公开(公告)号：WO2006029406A3

公开(公告)日：2006-06-22

申请号：PCT/US2005032521

申请日：2005-09-09

Applicant: STRYKER CORP ,  LEE JOHN C ,  TOTH CAROL A

Inventor： LEE JOHN C ,  TOTH CAROL A

IPC: A61K38/18

CPC classification number: A61K38/1875 ,  A61K48/00

Abstract: The present invention provides methods of treating bone cancer, inducing differentiation of bone tumor cells, inhibiting bone tumor growth, inducing bone tumor regression or treating a hyperproliferative cell disorder by administering a pharmaceutically effective amount of a bone morphogenic protein or a nucleic acid encoding the bone morphogenic protein.

Abstract translation: 本发明提供了通过施用药学有效量的骨形态发生蛋白或编码骨的核酸来治疗骨癌，诱导骨肿瘤细胞分化，抑制骨肿瘤生长，诱导骨肿瘤消退或治疗过度增殖性细胞病症的方法 形态发生蛋白。

公开(公告)号：WO1997036474A1

公开(公告)日：1997-10-09

申请号：PCT/US1996001691

申请日：1996-04-01

Applicant: LEE, John, C.

IPC: A01G25/00

CPC classification number: A01G27/02 ,  A01G27/003

Abstract: A self-watering and self-drying planter assembly (10) with a water reservoir (30) open to the air and a top downward system for supplying water into the soil through built-in water-feeding channels, (124, 126 and 128) each having a water-transfer control lever (136) for controlling the quantity of water supplied to the soil in the planter. There is an inner container assembly (100) including an inner container (20) for receiving a plant and soil, an outer container (300) spaced from and surrounding the inner container and defining therebetween a water-receiving chamber (30), and a water-supplying chamber (40) below for receiving water form said water-receiving chamber (30). A float assembly (218) automatically supplies water from the water-receiving chamber (30) to the water-supplying chamber (40).

Abstract translation: 一种具有向空气敞开的储水器（30）和通过内置给水通道（124,126和128）向土壤供水的顶部向下系统的自流水和自干燥播种机组件（10） ），每个都具有用于控制供给到种植机中的土壤的水的量的输水控制杆（136）。 存在内容器组件（100），其包括用于容纳植物和土壤的内部容器（20），与内部容器间隔开并围绕内部容器的外部容器（300），并在其间限定了水接收室（30） 供水室（40），用于从所述吸水室（30）接收水。 浮子组件（218）自动从供水室（30）向供水室（40）供水。

公开(公告)号：WO1995003297A1

公开(公告)日：1995-02-02

申请号：PCT/US1994008297

申请日：1994-07-21

Applicant: SMITHKLINE BEECHAM CORPORATION ,  ADAMS, Jerry, Leroy ,  GALLAGHER, Timothy, Francis ,  LEE, John, C. ,  WHITE, John, Richard

Inventor： SMITHKLINE BEECHAM CORPORATION

IPC: C07D401/04

CPC classification number: C07D401/04 ,  C07D403/04 ,  C07D409/14 ,  C07D495/04

Abstract: Novel 2,4,5-triaryl imidazole compounds and compositions for use in therapy, such as cytokine mediated diseases.

Abstract translation: 新型2,4,5-三芳基咪唑化合物和用于治疗的组合物，例如细胞因子介导的疾病。

公开(公告)号：WO1993014081A1

公开(公告)日：1993-07-22

申请号：PCT/US1993000674

申请日：1993-01-13

Applicant: SMITHKLINE BEECHAM CORPORATION ,  ADAMS, Jerry, Leroy ,  GALLAGHER, Timothy, Francis ,  LEE, John, C. ,  WHITE, John, Richard

Inventor： SMITHKLINE BEECHAM CORPORATION

IPC: C07D401/04

CPC classification number: C07D401/04 ,  C07D403/04 ,  C07D413/14

Abstract: Novel 2,4,5-triarylimidazole compounds and compositions for use in therapy.

Abstract translation: 新型2,4,5-三芳基咪唑化合物和用于治疗的组合物。

公开(公告)号：WO2005077403A1

公开(公告)日：2005-08-25

申请号：PCT/US2005/003229

申请日：2005-02-04

Applicant: STRYKER CORPORATION ,  LEE, John C. ,  YEH, Lee-Chuan C.

Inventor： LEE, John C. ,  YEH, Lee-Chuan C.

IPC: A61K38/18

CPC classification number: A61K38/1841 ,  A61K38/179 ,  A61K38/1875 ,  A61K2300/00

Abstract: Methods of inducing the expression of a Smad in a cell or tissue comprising the step of contacting the cell or tissue capable of expressing the Smad with a bone morphogenic protein are provided. Methods of inducing tissue formation and repairing a tissue defect or regenerating tissue, at a target locus in a mammal comprising the step of administering to the target locus a Smad are also provided.

Abstract translation: 提供诱导细胞或组织中Smad表达的方法，包括使能够表达Smad的细胞或组织与骨形态发生蛋白接触的步骤。 还提供了在哺乳动物的靶标位点诱导组织形成和修复组织缺陷或再生组织的方法，所述方法包括向目标基因座施用Smad的步骤。

公开(公告)号：WO2004004663A2

公开(公告)日：2004-01-15

申请号：PCT/US2003/021697

申请日：2003-07-09

Applicant: STRYKER CORPORATION ,  LEE, John, C. ,  YEH, Lee-Chuan, C.

