing, and diagnosing IL- 17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.

Abstract translation: 与用于治疗，预防和诊断IL-17相关疾病和检测细胞，组织，样品和组合物中的IL-17的组合物和方法一起描述了结合IL-17和/或IL-17F的蛋白质。

公开(公告)号：WO2010102251A3

公开(公告)日：2010-11-25

申请号：PCT/US2010026424

申请日：2010-03-05

Applicant: ABBOTT LAB ,  HSIEH CHUNG-MING ,  HUGUNIN MARGARET ,  MURTAZA ANWAR ,  MCRAE BRADFORD L ,  KUTSKOVA YULIYA ,  MEMMOTT JOHN E ,  PEREZ JENNIFER M ,  ZHONG SUJU ,  TARCSA EDIT ,  CLABBERS ANCA ,  WALLACE CRAIG ,  BRYANT SHAUGHN H ,  LEDDY MARY R

Inventor： HSIEH CHUNG-MING ,  HUGUNIN MARGARET ,  MURTAZA ANWAR ,  MCRAE BRADFORD L ,  KUTSKOVA YULIYA ,  MEMMOTT JOHN E ,  PEREZ JENNIFER M ,  ZHONG SUJU ,  TARCSA EDIT ,  CLABBERS ANCA ,  WALLACE CRAIG ,  BRYANT SHAUGHN H ,  LEDDY MARY R

IPC: A61K39/395

CPC classification number: C07K16/468 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2300/00 ,  C07K16/241 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/50 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92

Abstract: Proteins that bind IL- 17 and/or IL- 17F are described along with there use in composition and methods for treating, preventing, and diagnosing IL- 17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.

Abstract translation: 描述了结合IL-17和/或IL-17F的蛋白以及其在用于治疗，预防和诊断IL-17相关疾病和检测细胞，组织，样品和组合物中的IL-17的组合物和方法中的应用。

公开(公告)号：WO2009106356A1

公开(公告)日：2009-09-03

申请号：PCT/EP2009/001437

申请日：2009-02-27

Applicant: ABBOTT GMBH & CO. KG ,  ABBOTT LABORATORIES ,  MÜLLER, Bernhard, K. ,  SCHMIDT, Martin ,  BARLOW, Eve, H. ,  LEDDY, Mary, R. ,  HSIEH, Chung-ming ,  BARDWELL, Phillip, D.

Inventor： MÜLLER, Bernhard, K. ,  SCHMIDT, Martin ,  BARLOW, Eve, H. ,  LEDDY, Mary, R. ,  HSIEH, Chung-ming ,  BARDWELL, Phillip, D.

IPC: C07K16/22 ,  A61K39/395

CPC classification number: C07K16/22 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/466

Abstract: The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind and neutralize RGM A protein. Specifically, these antibodies have the ability to inhibit the binding of RGM A to its receptor and/or coreceptors. These antibodies or portions thereof of the invention are useful for detecting RGM A and for inhibiting RGM A activity, for example in a human suffering from a disorder including but not limited to multiple sclerosis, mammalian brain trauma, spinal cord injury, stroke, neurodegenerative diseases, and schizophrenia.

Abstract translation: 本发明涉及结合并中和RGM A蛋白的分离的蛋白质，特别是单克隆抗体。 具体地说，这些抗体具有抑制RGM A与其受体和/或共受体结合的能力。 本发明的这些抗体或其部分可用于检测RGM A和抑制RGM A的活性，例如在患有包括但不限于多发性硬化，哺乳动物脑外伤，脊髓损伤，中风，神经变性疾病 和精神分裂症。