Inventor： LEE, John, C. ,  YEH, Lee-Chuan, C.

IPC: A61K

CPC classification number: A61L27/3804 ,  A61K35/12 ,  A61K35/32 ,  A61K38/18 ,  A61K38/1875 ,  A61L27/227 ,  A61L27/386 ,  A61L27/3895

Abstract: The present invention provides methods and compositions for treating and repairing ligament defects using a bone morphogenic protein. The present invention provides methods of treating ligament defects, repairing ligament defects, forming ligament tissue, regenerating ligament tissue, and promoting growth of ligament tissue by transplanting into a patient in need thereof ligament cells cultured ex-vivo.

Abstract translation: 本发明提供使用骨形态发生蛋白治疗和修复韧带缺陷的方法和组合物。 本发明提供了治疗韧带缺陷，修复韧带缺损，形成韧带组织，再生韧带组织，以及通过移植到有需要的患者体外培养的韧带细胞来促进韧带组织的生长的方法。

公开(公告)号：WO2006029406A2

公开(公告)日：2006-03-16

申请号：PCT/US2005/032521

申请日：2005-09-09

Applicant: STRYKER CORPORATION ,  LEE, John C. ,  TOTH, Carol A.

Inventor： LEE, John C. ,  TOTH, Carol A.

IPC: A61K38/18

CPC classification number: A61K38/1875 ,  A61K48/00

Abstract: The present invention provides methods of treating bone cancer, inducing differentiation of bone tumor cells, inhibiting bone tumor growth, inducing bone tumor regression or treating a hyperproliferative cell disorder by administering a pharmaceutically effective amount of a bone morphogenic protein or a nucleic acid encoding the bone morphogenic protein.

Abstract translation: 本发明提供了通过施用药学有效量的骨形态发生蛋白或编码骨的核酸来治疗骨癌，诱导骨肿瘤细胞分化，抑制骨肿瘤生长，诱导骨肿瘤消退或治疗过度增殖性细胞病症的方法 形态发生蛋白。

公开(公告)号：WO2005111069A3

公开(公告)日：2006-02-23

申请号：PCT/US2005016426

申请日：2005-05-11

Applicant: STRYKER CORP ,  LEE JOHN C ,  YEH LEE-CHUAN C

Inventor： LEE JOHN C ,  YEH LEE-CHUAN C

IPC: C07K14/51 ,  A61K38/18 ,  A61K38/19 ,  A61K38/20 ,  A61K38/25 ,  A61K38/29 ,  A61K38/30 ,  A61K48/00 ,  A61P19/08 ,  C12N5/077

CPC classification number: A61K48/0058 ,  A61K48/005 ,  C12N5/0654 ,  C12N2501/105 ,  C12N2501/155 ,  C12N2510/00

Abstract: Gene therapy methods for tissue formation, repair and regeneration using nucleic acids encoding morphogenic proteins and morphogenic protein stimulatory factors (MPSFs) are provided.

Abstract translation: 提供了使用编码形态发生蛋白和形态发生蛋白刺激因子（MPSF）的核酸进行组织形成，修复和再生的基因治疗方法。

公开(公告)号：WO1995007922A1

公开(公告)日：1995-03-23

申请号：PCT/US1994010529

申请日：1994-09-16

Applicant: SMITHKLINE BEECHAM CORPORATION ,  LEE, John, C. ,  ADAMS, Jerry, L. ,  GALLAGHER, Timothy, F. ,  GREEN, David, W. ,  HEYS, John, Richard ,  McDONNELL, Peter, C. ,  McNULTY, Dean, E. ,  STRICKLER, James, E. ,  YOUNG, Peter, R.

Inventor： SMITHKLINE BEECHAM CORPORATION

IPC: C07H21/00

CPC classification number: C07K14/705 ,  A61K38/00 ,  C07K14/47 ,  C12N9/12 ,  C12Q1/6876 ,  C12Q2600/136

Abstract: This invention relates to drug binding proteins, to genes encoding same and to assays and methods for screening pharmaceuticals. More specifically, this invention relates to a Cytokine Suppressive Anti-Inflammatory Drug (CSAID) binding protein, to a gene encoding same and to assays and screens useful in the evaluation and characterization of drugs of this pharmacologic class.

Abstract translation: 本发明涉及药物结合蛋白，与编码该基因的基因以及用于筛选药物的测定和方法。 更具体地，本发明涉及细胞因子抑制性抗炎药（CSAID）结合蛋白，涉及编码该基因的基因以及可用于该药理学类药物的评估和表征的测定和筛选。

公开(公告)号：WO2005111069A2

公开(公告)日：2005-11-24

申请号：PCT/US2005/016426

申请日：2005-05-11

Applicant: STRYKER CORPORATION ,  LEE, John C. ,  YEH, Lee-Chuan C.

Inventor： LEE, John C. ,  YEH, Lee-Chuan C.

IPC: C07K14/475

CPC classification number: A61K48/0058 ,  A61K48/005 ,  C12N5/0654 ,  C12N2501/105 ,  C12N2501/155 ,  C12N2510/00

Abstract: Gene therapy methods for tissue formation, repair and regeneration using nucleic acids encoding morphogenic proteins and morphogenic protein stimulatory factors (MPSFs) are provided.

Abstract translation: 提供了使用编码形态发生蛋白和形态发生蛋白刺激因子（MPSF）的核酸进行组织形成，修复和再生的基因治疗方法。